(2R)-2-azaniumyl-3-[(prop-2-en-1-yl)sulfanyl]propanoate (BioDeep_00000899033)
代谢物信息卡片
(2R)-2-azaniumyl-3-[(prop-2-en-1-yl)sulfanyl]propanoate
化学式: C6H11NO2S (161.051)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 60.81%
分子结构信息
SMILES: C=CCSCC(C(=O)[O-])[NH3+]
InChI: InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
代谢反应
4 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- superpathway of Allium flavor precursors:
(E) 1-propenylsulfenate ⟶ (Z)-propanethial S-oxide - alliin metabolism:
allicin ⟶ allylsulfenate + thioacrolein
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(2)
- superpathway of Allium flavor precursors:
(E) 1-propenylsulfenate ⟶ (Z)-propanethial S-oxide - alliin metabolism:
S-allyl-L-cysteine + H2O + O2 ⟶ alliin + hydrogen peroxide
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hatice Kubra Sasmaz, Eda Adal, Pınar Kadiroğlu, Serkan Selli, Turkan Uzlasir, Hasim Kelebek. Optimization of complex coacervation parameters for the production of encapsulated black garlic using response surface methodology.
Journal of food science.
2023 Oct; ?(?):. doi:
10.1111/1750-3841.16768. [PMID: 37786327] - José C E Serrano, Eva Castro-Boqué, Alicia García-Carrasco, María Inés Morán-Valero, Daniel González-Hedström, Marcelino Bermúdez-López, José Manuel Valdivielso, Alberto E Espinel, Manuel Portero-Otín. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial.
Nutrients.
2023 Aug; 15(17):. doi:
10.3390/nu15173691. [PMID: 37686723] - Tomoki Nishioka, Haruhisa Suga, Masafumi Shimizu. The Stimulation of Indigenous Bacterial Antagonists by γ-Glutamyl-S-Allyl-l-Cysteine Increases Soil Suppressiveness to Fusarium Wilt.
Applied and environmental microbiology.
2022 12; 88(24):e0155422. doi:
10.1128/aem.01554-22. [PMID: 36445356] - Taku Mizutani, Ryotaro Hara, Takayuki Iihoshi, Shoko Kozono, Michiki Takeuchi, Makoto Hibi, Satomi Takahashi, Makoto Ueda, Jun Ogawa. Identification of tryptophanase from Escherichia coli for the synthesis of S-allyl-l-cysteine and related S-substituted cysteine derivatives.
Journal of bioscience and bioengineering.
2022 Sep; 134(3):182-186. doi:
10.1016/j.jbiosc.2022.06.001. [PMID: 35764447] - Zubeyir Elmazoglu, Zehra Aydın Bek, Sanem Gulistan Sarıbaş, Candan Özoğul, Berna Goker, Berivan Bitik, Cem Nuri Aktekin, Çimen Karasu. S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2021 10; 99(5):645-654. doi:
10.1139/bcb-2021-0004. [PMID: 33930279] - Syed Mohammed Basheeruddin Asdaq, Obulesu Challa, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani, Abdulrahman Hadi Almutiri, Majed Sadun Alshammari. Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113203. [PMID: 34071846] - Md Masud Rana, Kota Shiozawa, Katsuyuki Mukai, Katsuhiko Takayanagi, Koichi Eguchi, Halima Sultana, Yusuke Ohsaki, Michio Komai, Hitoshi Shirakawa. S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells.
Molecules (Basel, Switzerland).
2021 Mar; 26(6):. doi:
10.3390/molecules26061697. [PMID: 33803601] - Mario Orozco-Morales, Norma Yanet Hernández-Pedro, Pedro Barrios-Bernal, Oscar Arrieta, Luz María Ruiz-Godoy, Michael Aschner, Abel Santamaría, Ana Laura Colín-González. S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis.
Anti-cancer drugs.
