4-carbamoyl-1-(5-O-phosphonato-beta-D-ribofuranosyl)-1H-imidazol-3-ium-5-olate (BioDeep_00000900469)
代谢物信息卡片
4-carbamoyl-1-(5-O-phosphonato-beta-D-ribofuranosyl)-1H-imidazol-3-ium-5-olate
化学式: C9H12N3O9P-2 (337.0311152)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=C(N1C2C(C(C(O2)COP(=O)([O-])[O-])O)O)O)C(=O)N
InChI: InChI=1S/C9H14N3O9P/c10-7(15)4-8(16)12(2-11-4)9-6(14)5(13)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,13-14,16H,1H2,(H2,10,15)(H2,17,18,19)/p-2/t3-,5-,6-,9-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(6)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li, Jinsong Chen. Conversion from mycophenolate mofetil to mizoribine in the early stages of BK polyomavirus infection could improve kidney allograft prognosis: a single-center study from China.
BMC nephrology.
2021 10; 22(1):328. doi:
10.1186/s12882-021-02527-3. [PMID: 34600511] - Xichao Wang, Miaomiao Zhang, Wenyu Zhang, Ying Liu, Yingying Han, Wenxiu Chang. Effect of mizoribine pulse therapy in adult membranous nephropathy.
International urology and nephrology.
2021 Apr; 53(4):725-731. doi:
10.1007/s11255-020-02680-y. [PMID: 33159256] - Hikaru Sugimoto, Shiho Matsuno, Noriko Yamanaka, Wako Yumura, Mitsuyo Itabashi, Takashi Takei. Low-dose corticosteroid with mizoribine might be an effective therapy for elderly-onset ISKDC grade VI IgA vasculitis.
CEN case reports.
2021 02; 10(1):46-52. doi:
10.1007/s13730-020-00513-6. [PMID: 32754805] - Rui Dai, Jingjie Li, Jingjing Wu, Qian Fu, Jiajia Yan, Guoping Zhong, Changxi Wang, Xiao Chen, Pan Chen. Genetic and clinical determinants of mizoribine pharmacokinetics in renal transplant recipients.
European journal of clinical pharmacology.
2021 Jan; 77(1):45-53. doi:
10.1007/s00228-020-02936-7. [PMID: 32803290] - Shuichiro Fujinaga, Akira Mizutani. Should rituximab be administered before cyclophosphamide as a first-line steroid-sparing agent to young children with steroid-dependent nephrotic syndrome?.
Clinical and experimental nephrology.
2020 Dec; 24(12):1187-1188. doi:
10.1007/s10157-020-01938-0. [PMID: 32728924] - Hrvoje Jakovac. COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?.
American journal of physiology. Heart and circulatory physiology.
2020 10; 319(4):H793-H796. doi:
10.1152/ajpheart.00506.2020. [PMID: 32886002] - Patrizia Natale, Suetonia C Palmer, Marinella Ruospo, Valeria M Saglimbene, Jonathan C Craig, Mariacristina Vecchio, Joshua A Samuels, Donald A Molony, Francesco Paolo Schena, Giovanni Fm Strippoli. Immunosuppressive agents for treating IgA nephropathy.
The Cochrane database of systematic reviews.
2020 03; 3(?):CD003965. doi:
10.1002/14651858.cd003965.pub3. [PMID: 32162319] - Keisuke Sugimoto, Takuji Enya, Kohei Miyazaki, Tomoki Miyazawa, Tsukasa Takemura, Mitsuru Okada. Membranoproliferative glomerulonephritis related to a streptococcal infection in a girl with IgA deficiency: a case report.
BMC nephrology.
2020 02; 21(1):68. doi:
10.1186/s12882-020-01735-7. [PMID: 32103732] - Zhiguo Peng, Wanhua Xian, Huaibin Sun, Engang Li, Lina Geng, Jun Tian. Efficacy and Safety of a Quadruple Regimen Compared with Triple Regimens in Patients with Mycophenolic Acid-Related Gastrointestinal Complications After Renal Transplantation: A Short-Term Single-Center Study.
Annals of transplantation.
2020 Feb; 25(?):e919875. doi:
10.12659/aot.919875. [PMID: 32107364] - Yuki Ikeda, Kenichi Fukunari, Saori Uchiumi, Yuki Awanami, Akiko Kanaya, Keiichiro Matsumoto, Makoto Fukuda, Tsuyoshi Takashima, Motoaki Miyazono, Yuji Ikeda. A case of anti-neutrophil cytoplasmic antibody-associated vasculitis with anti-glomerular basement membrane antibodies that was successfully treated with mizoribine as a safe and effective remission maintenance therapy with prednisolone and plasma exchange.
CEN case reports.
2020 02; 9(1):42-47. doi:
10.1007/s13730-019-00423-2. [PMID: 31612361] - Dongyeol Lee, Hee Yeoun Kim, Jin Ho Lee, Yong Hun Sin, Joong Kyung Kim, Joon Seok Oh. Long-term Survival Analysis of Kidney Transplant Recipients Receiving Mizoribine as a Maintenance Immunosuppressant: A Single-Center Study.
Transplantation proceedings.
