1-Oleoyl-sn-glycero-3-phosphate(2-) (BioDeep_00000899932)
代谢物信息卡片
1-Oleoyl-sn-glycero-3-phosphate(2-)
化学式: C21H39O7P-2 (434.2433274)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 10.39%
分子结构信息
SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)([O-])[O-])O
InChI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/p-2/b10-9-/t20-/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
71 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- monoacylglycerol metabolism:
1-oleoyl-sn-glycerol + H2O ⟶ H+ + glycerol + oleate - monoacylglycerol metabolism (yeast):
2-oleoylglycerol + CTP ⟶ 1-oleoyl-sn-glycerol 3-phosphate + CDP + H+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(68)
- monoacylglycerol metabolism (yeast):
1-oleoyl-sn-glycerol + H2O ⟶ H+ + glycerol + oleate - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - monoacylglycerol metabolism (yeast):
2-oleoylglycerol + H2O ⟶ H+ + glycerol + oleate - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - monoacylglycerol metabolism (yeast):
1-oleoyl-sn-glycerol + H2O ⟶ H+ + glycerol + oleate - monoacylglycerol metabolism (yeast):
2-oleoylglycerol + H2O ⟶ H+ + glycerol + oleate - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - triacylglycerol biosynthesis (Chlamydomonas):
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
a 1,2-diacyl-sn-glycerol + an acyl-CoA ⟶ a triacyl-sn-glycerol + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
a 1-acyl-sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1,2-diacyl-sn-glycerol 3-phosphate + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
a 1-acyl-sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1,2-diacyl-sn-glycerol 3-phosphate + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - phosphatidylglycerol biosynthesis II (non-plastidic):
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - diacylglycerol and triacylglycerol biosynthesis:
sn-glycerol 3-phosphate + an acyl-CoA ⟶ a 1-acyl-sn-glycerol 3-phosphate + coenzyme A - CDP-diacylglycerol biosynthesis I:
sn-glycerol 3-phosphate + NAD(P)+ ⟶ DHAP + H+ + NAD(P)H
COVID-19 Disease Map(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Beth B McConnell, Zhongxing Liang, Chad Xu, Yiran Han, C Chris Yun. LPA5-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation.
American journal of physiology. Gastrointestinal and liver physiology.
2024 Jun; 326(6):G631-G642. doi:
10.1152/ajpgi.00269.2023. [PMID: 38593468] - Raimund Dietze, Witold Szymanski, Kaire Ojasalu, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Rolf Müller. Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages.
Cells.
2024 May; 13(10):. doi:
10.3390/cells13100810. [PMID: 38786034] - Hiroko Ikeda, Miwa Takai, Toshifumi Tsujiuchi. Lysophosphatidic acid (LPA) receptor-mediated signaling and cellular responses to anticancer drugs and radiation of cancer cells.
Advances in biological regulation.
2024 May; 92(?):101029. doi:
10.1016/j.jbior.2024.101029. [PMID: 38377635] - Rajesh Chaudhary, Tahra Suhan, Mahmud W Tarhuni, Ahmed Abdel-Latif. Lysophosphatidic Acid-Mediated Inflammation at the Heart of Heart Failure.
Current cardiology reports.
2024 03; 26(3):113-120. doi:
10.1007/s11886-024-02023-8. [PMID: 38340272] - Aimi Yamamoto-Mikami, Yu Tanaka, Toshihiko Tsutsumi, Akira Kuwahara, Akira Tokumura. Altered ovarian tissue level of lysophosphatidic acid and mRNA expressions of its metabolic enzymes and receptors in rats received gonadotropin-hyperstimulation.
Reproductive biology.
2024 Mar; 24(1):100849. doi:
10.1016/j.repbio.2023.100849. [PMID: 38306852] - Kim E Dzobo, Arjen J Cupido, Barend M Mol, Lotte C A Stiekema, Miranda Versloot, Maaike Winkelmeijer, Jorge Peter, Anne-Marije Pennekamp, Stefan R Havik, Frédéric M Vaz, Michel van Weeghel, Koen H M Prange, Johannes H M Levels, Menno P J de Winther, Sotirios Tsimikas, Albert K Groen, Erik S G Stroes, Dominique P V de Kleijn, Jeffrey Kroon. Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation.
Arteriosclerosis, thrombosis, and vascular biology.
2024 03; 44(3):720-740. doi:
10.1161/atvbaha.123.319937. [PMID: 38269588] - Hideaki Isago, Baasanjav Uranbileg, Akihisa Mitani, Makoto Kurano. Understanding the modulations of glycero-lysophospholipids in an elastase-induced murine emphysema model.
Biochemical and biophysical research communications.
