6-Hydroxymelatoninsulfate (BioDeep_00000900433)
代谢物信息卡片
6-Hydroxymelatoninsulfate
化学式: C13H15N2O6S- (327.065079)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 58.46%
分子结构信息
SMILES: CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)OS(=O)(=O)[O-]
InChI: InChI=1S/C13H16N2O6S/c1-8(16)14-4-3-9-7-15-11-6-13(21-22(17,18)19)12(20-2)5-10(9)11/h5-7,15H,3-4H2,1-2H3,(H,14,16)(H,17,18,19)/p-1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
5 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(5)
- superpathway of tryptophan utilization:
N-formylkynurenine + H2O ⟶ H+ + L-kynurenine + formate - superpathway of melatonin degradation:
hydrogen peroxide + melatonin ⟶ N1-acetyl-N2-formyl-5-methoxykynuramine + H2O - melatonin degradation I:
O2 + a reduced [NADPH-hemoprotein reductase] + melatonin ⟶ N-acetyl-serotonin + H2O + an oxidized [NADPH-hemoprotein reductase] + formaldehyde - superpathway of melatonin degradation:
N1-acetyl-N2-formyl-5-methoxykynuramine + H2O ⟶ N-acetyl-5-methoxykynurenamine + H+ + formate - melatonin degradation I:
O2 + a reduced [NADPH-hemoprotein reductase] + melatonin ⟶ N-acetyl-serotonin + H2O + an oxidized [NADPH-hemoprotein reductase] + formaldehyde
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wiebe Braam, Karen Spruyt. Reference intervals for 6-sulfatoxymelatonin in urine: A meta-analysis.
Sleep medicine reviews.
2022 06; 63(?):101614. doi:
10.1016/j.smrv.2022.101614. [PMID: 35303691] - Jane B Vaselkiv, Iona Cheng, Ilkania M Chowdhury-Paulino, Amparo G Gonzalez-Feliciano, Lynne R Wilkens, Alda M Hauksdóttir, Gudny Eiriksdottir, Loïc Le Marchand, Christopher A Haiman, Unnur Valdimarsdóttir, Lorelei A Mucci, Sarah C Markt. Urinary 6-sulfatoxymelatonin Levels and Prostate Cancer Risk among Men in the Multiethnic Cohort.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2022 Mar; 31(3):688-691. doi:
10.1158/1055-9965.epi-21-1041. [PMID: 34937795] - Leonid V Lopukhov, Anna V Balandina, Lilia S Nigmatullina, Adelya F Mullakhmetova, Gulnaz E Synbulatova, Alexander V Laikov, Victor L Lopukhov, Tatiana V Grigoryeva. Evaluation of multiple reaction monitoring cubed performed by a quadrupole-linear ion trap mass spectrometer for quantitative determination of 6-sulfatoxymelatonin in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Feb; 1190(?):123094. doi:
10.1016/j.jchromb.2021.123094. [PMID: 35030474] - Asuka Ishihara, Insung Park, Yoko Suzuki, Katsuhiko Yajima, Huiyun Cui, Masashi Yanagisawa, Takeshi Sano, Junji Kido, Kumpei Tokuyama. Metabolic responses to polychromatic LED and OLED light at night.
Scientific reports.
2021 06; 11(1):12402. doi:
10.1038/s41598-021-91828-6. [PMID: 34117328] - Supamas Sirisreetreerux, Tharikarn Sujirakul, Hataikarn Nimitphong, Sittichai Pinyopodjanard, Sunee Saetung, La-Or Chailurkit, Naricha Chirakalwasan, Ben S Gerber, Sirimon Reutrakul. Sleep variability, 6-sulfatoxymelatonin, and diabetic retinopathy.
Sleep & breathing = Schlaf & Atmung.
2021 Jun; 25(2):1069-1074. doi:
10.1007/s11325-020-02165-3. [PMID: 32951070] - Latifa A Bazzi, Lara G Sigurdardottir, Sigurdur Sigurdsson, Unnur Valdimarsdottir, Johanna Torfadottir, Thor Aspelund, Charles A Czeisler, Steven W Lockley, Eirikur Jonsson, Lenore Launer, Tamara Harris, Vilmundur Gudnason, Lorelei A Mucci, Sarah C Markt. Exploratory assessment of pineal gland volume, composition, and urinary 6-sulfatoxymelatonin levels on prostate cancer risk.
The Prostate.
2021 06; 81(8):487-496. doi:
10.1002/pros.24130. [PMID: 33860950] - Sanseray da Silveira Cruz-Machado, Leila Maria Guissoni Campos, Cintia Cristina Fadini, George Anderson, Regina P Markus, Luciana Pinato. Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances.
Journal of pineal research.
2021 Apr; 70(3):e12715. doi:
10.1111/jpi.12715. [PMID: 33421193] - Kenichi Tanaka, Yosuke Okada, Hajime Maiko, Hiroko Mori, Yoshiya Tanaka. Associations between urinary 6-sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes.
Journal of diabetes investigation.
2021 Apr; 12(4):601-609. doi:
10.1111/jdi.13374. [PMID: 33460308] - Kemal Kurt, Ersen Karakılıç, Ozgul Ocak, Suat Cakin. Presence of Peripheral Neuropathy Does Not Affect Urine 6-Sulfatoxymelatonin Levels in Type 2 Diabetics.