2019 Oct; 51(8):2637-2642. doi:
10.1016/j.transproceed.2019.03.060. [PMID: 31349984] - Tomomi Kondoh, Yohei Ikezumi, Katsuyuki Yokoi, Yoko Nakajima, Yuji Matsumoto, Masahiro Kaneko, Hiroya Hasegawa, Takeshi Yamada, Naonori Kumagai, Tetsuya Ito, Tetsushi Yoshikawa. Assessment of factors associated with mizoribine responsiveness in children with steroid-dependent nephrotic syndrome.
Clinical and experimental nephrology.
2019 Sep; 23(9):1154-1160. doi:
10.1007/s10157-019-01754-1. [PMID: 31187341] - Yuka Kurokawa, Kiyomi Koike, Yusuke Kaida, Sakuya Ito, Hirotane Chiba, Kengo Urae, Tomofumi Moriyama, Nao Nakamura, Tetsurou Imai, Ryo Shibata, Takuma Hazama, Daisuke Wakasugi, Seiya Okuda, Kei Fukami. Effectiveness of cryofiltration and mizoribine combination with oral steroid therapy in a patient with membranoproliferative glomerulonephritis due to essential cryoglobulinemia.
CEN case reports.
2019 08; 8(3):205-211. doi:
10.1007/s13730-019-00394-4. [PMID: 30927247] - Yi Shi, Hang Liu, Xin-Guo Chen, Zhong-Yang Shen. Efficacy and Safety of Mizoribine Combined With Tacrolimus in Living Donor Kidney Transplant Recipients: 3-Year Results by a Chinese Single Center Study.
Transplantation proceedings.
2019 Jun; 51(5):1337-1342. doi:
10.1016/j.transproceed.2019.03.014. [PMID: 31155174] - Zheng-Kun Xia, Yuan-Fu Gao, Li-Ping Rong, Xi-Qiang Dang, Qian Shen, Xiao-Yun Jiang, Zhu-Wen Yi, Hong Xu. Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China.
World journal of pediatrics : WJP.
2019 Jun; 15(3):262-269. doi:
10.1007/s12519-019-00241-7. [PMID: 30864060] - Yi Shi, Hang Liu, Xin-Guo Chen, Zhong-Yang Shen. Hyperuricemia in Living Donor Kidney Transplantation Patients During Mizoribine Administration Caused Mainly by Changes in Kidney Function.
Transplantation proceedings.
2019 Jun; 51(5):1392-1396. doi:
10.1016/j.transproceed.2019.01.133. [PMID: 31155176] - Pan Chen, Xuan Xu, Longshan Liu, Jingjing Wu, Jingjie Li, Qian Fu, Jie Chen, Changxi Wang. Prediction of mizoribine pharmacokinetic parameters by serum creatinine in renal transplant recipients.
European journal of clinical pharmacology.
2019 Mar; 75(3):363-369. doi:
10.1007/s00228-018-2584-4. [PMID: 30386911] - X Yuan, C Chen, Y Zheng, C Wang. Conversion From Mycophenolates to Mizoribine Is Associated With Lower BK Virus Load in Kidney Transplant Recipients: A Prospective Study.
Transplantation proceedings.
2018 Dec; 50(10):3356-3360. doi:
10.1016/j.transproceed.2018.01.059. [PMID: 30577207] - Yuko Shima, Koichi Nakanishi, Yoshitsugu Kaku, Kenji Ishikura, Hiroshi Hataya, Takeshi Matsuyama, Masataka Honda, Mayumi Sako, Kandai Nozu, Ryojiro Tanaka, Kazumoto Iijima, Norishige Yoshikawa. Combination therapy with or without warfarin and dipyridamole for severe childhood IgA nephropathy: an RCT.
Pediatric nephrology (Berlin, Germany).
2018 11; 33(11):2103-2112. doi:
10.1007/s00467-018-4011-6. [PMID: 29987456] - Ayumi Ishiwatari, Mariko Endo, Sachiko Wakai. Ruptured renal artery in microscopic polyangiitis: a case report and literature review.
CEN case reports.
2018 11; 7(2):301-306. doi:
10.1007/s13730-018-0347-9. [PMID: 29951966] - Akiko Mii, Akira Shimizu, Daisuke Takada, Shuichi Tsuruoka. Proliferative glomerulonephritis with unusual microlamellar organized deposits related to monoclonal immunoglobulin G3 (IgG3) kappa.
CEN case reports.
2018 11; 7(2):320-324. doi:
10.1007/s13730-018-0351-0. [PMID: 29987665] - Keisuke Oda, Nobuhiro Mori, Masayoshi Okumi, Miyuki Furusawa, Masashi Ishiguro, Kazuyuki Inoue, Satoshi Shuto, Kohei Unagami, Hideki Ishida, Kazunari Tanabe, Teruo Murakami. Uptake and metabolism of mizoribine, an immunosuppressant, in L5178Y-R mouse lymphoma cells in vitro and peripheral blood mononuclear cells of rats and kidney transplant recipients in vivo.
Drug metabolism and pharmacokinetics.