2024 Jan; 694(?):149419. doi:
10.1016/j.bbrc.2023.149419. [PMID: 38145597] - Tae-Young Kim, Anna Kim, Yam Prasad Aryal, Shijin Sung, Elina Pokharel, Sanjiv Neupane, So-Young Choi, Jung-Hong Ha, Jae-Kwang Jung, Hitoshi Yamamoto, Chang-Hyeon An, Jo-Young Suh, Wern-Joo Sohn, Youngkyun Lee, Il-Ho Jang, Derek D Norman, Gabor J Tigyi, Seo-Young An, Jae-Young Kim. Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation.
Journal of cellular physiology.
2024 Jan; 239(1):112-123. doi:
10.1002/jcp.31148. [PMID: 38149778] - Jacqueline A Turner, Malia A Fredrickson, Marc D'Antonio, Elizabeth Katsnelson, Morgan MacBeth, Robert Van Gulick, Tugs-Saikhan Chimed, Martin McCarter, Angelo D'Alessandro, William A Robinson, Kasey L Couts, Roberta Pelanda, Jared Klarquist, Richard P Tobin, Raul M Torres. Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity.
Nature communications.
2023 06; 14(1):3214. doi:
10.1038/s41467-023-38933-4. [PMID: 37270644] - Keisuke Yanagida, Takao Shimizu. Lysophosphatidic acid, a simple phospholipid with myriad functions.
Pharmacology & therapeutics.
2023 06; 246(?):108421. doi:
10.1016/j.pharmthera.2023.108421. [PMID: 37080433] - Christiana Magkrioti, Eleanna Kaffe, Vassilis Aidinis. The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer.
International journal of molecular sciences.
2023 May; 24(9):. doi:
10.3390/ijms24098325. [PMID: 37176032] - Miguel Benítez-Angeles, Ana E López Romero, Itzel Llorente, Ileana Hernández-Araiza, Ariela Vergara-Jaque, Fernando H Real, Óscar Eduardo Gutiérrez Castañeda, Marcelino Arciniega, Luis E Morales-Buenrostro, Francisco Torres-Quiroz, Refugio García-Villegas, Luis B Tovar-Y-Romo, Wolfgang B Liedtke, León D Islas, Tamara Rosenbaum. Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel.
The Journal of physiology.
2023 05; 601(9):1655-1673. doi:
10.1113/jp284262. [PMID: 36625071] - Raul M Torres, Jacqueline A Turner, Marc D'Antonio, Roberta Pelanda, Kimberly N Kremer. Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid.
Immunological reviews.
2023 Apr; ?(?):. doi:
10.1111/imr.13208. [PMID: 37096808] - Margaret Neighbors, Qingling Li, Sha Joe Zhu, Jia Liu, Weng Ruh Wong, Guiquan Jia, Wendy Sandoval, Gaik W Tew. Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis.
Journal of lipid research.
2023 Apr; ?(?):100375. doi:
10.1016/j.jlr.2023.100375. [PMID: 37075981] - Shun Yaginuma, Jumpei Omi, Kuniyuki Kano, Junken Aoki. Lysophospholipids and their producing enzymes: Their pathological roles and potential as pathological biomarkers.
Pharmacology & therapeutics.
2023 Apr; 246(?):108415. doi:
10.1016/j.pharmthera.2023.108415. [PMID: 37061204] - Alba Clara Fernández-Rilo, Nicola Forte, Letizia Palomba, Lea Tunisi, Fabiana Piscitelli, Roberta Imperatore, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristino. Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Molecular metabolism.
2023 Mar; ?(?):101713. doi:
10.1016/j.molmet.2023.101713. [PMID: 36977433] - Guoqiang Fan, Yanfei Li, Yibo Zong, Xiaoyi Suo, Yimin Jia, Mingming Gao, Xiaojing Yang. GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
Cell death & disease.
2023 03; 14(3):208. doi:
10.1038/s41419-023-05741-z. [PMID: 36964139] - Yusuke Nakamura, Yasuo Shimizu. Cellular and Molecular Control of Lipid Metabolism in Idiopathic Pulmonary Fibrosis: Clinical Application of the Lysophosphatidic Acid Pathway.
Cells.
2023 02; 12(4):. doi:
10.3390/cells12040548. [PMID: 36831215] - Yoshibumi Shimizu, Keiko Tamiya-Koizumi, Toshihiko Tsutsumi, Mamoru Kyogashima, Reiji Kannagi, Soichiro Iwaki, Mineyoshi Aoyama, Akira Tokumura. Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco-2 cells.
Lipids.
2023 Jan; ?(?):. doi:
10.1002/lipd.12366. [PMID: 36708255] - Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju. MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer.
Cell death & disease.
