(2S)-2-azaniumyl-6-[4-[(4S)-4-azaniumyl-4-carboxylatobutyl]-3,5-bis[(3S)-3-azaniumyl-3-carboxylatopropyl]pyridin-1-ium-1-yl]hexanoate (BioDeep_00000899219)
代谢物信息卡片
(2S)-2-azaniumyl-6-[4-[(4S)-4-azaniumyl-4-carboxylatobutyl]-3,5-bis[(3S)-3-azaniumyl-3-carboxylatopropyl]pyridin-1-ium-1-yl]hexanoate
化学式: C24H40N5O8+ (526.287674)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C(=C(C=[N+]1CCCCC(C(=O)[O-])[NH3+])CCC(C(=O)[O-])[NH3+])CCCC(C(=O)[O-])[NH3+])CCC(C(=O)[O-])[NH3+]
InChI: InChI=1S/C24H39N5O8/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37)/p+1/t17-,18-,19-,20-/m0/s1
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Jerome O Cantor, Shuren Ma, Xingjian Liu, Michael A Campos, Charlton Strange, James M Stocks, Megan S Devine, Sherif G El Bayadi, Randolph J Lipchik, Robert A Sandhaus, Gerard M Turino. A 28-day clinical trial of aerosolized hyaluronan in alpha-1 antiprotease deficiency COPD using desmosine as a surrogate marker for drug efficacy.
Respiratory medicine.
2021 06; 182(?):106402. doi:
10.1016/j.rmed.2021.106402. [PMID: 33906126] - Ify R Mordi, Rachael O Forsythe, Corry Gellatly, Zaid Iskandar, Olivia M McBride, Athanasios Saratzis, Rod Chalmers, Calvin Chin, Matthew J Bown, David E Newby, Chim C Lang, Jeffrey T J Huang, Anna-Maria Choy. Plasma Desmosine and Abdominal Aortic Aneurysm Disease.
Journal of the American Heart Association.
2019 10; 8(20):e013743. doi:
10.1161/jaha.119.013743. [PMID: 31595818] - Jerome Cantor, Arnulfo Ochoa, Shuren Ma, Xingjian Liu, Gerard Turino. Free Desmosine is a Sensitive Marker of Smoke-Induced Emphysema.
Lung.
2018 12; 196(6):659-663. doi:
10.1007/s00408-018-0163-1. [PMID: 30218154] - Pratikkumar Rathod, Manjeet Kaur, Hsin-Pin Ho, Marissa E Louis, Basant Dhital, Philip Durlik, Gregory S Boutis, Kevin J Mark, Jong I Lee, Emmanuel J Chang. Quantification of desmosine and isodesmosine using MALDI-ion trap tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2018 Oct; 410(26):6881-6889. doi:
10.1007/s00216-018-1288-z. [PMID: 30062515] - Gerard M Turino. Chronic Obstructive Pulmonary Disease. A Biomarker and a Potential Therapy.
Annals of the American Thoracic Society.
2018 02; 15(Suppl 1):S15-S17. doi:
10.1513/annalsats.201707-568kv. [PMID: 29461896] - Changhwan Kim, Yousang Ko, Su Hee Kim, Hyun Ju Yoo, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park. Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD.
Respirology (Carlton, Vic.).
2018 02; 23(2):176-181. doi:
10.1111/resp.13170. [PMID: 28905464] - Rob Janssen, Cees Vermeer. Vitamin K deficit and elastolysis theory in pulmonary elasto-degenerative diseases.
Medical hypotheses.
2017 Oct; 108(?):38-41. doi:
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American journal of therapeutics.
2017 Jul; 24(4):e399-e404. doi:
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American journal of respiratory and critical care medicine.
2017 05; 195(10):1384-1393. doi:
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COPD.
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Respiratory medicine.
2017 02; 123(?):63-70. doi:
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International journal of chronic obstructive pulmonary disease.
2017; 12(?):2747-2752. doi:
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The European respiratory journal.
2016 05; 47(5):1365-73. doi:
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Lung.
2015 Jun; 193(3):329-34. doi:
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Journal of chromatography. A.
2014 Jan; 1326(?):13-9. doi:
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Electrophoresis.
2014 Jan; 35(1):109-18. doi:
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The Journal of infectious diseases.
2013 Nov; 208(10):1571-9. doi:
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Bioanalysis.