2018 Oct; 33(5):232-239. doi:
10.1016/j.dmpk.2018.08.007. [PMID: 30241694] - L Liu, B Ren, H Zhang, J Li, Q Fu, J Jiang, S Deng, J Qiu, G Chen, J Fei, L Chen, C Wang. Population Pharmacokinetic Analysis of Mizoribine in Chinese Renal Transplant Recipients.
Transplantation proceedings.
2018 Oct; 50(8):2392-2397. doi:
10.1016/j.transproceed.2018.03.030. [PMID: 30316364] - Yasumori Izumi, Kenjiro Nakaoka, Masatsugu Kamata, Nozomi Iwanaga, Shunsuke Imadachi, Hirokazu Kurohama, Masahiro Ito, Kiyoshi Migita. Steroid-resistant protein-losing gastroenteropathy complicated with Sjögren's syndrome successfully treated with mizoribine.
Modern rheumatology.
2018 Jul; 28(4):716-720. doi:
10.3109/14397595.2016.1145570. [PMID: 26872871] - Y Maruyama, T Sadahira, Y Mitsui, K Wada, R Tanimoto, S Nishimura, Y Kobayashi, T Watanabe, Y Nasu, M Araki. Acute Inflammatory Syndrome Paradoxically Induced by De Novo Purine Inhibitors Synthesis Before Renal Transplantation: A Case Report and Review of the Literature.
Transplantation proceedings.
2018 Apr; 50(3):895-897. doi:
10.1016/j.transproceed.2017.12.030. [PMID: 29571743] - Tsukasa Nishioka, Norio Yoshimura, Hidetaka Ushigome, Yoshihiko Watarai, Kenji Nishimura, Kiyokazu Akioka, Nobuyuki Nakamura, Mutsushi Kawakita, Kenji Yuzawa, Tatsuya Nakatani. High-dose mizoribine combined with calcineurin inhibitor (cyclosporine or tacrolimus), basiliximab and corticosteroids for renal transplantation: A Japanese multicenter study.
International journal of urology : official journal of the Japanese Urological Association.
2018 02; 25(2):141-145. doi:
10.1111/iju.13476. [PMID: 29068092] - Yukihiko Kawasaki, Ryo Maeda, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya. Serum IgA/C3 and glomerular C3 staining predict severity of IgA nephropathy.
Pediatrics international : official journal of the Japan Pediatric Society.
2018 Feb; 60(2):162-167. doi:
10.1111/ped.13461. [PMID: 29178575] - Tsutomu Takeuchi, Kenya Okada, Hisao Yoshida, Nobuyuki Yagi. Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results.
Modern rheumatology.
2018 Jan; 28(1):85-94. doi:
10.1080/14397595.2017.1349573. [PMID: 28722500] - Jumpei Hasegawa, Shuji Hatakeyama, Sachiko Wakai, Kazuya Omoto, Masayoshi Okumi, Kazunari Tanabe, Makiko Mieno, Hiroki Shirakawa. Preemptive anti-cytomegalovirus therapy in high-risk (donor-positive, recipient-negative cytomegalovirus serostatus) kidney transplant recipients.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2017 Dec; 65(?):50-56. doi:
10.1016/j.ijid.2017.09.023. [PMID: 28986314] - Takao Saito, Masayuki Iwano, Koichi Matsumoto, Tetsuya Mitarai, Hitoshi Yokoyama, Noriaki Yorioka, Shinichi Nishi, Ashio Yoshimura, Hiroshi Sato, Satoru Ogahara, Yoshie Sasatomi, Yasufumi Kataoka, Shiro Ueda, Akio Koyama, Shoichi Maruyama, Masaomi Nangaku, Enyu Imai, Seiichi Matsuo, Yasuhiko Tomino. Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome.
Clinical and experimental nephrology.
2017 Dec; 21(6):961-970. doi:
10.1007/s10157-016-1340-2. [PMID: 27783276] - Takuhito Nagai, Osamu Uemura, Hisashi Kaneda, Katsumi Ushijima, Kazuhide Ohta, Yoshimitsu Gotoh, Kenichi Satomura, Masaki Shimizu, Mikiya Fujieda, Masashi Morooka, Takuji Yamada, Masayoshi Yamada, Naohiro Wada, Yukiya Hashimoto. The true distribution volume and bioavailability of mizoribine in children with chronic kidney disease.
Clinical and experimental nephrology.
2017 Oct; 21(5):884-888. doi:
10.1007/s10157-016-1353-x. [PMID: 27873037] - Akira Mima. Efficacy of mizoribine and prednisolone combination therapy in adult patients with IgA vasculitis.
Rheumatology international.
2017 Aug; 37(8):1387-1393. doi:
10.1007/s00296-017-3685-6. [PMID: 28255645] - S Harada, T Nakamura, H Ushigome, N Akutsu, K Akioka, T Nakatani, N Yoshimura. Beneficial Effects of High-Dose Mizoribine on ABO-Incompatible Living-Related Kidney Transplantation: Two-Year Results by a Japanese Multicenter Study.
Transplantation proceedings.
2017 Jun; 49(5):967-970. doi:
10.1016/j.transproceed.2017.03.033. [PMID: 28583569] - Keigo Ikeda, Kozo Watanabe, Takuya Hirai, Kana Tanji, Tomoko Miyashita, Shihoko Nakajima, Kaori Uomori, Shinji Morimoto, Kenji Takamori, Hideoki Ogawa, Yoshinari Takasaki, Iwao Sekigawa. Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies.