2023 01; 14(1):62. doi:
10.1038/s41419-023-05584-8. [PMID: 36702852] - Qianru Jia, Yang Bai, Hui Xu, Qingyun Liu, Wenyan Li, Teng Li, Feng Lin, Like Shen, Wei Xuan, Wenhua Zhang, Qun Zhang. Mitochondrial GPAT-derived LPA controls auxin-dependent embryonic and postembryonic development.
Proceedings of the National Academy of Sciences of the United States of America.
2022 12; 119(49):e2212881119. doi:
10.1073/pnas.2212881119. [PMID: 36454754] - Toshihiko Tsutsumi, Katsuhiko Yasuda, Mariko Neya, Hidetaka Okada, Akira Tokumura. Lysophosphatidic acid production from lysophosphatidylcholine by lysophospholipase D activity of autotaxin in plasma of women with normal and adverse pregnancies.
Prostaglandins & other lipid mediators.
2022 12; 163(?):106670. doi:
10.1016/j.prostaglandins.2022.106670. [PMID: 35963509] - Trine L Toft-Bertelsen, Dagne Barbuskaite, Eva Kjer Heerfordt, Sara Diana Lolansen, Søren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H Norager, Tenna Capion, Martin Fredensborg Rath, Marianne Juhler, Nanna MacAulay. Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1.
Fluids and barriers of the CNS.
2022 Sep; 19(1):69. doi:
10.1186/s12987-022-00361-9. [PMID: 36068581] - Xueyan Huang, Bin Feng, Meihui Liu, Zuyuan Liu, Shi Li, Wenbin Zeng. Preclinical detection of lysophosphatidic acid: A new window for ovarian cancer diagnostics.
Talanta.
2022 Sep; 247(?):123561. doi:
10.1016/j.talanta.2022.123561. [PMID: 35609485] - Ye-Ji Lee, Dong-Soon Im. Efficacy Comparison of LPA2 Antagonist H2L5186303 and Agonist GRI977143 on Ovalbumin-Induced Allergic Asthma in BALB/c Mice.
International journal of molecular sciences.
2022 Aug; 23(17):. doi:
10.3390/ijms23179745. [PMID: 36077141] - Jose R Conejo-Garcia, Tyler J Curiel. Belly Fat Weakens Immune Fitness.
Cancer discovery.
2022 08; 12(8):1841-1843. doi:
10.1158/2159-8290.cd-22-0611. [PMID: 35929132] - Chang-Suk Chae, Tito A Sandoval, Sung-Min Hwang, Eun Sil Park, Paolo Giovanelli, Deepika Awasthi, Camilla Salvagno, Alexander Emmanuelli, Chen Tan, Vidyanath Chaudhary, Julia Casado, Andrew V Kossenkov, Minkyung Song, Franck J Barrat, Kevin Holcomb, E Alfonso Romero-Sandoval, Dmitriy Zamarin, David Pépin, Alan D D'Andrea, Anniina Färkkilä, Juan R Cubillos-Ruiz. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
Cancer discovery.
2022 08; 12(8):1904-1921. doi:
10.1158/2159-8290.cd-21-1181. [PMID: 35552618] - Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G Alexopoulos, Christoph Ullmer, Vassilis Aidinis. Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells.
International journal of molecular sciences.
2022 Jul; 23(13):. doi:
10.3390/ijms23137452. [PMID: 35806457] - Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J Grabe, Frauke Zipp, Bence Rácz, Tamas L Horvath, Robert Nitsch, Johannes Vogt. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids.
Nature metabolism.
2022 06; 4(6):683-692. doi:
10.1038/s42255-022-00589-7. [PMID: 35760867] - Kimberly N Kremer, Alan Buser, Dean Thumkeo, Shuh Narumiya, Jordan Jacobelli, Roberta Pelanda, Raul M Torres. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.
Proceedings of the National Academy of Sciences of the United States of America.
2022 04; 119(15):e2118816119. doi:
10.1073/pnas.2118816119. [PMID: 35394866] - Susmita Bhattarai, Sudha Sharma, Utsab Subedi, Hosne Ara, Alika Shum, Murov Milena, Md Shenuarin Bhuiyan, Srivatsan Kidambi, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam. The ATX-LPA Axis Regulates Vascular Permeability during Cerebral Ischemic-Reperfusion.
International journal of molecular sciences.
2022 Apr; 23(8):. doi:
10.3390/ijms23084138. [PMID: 35456953] - Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito. Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 04; 36(4):e22236. doi:
10.1096/fj.202101678r. [PMID: 35218596] - Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Zhanat Koshenov, Wolfgang F Graier, Nemanja Vujic, Dagmar Kratky, Richard Rivera, Jerold Chun, Wolfgang Sattler. Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
Cells.
