Etopofos (BioDeep_00000900153)
代谢物信息卡片
Etopofos
化学式: C29H31O16P-2 (666.1349656)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)OP(=O)([O-])[O-])OC)O)O
InChI: InChI=1S/C29H33O16P/c1-11-38-9-20-27(42-11)23(30)24(31)29(43-20)44-25-14-7-17-16(40-10-41-17)6-13(14)21(22-15(25)8-39-28(22)32)12-4-18(36-2)26(19(5-12)37-3)45-46(33,34)35/h4-7,11,15,20-25,27,29-31H,8-10H2,1-3H3,(H2,33,34,35)/p-2/t11-,15+,20-,21-,22+,23-,24-,25-,27-,29+/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pierre Boyé, François Serres, Franck Floch, Corinne Fournel-Fleury, Dominique Tierny. Prognostic value of pretreatment plasma D-dimer level in dogs with intermediate to high-grade non-Hodgkin lymphoma.
Veterinary and comparative oncology.
2021 Mar; 19(1):44-52. doi:
10.1111/vco.12629. [PMID: 32643242] - Delphine Barnoud, Claire Pinçon, Bénédicte Bruno, Johana Béné, Sophie Gautier, Annie Lahoche, Nadine Petitpain, Michèle Vasseur, Christine Barthélémy, Bertrand Décaudin, Nicolas Simon, Pascal Odou. Acute kidney injury after high dose etoposide phosphate: A retrospective study in children receiving an allogeneic hematopoetic stem cell transplantation.
Pediatric blood & cancer.
2018 07; 65(7):e27038. doi:
10.1002/pbc.27038. [PMID: 29528179] - C Cordero, C Loboda, I Clerc-Urmès, L Clément, C Pochon, P Chastagner. Unexpected acute renal injury after high-dose etoposide phosphate and total body irradiation in children undergoing hematopoietic stem cell transplantation.
Pediatric blood & cancer.
2017 Dec; 64(12):. doi:
10.1002/pbc.26669. [PMID: 28696051] - Hiren Patel, Abhay Joshi, Amit Joshi, Grazia Stagni. Transdermal Delivery of Etoposide Phosphate II: In Vitro In Vivo Correlations (IVIVC).
Journal of pharmaceutical sciences.
2016 07; 105(7):2139-45. doi:
10.1016/j.xphs.2016.04.022. [PMID: 27233686] - Hiren Patel, Abhay Joshi, Amit Joshi, Grazia Stagni. Transdermal Delivery of Etoposide Phosphate I: In Vitro and In Vivo Evaluation.
Journal of pharmaceutical sciences.
2016 07; 105(7):2114-22. doi:
10.1016/j.xphs.2016.04.014. [PMID: 27233689] - Somnath Kandekar, Ranjan Preet, Maneesh Kashyap, M U Renu Prasad, Purusottam Mohapatra, Dipon Das, Shakti Ranjan Satapathy, Sumit Siddharth, Vaibhav Jain, Maitrayee Choudhuri, Chanakya N Kundu, Sankar K Guchhait, Prasad V Bharatam. Structural elaboration of a natural product: identification of 3,3'-diindolylmethane aminophosphonate and urea derivatives as potent anticancer agents.
ChemMedChem.
2013 Nov; 8(11):1873-84. doi:
10.1002/cmdc.201300273. [PMID: 23983049] - Fan Zhang, Ling Xu, Xiujuan Qu, Mingfang Zhao, Bo Jin, Jian Kang, Yunpeng Liu, Xuejun Hu. Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells.
Molecular medicine reports.
2011 Nov; 4(6):1189-93. doi:
10.3892/mmr.2011.537. [PMID: 21904777] - N C Levitt, D J Propper, S Madhusudan, J P Braybrooke, C Echeta, R Te Poele, S L Davies, E Flanagan, I D Hickson, S Joel, T S Ganesan. Pharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancer.
British journal of cancer.
2005 Jul; 93(1):60-9. doi:
10.1038/sj.bjc.6602657. [PMID: 15956976] - Martin G Belinsky, Paul A Dawson, Irina Shchaveleva, Lisa J Bain, Renxue Wang, Victor Ling, Zhe-Sheng Chen, Alex Grinberg, Heiner Westphal, Andres Klein-Szanto, Anthony Lerro, Gary D Kruh. Analysis of the in vivo functions of Mrp3.
Molecular pharmacology.
2005 Jul; 68(1):160-8. doi:
10.1124/mol.104.010587. [PMID: 15814571] - Sunita Farkya, V S Bisaria, A K Srivastava. Biotechnological aspects of the production of the anticancer drug podophyllotoxin.
Applied microbiology and biotechnology.
2004 Oct; 65(5):504-19. doi:
10.1007/s00253-004-1680-9. [PMID: 15378293] - Natalia Y Ragozina, Michael Pütz, Stefan Heissler, Werner Faubel, Ute Pyell. Quantification of etoposide and etoposide phosphate in human plasma by micellar electrokinetic chromatography and near-field thermal lens detection.