Internal medicine (Tokyo, Japan).
2017; 56(10):1147-1152. doi:
10.2169/internalmedicine.56.7886. [PMID: 28502927] - Y Shi, H Liu, X-G Chen, Z-Y Shen. Comparison of Mizoribine and Mycophenolate Mofetil With a Tacrolimus-Based Immunosuppressive Regimen in Living-Donor Kidney Transplantation Recipients: A Retrospective Study in China.
Transplantation proceedings.
2017 Jan; 49(1):26-31. doi:
10.1016/j.transproceed.2016.10.018. [PMID: 28104150] - N Nakamura, T Miyazaki, H Matsuzaki, R Furuya, S Miyajima, S Irie, H Matsuoka, M Tanaka. Experience of Quatro-Therapy With Everolimus to Minimize Calcineurin Inhibitor for Kidney Transplant Recipients.
Transplantation proceedings.
2017 Jan; 49(1):32-36. doi:
10.1016/j.transproceed.2016.11.005. [PMID: 28104152] - Takuya Hirai, Keigo Ikeda, Maki Fujishiro, Hiroshi Tsushima, Kunihiro Hayakawa, Satoshi Suzuki, Ayako Yamaguchi, Kazuhisa Nozawa, Shinji Morimoto, Yoshinari Takasaki, Hideoki Ogawa, Kenji Takamori, Naoto Tamura, Iwao Sekigawa. The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study.
Clinical rheumatology.
2017 Jan; 36(1):51-58. doi:
10.1007/s10067-016-3458-8. [PMID: 27783236] - K Akioka, T Ishikawa, M Osaka, Y Kadotani, K Okugawa, K Nakano, Y Osaka, K Tsuchiya, H Sako. Hyperuricemia and Acute Renal Failure in Renal Transplant Recipients Treated With High-Dose Mizoribine.
Transplantation proceedings.
2017 Jan; 49(1):73-77. doi:
10.1016/j.transproceed.2016.11.015. [PMID: 28104163] - Kosuke Masutani, Akihiro Tsuchimoto, Tomomi Yamada, Makoto Hirakawa, Koji Mitsuiki, Ritsuko Katafuchi, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya. Comparison of steroid-pulse therapy and combined with mizoribine in IgA nephropathy: a randomized controlled trial.
Clinical and experimental nephrology.
2016 Dec; 20(6):896-903. doi:
10.1007/s10157-016-1226-3. [PMID: 26758039] - Hisashi Kaneda, Masaki Shimizu, Kazuhide Ohta, Katsumi Ushijima, Yoshimitsu Gotoh, Kenichi Satomura, Takuhito Nagai, Mikiya Fujieda, Masashi Morooka, Takuji Yamada, Masayoshi Yamada, Naohiro Wada, Mari Takaai, Yukiya Hashimoto, Osamu Uemura. Population pharmacokinetics of mizoribine in pediatric patients with kidney disease.
Clinical and experimental nephrology.
2016 Oct; 20(5):757-763. doi:
10.1007/s10157-015-1209-9. [PMID: 26649561] - Hideki Ishida, Shiro Takahara, Noritoshi Amada, Shinji Tomikawa, Tatsuya Chikaraishi, Kota Takahashi, Kazuhiro Uchida, Takahiro Akiyama, Kazunari Tanabe, Hiroshi Toma. A Prospective Randomized, Comparative Trial of High-Dose Mizoribine Versus Mycophenolate Mofetil in Combination With Tacrolimus and Basiliximab for Living Donor Renal Transplant: A Multicenter Trial.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2016 Oct; 14(5):518-525. doi:
NULL. [PMID: 27733107] - Kimberly Trotter, Marcus R Clark, Vladimir M Liarski. Overview of pathophysiology and treatment of human lupus nephritis.
Current opinion in rheumatology.
2016 09; 28(5):460-7. doi:
10.1097/bor.0000000000000319. [PMID: 27341623] - Jishi Liu, Ke Zhang, Ying Ji, Wei Zhang, Wei Li, Qing Yong, Jianwen Wang, Jian Sun, Hao Zhang. Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study.
Renal failure.
2016 Jun; 38(5):723-7. doi:
10.3109/0886022x.2016.1158035. [PMID: 26983690] - Xichao Wang, Xinyuan Song, Ying Liu, Wenyu Zhang, Wenwen An, Yangke Tu. Treatment of membranous nephropathy with mizoribine: A control trial.
Life sciences.
2016 Jun; 154(?):75-8. doi:
10.1016/j.lfs.2016.04.012. [PMID: 27079740] - N Yoshimura, T Nakao, T Nakamura, S Harada, K Koshino, T Suzuki, T Ito, S Nobori, H Ushigome. Effectiveness of the Combination of Everolimus and Tacrolimus With High Dosage of Mizoribine for Living Donor-Related Kidney Transplantation.
Transplantation proceedings.