2022 03; 11(7):. doi:
10.3390/cells11071071. [PMID: 35406635] - Beata Małachowska, Justyna Janikiewicz, Karolina Pietrowska, Krystyna Wyka, Joanna Madzio, Kamila Wypyszczak, Marcin Tkaczyk, Sławomir Chrul, Rafał Zwiech, Anna Hogendorf, Maciej T Małecki, Maciej Borowiec, Adam Krętowski, Wojciech Młynarski, Agnieszka Dobrzyń, Michał Ciborowski, Wojciech Fendler. Elevated level of lysophosphatidic acid among patients with HNF1B mutations and its role in RCAD syndrome: a multiomic study.
Metabolomics : Official journal of the Metabolomic Society.
2022 02; 18(3):15. doi:
10.1007/s11306-022-01873-z. [PMID: 35179657] - Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda. Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer.
International journal of molecular sciences.
2022 Feb; 23(4):. doi:
10.3390/ijms23041967. [PMID: 35216080] - Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K Hite, Xin-Yun Huang. Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nature communications.
2022 02; 13(1):731. doi:
10.1038/s41467-022-28417-2. [PMID: 35136060] - Kuniyuki Kano, Junken Aoki, Timothy Hla. Lysophospholipid Mediators in Health and Disease.
Annual review of pathology.
2022 01; 17(?):459-483. doi:
10.1146/annurev-pathol-050420-025929. [PMID: 34813354] - Supriya Vishwakarma, Neha Arya, Ashok Kumar. Regulation of Tumor Immune Microenvironment by Sphingolipids and Lysophosphatidic Acid.
Current drug targets.
2022; 23(6):559-573. doi:
10.2174/1389450122666211208111833. [PMID: 34879798] - Jia Yang, Hong Wei, Yunfei Zhou, Chun-Ho Szeto, Chuangen Li, Yufeng Lin, Olabisi O Coker, Harry Cheuk Hay Lau, Anthony W H Chan, Joseph J Y Sung, Jun Yu. High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Gastroenterology.
2022 01; 162(1):135-149.e2. doi:
10.1053/j.gastro.2021.08.041. [PMID: 34461052] - Yugo Takagi, Shun Nishikado, Jumpei Omi, Junken Aoki. The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field.
Biological & pharmaceutical bulletin.
2022; 45(8):1008-1021. doi:
10.1248/bpb.b22-00304. [PMID: 35908884] - Zhongxing Liang, Peijian He, Yiran Han, C Chris Yun. Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling.
Cellular and molecular gastroenterology and hepatology.
2022; 14(1):129-150. doi:
10.1016/j.jcmgh.2022.03.012. [PMID: 35390517] - Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding. Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors.
Mediators of inflammation.
2022; 2022(?):1818758. doi:
10.1155/2022/1818758. [PMID: 36248188] - Kang-Bo Huang, Yi-Hui Pan, Guan-Nan Shu, Hao-Hua Yao, Xi Liu, Mi Zhou, Jin-Huan Wei, Zhen-Hua Chen, Jun Lu, Zi-Hao Feng, Wei Chen, Hui Han, Zhou-San Zheng, Jun-Hang Luo, Jia-Xing Zhang. Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis.
Cancer letters.
2021 12; 523(?):121-134. doi:
10.1016/j.canlet.2021.10.003. [PMID: 34626691] - Seul Kee Byeon, Rasheda Khanam, Sayedur Rahman, Tarik Hasan, Syed Jafar Raza Rizvi, Anil K Madugundu, Madan Gopal Ramarajan, Jae Hun Jung, Nabidul H Chowdhury, Salahuddin Ahmed, Rubhana Raqib, Kwang Pyo Kim, Amy L Piazza, Piero Rinaldo, Akhilesh Pandey, Abdullah H Baqui, Amanhi Bio-Banking Study Group. Maternal serum lipidomics identifies lysophosphatidic acid as a predictor of small for gestational age neonates.
Molecular omics.
2021 12; 17(6):956-966. doi:
10.1039/d1mo00131k. [PMID: 34519752] - Yi-Shaun Sheen, Hsin-Yi Huang, Yi-Hua Liao. The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial.
Journal of cosmetic dermatology.
2021 Dec; 20(12):3960-3967. doi:
10.1111/jocd.14063. [PMID: 33690913] - Faxiang Xu, Chunhao Deng, Zhili Ren, Liangyu Sun, Ya Meng, Weiwei Liu, Jianbo Wan, Guokai Chen. Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells.
Cell reports.
2021 11; 37(9):110063. doi:
10.1016/j.celrep.2021.110063. [PMID: 34852227] - Yiming Ma, Xinyi Du, Dandan Zhao, Kegong Tang, Xiaona Wang, Shaoting Guo, Xiaobei Li, Song Mei, Na Sun, Jiaqi Liu, Chengyu Jiang. 18:0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice.
Biochemical and biophysical research communications.