2013 Aug; 5(16):1991-2001. doi:
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Analytical biochemistry.
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Pediatric pulmonology.
2012 Sep; 47(9):856-63. doi:
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2012 Jun; 24(4):263-9. doi:
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The European respiratory journal.
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Clinical physiology and functional imaging.
2012 Jan; 32(1):71-9. doi:
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PloS one.
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2011 Dec; 879(32):3797-801. doi:
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COPD.
2011 Oct; 8(5):329-33. doi:
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Chest.
2011 Oct; 140(4):946-953. doi:
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American journal of respiratory and critical care medicine.
2011 Sep; 184(6):637-41. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jul; 879(21):1893-8. doi:
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Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2010 May; 9(3):217-27. doi:
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Analytical chemistry.
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Journal of oleo science.
2010; 59(8):431-9. doi:
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Chest.
2009 Dec; 136(6):1561-1568. doi:
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Analytical chemistry.
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Analytical chemistry.
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The European respiratory journal.
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Thorax.
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European journal of clinical investigation.
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Electrophoresis.
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Proceedings of the National Academy of Sciences of the United States of America.
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The international journal of biochemistry & cell biology.
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Respiratory medicine.
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American journal of respiratory and critical care medicine.
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10.1164/ajrccm.162.6.2002032. [PMID: 11112116] - P J Stone. Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasis.
Acta tropica.
2000 Oct; 77(1):97-9. doi:
10.1016/s0001-706x(00)00118-2. [PMID: 10996125] - S Viglio, P Iadarola, A Lupi, R Trisolini, C Tinelli, B Balbi, V Grassi, D Worlitzsch, G Döring, F Meloni, K C Meyer, L Dowson, S L Hill, R A Stockley, M Luisetti. MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients.
The European respiratory journal.
2000 Jun; 15(6):1039-45. doi:
10.1034/j.1399-3003.2000.01511.x. [PMID: 10885422] - D C Bode, E D Pagani, W R Cumiskey, R von Roemeling, L Hamel, P J Silver. Comparison of urinary desmosine excretion in patients with chronic obstructive pulmonary disease or cystic fibrosis.
Pulmonary pharmacology & therapeutics.
2000; 13(4):175-80. doi:
10.1006/pupt.2000.0245. [PMID: 10930356] - T Osakabe, E Usami, A Sato, S Sasaki, T Watanabe, Y Seyama. Characteristic change of urinary elastin peptides and desmosine in the aortic aneurysm.
Biological & pharmaceutical bulletin.
1999 Aug; 22(8):854-7. doi:
10.1248/bpb.22.854. [PMID: 10480325] - B Starcher, B Peterson. The kinetics of elastolysis: elastin catabolism during experimentally induced fibrosis.
Experimental lung research.
1999 Jul; 25(5):407-24. doi:
10.1080/019021499270169. [PMID: 10483524] - S Viglio, G Zanaboni, M Luisetti, R Trisolini, R Grimm, G Cetta, P Iadarola. Micellar electrokinetic chromatography for the determination of urinary desmosine and isodesmosine in patients affected by chronic obstructive pulmonary disease.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Aug; 714(1):87-98. doi:
10.1016/s0378-4347(98)00046-2. [PMID: 9746238] - P J Stone, A Beiser, D J Gottlieb. Circadian variation of urinary excretion of elastin and collagen crosslinks.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1998 Jul; 218(3):229-33. doi:
10.3181/00379727-218-44291. [PMID: 9648941] - N H Afdhal, A P Keaveny, S B Cohen, D P Nunes, N Maldonado, M O'Brien, P J Stone. Urinary assays for desmosine and hydroxylysylpyridinoline in the detection of cirrhosis.
Journal of hepatology.
1997 Dec; 27(6):993-1002. doi:
10.1016/s0168-8278(97)80142-0. [PMID: 9453424] - P J Stone, E C Lucey, G L Snider, C Franzblau. Distribution of elastin in hamsters and the turnover rates of different elastin pools.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1997 May; 215(1):94-101. doi:
10.3181/00379727-215-44118. [PMID: 9142143] - D J Gottlieb, P J Stone, D Sparrow, M E Gale, S T Weiss, G L Snider, G T O'Connor. Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study.
American journal of respiratory and critical care medicine.