Analytical chemistry.
2004 Jul; 76(13):3804-9. doi:
10.1021/ac0304222. [PMID: 15228358] - Jeremy P Braybrooke, Nicola C Levitt, Simon Joel, Theresa Davis, Srinivasan Madhusudan, Helen Turley, Sue Wilner, Adrian L Harris, Denis C Talbot. Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase IIalpha expression.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Oct; 9(13):4682-8. doi:
NULL. [PMID: 14581337] - R T Dorr, A Briggs, P Kintzel, R Meyers, H-H S Chow, A List. Comparative pharmacokinetic study of high-dose etoposide and etoposide phosphate in patients with lymphoid malignancy receiving autologous stem cell transplantation.
Bone marrow transplantation.
2003 Apr; 31(8):643-9. doi:
10.1038/sj.bmt.1703906. [PMID: 12692603] - S Reif, D Kingreen, C Kloft, J Grimm, W Siegert, W Schunack, U Jaehde. Bioequivalence investigation of high-dose etoposide and etoposide phosphate in lymphoma patients.
Cancer chemotherapy and pharmacology.
2001 Aug; 48(2):134-40. doi:
10.1007/s002800100280. [PMID: 11561779] - U B Soetebeer, M O Schierenberg, H Schulz, G Hempel, P Andresen, G Blaschke. Simultaneous quantification of etoposide and etoposide phosphate in human plasma by capillary electrophoresis using laser-induced native fluorescence detection.
Analytical chemistry.
2001 May; 73(10):2178-82. doi:
10.1021/ac001467v. [PMID: 11393838] - N Morlet, J Stayt, Vaegan, C Salonikas, D Naidoo, R Crouch, G Graham, M Coroneo. Etoposide as a virocidal anticytomegalovirus therapy: intravitreal toxicology and pharmacology in rabbits.
Australian and New Zealand journal of ophthalmology.
1999 Oct; 27(5):342-9. doi:
10.1046/j.1440-1606.1999.00223.x. [PMID: 10571395] - S Joel, K O'Byrne, R Penson, D Papamichael, A Higgins, H Robertshaw, R Rudd, D Talbot, M Slevin. A randomised, concentration-controlled, comparison of standard (5-day) vs. prolonged (15-day) infusions of etoposide phosphate in small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology.
1998 Nov; 9(11):1205-11. doi:
10.1023/a:1008437805286. [PMID: 9862051] - Y Mrestani, R Neubert. Separation of etoposide phosphate and methotrexate by capillary zone electrophoresis using UV detection with a high sensitivity cell.
Electrophoresis.
1998 Nov; 19(16-17):3022-5. doi:
10.1002/elps.1150191638. [PMID: 9870407] - J Wijnholds, G L Scheffer, M van der Valk, P van der Valk, J H Beijnen, R J Scheper, P Borst. Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage.
The Journal of experimental medicine.
1998 Sep; 188(5):797-808. doi:
10.1084/jem.188.5.797. [PMID: 9730882] - A Lorico, G Rappa, R A Finch, D Yang, R A Flavell, A C Sartorelli. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
Cancer research.
1997 Dec; 57(23):5238-42. doi:
NULL. [PMID: 9393741] - N Soni, N J Meropol, L Pendyala, D Noel, L P Schacter, K E Gunton, P J Creaven. Phase I and pharmacokinetic study of etoposide phosphate by protracted venous infusion in patients with advanced cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1997 Feb; 15(2):766-72. doi:
10.1200/jco.1997.15.2.766. [PMID: 9053503] - D Porter, A Boddy, H Thomas, M Lind, D Newell, A H Calvert, L Robson, M Brampton, D Abrahamsen, B Winograd. Etoposide phosphate infusion with therapeutic drug monitoring in combination with carboplatin dosed by area under the curve: a cancer research campaign phase I/II committee study.
Seminars in oncology.
1996 Dec; 23(6 Suppl 13):34-44. doi:
NULL. [PMID: 8996574] - S Kaul, N R Srinivas, V Mummaneni, L N Igwemezie, R H Barbhaiya. Effects of gender, age, and race on the pharmacokinetics of etoposide after intravenous administration of etoposide phosphate in cancer patients.
Seminars in oncology.
1996 Dec; 23(6 Suppl 13):23-9. doi:
NULL. [PMID: 8996572] - S Kaul, N R Srinivas, L N Igwemezie, R H Barbhaiya. A pharmacodynamic evaluation of hematologic toxicity observed with etoposide phosphate in the treatment of cancer patients.
Seminars in oncology.
1996 Dec; 23(6 Suppl 13):15-22. doi:
NULL. [PMID: 8996571] - L Schacter. Etoposide phosphate: what, why, where, and how?.