2021 11; 579(?):168-174. doi:
10.1016/j.bbrc.2021.09.059. [PMID: 34607170] - Nada F Abo El-Magd, Nehal M Ramadan, Salma M Eraky. The ameliorative effect of bromelain on STZ-induced type 1 diabetes in rats through Oxi-LDL/LPA/LPAR1 pathway.
Life sciences.
2021 Nov; 285(?):119982. doi:
10.1016/j.lfs.2021.119982. [PMID: 34592232] - Estibaliz González de San Román, Alberto Llorente-Ovejero, Jonatan Martínez-Gardeazabal, Marta Moreno-Rodríguez, Lydia Giménez-Llort, Iván Manuel, Rafael Rodríguez-Puertas. Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer's Disease.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212256. [PMID: 34830150] - Jacqueline A G M Langedijk, Dagmar Tolenaars, Ruth Bolier, Yi-Té Lee, Amber Meurs, Catherine Williamson, Luciano Adorini, Stan F J van de Graaf, Ulrich Beuers, Ronald Oude Elferink. Inhibition of autotaxin by bile salts and bile salt-like molecules increases its expression by feedback regulation.
Biochimica et biophysica acta. Molecular basis of disease.
2021 11; 1867(11):166239. doi:
10.1016/j.bbadis.2021.166239. [PMID: 34389475] - Feng Hao, Qiwei Liu, Fuqiang Zhang, Jiaxin Du, Amanda Dumire, Xuemin Xu, Mei-Zhen Cui. LPA1-mediated PKD2 activation promotes LPA-induced tissue factor expression via the p38α and JNK2 MAPK pathways in smooth muscle cells.
The Journal of biological chemistry.
2021 10; 297(4):101152. doi:
10.1016/j.jbc.2021.101152. [PMID: 34478715] - Toshihiko Tsutsumi, Masaki Ino, Yoshibumi Shimizu, Kohei Kawabata, Hiroyuki Nishi, Akira Tokumura. Altered plasma levels of lysophospholipids in response to adrenalectomy of rats.
Prostaglandins & other lipid mediators.
2021 10; 156(?):106579. doi:
10.1016/j.prostaglandins.2021.106579. [PMID: 34245896] - Stephan Hasse, Anne-Claire Duchez, Paul Fortin, Eric Boilard, Sylvain G Bourgoin. Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes.
Biochemical pharmacology.
2021 10; 192(?):114667. doi:
10.1016/j.bcp.2021.114667. [PMID: 34216604] - Qingling Li, Weng Wong, Andrew Birnberg, Arindam Chakrabarti, Xiaoying Yang, David F Choy, Julie Olsson, Erik Verschueren, Margaret Neighbors, Wendy Sandoval, Carrie M Rosenberger, Michele A Grimbaldeston, Gaik W Tew. Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease.
BMC pulmonary medicine.
2021 Sep; 21(1):301. doi:
10.1186/s12890-021-01670-9. [PMID: 34556083] - Susmita Bhattarai, Sudha Sharma, Hosne Ara, Utsab Subedi, Grace Sun, Chun Li, Md Shenuarin Bhuiyan, Christopher Kevil, William P Armstrong, Miles T Minvielle, Sumitra Miriyala, Manikandan Panchatcharam. Disrupted Blood-Brain Barrier and Mitochondrial Impairment by Autotaxin-Lysophosphatidic Acid Axis in Postischemic Stroke.
Journal of the American Heart Association.
2021 09; 10(18):e021511. doi:
10.1161/jaha.121.021511. [PMID: 34514847] - Anu Jose, Petra C Kienesberger. Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease.
International journal of molecular sciences.
2021 Sep; 22(17):. doi:
10.3390/ijms22179575. [PMID: 34502491] - Kevin C Tran, Jing Zhao. Lysophosphatidic Acid Regulates Rho Family of GTPases in Lungs.
Cell biochemistry and biophysics.
2021 Sep; 79(3):493-496. doi:
10.1007/s12013-021-00993-y. [PMID: 34110567] - Narasimham L Parinandi, Lawrence J Berliner. Chemistry and Biology of Bioactive Lipids-A Tribute to Prof. Viswanathan Natarajan for his 50 Years of Research in Lipid Biochemistry.
Cell biochemistry and biophysics.
2021 09; 79(3):419-421. doi:
10.1007/s12013-021-01037-1. [PMID: 34652686] - Satoshi Takagi, Yuki Sasaki, Sumie Koike, Ai Takemoto, Yosuke Seto, Mizuki Haraguchi, Takao Ukaji, Tokuichi Kawaguchi, Minoru Sugawara, Masanori Saito, Yuki Funauchi, Keisuke Ae, Seiichi Matsumoto, Naoya Fujita, Ryohei Katayama. Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis.
Oncogene.