Neuro endocrinology letters.
2021 Mar; 42(1):33-42. doi:
NULL. [PMID: 33932966] - Sébastien Lalanne, Claire Fougerou-Leurent, George M Anderson, Carmen M Schroder, Tali Nir, Sylvie Chokron, Richard Delorme, Bruno Claustrat, Eric Bellissant, Solenn Kermarrec, Patricia Franco, Laure Denis, Sylvie Tordjman. Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder.
International journal of molecular sciences.
2021 Feb; 22(3):. doi:
10.3390/ijms22031490. [PMID: 33540815] - Alex Gomez-Gomez, Blanca Montero-San-Martin, Noemí Haro, Oscar J Pozo. Nail Melatonin Content: A Suitable Non-Invasive Marker of Melatonin Production.
International journal of molecular sciences.
2021 Jan; 22(2):. doi:
10.3390/ijms22020921. [PMID: 33477696] - Angel T Y Wong, Georgina K Fensom, Timothy J Key, N Charlotte Onland-Moret, Tammy Y N Tong, Ruth C Travis. Urinary Melatonin in Relation to Breast Cancer Risk: Nested Case-Control Analysis in the DOM Study and Meta-analysis of Prospective Studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2021 01; 30(1):97-103. doi:
10.1158/1055-9965.epi-20-0822. [PMID: 33144281] - Katarina Stebelova, Jan Roska, Michal Zeman. Impact of Dim Light at Night on Urinary 6-Sulphatoxymelatonin Concentrations and Sleep in Healthy Humans.
International journal of molecular sciences.
2020 Oct; 21(20):. doi:
10.3390/ijms21207736. [PMID: 33086713] - Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata. Decreased melatonin secretion in patients with glaucoma: Quantitative association with glaucoma severity in the LIGHT study.
Journal of pineal research.
2020 Sep; 69(2):e12662. doi:
10.1111/jpi.12662. [PMID: 32333450] - Marie Aarrebo Jensen, Julie Boye Kjærgaard, Jindong Ding Petersen, Åse Marie Hansen, Jesper Kristiansen, Anne Helene Garde. The urinary 6-sulfatoxymelatonin level after three different work schedules with 2, 4 and 7 consecutive night shifts among Danish police officers.
Chronobiology international.
2020 Sep; 37(9-10):1400-1403. doi:
10.1080/07420528.2020.1807560. [PMID: 32835513] - Martijn van Faassen, Anna van der Veen, Sonja van Ockenburg, Helma de Jong, Elisabeth G E de Vries, Ido P Kema. Mass spectrometric quantification of urinary 6-sulfatoxymelatonin: age-dependent excretion and biological variation.
Clinical chemistry and laboratory medicine.
2020 07; 59(1):187-195. doi:
10.1515/cclm-2020-0455. [PMID: 32673281] - Ioannis Liampas, Vasileios Siokas, Alexandros Brotis, Michail Vikelis, Efthimios Dardiotis. Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis.
Headache.
2020 07; 60(7):1273-1299. doi:
10.1111/head.13828. [PMID: 32352572] - Julia Ribeiro da Silva Vallim, Fernanda Gaspar do Amaral, Vânia D'Almeida. Sleep parameters assessed by actigraphy in Fabry's disease patients: a proof-of-concept.
Sleep medicine.
2020 05; 69(?):213-216. doi:
10.1016/j.sleep.2020.01.012. [PMID: 32145683] - Carlos Acuña-Fernández, Jorge Solera Marín, María E Díaz-Casado, Iryna Rusanova, Beneharo Darias-Delbey, Luis Pérez-Guillama, Javier Florido-Ruiz, Darío Acuña-Castroviejo. Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin.
Shock (Augusta, Ga.).
2020 05; 53(5):550-559. doi:
10.1097/shk.0000000000001433. [PMID: 31403491] - Niki Rensen, Lindsay M H Steur, Noa Wijnen, Eus J W van Someren, Gertjan J L Kaspers, Raphaële R L van Litsenburg. Actigraphic estimates of sleep and the sleep-wake rhythm, and 6-sulfatoxymelatonin levels in healthy Dutch children.
Chronobiology international.
2020 05; 37(5):660-672. doi:
10.1080/07420528.2020.1727916. [PMID: 32126835] - Tomo Nishi, Keigo Saeki, Kimie Miyata, Tadanobu Yoshikawa, Tetsuo Ueda, Norio Kurumatani, Kenji Obayashi, Nahoko Ogata. Effects of Cataract Surgery on Melatonin Secretion in Adults 60 Years and Older: A Randomized Clinical Trial.
JAMA ophthalmology.
2020 04; 138(4):405-411. doi:
10.1001/jamaophthalmol.2020.0206. [PMID: 32134436] - Sirimon Reutrakul, Stephanie J Crowley, Jason C Park, Felix Y Chau, Medha Priyadarshini, Erin C Hanlon, Kirstie K Danielson, Ben S Gerber, Tracy Baynard, Jade J Yeh, J Jason McAnany. Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy.
Scientific reports.