1996 Nov; 154(5):1290-5. doi:
10.1164/ajrccm.154.5.8912738. [PMID: 8912738] - M Luisetti, C Sturani, D Sella, E Madonini, V Galavotti, G Bruno, V Peona, U Kucich, G Dagnino, J Rosenbloom, B Starcher, C Grassi. MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial.
The European respiratory journal.
1996 Jul; 9(7):1482-6. doi:
10.1183/09031936.96.09071482. [PMID: 8836663] - M Shiraishi, M Yoshida, T Aritomi, H Murakami, H Toyoshima, S Senju, M Ishibashi, K Watanabe. [Levels of alpha-elastin and of desmosine as indexes of elastase-induced lung injury in rats].
Nihon Kyobu Shikkan Gakkai zasshi.
1996 Apr; 34(4):404-12. doi:
NULL. [PMID: 8691660] - P J Stone, C Franzblau. Increase in urinary desmosine and pyridinoline during postpartum involution of the uterus in humans.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1995 Oct; 210(1):39-42. doi:
10.3181/00379727-210-43922. [PMID: 7675796] - P J Stone, M W Konstan, M Berger, H L Dorkin, C Franzblau, G L Snider. Elastin and collagen degradation products in urine of patients with cystic fibrosis.
American journal of respiratory and critical care medicine.
1995 Jul; 152(1):157-62. doi:
10.1164/ajrccm.152.1.7599816. [PMID: 7599816] - W R Cumiskey, E D Pagani, D C Bode. Enrichment and analysis of desmosine and isodesmosine in biological fluids.
Journal of chromatography. B, Biomedical applications.
1995 Jun; 668(2):199-207. doi:
10.1016/0378-4347(95)00092-w. [PMID: 7581855] - P J Stone, J H Korn, H North, E V Lally, L C Miller, L B Tucker, S Strongwater, G L Snider, C Franzblau. Cross-linked elastin and collagen degradation products in the urine of patients with scleroderma.
Arthritis and rheumatism.
1995 Apr; 38(4):517-24. doi:
10.1002/art.1780380409. [PMID: 7718005] - P J Stone, D J Gottlieb, G T O'Connor, D E Ciccolella, R Breuer, J Bryan-Rhadfi, H A Shaw, C Franzblau, G L Snider. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine.
1995 Apr; 151(4):952-9. doi:
10.1164/ajrccm.151.4.7697272. [PMID: 7697272] - B Starcher, M Green, M Scott. Measurement of urinary desmosine as an indicator of acute pulmonary disease.
Respiration; international review of thoracic diseases.
1995; 62(5):252-7. doi:
10.1159/000196458. [PMID: 8560091] - P J Stone, T A Morris, C Franzblau, G L Snider. Preliminary evidence that augmentation therapy diminishes degradation of cross-linked elastin in alpha-1-antitrypsin-deficient humans.
Respiration; international review of thoracic diseases.
1995; 62(2):76-9. doi:
10.1159/000196395. [PMID: 7784713] - P J Stone, E C Lucey, G L Snider, C Franzblau. Effect of diet on urinary excretion of desmosine and hydroxylysyl pyridinoline.
American journal of respiratory and critical care medicine.
1994 Jan; 149(1):174-7. doi:
10.1164/ajrccm.149.1.8111578. [PMID: 8111578] - J Marks-Kończalik, J Rozniecki. [Evaluation of desmosine excretion in urine and activity of elastase in neutrophils of patients with pulmonary emphysema].
Pneumonologia i alergologia polska.
1994; 62(1-2):18-23. doi:
NULL. [PMID: 8075606] - Y Yamaguchi, S Kitagawa, N Imaizumi, M Kunitomo, M Fujiwara. Enhancement of aortic cholesterol deposition by dietary linoleic acid in cholesterol-fed mice: an animal model for primary screening of antiatherosclerotic agents.
Journal of pharmacological and toxicological methods.
1993 Nov; 30(3):169-75. doi:
10.1016/1056-8719(93)90042-d. [PMID: 8305719] - T Watanabe, H Nakasaki, A Kamijou, T Mitomi, H Matsuki, H Kasuga. The technical problems shoot for the production of anti low molecular weight hapten antibody.
The Kitasato archives of experimental medicine.