2021 09; 40(36):5548-5558. doi:
10.1038/s41388-021-01956-6. [PMID: 34302117] - Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Häussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona, Giulia Casorati. Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia.
Nature communications.
2021 08; 12(1):4844. doi:
10.1038/s41467-021-25223-0. [PMID: 34381053] - Qingling Li, Weng R Wong, Arindam Chakrabarti, Andrew Birnberg, Xiaoying Yang, Erik Verschueren, Margaret Neighbors, Carrie Rosenberger, Michele Grimbaldeston, Gaik W Tew, Wendy Sandoval. Serum Lysophosphatidic Acid Measurement by Liquid Chromatography-Mass Spectrometry in COPD Patients.
Journal of the American Society for Mass Spectrometry.
2021 Aug; 32(8):1987-1997. doi:
10.1021/jasms.0c00429. [PMID: 33754705] - Francesca M Trovato, Rabiya Zia, Salvatore Napoli, Kate Wolfer, Xiaohong Huang, Phillip E Morgan, Hannah Husbyn, Marwa Elgosbi, Manuele Lucangeli, Rosa Miquel, Ian Wilson, Nigel David Heaton, Michael A Heneghan, Georg Auzinger, Charalambos G Antoniades, Julia A Wendon, Vishal C Patel, Muireann Coen, Evangelos Triantafyllou, Mark J McPhail. Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute-on-Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid-Dependent Monocyte Activation.
Hepatology (Baltimore, Md.).
2021 08; 74(2):907-925. doi:
10.1002/hep.31738. [PMID: 33908067] - Kazue Hisaoka-Nakashima, Toshiki Yokoe, Shintaro Watanabe, Yoki Nakamura, Naoto Kajitani, Mami Okada-Tsuchioka, Minoru Takebayashi, Yoshihiro Nakata, Norimitsu Morioka. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes.
Journal of neurochemistry.
2021 08; 158(4):849-864. doi:
10.1111/jnc.15227. [PMID: 33118159] - Amy O'Regan, Colm J O'Brien, Sarah B Eivers. The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
2021 07; 29(4):613-626. doi:
10.1111/wrr.12929. [PMID: 34009724] - Bo Young Jeong, Kyung Hwa Cho, Se-Hee Yoon, Chang Gyo Park, Hwan-Woo Park, Hoi Young Lee. Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
International journal of molecular sciences.
2021 May; 22(10):. doi:
10.3390/ijms22105374. [PMID: 34065317] - Julliana F Sant'Anna, Vanessa S Baldez, Natalie A Razuck-Garrão, Thiago Lemos, Bruno L Diaz, Marcelo Einicker-Lamas. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules.
Journal of physiology and biochemistry.
2021 May; 77(2):321-329. doi:
10.1007/s13105-021-00800-5. [PMID: 33704695] - Eva Knuplez, Eva Maria Sturm, Gunther Marsche. Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094356. [PMID: 33919453] - Manisha Ray, Yasuyuki Kihara, Darryl J Bornhop, Jerold Chun. Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding.
Lipids in health and disease.
2021 Apr; 20(1):32. doi:
10.1186/s12944-021-01454-4. [PMID: 33853612] - Baasanjav Uranbileg, Nobuko Ito, Makoto Kurano, Kuniyuki Kano, Kanji Uchida, Masahiko Sumitani, Junken Aoki, Yutaka Yatomi. Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis.
Scientific reports.
2021 02; 11(1):3984. doi:
10.1038/s41598-021-83569-3. [PMID: 33597645] - Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Chintan N Koyani, Tobias Madl, Corina Madreiter-Sokolowski, Zhanat Koshenov, Wolfgang F Graier, Seth Hallström, Wolfgang Sattler. Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041968. [PMID: 33671212] - Jiang Chen, Hongyu Li, Wenda Xu, Xiaozhong Guo. Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.
BMC gastroenterology.
2021 Feb; 21(1):58. doi:
10.1186/s12876-021-01635-6. [PMID: 33568105] - Luiz Henrique Medeiros Geraldo, Tânia Cristina Leite de Sampaio Spohr, Rackele Ferreira do Amaral, Anna Carolina Carvalho da Fonseca, Celina Garcia, Fabio de Almeida Mendes, Catarina Freitas, Marcos Fabio dosSantos, Flavia Regina Souza Lima. Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies.
Signal transduction and targeted therapy.
2021 02; 6(1):45. doi:
10.1038/s41392-020-00367-5. [PMID: 33526777] - Cinzia Parolini. Biotechnology Approaches for the Treatment of Dyslipidemia.
Cardiovascular drugs and therapy.
2021 02; 35(1):167-183. doi:
10.1007/s10557-020-07017-6. [PMID: 32519066] - Takashi Hirata, Stanley V Smith, Teisuke Takahashi, Noriyuki Miyata, Richard J Roman. Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.