2020 01; 10(1):1560. doi:
10.1038/s41598-020-58205-1. [PMID: 32005914] - Catherine Duclos, Marie Dumont, Jean Paquet, Hélène Blais, Solenne Van der Maren, David K Menon, Francis Bernard, Nadia Gosselin. Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm.
Sleep.
2020 01; 43(1):. doi:
10.1093/sleep/zsz191. [PMID: 31562742] - Ting-Hsuan Yang, Yi Chun Chen, Tzu-Hsuan Ou, Yi-Wen Chien. Dietary supplement of tomato can accelerate urinary aMT6s level and improve sleep quality in obese postmenopausal women.
Clinical nutrition (Edinburgh, Scotland).
2020 01; 39(1):291-297. doi:
10.1016/j.clnu.2019.02.009. [PMID: 30792141] - Trevor Simper, Molly Gilmartin, Daniel Allwood, Luke Taylor, Andrew Chappell. The effects of a sleep/recovery supplement: 'Night Time Recharge' on sleep parameters in young adults.
Nutrition and health.
2019 Dec; 25(4):265-274. doi:
10.1177/0260106019875911. [PMID: 31512550] - M L Blagonravov, A A Bryk, V A Goryachev, E V Medvedeva, E A Demurov, A Yu Korshunova. Bright Light Therapy Increases Blood Pressure and Changes the Structure of Circadian Rhythm of Melatonin Secretion in Spontaneously Hypertensive Rats.
Bulletin of experimental biology and medicine.
2019 Dec; 168(2):214-218. doi:
10.1007/s10517-019-04677-9. [PMID: 31776953] - Annie Oh, Melanie L Foster, Katharine F Lunn, Freya M Mowat. Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism.
Journal of veterinary internal medicine.
2019 Nov; 33(6):2587-2594. doi:
10.1111/jvim.15646. [PMID: 31660652] - C Blume, M Angerer, M Raml, R Del Giudice, N Santhi, G Pichler, A B Kunz, M Scarpatetti, E Trinka, M Schabus. Healthier rhythm, healthier brain? Integrity of circadian melatonin and temperature rhythms relates to the clinical state of brain-injured patients.
European journal of neurology.
2019 08; 26(8):1051-1059. doi:
10.1111/ene.13935. [PMID: 30770613] - Julia E Stone, Xavier L Aubert, Henning Maass, Andrew J K Phillips, Michelle Magee, Mark E Howard, Steven W Lockley, Shantha M W Rajaratnam, Tracey L Sletten. Application of a Limit-Cycle Oscillator Model for Prediction of Circadian Phase in Rotating Night Shift Workers.
Scientific reports.
2019 07; 9(1):11032. doi:
10.1038/s41598-019-47290-6. [PMID: 31363110] - Anthony Berger, Jessica Litwin, Isabel Elaine Allen, William Qubty, Samantha Irwin, Maggie Waung, Amy A Gelfand. Preliminary Evidence that Melatonin Is not a Biomarker in Children and Adolescents With Episodic Migraine.
Headache.
2019 07; 59(7):1014-1023. doi:
10.1111/head.13547. [PMID: 31054199] - Anastasiya Slyepchenko, Olivia R Allega, Xiamin Leng, Luciano Minuzzi, Maha M Eltayebani, Matthew Skelly, Roberto B Sassi, Claudio N Soares, Sidney H Kennedy, Benicio N Frey. Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder.
The Australian and New Zealand journal of psychiatry.
2019 07; 53(7):683-696. doi:
10.1177/0004867419829228. [PMID: 30759998] - Megan D Mulhall, Tracey L Sletten, Michelle Magee, Julia E Stone, Saranea Ganesan, Allison Collins, Clare Anderson, Steven W Lockley, Mark E Howard, Shantha M W Rajaratnam. Sleepiness and driving events in shift workers: the impact of circadian and homeostatic factors.
Sleep.
2019 06; 42(6):. doi:
10.1093/sleep/zsz074. [PMID: 30882154] - Naro Ohashi, Sayaka Ishigaki, Shinsuke Isobe, Takashi Matsuyama, Taichi Sato, Tomoyuki Fujikura, Takayuki Tsuji, Akihiko Kato, Hideo Yasuda. Salt Loading Aggravates the Relationship between Melatonin and Proteinuria in Patients with Chronic Kidney Disease.
Internal medicine (Tokyo, Japan).
2019 Jun; 58(11):1557-1564. doi:
10.2169/internalmedicine.1929-18. [PMID: 30713312] - Mohamad Yonis, Abraham Haim, A Elsalam Zubidat. Altered metabolic and hormonal responses in male rats exposed to acute bright light-at-night associated with global DNA hypo-methylation.
Journal of photochemistry and photobiology. B, Biology.
2019 May; 194(?):107-118. doi:
10.1016/j.jphotobiol.2019.03.020. [PMID: 30953912] - Valérie Biran, Fabrice Decobert, Nathalie Bednarek, Priscilla Boizeau, Jean-François Benoist, Bruno Claustrat, Jérôme Barré, Marina Colella, Alice Frérot, Roselyne Garnotel, Olivier Graesslin, Bassam Haddad, Jean-Marie Launay, Thomas Schmitz, Julien Schroedt, Anne-Laure Virlouvet, Sophie Guilmin-Crépon, Adyla Yacoubi, Evelyne Jacqz-Aigrain, Pierre Gressens, Corinne Alberti, Olivier Baud. Melatonin Levels in Preterm and Term Infants and Their Mothers.