2021 02; 32(2):117-126. doi:
10.1097/cad.0000000000001015. [PMID: 33136700] - Carolina Y Reyes-Soto, Edgar Rangel-López, Sonia Galván-Arzate, Ana Laura Colín-González, Alejandro Silva-Palacios, Cecilia Zazueta, José Pedraza-Chaverri, Jair Ramírez, Anahí Chavarria, Isaac Túnez, Tao Ke, Michael Aschner, Abel Santamaría. S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF Preservation.
Neurotoxicity research.
2020 Dec; 38(4):929-940. doi:
10.1007/s12640-020-00260-7. [PMID: 32813208] - Prachi Gupta, Vikas Dutt, Nirmaljeet Kaur, Priya Kalra, Sanjeev Gupta, Anita Dua, Rajesh Dabur, Vikram Saini, Ashwani Mittal. S-allyl cysteine: A potential compound against skeletal muscle atrophy.
Biochimica et biophysica acta. General subjects.
2020 10; 1864(10):129676. doi:
10.1016/j.bbagen.2020.129676. [PMID: 32649980] - Murugan Sesha Subramanian, Giri Nandagopal Ms, Syafinaz Amin Nordin, Karuppiah Thilakavathy, Narcisse Joseph. Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184111. [PMID: 32916777] - Masakazu Hashimoto, Tsuyoshi Nakai, Teruaki Masutani, Keiko Unno, Yukihiro Akao. Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract.
Nutrients.
2020 Jun; 12(6):. doi:
10.3390/nu12061834. [PMID: 32575593] - Patrycja Bronowicka-Adamska, Anna Bentke, Małgorzata Lasota, Maria Wróbel. Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21031090. [PMID: 32041330] - Carlos Daniel Gomez, Penélope Aguilera, Alma Ortiz-Plata, Felipe Nares López, María Elena Chánez-Cárdenas, Eugenia Flores-Alfaro, Martha Eugenia Ruiz-Tachiquín, Monica Espinoza-Rojo. Aged garlic extract and S-allylcysteine increase the GLUT3 and GCLC expression levels in cerebral ischemia.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2019 Dec; 28(12):1609-1614. doi:
10.17219/acem/110328. [PMID: 31851788] - Li-Jun Yue, Xi-Yu Zhu, Rui-Sha Li, Hui-Jing Chang, Bing Gong, Chong-Chong Tian, Chang Liu, Yun-Xing Xue, Qing Zhou, Tian-Shu Xu, Dong-Jin Wang. S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy.
International journal of molecular medicine.
2019 Nov; 44(5):1943-1951. doi:
10.3892/ijmm.2019.4351. [PMID: 31573046] - Mohammad-Reza Khajevand-Khazaei, Shekoofe Azimi, Ladan Sedighnejad, Sepide Salari, Atefeh Ghorbanpour, Tourandokht Baluchnejadmojarad, Parvaneh Mohseni-Moghaddam, Safoura Khamse, Mehrdad Roghani. S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.
International immunopharmacology.
2019 Apr; 69(?):19-26. doi:
10.1016/j.intimp.2019.01.026. [PMID: 30665040] - Saddia Bano, Muhammad Asif Rasheed, Farrukh Jamil, Muhammad Ibrahim, Sumaira Kanwal. In Silico Identification of Novel Apolipoprotein E4 Inhibitor for Alzheimer's Disease Therapy.
Current computer-aided drug design.
2019; 15(1):97-103. doi:
10.2174/1573409914666181008164209. [PMID: 30306878] - Marisol Maya-López, María Verónica Mireles-García, Monserrat Ramírez-Toledo, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Abel Santamaría. Thallium-Induced Toxicity in Rat Brain Crude Synaptosomal/Mitochondrial Fractions is Sensitive to Anti-excitatory and Antioxidant Agents.
Neurotoxicity research.
2018 04; 33(3):634-640. doi:
10.1007/s12640-017-9863-1. [PMID: 29313218] - B W Lembede, K H Erlwanger, P Nkomozepi, E Chivandi. Effect of neonatal orally administered S-allyl cysteine in high-fructose diet fed Wistar rats.