The Journal of pharmacology and experimental therapeutics.
2021 02; 376(2):240-249. doi:
10.1124/jpet.120.000353. [PMID: 33277348] - Sue Chin Lee, Kuan-Hung Lin, Andrea Balogh, Derek D Norman, Mitul Bavaria, Bryan Kuo, Junming Yue, Louisa Balázs, Zoltán Benyó, Gábor Tigyi. Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment.
Cellular signalling.
2021 02; 78(?):109850. doi:
10.1016/j.cellsig.2020.109850. [PMID: 33253914] - Huai-Bin Hu, Zeng-Qing Song, Guang-Ping Song, Sen Li, Hai-Qing Tu, Min Wu, Yu-Cheng Zhang, Jin-Feng Yuan, Ting-Ting Li, Pei-Yao Li, Yu-Ling Xu, Xiao-Lin Shen, Qiu-Ying Han, Ai-Ling Li, Tao Zhou, Jerold Chun, Xue-Min Zhang, Hui-Yan Li. LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.
Nature communications.
2021 01; 12(1):662. doi:
10.1038/s41467-021-20986-y. [PMID: 33510165] - Murielle M Morales, Nichole J Pedowitz, Matthew R Pratt. O-GlcNAc modification of MYPT1 modulates lysophosphatidic acid-induced cell contraction in fibroblasts.
The Journal of biological chemistry.
2021 Jan; 296(?):100800. doi:
10.1016/j.jbc.2021.100800. [PMID: 34019870] - Mo Wang, Peijian He, Yiran Han, Lei Dong, C Chris Yun. Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
Cellular and molecular gastroenterology and hepatology.
2021; 12(3):1073-1092. doi:
10.1016/j.jcmgh.2021.05.003. [PMID: 33975030] - Jui-Chung Chiang, Wei-Min Chen, Kuan-Hung Lin, Kai Hsia, Ya-Hsuan Ho, Yueh-Chien Lin, Tang-Long Shen, Jen-Her Lu, Shih-Kuo Chen, Chao-Ling Yao, Benjamin P C Chen, Hsinyu Lee. Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2021 01; 1866(1):158818. doi:
10.1016/j.bbalip.2020.158818. [PMID: 33035680] - Konstantinos Ntatsoulis, Theodoros Karampitsakos, Eliza Tsitoura, Elli-Anna Stylianaki, Alexios N Matralis, Argyrios Tzouvelekis, Katerina Antoniou, Vassilis Aidinis. Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target.
Frontiers in immunology.
2021; 12(?):687397. doi:
10.3389/fimmu.2021.687397. [PMID: 34671341] - Hiroshi Ueda. Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain.
Progress in lipid research.
2021 01; 81(?):101079. doi:
10.1016/j.plipres.2020.101079. [PMID: 33259854] - Kuniyuki Kano, Hirotaka Matsumoto, Nozomu Kono, Makoto Kurano, Yutaka Yatomi, Junken Aoki. Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification.
Journal of lipid research.
2021; 62(?):100029. doi:
10.1016/j.jlr.2021.100029. [PMID: 33524376] - Whitney S McDonald, Kyoko Miyamoto, Richard Rivera, Grace Kennedy, Beatriz S V Almeida, Marcy A Kingsbury, Jerold Chun. Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
Molecular brain.
2020 12; 13(1):169. doi:
10.1186/s13041-020-00709-y. [PMID: 33317583] - Ying Zhou, Peter J Little, Yingnan Cao, Hang T Ta, Danielle Kamato. Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3.
Biochimica et biophysica acta. Molecular cell research.
2020 12; 1867(12):118848. doi:
10.1016/j.bbamcr.2020.118848. [PMID: 32920014] - Himi Tripathi, Ahmed Al-Darraji, Mohamed Abo-Aly, Hsuan Peng, Elica Shokri, Lakshman Chelvarajan, Renee R Donahue, Bryana M Levitan, Erhe Gao, Gabriela Hernandez, Andrew J Morris, Susan S Smyth, Ahmed Abdel-Latif. Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Journal of molecular and cellular cardiology.
2020 12; 149(?):95-114. doi:
10.1016/j.yjmcc.2020.09.011. [PMID: 33017574] - Felix Yemanyi, VijayKrishna Raghunathan. Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells.
Investigative ophthalmology & visual science.
2020 11; 61(13):29. doi:
10.1167/iovs.61.13.29. [PMID: 33216119] - Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi. Updating Phospholipase A2 Biology.
Biomolecules.