1993 Apr; 65 Suppl(?):47-55. doi:
NULL. [PMID: 7967380] - M J Klin, A Wystrychowski, E Grzebieniak, A Sobczak, R Bochenek, W Wesołowski, Z S Herman. Influence of nifedipine on aortal cholesterol content, blood coagulation and elastin metabolism in cholesterol-fed rabbits.
Polish journal of pharmacology and pharmacy.
1992 Sep; 44(5):461-8. doi:
NULL. [PMID: 1297110] - J L Adgate, H F Reid, R Morris, R W Helms, R A Berg, P C Hu, P W Cheng, O L Wang, P A Muelenaer, A M Collier. Nitrogen dioxide exposure and urinary excretion of hydroxyproline and desmosine.
Archives of environmental health.
1992 Sep; 47(5):376-84. doi:
10.1080/00039896.1992.9938378. [PMID: 1444601] - M C Bruce, M Schuyler, R J Martin, B C Starcher, J F Tomashefski, K E Wedig. Risk factors for the degradation of lung elastic fibers in the ventilated neonate. Implications for impaired lung development in bronchopulmonary dysplasia.
The American review of respiratory disease.
1992 Jul; 146(1):204-12. doi:
10.1164/ajrccm/146.1.204. [PMID: 1626805] - G A Campos, F A Guerra, E Brümmer, M L Muñoz, I A Vega. Synergistic effect of cortisol and thyrotrophin releasing hormone on lung maturation in the fetal sheep entails connective tissue maturation.
Biological research.
1992; 25(2):95-100. doi:
NULL. [PMID: 1365707] - B Starcher, M Scott. Fractionation of urine to allow desmosine analysis by radioimmunoassay.
Annals of clinical biochemistry.
1992 Jan; 29 ( Pt 1)(?):72-8. doi:
10.1177/000456329202900111. [PMID: 1536530] - J Rosenbloom, E J Campbell, R Mumford, T Saldeen, R M Senior, B Starcher, P Stone. Biochemical/immunologic markers of emphysema.
Annals of the New York Academy of Sciences.
1991 Dec; 624 Suppl(?):7-12. doi:
10.1111/j.1749-6632.1991.tb55333.x. [PMID: 1686164] - M F Tenholder, K R Rajagopal, Y Y Phillips, T A Dillard, L L Bennett, T G Mundie, C J Tellis. Urinary desmosine excretion as a marker of lung injury in the adult respiratory distress syndrome.
Chest.
1991 Nov; 100(5):1385-90. doi:
10.1378/chest.100.5.1385. [PMID: 1935298] - P J Stone, J Bryan-Rhadfi, E C Lucey, D E Ciccolella, G Crombie, B Faris, G L Snider, C Franzblau. Measurement of urinary desmosine by isotope dilution and high performance liquid chromatography. Correlation between elastase-induced air-space enlargement in the hamster and elevation of urinary desmosine.
The American review of respiratory disease.
1991 Aug; 144(2):284-90. doi:
10.1164/ajrccm/144.2.284. [PMID: 1859049] - V Pai, A Guz, G J Phillips, N T Cooke, D C Hutchison, T D Tetley. Urinary desmosine, elastolysis, and lung disease.
Metabolism: clinical and experimental.
1991 Feb; 40(2):139-45. doi:
10.1016/0026-0495(91)90164-r. [PMID: 1988771] - P J Stone, E C Lucey, J Bryan-Rhadfi, G L Snider, C Franzblau. Isolation of urinary desmosine by HPLC, amino acid analysis, and quantification by isotope dilution.
Annals of the New York Academy of Sciences.
1991; 624(?):355-7. doi:
10.1111/j.1749-6632.1991.tb17047.x. [PMID: 2064245] - K Nishimura. [An enzyme-linked immunosorbent assay for measuring desmosine in vivo].
Nihon Kyobu Shikkan Gakkai zasshi.
1989 Dec; 27(12):1502-8. doi:
NULL. [PMID: 2630771] - J N Evans, D R Hemenway, J Kelley. Early markers of lung injury.
Research report (Health Effects Institute).
1989 Sep; ?(29):1-17. doi:
. [PMID: 2557865] - T Watanabe, K Ishimori, A J Verplanke, H Matsuki, H Kasuga. An enzyme-linked immunosorbent assay (ELISA) for the quantitation of urinary desmosine.
The Tokai journal of experimental and clinical medicine.
1989 Sep; 14(4):347-56. doi:
NULL. [PMID: 2487974]