Journal of developmental origins of health and disease.
2018 04; 9(2):160-171. doi:
10.1017/s2040174417000940. [PMID: 29151399] - Chitra Basu, Runa Sur. S-Allyl Cysteine Alleviates Hydrogen Peroxide Induced Oxidative Injury and Apoptosis through Upregulation of Akt/Nrf-2/HO-1 Signaling Pathway in HepG2 Cells.
BioMed research international.
2018; 2018(?):3169431. doi:
10.1155/2018/3169431. [PMID: 30515391] - B M Escribano, E Luque, M Aguilar-Luque, M Feijóo, J Caballero-Villarraso, L A Torres, V Ramirez, F I García-Maceira, E Agüera, A Santamaria, I Túnez. Dose-dependent S-allyl cysteine ameliorates multiple sclerosis disease-related pathology by reducing oxidative stress and biomarkers of dysbiosis in experimental autoimmune encephalomyelitis.
European journal of pharmacology.
2017 Nov; 815(?):266-273. doi:
10.1016/j.ejphar.2017.09.025. [PMID: 28939293] - Taehoon Park, Ju-Hee Oh, Joo Hyun Lee, Sang Cheol Park, Young Pyo Jang, Young-Joo Lee. Oral Administration of (S)-Allyl-l-Cysteine and Aged Garlic Extract to Rats: Determination of Metabolites and Their Pharmacokinetics.
Planta medica.
2017 Nov; 83(17):1351-1360. doi:
10.1055/s-0043-111895. [PMID: 28561204] - S K Anandasadagopan, C Sundaramoorthy, A K Pandurangan, V Nagarajan, K Srinivasan, S Ganapasam. S-Allyl cysteine alleviates inflammation by modulating the expression of NF-κB during chromium (VI)-induced hepatotoxicity in rats.
Human & experimental toxicology.
2017 Nov; 36(11):1186-1200. doi:
10.1177/0960327116680275. [PMID: 28988497] - Jia-Ning Syu, Mei-Due Yang, Shu-Yao Tsai, En-Pei Isabel Chiang, Shao-Chih Chiu, Che-Yi Chao, Raymond L Rodriguez, Feng-Yao Tang. S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis.
Cell transplantation.
2017 10; 26(10):1636-1647. doi:
10.1177/0963689717724792. [PMID: 29251114] - Parim Brahmanaidu, V V Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Ramavat Ravindar Naik, Suresh Pothani, Mustapha Sabana Begum, M Prasanna Rajeshkumar, Chandrasekar Varatharaju, Balaji Meriga, P Rameshreddy, A Kalaivani, Ganapathy Saravanan. Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine.
Molecular and cellular biochemistry.
2017 Aug; 432(1-2):25-32. doi:
10.1007/s11010-017-2994-0. [PMID: 28258439] - Mahboubeh Zarezadeh, Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Mehrdad Roghani. Garlic active constituent s-allyl cysteine protects against lipopolysaccharide-induced cognitive deficits in the rat: Possible involved mechanisms.
European journal of pharmacology.
2017 Jan; 795(?):13-21. doi:
10.1016/j.ejphar.2016.11.051. [PMID: 27915041] - Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Zahra Ghasemi, Mehrdad Roghani. S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase.
European journal of pharmacology.
2017 Jan; 794(?):69-76. doi:
10.1016/j.ejphar.2016.11.033. [PMID: 27887948] - De-Cheng Tsai, Meng-Chieh Liu, Yi-Reng Lin, Mei-Fang Huang, Shih-Shin Liang. A novel reductive amination method with isotopic formaldehydes for the preparation of internal standard and standards for determining organosulfur compounds in garlic.
Food chemistry.
2016 Apr; 197(Pt A):692-8. doi:
10.1016/j.foodchem.2015.11.022. [PMID: 26617005] - Hirotaka Amano, Daichi Kazamori, Kenji Itoh. Pharmacokinetics of S-Allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption.
The Journal of nutrition.