2016 Apr; 48(3):786-9. doi:
10.1016/j.transproceed.2015.12.102. [PMID: 27234736] - H Ushigome, K Uchida, K Nishimura, K Akioka, Y Fukuda, K Yuzawa, M Fujisawa, A Sugitani, S-I Ito, T Nakatani, T Horimi, N Yoshimura. Efficacy and Safety of High-Dose Mizoribine Combined With Cyclosporine, Basiliximab, and Corticosteroids in Renal Transplantation: A Japanese Multicenter Study.
Transplantation proceedings.
2016 Apr; 48(3):794-8. doi:
10.1016/j.transproceed.2015.12.117. [PMID: 27234738] - Ji Hong Kim, Yeon Hee Lee, Beom Jin Lim, Hyeon Joo Jeong, Pyung Kil Kim, Jae Il Shin. Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats.
Scientific reports.
2016 Mar; 6(?):22374. doi:
10.1038/srep22374. [PMID: 26947764] - Yuan Feng, Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Jianhua Qin, Kexin Liu. Bezafibrate-mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Jan; 81(?):119-28. doi:
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Internal medicine (Tokyo, Japan).
2016; 55(15):2005-10. doi:
10.2169/internalmedicine.55.5968. [PMID: 27477406] - Norihiko Sakai, Takashi Wada. [Immunosuppressants-induced kidney injury].
Nihon Jinzo Gakkai shi.
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Clinical and experimental nephrology.
2015 Jun; 19(3):496-505. doi:
10.1007/s10157-014-1022-x. [PMID: 25230687] - Hiroshi Tanaka, Kazushi Tsuruga, Taddatsu Imaizumi. Mizoribine in the treatment of pediatric-onset glomerular disease.
World journal of pediatrics : WJP.
2015 May; 11(2):108-12. doi:
10.1007/s12519-015-0013-7. [PMID: 25754750] - N Ichimaru, K Yamanaka, T Kato, Y Kakuta, T Abe, R Imamura, N Nonomura, J-Y Kaimori, S Takahara. Risk factors and incidence for lipid abnormalities in kidney transplant patients.
Transplantation proceedings.
2015 Apr; 47(3):672-4. doi:
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International urology and nephrology.
2015 Jan; 47(1):131-5. doi:
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Nature reviews. Nephrology.
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Modern rheumatology.
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Nephrology (Carlton, Vic.).
2014 Jul; 19(7):384-91. doi:
10.1111/nep.12232. [PMID: 24646214] - Shuai Xing, Jun Yang, Xue Zhang, Ping Zhou. Comparative efficacy and safety of mizoribine with mycophenolate mofetil for Asian renal transplantation--a meta-analysis.
Clinical biochemistry.
2014 May; 47(7-8):663-9. doi:
10.1016/j.clinbiochem.2014.01.014. [PMID: 24463228] - Koji Sakuraya, Amane Endo, Tomonosuke Someya, Daishi Hirano, Yayoi Murano, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu. The synergistic effect of mizoribine and a direct renin inhibitor, aliskiren, on unilateral ureteral obstruction induced renal fibrosis in rats.
The Journal of urology.
2014 Apr; 191(4):1139-46. doi:
10.1016/j.juro.2013.10.053. [PMID: 24140549] - Toshiki Doi, Shigehiro Doi, Ayumu Nakashima, Toshinori Ueno, Yukio Yokoyama, Nobuoki Kohno, Takao Masaki. Mizoribine ameliorates renal injury and hypertension along with the attenuation of renal caspase-1 expression in aldosterone-salt-treated rats.
PloS one.
2014; 9(4):e93513. doi:
10.1371/journal.pone.0093513. [PMID: 24695748] - Xuebing Feng, Fei Gu, Weiwei Chen, Yan Liu, Hua Wei, Lin Liu, Songlou Yin, Zhanyun Da, Lingyun Sun. Mizoribine versus mycophenolate mofetil or intravenous cyclophosphamide for induction treatment of active lupus nephritis.
Chinese medical journal.
2014; 127(21):3718-23. doi:
NULL. [PMID: 25382325] - Amane Endo, Tomonosuke Someya, Mayu Nakagawa, Yayoi Murano, Koji Sakuraya, Satoshi Hara, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Hitohiko Murakami, Toshiaki Shimizu. Synergistic protective effects of mizoribine and angiotensin II receptor blockade on cyclosporine A nephropathy in rats.
Pediatric research.
2014 Jan; 75(1-1):38-44. doi:
10.1038/pr.2013.169. [PMID: 24121426] - Naoya Horimoto, Shinji Kitamura, Kenji Tsuji, Hirofumi Makino. Mizoribine inhibits the proliferation of renal stem/progenitor cells by G1/S arrest during renal regeneration.
Acta medica Okayama.
2014; 68(1):7-15. doi:
10.18926/amo/52138. [PMID: 24553483] - N Yoshimura, H Ushigome, S Nobori, T Suzuki, K Sakai, K Koshino, T Nakamura, T Nakao, S Harada, T Ito. Usefulness and safety of high-dose mizoribine on ABO-incompatible living related kidney transplantation using anti-CD20 and anti-CD25 antibodies without splenectomy: 3-year results.
Transplantation proceedings.