Seminars in oncology.
1996 Dec; 23(6 Suppl 13):1-7. doi:
". [PMID: 8996569] - S Z Fields, D R Budman, R R Young, W Kreis, R Ingram, P Schulman, R C Cherny, J Wright, J Behr, C Snow, L P Schacter. Phase I study of high-dose etoposide phosphate in man.
Bone marrow transplantation.
1996 Nov; 18(5):851-6. doi:
NULL. [PMID: 8932836] - V Mummaneni, S Kaul, L N Igwemezie, D R Newell, D Porter, H Thomas, A H Calvert, B Winograd, R H Barbhaiya. Bioequivalence assessment of etoposide phosphate and etoposide using pharmacodynamic and traditional pharmacokinetic parameters.
Journal of pharmacokinetics and biopharmaceutics.
1996 Aug; 24(4):313-25. doi:
10.1007/bf02353515. [PMID: 9044163] - G G Chabot, J P Armand, C Terret, M de Forni, D Abigerges, B Winograd, L Igwemezie, L Schacter, S Kaul, J Ropers, M Bonnay. Etoposide bioavailability after oral administration of the prodrug etoposide phosphate in cancer patients during a phase I study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1996 Jul; 14(7):2020-30. doi:
10.1200/jco.1996.14.7.2020. [PMID: 8683232] - W Kreis, D R Budman, V Vinciguerra, K Hock, J Baer, R Ingram, L P Schacter, S Z Fields. Pharmacokinetic evaluation of high-dose etoposide phosphate after a 2-hour infusion in patients with solid tumors.
Cancer chemotherapy and pharmacology.
1996; 38(4):378-84. doi:
10.1007/s002800050498. [PMID: 8674162] - M J Millward, D R Newell, V Mummaneni, L N Igwemezie, K Balmanno, C J Charlton, L Gumbrell, M J Lind, F Chapman, M Proctor. Phase I and pharmacokinetic study of a water-soluble etoposide prodrug, etoposide phosphate (BMY-40481).
European journal of cancer (Oxford, England : 1990).
1995 Dec; 31A(13-14):2409-11. doi:
10.1016/0959-8049(95)00331-2. [PMID: 8652278] - S Kaul, L N Igwemezie, D J Stewart, S Z Fields, M Kosty, N Levithan, R Bukowski, D Gandara, G Goss, P O'Dwyer. Pharmacokinetics and bioequivalence of etoposide following intravenous administration of etoposide phosphate and etoposide in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1995 Nov; 13(11):2835-41. doi:
10.1200/jco.1995.13.11.2835. [PMID: 7595746] - D J Brooks, N R Srinivas, D S Alberts, T Thomas, L M Igwemzie, L M McKinney, J Randolph, L Schacter, S Kaul, R H Barbhaiya. Phase I and pharmacokinetic study of etoposide phosphate.
Anti-cancer drugs.
1995 Oct; 6(5):637-44. doi:
10.1097/00001813-199510000-00002. [PMID: 8845473] - D S Thompson, A Greco, A A Miller, N R Srinivas, K B Igwenezue, J D Hainsworth, L P Schacter, S Kaul, R H Barbhaiya, C Garrow. A phase I study of etoposide phosphate administered as a daily 30-minute infusion for 5 days.
Clinical pharmacology and therapeutics.
1995 May; 57(5):499-507. doi:
10.1016/0009-9236(95)90034-9. [PMID: 7768072] - C Sessa, M Zucchetti, T Cerny, O Pagani, F Cavalli, M De Fusco, J De Jong, D Gentili, C McDaniel, C Prins. Phase I clinical and pharmacokinetic study of oral etoposide phosphate.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1995 Jan; 13(1):200-9. doi:
10.1200/jco.1995.13.1.200. [PMID: 7799021] - S Z Fields, L N Igwemezie, S Kaul, L P Schacter, R J Schilder, P P Litam, B S Himpler, C McAleer, J Wright, R H Barbhaiya. Phase I study of etoposide phosphate (etopophos) as a 30-minute infusion on days 1, 3, and 5.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1995 Jan; 1(1):105-11. doi:
NULL. [PMID: 9815892] - L N Igwemezie, S Kaul, R H Barbhaiya. Assessment of toxicokinetics and toxicodynamics following intravenous administration of etoposide phosphate in beagle dogs.
Pharmaceutical research.
1995 Jan; 12(1):117-23. doi:
10.1023/a:1016203107497. [PMID: 7724471] - D R Budman, L N Igwemezie, S Kaul, J Behr, S Lichtman, P Schulman, V Vinciguerra, S L Allen, J Kolitz, K Hock. Phase I evaluation of a water-soluble etoposide prodrug, etoposide phosphate, given as a 5-minute infusion on days 1, 3, and 5 in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1994 Sep; 12(9):1902-9. doi:
10.1200/jco.1994.12.9.1902. [PMID: 8083713]