International journal of molecular sciences.
2019 Apr; 20(9):. doi:
10.3390/ijms20092077. [PMID: 31035572] - Florent Gobert, Jacques Luauté, Véronique Raverot, François Cotton, Frédéric Dailler, Bruno Claustrat, Fabien Perrin, Claude Gronfier. Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients.
Journal of pineal research.
2019 Apr; 66(3):e12555. doi:
10.1111/jpi.12555. [PMID: 30633817] - Julia Ribeiro da Silva Vallim, Fernanda Gaspar do Amaral, José Cipolla-Neto, Vânia D'Almeida. Rhythmic changes in Fabry disease: Inversion and non-oscillatory pattern in 6-sulfatoxymelatonin daily profile.
Chronobiology international.
2019 04; 36(4):470-480. doi:
10.1080/07420528.2018.1560308. [PMID: 30614280] - Jung Yong Kim, Ah Reum Jeong, Hee Seung Chin, Na Rae Kim. Melatonin Levels in Patients With Primary Open-angle Glaucoma With High or Low Intraocular Pressure.
Journal of glaucoma.
2019 02; 28(2):154-160. doi:
10.1097/ijg.0000000000001130. [PMID: 30394980] - K Babinska, L Siklenkova, K Stebelova, I Waczulikova, H Celusakova, M Vidosovicova, K Bartakovicova, Z Szapuova, P Kemenyova. Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder.
Bratislavske lekarske listy.
2019; 120(11):849-855. doi:
10.4149/bll_2019_141. [PMID: 31747766] - Wiebe Braam, Friederike Ehrhart, Anneke P H M Maas, Marcel G Smits, Leopold Curfs. Low maternal melatonin level increases autism spectrum disorder risk in children.
Research in developmental disabilities.
2018 Nov; 82(?):79-89. doi:
10.1016/j.ridd.2018.02.017. [PMID: 29501372] - Linchen He, Xing Lucy Liu, Junfeng Jim Zhang. Simultaneous quantification of urinary 6‑sulfatoxymelatonin and 8‑hydroxy‑2'‑deoxyguanosine using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):119-126. doi:
10.1016/j.jchromb.2018.07.035. [PMID: 30077091] - Aixa M Pérez-Caraballo, Yunsheng Ma, Judith K Ockene, Katherine W Reeves, Raji Balasubramanian, Frank Z Stanczyk, Matthew A Allison, Chu Chen, Lu Wang, JoAnn E Manson, Susan R Sturgeon. Association of urinary levels of 6-sulfatoxymelatonin (aMT6s) with prevalent and incident hypertension.
Chronobiology international.
2018 08; 35(8):1115-1121. doi:
10.1080/07420528.2018.1461109. [PMID: 29750588] - Romesh G Abeysuriya, Steven W Lockley, Peter A Robinson, Svetlana Postnova. A unified model of melatonin, 6-sulfatoxymelatonin, and sleep dynamics.
Journal of pineal research.
2018 May; 64(4):e12474. doi:
10.1111/jpi.12474. [PMID: 29437238] - C Chojnacki, A Kaczka, A Gasiorowska, J Fichna, J Chojnacki, T Brzozowski. The effect of long-term melatonin supplementation on psychosomatic disorders in postmenopausal women.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2018 Apr; 69(2):. doi:
10.26402/jpp.2018.2.15. [PMID: 30045006] - A E Zubidat, B Fares, F Fares, A Haim. Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways.
Cancer control : journal of the Moffitt Cancer Center.
2018 Jan; 25(1):1073274818812908. doi:
10.1177/1073274818812908. [PMID: 30477310] - Olivia R Allega, Xiamin Leng, Anthony Vaccarino, Matthew Skelly, Mariana Lanzini, Maria Paz Hidalgo, Claudio N Soares, Sidney H Kennedy, Benicio N Frey. Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis.
Journal of affective disorders.
2018 01; 225(?):54-63. doi:
10.1016/j.jad.2017.07.047. [PMID: 28787704] - RatnaKala Sithravel, Rahinah Ibrahim, Munn Sann Lye, Enoch Kumar Perimal, Normala Ibrahim, Nur Dalilah Dahlan. Morning boost on individuals' psychophysiological wellbeing indicators with supportive, dynamic lighting in windowless open-plan workplace in Malaysia.
PloS one.
2018; 13(11):e0207488. doi:
10.1371/journal.pone.0207488. [PMID: 30496193] - P P Han, M Y Zou, X L Yang, X C Liu, S Liang, C H Sun, W Xia, L J Wu. [Sleep problems and the association with the levels of 6-sulfatoxymelatonin in children with autism spectrum disorder].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2017 Dec; 55(12):911-915. doi:
10.3760/cma.j.issn.0578-1310.2017.12.009. [PMID: 29262470] - Marta Batllori, Marta Molero-Luis, Luisa Arrabal, Javier de Las Heras, Joaquín-Alejandro Fernandez-Ramos, Luis González Gutiérrez-Solana, Salvador Ibáñez-Micó, Rosario Domingo, Jaume Campistol, Aida Ormazabal, Frederic Sedel, Thomas Opladen, Basiliki Zouvelou, Roser Pons, Angels Garcia-Cazorla, Eduardo Lopez-Laso, Rafael Artuch. Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Scientific reports.