2014; 46(2):391-4. doi:
10.1016/j.transproceed.2013.10.061. [PMID: 24655971] - Shiro Takahara, Kota Takahashi, Takahiro Akiyama, Kazuharu Uchida, Kazunari Tanabe, Noritoshi Amada, Hiroshi Toma. Randomized comparative trial of mizoribine versus mycophenolate mofetil in combination with tacrolimus for living donor renal transplantation.
Clinical and experimental nephrology.
2013 Dec; 17(6):899-904. doi:
10.1007/s10157-013-0780-1. [PMID: 23430390] - Nanthiya Pravitsitthikul, Narelle S Willis, Elisabeth M Hodson, Jonathan C Craig. Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2013 Oct; ?(10):CD002290. doi:
10.1002/14651858.cd002290.pub4. [PMID: 24166716] - Tomokazu Nagao, Reina Kusunoki, Chiaki Iwamura, Shigeto Kobayashi, Wako Yumura, Yosuke Kameoka, Toshinori Nakayama, Kazuo Suzuki. Correlation of interleukin-6 and monocyte chemotactic protein-1 concentrations with crescent formation and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody titer in SCG/Kj mice by treatment with anti-interleukin-6 receptor antibody or mizoribine.
Microbiology and immunology.
2013 Sep; 57(9):640-50. doi:
10.1111/1348-0421.12080. [PMID: 23829825] - K Akioka, K Masuda, S Harada, T Nakamura, K Okugawa, K Nakano, Y Osaka, K Tsuchiya, H Sako. Acute renal failure caused by hyperuremic acidemia in ABO-incompatible kidney transplant maintained with cyclosporine and high-dose mizoribine: a case report.
Transplantation proceedings.
2013 Sep; 45(7):2815-8. doi:
10.1016/j.transproceed.2013.03.052. [PMID: 24034056] - B Ren, X H Fu, Z H Zhang, L Huang, C X Wang, X Chen. Determination of mizoribine in human plasma using high-performance liquid chromatography: application to a pharmacokinetic study in Chinese renal transplant recipients.
Drug research.
2013 Jul; 63(7):376-81. doi:
10.1055/s-0033-1341499. [PMID: 23585305] - M K Ju, K H Huh, K T Park, S J Kim, B H Cho, C D Kim, B J So, C M Kang, S Lee, D J Joo, Y S Kim. Mizoribine versus mycophenolate mofetil in combination therapy with tacrolimus for de novo kidney transplantation: evaluation of efficacy and safety.
Transplantation proceedings.
2013 May; 45(4):1481-6. doi:
10.1016/j.transproceed.2012.12.028. [PMID: 23726602] - N Yoshimura, H Ushigome, S Nobori, T Suzuki, K Sakai, K Koshino, H Okajima, M Okamoto. Excellent results of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids in renal transplant recipients--4-year results.
Transplantation proceedings.
2013 May; 45(4):1472-5. doi:
10.1016/j.transproceed.2013.01.055. [PMID: 23726600] - Y Oshiro, K Nakagawa, K Hoshinaga, A Aikawa, S Shishido, K Yoshida, T Asano, M Murai, A Hasegawa. A Japanese multicenter study of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroid in renal transplantation (the fourth report).
Transplantation proceedings.
2013 May; 45(4):1476-80. doi:
10.1016/j.transproceed.2013.03.016. [PMID: 23726601] - Xin Zhang, Shangxi Fu, Shu Han, Xueyang Zheng, Liming Wang. The argument for the use of mizoribine in renal transplantation: a meta-analysis and systemic review.
Transplant immunology.
2013 Mar; 28(2-3):106-11. doi:
10.1016/j.trim.2012.12.003. [PMID: 23313278] - Shigeaki Nakazawa, Ryoichi Imamura, Yoshiyuki Yamamoto, Takuji Hayashi, Go Tanigawa, Kazutoshi Fujita, Masahiro Hosomi, Seiji Yamaguchi. [Hyperuricemia and acute kidney injury following kidney transplantation : a case report].
Hinyokika kiyo. Acta urologica Japonica.
2013 Feb; 59(2):103-6. doi:
NULL. [PMID: 23552752] - Norio Yoshimura, Hidetaka Ushigome, Kiyokazu Akioka, Syuuji Nobori, Tomoyuki Suzuki, Kazuki Sakai, Masahiko Okamoto. The beneficial effect of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids on CMV infection in renal transplant recipients.
Clinical and experimental nephrology.
2013 Feb; 17(1):127-33. doi:
10.1007/s10157-012-0669-4. [PMID: 23011290] - Kazuya Ishida, Miki Fukao, Hitomi Watanabe, Masato Taguchi, Toshio Miyawaki, Hiroyoshi Matsukura, Osamu Uemura, Zufei Zhang, Jashvant D Unadkat, Yukiya Hashimoto. Effect of salt intake on bioavailability of mizoribine in healthy Japanese males.
Drug metabolism and pharmacokinetics.
2013; 28(1):75-80. doi:
10.2133/dmpk.dmpk-12-nt-043. [PMID: 22813716] - Masabumi Yoshino, Naoto Miura, Takahiro Ohnishi, Keisuke Suzuki, Wataru Kitagawa, Kazuhiro Nishikawa, Hirokazu Imai. Clinicopathological analysis of glomerulopathy with fibronectin deposits (GFND): a case of sporadic, elderly-onset GFND with codeposition of IgA, C1q, and fibrinogen.