2020 10; 10(10):. doi:
10.3390/biom10101457. [PMID: 33086624] - Nuria García-Marchena, Nieves Pizarro, Francisco J Pavón, Miriam Martínez-Huélamo, María Flores-López, Nerea Requena-Ocaña, Pedro Araos, Daniel Silva-Peña, Juan Suárez, Luis J Santín, Rafael de la Torre, Fernando Rodríguez de Fonseca, Antonia Serrano. Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients.
Scientific reports.
2020 10; 10(1):17163. doi:
10.1038/s41598-020-74155-0. [PMID: 33051508] - Midori Fukui, Toshihiko Tsutsumi, Aimi Yamamoto-Mikami, Katsuya Morito, NaokoTakahashi, Tamotsu Tanaka, Takeshi Iwasa, Akira Kuwahara, Minoru Irahara, Akira Tokumura. Distinct contributions of two choline-producing enzymatic activities to lysophosphatidic acid production in human amniotic fluid from pregnant women in the second trimester and after parturition.
Prostaglandins & other lipid mediators.
2020 10; 150(?):106471. doi:
10.1016/j.prostaglandins.2020.106471. [PMID: 32585250] - Wei Wang, Jinhua Wu, Abir Mukherjee, Tianhai He, Xiang-Yang Wang, Yibao Ma, Xianjun Fang. Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 10; 34(10):13935-13948. doi:
10.1096/fj.202001136r. [PMID: 32851734] - Denise G Hemmings, David N Brindley. Signalling by lysophosphatidate and its health implications.
Essays in biochemistry.
2020 09; 64(3):547-563. doi:
10.1042/ebc20190088. [PMID: 32451553] - Pradeep K Shukla, Avtar S Meena, Ruchika Gangwar, Erzsebet Szabo, Andrea Balogh, Sue Chin Lee, Alain Vandewalle, Gabor Tigyi, RadhaKrishna Rao. LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 09; 34(9):11641-11657. doi:
10.1096/fj.202000544r. [PMID: 32654268] - Jie Li, Chendong Ji, Baozhong Lü, Maksim Rodin, Jan Paradies, Meizhen Yin, Dirk Kuckling. Dually Crosslinked Supramolecular Hydrogel for Cancer Biomarker Sensing.
ACS applied materials & interfaces.
2020 Aug; 12(33):36873-36881. doi:
10.1021/acsami.0c08722. [PMID: 32701258] - Xiaoyun Tang, Matthew G K Benesch, David N Brindley. Role of the autotaxin-lysophosphatidate axis in the development of resistance to cancer therapy.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 08; 1865(8):158716. doi:
10.1016/j.bbalip.2020.158716. [PMID: 32305571] - Susan S Smyth, Maria Kraemer, Liping Yang, Patrick Van Hoose, Andrew J Morris. Roles for lysophosphatidic acid signaling in vascular development and disease.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 08; 1865(8):158734. doi:
10.1016/j.bbalip.2020.158734. [PMID: 32376340] - Shuko Iwatani, Hideki Iijima, Yuriko Otake, Takahiro Amano, Mizuki Tani, Takeo Yoshihara, Taku Tashiro, Yoshiki Tsujii, Takahiro Inoue, Yoshito Hayashi, Kiyoshi Takeda, Akio Hayashi, Setsuko Fujita, Shinichiro Shinzaki, Tetsuo Takehara. Novel mass spectrometry-based comprehensive lipidomic analysis of plasma from patients with inflammatory bowel disease.
Journal of gastroenterology and hepatology.
2020 Aug; 35(8):1355-1364. doi:
10.1111/jgh.15067. [PMID: 32285970] - Tiewei Li, Rui Peng, Fang Wang, Lu Hua, Sheng Liu, Zhiyan Han, Jianqiu Pei, Shengqiang Pei, Zhenwen Zhao, Xin Jiang, Xi Chen. Lysophosphatidic acid promotes thrombus stability by inducing rapid formation of neutrophil extracellular traps: A new mechanism of thrombosis.
Journal of thrombosis and haemostasis : JTH.
2020 08; 18(8):1952-1964. doi:
10.1111/jth.14839. [PMID: 32291893] - Tamae Matsumoto, Koichiro Awai. Adaptations in chloroplast membrane lipid synthesis from synthesis in ancestral cyanobacterial endosymbionts.
Biochemical and biophysical research communications.
2020 07; 528(3):473-477. doi:
10.1016/j.bbrc.2020.05.175. [PMID: 32507278] - Thomas Öhlinger, Ernst W Müllner, Magdalena Fritz, Thomas Sauer, Maike Werning, David M Baron, Ulrich Salzer. Lysophosphatidic acid-induced pro-thrombotic phosphatidylserine exposure and ionophore-induced microvesiculation is mediated by the scramblase TMEM16F in erythrocytes.
Blood cells, molecules & diseases.
2020 07; 83(?):102426. doi:
10.1016/j.bcmd.2020.102426. [PMID: 32222693]