2017 11; 7(1):14675. doi:
10.1038/s41598-017-15063-8. [PMID: 29116116] - Tracey L Sletten, Suzanne Ftouni, Christian L Nicholas, Michelle Magee, Ronald R Grunstein, Sally Ferguson, David J Kennaway, Darren O'Brien, Steven W Lockley, Shantha M W Rajaratnam. Randomised controlled trial of the efficacy of a blue-enriched light intervention to improve alertness and performance in night shift workers.
Occupational and environmental medicine.
2017 11; 74(11):792-801. doi:
10.1136/oemed-2016-103818. [PMID: 28630378] - Ana Checa-Ros, Antonio Muñoz-Hoyos, Antonio Molina-Carballo, Antonio Muñoz-Gallego, Susana Narbona-Galdó, Antonio Jerez-Calero, María Del Carmen Augustín-Morales. Analysis of Different Melatonin Secretion Patterns in Children With Sleep Disorders: Melatonin Secretion Patterns in Children.
Journal of child neurology.
2017 Oct; 32(12):1000-1008. doi:
10.1177/0883073817726680. [PMID: 28911277] - Necdet Fatih Yaşar, Bartu Badak, Ağgül Canik, Sema Şanal Baş, Sema Uslu, Setenay Öner, Ersin Ateş. Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit.
Molecules (Basel, Switzerland).
2017 Sep; 22(9):. doi:
10.3390/molecules22091537. [PMID: 28895895] - M Turco, A Biscontin, M Corrias, L Caccin, M Bano, F Chiaromanni, M Salamanca, D Mattei, C Salvoro, G Mazzotta, C De Pittà, B Middleton, D J Skene, S Montagnese, R Costa. Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3.
Scientific reports.
2017 07; 7(1):6967. doi:
10.1038/s41598-017-06769-w. [PMID: 28761043] - Jing Xu, Lei Huang, Guo-Ping Sun. Urinary 6-sulfatoxymelatonin level and breast cancer risk: systematic review and meta-analysis.
Scientific reports.
2017 07; 7(1):5353. doi:
10.1038/s41598-017-05752-9. [PMID: 28706222] - Denise M Ney, Sangita G Murali, Bridget M Stroup, Nivedita Nair, Emily A Sawin, Fran Rohr, Harvey L Levy. Metabolomic changes demonstrate reduced bioavailability of tyrosine and altered metabolism of tryptophan via the kynurenine pathway with ingestion of medical foods in phenylketonuria.
Molecular genetics and metabolism.
2017 06; 121(2):96-103. doi:
10.1016/j.ymgme.2017.04.003. [PMID: 28400091] - Ingrid van der Merwe, Maria K Oosthuizen, Andre Ganswindt, Abraham Haim, Nigel C Bennett. Effects of photophase illuminance on locomotor activity, urine production and urinary 6-sulfatoxymelatonin in nocturnal and diurnal South African rodents.
The Journal of experimental biology.
2017 05; 220(Pt 9):1684-1692. doi:
10.1242/jeb.146951. [PMID: 28209805] - Ciaran J McMullan, Eric B Rimm, Eva S Schernhammer, John P Forman. A nested case-control study of the association between melatonin secretion and incident myocardial infarction.
Heart (British Cardiac Society).
2017 05; 103(9):694-701. doi:
10.1136/heartjnl-2016-310098. [PMID: 27806988] - Juliana de Almeida Faria, Thiago Matos F de Araújo, Daniela S Razolli, Letícia Martins Ignácio-Souza, Dailson Nogueira Souza, Silvana Bordin, Gabriel Forato Anhê. Metabolic Impact of Light Phase-Restricted Fructose Consumption Is Linked to Changes in Hypothalamic AMPK Phosphorylation and Melatonin Production in Rats.
Nutrients.
2017 Mar; 9(4):. doi:
10.3390/nu9040332. [PMID: 28346369] - S S Konovalov, V O Polyakova, A O Drobintseva, I M Kvetnoy, T V Kvetnaia, N S Linkova. [MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE].
Klinicheskaia meditsina.
2017 ; 95(2):136-9. doi:
NULL. [PMID: 30303666] - K Stebelova, J Kosnacova, M Zeman. Intense blue light therapy during the night-time does not suppress the rhythmic melatonin biosynthesis in a young boy.
Endocrine regulations.
2017 Jan; 51(1):31-34. doi:
10.1515/enr-2017-0004. [PMID: 28222021] - S V Trofimova, N S Linkova, A A Klimenko, T V Kvetnaia, V Kh Khavinson. [Pineamin increased pineal melatonin synthesis in elderly people].
Advances in gerontology = Uspekhi gerontologii.
2017; 30(3):422-426. doi:
NULL. [PMID: 28849889] - Gunilla Malm, Trine B Haugen, Lars Rylander, Aleksander Giwercman. Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage.
Asian journal of andrology.