Internal medicine (Tokyo, Japan).
2013; 52(15):1715-20. doi:
10.2169/internalmedicine.52.0046. [PMID: 23903505] - Tomohiro Kaneko, Akira Shimizu, Shuichi Tsuruoka, Yasuhiko Iino, Yasuo Katayama. Efficacy of steroid pulse therapy in combination with mizoribine following tonsillectomy for immunoglobulin A nephropathy in renally impaired patients.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2013; 80(4):279-86. doi:
10.1272/jnms.80.279. [PMID: 23995570] - X Ding, X Zhu, Y Zhang, L Zhang, M Cheng, Y Yu, L Xu, G Li. Influence of serum uric acid levels in response to the conversion from mycophenolate mofetil to mizoribine in kidney transplant recipients.
Transplantation proceedings.
2013 Jan; 45(1):190-3. doi:
10.1016/j.transproceed.2012.10.030. [PMID: 23375297] - Maki Kabara, Naoki Nakagawa, Motoki Matsuki, Junko Chinda, Takayuki Fujino, Naoyuki Hasebe. Mizoribine for crescentic glomerulonephritis with sarcoidosis: effectiveness not only for urinalysis abnormalities but also for hilar lymph node enlargement.
Modern rheumatology.
2013 Jan; 23(1):146-50. doi:
10.1007/s10165-012-0614-0. [PMID: 22350640] - Eiko Nishi, Hideto Kameda, Hiroe Ogawa, Hayato Nagasawa, Hirofumi Takei, Ayumi Okuyama, Takahiko Kurasawa, Tsuneo Kondo, Koji Nishimura, Yuichiro Shirai, Ryota Sakai, Tatsuya Ito, Tsutomu Takeuchi, Koichi Amano. Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis.
Modern rheumatology.
2013 Jan; 23(1):97-103. doi:
10.1007/s10165-012-0645-6. [PMID: 22526831] - Toshiya Fuke, Yoshifusa Abe, Satoshi Hibino, Mikawa Takeshi, Takako Saito, Shunsuke Sakurai, Shuichiro Watanabe, Jun-ichiro Murayama, Kazuo Itabashi, Yasuko Nakano. Mizoribine requires individual dosing due to variation of bioavailability.
Pediatrics international : official journal of the Japan Pediatric Society.
2012 Dec; 54(6):885-91. doi:
10.1111/j.1442-200x.2012.03733.x. [PMID: 23039376] - Hidetoshi Kagawa, Tsutomu Hiromasa, Takayuki Hara, Ayako Takaki, Ryutaro Yamanaka, Ken-ei Sada, Hirofumi Makino. Mizoribine, tacrolimus, and corticosteroid combination therapy successfully induces remission in patients with lupus nephritis.
Clinical and experimental nephrology.
2012 Oct; 16(5):760-6. doi:
10.1007/s10157-012-0632-4. [PMID: 22492013] - Kazuya Ishida, Osamu Motoyama, Seiichiro Shishido, Kazuo Tsuzuki, Yukiya Hashimoto. Population pharmacokinetics of mizoribine in pediatric recipients of renal transplantation.
Clinical and experimental nephrology.
2012 Oct; 16(5):799-804. doi:
10.1007/s10157-012-0616-4. [PMID: 22367565] - Takashi Hashimoto, Tamihiro Kawakami, Norito Ishii, Kaori Ishii, Tadashi Karashima, Takekuni Nakama, Daisuke Tsuruta, Teruki Dainichi, Michihiro Hide, Takahiro Hamada. Mizoribine treatment for antihistamine-resistant chronic autoimmune urticaria.
Dermatologic therapy.
2012 Jul; 25(4):379-81. doi:
10.1111/j.1529-8019.2012.01468.x. [PMID: 22950565] - M Shinoda, M Tanabe, S Kawachi, Y Ono, T Hayakawa, O Iketani, M Kojima, O Itano, H Obara, M Kitago, T Hibi, K Matsubara, N Shimojima, Y Fuchimoto, K Hoshino, G Wakabayashi, M Shimazu, Y Tanigawara, T Kuroda, Y Morikawa, M Kitajima, Y Kitagawa. Pharmacokinetics of mizoribine in adult living donor liver transplantation.
Transplantation proceedings.
2012 Jun; 44(5):1329-35. doi:
10.1016/j.transproceed.2012.01.139. [PMID: 22664010] - Kohei Miyazaki, Keisuke Sugimoto, Shoji Tsuji, Anna Iharada, Shinsuke Fujita, Hidehiko Yanagida, Naoki Sakata, Mitsuru Okada, Kazunari Kaneko, Tsukasa Takemura. GSTT1 gene abnormality in minimal change nephrotic syndrome with elevated serum immunoglobulin E.
Clinical nephrology.
2012 Apr; 77(4):261-6. doi:
10.5414/cn107187. [PMID: 22445468] - Naohiko Fukami, Vijay Subramanian, Nataraju Angaswamy, Wei Liu, T Mohanakumar, Kiyotaka Hoshinaga. Mizoribine--an inosine monophosphate dehydrogenase inhibitor--acts synergistically with cyclosporine A in prolonging survival of murine islet cell and heart transplants across major histocompatibility barrier.
