N1, N12-bis(ethyl)spermine (BioDeep_00000900761)
代谢物信息卡片
化学式: C14H38N4+4 (262.3096)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC[NH2+]CCC[NH2+]CCCC[NH2+]CCC[NH2+]CC
InChI: InChI=1S/C14H34N4/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2/h15-18H,3-14H2,1-2H3/p+4
描述信息
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lipika Goyal, Jeffrey G Supko, Jordan Berlin, Lawrence S Blaszkowsky, Amanda Carpenter, Douglas M Heuman, Sarah L Hilderbrand, Keith E Stuart, Scott Cotler, Neil N Senzer, Emily Chan, Carl L Berg, Jeffrey W Clark, Aram F Hezel, David P Ryan, Andrew X Zhu. Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma.
Cancer chemotherapy and pharmacology.
2013 Dec; 72(6):1305-14. doi:
10.1007/s00280-013-2293-8. [PMID: 24121453] - Yanmei Dong, Jing Li, Chao Wu, David Oupický. Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.
Pharmaceutical research.
2010 Sep; 27(9):1927-38. doi:
10.1007/s11095-010-0197-4. [PMID: 20577786] - R Beauchemin, C N N'soukpoé-Kossi, T J Thomas, T Thomas, R Carpentier, H A Tajmir-Riahi. Polyamine analogues bind human serum albumin.
Biomacromolecules.
2007 Oct; 8(10):3177-83. doi:
10.1021/bm700697a. [PMID: 17887793] - Hillary A Hahm, David S Ettinger, Kathy Bowling, Beth Hoker, Tian Ling Chen, Yelena Zabelina, Robert A Casero. Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2002 Mar; 8(3):684-90. doi:
NULL. [PMID: 11895896] - R J Bergeron, R L Merriman, S G Olson, J Wiegand, J Bender, R R Streiff, W R Weimar. Metabolism and pharmacokinetics of N1,N11-diethylnorspermine in a Cebus apella primate model.
Cancer research.
2000 Aug; 60(16):4433-9. doi:
NULL. [PMID: 10969789] - G P Zagaja, M Shrivastav, M J Fleig, L J Marton, C W Rinker-Schaeffer, M E Dolan. Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
Cancer chemotherapy and pharmacology.
1998; 41(6):505-12. doi:
10.1007/s002800050774. [PMID: 9554596] - P J Creaven, R Perez, L Pendyala, N J Meropol, G Loewen, E Levine, E Berghorn, D Raghavan. Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Investigational new drugs.
1997; 15(3):227-34. doi:
10.1023/a:1005827231849. [PMID: 9387045] - R J Bergeron, W R Weimar, G Luchetta, R R Streiff, J Wiegand, J Perrin, K M Schreier, C Porter, G W Yao, H Dimova. Metabolism and pharmacokinetics of N1,N11-diethylnorspermine.
Drug metabolism and disposition: the biological fate of chemicals.
1995 Oct; 23(10):1117-25. doi:
NULL. [PMID: 8654201] - P M Kanter, G A Bullard, J M King. Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs.
Anti-cancer drugs.
1994 Aug; 5(4):448-56. doi:
10.1097/00001813-199408000-00010. [PMID: 7949250] - C W Porter, R J Bernacki, J Miller, R J Bergeron. Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Cancer research.
1993 Feb; 53(3):581-6. doi:
NULL. [PMID: 8425191]