2017 Jan; 19(1):52-56. doi:
10.4103/1008-682x.186870. [PMID: 27748316] - Chisato Nagata, Takashi Tamura, Keiko Wada, Kie Konishi, Yuko Goto, Yasuko Nagao, Kazuhiro Ishihara, Satoru Yamamoto. Sleep duration, nightshift work, and the timing of meals and urinary levels of 8-isoprostane and 6-sulfatoxymelatonin in Japanese women.
Chronobiology international.
2017; 34(9):1187-1196. doi:
10.1080/07420528.2017.1355313. [PMID: 28933565] - Mirit Eynan, Adi Biram, Michael Mullokandov, Noga Kronfeld-Schor, Rotem Paz-Cohen, Dvir Menajem, Yehuda Arieli. The transition from day-to-night activity is a risk factor for the development of CNS oxygen toxicity in the diurnal fat sand rat (Psammomys obesus).
Chronobiology international.
2017; 34(5):578-586. doi:
10.1080/07420528.2017.1281822. [PMID: 28156158] - Sirimon Reutrakul, Nantaporn Siwasaranond, Hataikarn Nimitphong, Sunee Saetung, Naricha Chirakalwasan, La-Or Chailurkit, Kriangsuk Srijaruskul, Boonsong Ongphiphadhanakul, Ammarin Thakkinstian. Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes.
Chronobiology international.
2017; 34(3):382-392. doi:
10.1080/07420528.2016.1278382. [PMID: 28128991] - Sayaka Ishigaki, Naro Ohashi, Shinsuke Isobe, Naoko Tsuji, Takamasa Iwakura, Masafumi Ono, Yukitoshi Sakao, Takayuki Tsuji, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda. Impaired endogenous nighttime melatonin secretion relates to intrarenal renin-angiotensin system activation and renal damage in patients with chronic kidney disease.
Clinical and experimental nephrology.
2016 Dec; 20(6):878-884. doi:
10.1007/s10157-015-1224-x. [PMID: 26743744] - Nan Chen, Quan Wu, Yanlei Xiong, Guang Chen, Dandan Song, Chengli Xu. Circadian Rhythm and Sleep During Prolonged Antarctic Residence at Chinese Zhongshan Station.
Wilderness & environmental medicine.
2016 Dec; 27(4):458-467. doi:
10.1016/j.wem.2016.07.004. [PMID: 27912863] - Lara G Sigurdardottir, Sarah C Markt, Sigurdur Sigurdsson, Thor Aspelund, Katja Fall, Eva Schernhammer, Jennifer R Rider, Lenore Launer, Tamara Harris, Meir J Stampfer, Vilmundur Gudnason, Charles A Czeisler, Steven W Lockley, Unnur A Valdimarsdottir, Lorelei A Mucci. Pineal Gland Volume Assessed by MRI and Its Correlation with 6-Sulfatoxymelatonin Levels among Older Men.
Journal of biological rhythms.
2016 10; 31(5):461-9. doi:
10.1177/0748730416656948. [PMID: 27449477] - X-D Lv, S Liu, Z Cao, L-L Gong, X-P Feng, Q-F Gao, J Wang, L Hu, X-C Cheng, C-H Yu, Y-Q Xing. Correlation between serum melatonin and aMT6S level for age-related macular degeneration patients.
European review for medical and pharmacological sciences.
2016 10; 20(20):4196-4201. doi:
NULL. [PMID: 27831657] - Kenji Obayashi, Keigo Saeki, Taeko Maegawa, Junko Iwamoto, Takahide Sakai, Naoto Otaki, Hiroshi Kataoka, Norio Kurumatani. Melatonin Secretion and Muscle Strength in Elderly Individuals: A Cross-Sectional Study of the HEIJO-KYO Cohort.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2016 09; 71(9):1235-40. doi:
10.1093/gerona/glw030. [PMID: 26933161] - Parveen Bhatti, Dana K Mirick, Timothy W Randolph, Jicheng Gong, Diana Taibi Buchanan, Junfeng Jim Zhang, Scott Davis. Oxidative DNA damage during sleep periods among nightshift workers.
Occupational and environmental medicine.
2016 08; 73(8):537-44. doi:
10.1136/oemed-2016-103629. [PMID: 27307003] - Elizabeth E Devore, Stephanie L Harrison, Katie L Stone, Kathleen F Holton, Elizabeth Barrett-Connor, Sonia Ancoli-Israel, Kristine Yaffe, Kristine Ensrud, Peggy M Cawthon, Susan Redline, Eric Orwoll, Eva S Schernhammer. Association of urinary melatonin levels and aging-related outcomes in older men.
Sleep medicine.
2016 07; 23(?):73-80. doi:
10.1016/j.sleep.2016.07.006. [PMID: 27692280] - S W Chang, Y Gong, C W McDonough, T Y Langaee, N Nasiri Kenari, A L Beitelshees, J G Gums, A B Chapman, S T Turner, J A Johnson, R M Cooper-DeHoff. Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation?.
Clinical and translational science.
2016 Apr; 9(2):114-22. doi:
10.1111/cts.12389. [PMID: 26946962] - Ahmet Büber, Burcu Çakaloz, Yetiş Işıldar, Gülşen Ünlü, Hayrani Eren Bostancı, Hülya Aybek, Hasan Herken. Increased urinary 6-hydroxymelatoninsulfate levels in attention deficit hyperactivity disorder diagnosed children and adolescent.