Transplant immunology.
2012 Mar; 26(2-3):140-5. doi:
10.1016/j.trim.2011.10.007. [PMID: 22085688] - Osamu Motoyama, Akira Hasegawa, Atsushi Aikawa, Seiichirou Shishido, Masataka Honda, Kazuo Tsuzuki, Tsuneo Kinukawa, Motoshi Hattori, Osamu Ogawa, Toshio Yanagihara, Kazuhide Saito, Kota Takahashi, Shinichi Ohshima. Final height in a prospective trial of late steroid withdrawal after pediatric renal transplantation treated with cyclosporine and mizoribine.
Pediatric transplantation.
2012 Feb; 16(1):78-82. doi:
10.1111/j.1399-3046.2011.01614.x. [PMID: 22122015] - N Yoshimura, H Ushigome, M Matsuyama, S Nobori, T Suzuki, K Sakai, H Okajima, M Okamoto. The efficacy and safety of high-dose mizoribine in ABO-incompatible kidney transplantation using anti-CD20 and anti-CD25 antibody without splenectomy treatment.
Transplantation proceedings.
2012 Jan; 44(1):140-3. doi:
10.1016/j.transproceed.2011.12.009. [PMID: 22310599] - K Nishimura, K Uchida, K Yuzawa, Y Fukuda, Y Ichikawa, K Akioka, M Fujisawa, A Sugitani, S Ito, T Nakatani, T Horimi, N Yoshimura. Excellent results with high-dose mizoribine combined with cyclosporine, corticosteroid, and basiliximab in renal transplant recipients: multicenter study in Japan.
Transplantation proceedings.
2012 Jan; 44(1):147-9. doi:
10.1016/j.transproceed.2011.11.015. [PMID: 22310601] - Michitoshi Yamashita, Takuro Saito, Kazuya Ise, Show Ishii, Yoshihiro Satoh, Takaharu Saito, Ikuro Oshibe, Hirofumi Shimizu, Akira Kenjo, Takashi Kimura, Mitsukazu Gotoh. Mizoribine as sole immunosuppressive agent in islet xenotransplantation models: a candidate immunosuppressant causing no adverse effects on islets.
Cell transplantation.
2012; 21(2-3):535-45. doi:
10.3727/096368911x605457. [PMID: 22793062] - Hideaki Yamabe, Michiko Shimada, Reiichi Murakami, Takeshi Fujita, Yuko Shimaya, Norio Nakamura. Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 stimulated by thrombin.
Biological & pharmaceutical bulletin.
2012; 35(5):705-8. doi:
10.1248/bpb.35.705. [PMID: 22687405] - N Nakamura, H Mikami, H Matsuoka, S Irie, Y Abe, Y Sasatomi, S Ogawara, T Saitoh, M Tanaka. Experiences of high-dose mizoribine as antimetabolite immunosuppressants for kidney transplantation.
Transplantation proceedings.
2012 Jan; 44(1):150-3. doi:
10.1016/j.transproceed.2011.11.020. [PMID: 22310602] - Tomoya Nishino, Takeaki Shinzato, Yuuki Ohta, Hiroshi Yamashita, Yoko Obata, Ken Shinzato, Shigeru Kohno. A case of acute kidney injury with marked hyperuricemia during mizoribine administration.
Internal medicine (Tokyo, Japan).
2012; 51(10):1239-43. doi:
10.2169/internalmedicine.51.7230. [PMID: 22687797] - Kazuya Ishida, Masahiko Okamoto, Michio Ishibashi, Yukiya Hashimoto. Population pharmacokinetics of mizoribine in adult recipients of renal transplantation.
Clinical and experimental nephrology.
2011 Dec; 15(6):900-6. doi:
10.1007/s10157-011-0487-0. [PMID: 21751083] - Takahisa Hiramitsu, Hiroko Ota, Yoshihiko Watarai, Masahito Achiha, Harue Fukami, Shin-ichi Sakasegawa, Emisa Hino, Tamami Yamaguchi, Shigeru Ueda, Yoshitaka Kagimoto, Tomohiro Tamura, Kazuharu Uchida. Enzymatic assay method for measuring mizoribine levels in serum.
Journal of bioscience and bioengineering.
2011 Aug; 112(2):205-7. doi:
10.1016/j.jbiosc.2011.03.017. [PMID: 21530390] - Yuansheng Xie, Songmin Huang, Li Wang, Lining Miao, Aiping Zhang, Ying Li, Xiongfei Wu, Lining Wang, Shuxin Liu, Caihua Lie, Pu Chen, Xiangmei Chen. Efficacy and safety of mizoribine combined with losartan in the treatment of IgA nephropathy: a multicenter, randomized, controlled study.
The American journal of the medical sciences.
2011 May; 341(5):367-72. doi:
10.1097/maj.0b013e318207e02d. [PMID: 21293249] - Yukihiko Kawasaki, Kazuhide Suyama, Koichi Hashimoto, Mitsuaki Hosoya. Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis.
Clinical rheumatology.
2011 Apr; 30(4):529-35. doi:
10.1007/s10067-010-1572-6. [PMID: 20844911]