Neuroscience letters.
2016 Mar; 617(?):195-200. doi:
10.1016/j.neulet.2016.02.016. [PMID: 26879834] - Amanda L McBean, Steven G Kinsey, Hawley E Montgomery-Downs. Effects of a single night of postpartum sleep on childless women's daytime functioning.
Physiology & behavior.
2016 Mar; 156(?):137-47. doi:
10.1016/j.physbeh.2016.01.014. [PMID: 26776447] - Yolanda Aguilera, Miguel Rebollo-Hernanz, Teresa Herrera, L Tábata Cayuelas, Pilar Rodríguez-Rodríguez, Ángel L López de Pablo, Silvia M Arribas, María A Martin-Cabrejas. Intake of bean sprouts influences melatonin and antioxidant capacity biomarker levels in rats.
Food & function.
2016 Mar; 7(3):1438-45. doi:
10.1039/c5fo01538c. [PMID: 26841704] - Hugo L Fideleff, Gabriel Fideleff, Hugo R Boquete, Martha Suárez, Miriam Azaretzky. Male-female differences in 6-sulfatoxymelatonin excretion in hypopituitary patients.
Archives of endocrinology and metabolism.
2016 Feb; 60(3):223-30. doi:
10.1590/2359-3997000000153. [PMID: 26886086] - Alyson E Hanish, John A Butman, Francine Thomas, Jianhua Yao, Joan C Han. Pineal hypoplasia, reduced melatonin and sleep disturbance in patients with PAX6 haploinsufficiency.
Journal of sleep research.
2016 Feb; 25(1):16-22. doi:
10.1111/jsr.12345. [PMID: 26439359] - Huimin Zhao, Yifei Wang, Bo Yuan, Shu Liu, Shuang Man, Haiyan Xu, Xiumei Lu. A novel LC-MS/MS assay for the simultaneous determination of melatonin and its two major metabolites, 6-hydroxymelatonin and 6-sulfatoxymelatonin in dog plasma: Application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):390-7. doi:
10.1016/j.jpba.2015.09.028. [PMID: 26440286] - Pippa J Gunn, Benita Middleton, Sarah K Davies, Victoria L Revell, Debra J Skene. Sex differences in the circadian profiles of melatonin and cortisol in plasma and urine matrices under constant routine conditions.
Chronobiology international.
2016; 33(1):39-50. doi:
10.3109/07420528.2015.1112396. [PMID: 26731571] - Yung-Sen Chang, Ming-Hung Lin, Jyh-Hong Lee, Pei-Lin Lee, Yang-Shia Dai, Kuan-Hua Chu, Chi Sun, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Yao-Hsu Yang, Chun-An Chen, Kong-Sang Wan, Bor-Luen Chiang. Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
JAMA pediatrics.
2016 Jan; 170(1):35-42. doi:
10.1001/jamapediatrics.2015.3092. [PMID: 26569624] - Cezary Chojnacki, Ewa Walecka-Kapica, Aleksandra Błońska, Katarzyna Winczyk, Agnieszka Stępień, Jan Chojnacki. Serotonin and melatonin secretion in postmenopausal women with eating disorders.
Endokrynologia Polska.
2016; 67(3):299-304. doi:
10.5603/ep.2016.0012. [PMID: 27364373] - A A Kulesh, V E Drobakha, V V Shestakov. [The role of melatonin in the development of post-stroke cognitive impairment in elderly patients in comparison with middle-aged patients].
Advances in gerontology = Uspekhi gerontologii.
2016; 29(4):651-657. doi:
NULL. [PMID: 28539026] - Ingvild Saksvik-Lehouillier, Stephanie L Harrison, Lynn M Marshall, Greg J Tranah, Kristine Ensrud, Sonia Ancoli-Israel, Aaron Clemons, Susan Redline, Katie L Stone, Eva S Schernhammer. Association of Urinary 6-Sulfatoxymelatonin (aMT6s) Levels and Objective and Subjective Sleep Measures in Older Men: The MrOS Sleep Study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2015 Dec; 70(12):1569-77. doi:
10.1093/gerona/glv088. [PMID: 26265731] - Armand Mekontso Dessap, Ferran Roche-Campo, Jean-Marie Launay, Anais Charles-Nelson, Sandrine Katsahian, Christian Brun-Buisson, Laurent Brochard. Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation: An Ancillary Study of a Weaning Trial.
Chest.
2015 Nov; 148(5):1231-1241. doi:
10.1378/chest.15-0525. [PMID: 26158245] - Suzanne Ftouni, Tracey L Sletten, Christian L Nicholas, David J Kennaway, Steven W Lockley, Shantha M W Rajaratnam. Ocular Measures of Sleepiness Are Increased in Night Shift Workers Undergoing a Simulated Night Shift Near the Peak Time of the 6-Sulfatoxymelatonin Rhythm.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
2015 Oct; 11(10):1131-41. doi:
10.5664/jcsm.5086. [PMID: 26094925] - Elizabeth M Poole, Eva Schernhammer, Leigha Mills, Susan E Hankinson, Shelley S Tworoger. Urinary melatonin and risk of ovarian cancer.
Cancer causes & control : CCC.
2015 Oct; 26(10):1501-6. doi:
10.1007/s10552-015-0640-2. [PMID: 26223889] - Kenji Obayashi, Keigo Saeki, Junko Iwamoto, Nobuhiro Tone, Kunihiko Tanaka, Hiroshi Kataoka, Masayuki Morikawa, Norio Kurumatani. Physiological Levels of Melatonin Relate to Cognitive Function and Depressive Symptoms: The HEIJO-KYO Cohort.
The Journal of clinical endocrinology and metabolism.
2015 Aug; 100(8):3090-6. doi:
10.1210/jc.2015-1859. [PMID: 26052727] - Melissa A St Hilaire, Steven W Lockley. Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms.
Sleep medicine.
2015 Jun; 16(6):800-4. doi:
10.1016/j.sleep.2015.01.018. [PMID: 25891543] - Cody A Ramin, Jennifer Massa, Lani R Wegrzyn, Susan B Brown, Jeffrey Pierre-Paul, Elizabeth E Devore, Susan E Hankinson, Eva S Schernhammer. The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers.
BMC public health.
2015 May; 15(?):467. doi:
10.1186/s12889-015-1770-x. [PMID: 25943349] - Kyriaki Papantoniou, Oscar J Pozo, Ana Espinosa, Josep Marcos, Gemma Castaño-Vinyals, Xavier Basagaña, Elena Juanola Pagès, Joan Mirabent, Jordi Martín, Patricia Such Faro, Amparo Gascó Aparici, Benita Middleton, Debra J Skene, Manolis Kogevinas. Increased and mistimed sex hormone production in night shift workers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2015 May; 24(5):854-63. doi:
10.1158/1055-9965.epi-14-1271. [PMID: 25737330] - Colin R Young, Geoffrey E Jones, Mariana G Figueiro, Shawn E Soutière, Matthew W Keller, Annely M Richardson, Benjamin J Lehmann, Mark S Rea. At-sea trial of 24-h-based submarine watchstanding schedules with high and low correlated color temperature light sources.
Journal of biological rhythms.
2015 Apr; 30(2):144-54. doi:
10.1177/0748730415575432. [PMID: 25838419] - J Leston, C Harthé, C Mottolese, P Mertens, M Sindou, B Claustrat. Is pineal melatonin released in the third ventricle in humans? A study in movement disorders.
Neuro-Chirurgie.
2015 Apr; 61(2-3):85-9. doi:
10.1016/j.neuchi.2013.04.004. [PMID: 24975205] - Lars Neeb, Linn Anders, Philipp Euskirchen, Jan Hoffmann, Heike Israel, Uwe Reuter. Corticosteroids alter CGRP and melatonin release in cluster headache episodes.
Cephalalgia : an international journal of headache.
2015 Apr; 35(4):317-26. doi:
10.1177/0333102414539057. [PMID: 24958681] - Sara Montagnese, Benita Middleton, Michela Corrias, Ali Reza Mani, Debra J Skene, Marsha Y Morgan. Assessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: lessons from cirrhosis.
Chronobiology international.
2015 Mar; 32(2):187-94. doi:
10.3109/07420528.2014.961607. [PMID: 25264562] - Inés Gómez-Acebo, Trinidad Dierssen-Sotos, Kyriaki Papantoniou, María Teresa García-Unzueta, María Francisca Santos-Benito, Javier Llorca. Association between exposure to rotating night shift versus day shift using levels of 6-sulfatoxymelatonin and cortisol and other sex hormones in women.
Chronobiology international.
2015 Feb; 32(1):128-35. doi:
10.3109/07420528.2014.958494. [PMID: 25216206] - Taha Gholipour, Taher Ghazizadeh, Sahand Babapour, Behzad Mansouri, Majid Ghafarpour, Bahaadin Siroos, Mohammad Hossein Harirchian. Decreased urinary level of melatonin as a marker of disease severity in patients with multiple sclerosis.
Iranian journal of allergy, asthma, and immunology.
2015 Feb; 14(1):91-7. doi:
NULL. [PMID: 25530144] - Susan B Brown, Susan E Hankinson, A Heather Eliassen, Katherine W Reeves, Jing Qian, Kathleen F Arcaro, Lani R Wegrzyn, Walter C Willett, Eva S Schernhammer. Urinary melatonin concentration and the risk of breast cancer in Nurses' Health Study II.
American journal of epidemiology.
2015 Feb; 181(3):155-62. doi:
10.1093/aje/kwu261. [PMID: 25587174] - Lara G Sigurdardottir, Sarah C Markt, Jennifer R Rider, Sebastien Haneuse, Katja Fall, Eva S Schernhammer, Rulla M Tamimi, Erin Flynn-Evans, Julie L Batista, Lenore Launer, Tamara Harris, Thor Aspelund, Meir J Stampfer, Vilmundur Gudnason, Charles A Czeisler, Steven W Lockley, Unnur A Valdimarsdottir, Lorelei A Mucci. Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men.
European urology.
2015 Feb; 67(2):191-4. doi:
10.1016/j.eururo.2014.07.008. [PMID: 25107635]