2016 Feb; 146(2):456S-459S. doi:
10.3945/jn.114.201749. [PMID: 26764325] - Toshiaki Matsutomo, Yukihiro Kodera. Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection.
The Journal of nutrition.
2016 Feb; 146(2):450S-455S. doi:
10.3945/jn.114.208520. [PMID: 26764330] - Marisol Orozco-Ibarra, Jorge Muñoz-Sánchez, Martín E Zavala-Medina, Benjamín Pineda, Roxana Magaña-Maldonado, Edgar Vázquez-Contreras, Perla D Maldonado, José Pedraza-Chaverri, María Elena Chánez-Cárdenas. Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model.
Biological research.
2016 Feb; 49(?):7. doi:
10.1186/s40659-016-0067-6. [PMID: 26830333] - Naoko Yoshimoto, Misato Onuma, Shinya Mizuno, Yuka Sugino, Ryo Nakabayashi, Shinsuke Imai, Tadamitsu Tsuneyoshi, Shin-ichiro Sumi, Kazuki Saito. Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic.
The Plant journal : for cell and molecular biology.
2015 Sep; 83(6):941-51. doi:
10.1111/tpj.12954. [PMID: 26345717] - Ana Laura Colín-González, Hugo Becerríl, Bianca Rubí Flores-Reyes, Ismael Torres, Enrique Pinzón, Daniel Santamaría-Del Angel, Isaac Túnez, Iris Serratos, José Pedraza-Chaverrí, Abel Santamaría, Perla D Maldonado. Acute restraint stress reduces hippocampal oxidative damage and behavior in rats: Effect of S-allyl cysteine.
Life sciences.
2015 Aug; 135(?):165-72. doi:
10.1016/j.lfs.2015.06.009. [PMID: 26135627] - B K Nirala, N K Gohil. Effect of garlic component s-allyl cysteine sulfoxide on glycated human serum albumin induced activation of endothelial cells: an in vitro study.
European review for medical and pharmacological sciences.
2015; 19(11):2125-31. doi:
NULL. [PMID: 26125278] - Su-Chen Ho, Min-Sheng Su. Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds.
Molecules (Basel, Switzerland).
2014 Oct; 19(11):17697-714. doi:
10.3390/molecules191117697. [PMID: 25365295] - Tania Gómez-Sierra, Eduardo Molina-Jijón, Edilia Tapia, Rogelio Hernández-Pando, Wylly Ramsés García-Niño, Perla D Maldonado, José Luis Reyes, Diana Barrera-Oviedo, Ismael Torres, José Pedraza-Chaverri. S-allylcysteine prevents cisplatin-induced nephrotoxicity and oxidative stress.
The Journal of pharmacy and pharmacology.
2014 Sep; 66(9):1271-81. doi:
10.1111/jphp.12263. [PMID: 24779924] - Reem Shouk, Aya Abdou, Kalidas Shetty, Dipayan Sarkar, Ali H Eid. Mechanisms underlying the antihypertensive effects of garlic bioactives.
Nutrition research (New York, N.Y.).
2014 Feb; 34(2):106-15. doi:
10.1016/j.nutres.2013.12.005. [PMID: 24461311] - Pulla Reddy Avula, Syed Mohammed Asdaq, Mohammed Asad. Effect of aged garlic extract and s-allyl cysteine and their interaction with atenolol during isoproterenol induced myocardial toxicity in rats.
Indian journal of pharmacology.
2014 Jan; 46(1):94-9. doi:
10.4103/0253-7613.125185. [PMID: 24550592] - Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Minh Truong Do, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
The Journal of nutritional biochemistry.
2013 Aug; 24(8):1469-78. doi:
10.1016/j.jnutbio.2012.12.006. [PMID: 23465592] - Zahra Malekpour-Dehkordi, Ebrahim Javadi, Mahmood Doosti, Maliheh Paknejad, Mitra Nourbakhsh, Narguess Yassa, Siavash Gerayesh-Nejad, Ramin Heshmat. S-Allylcysteine, a garlic compound, increases ABCA1 expression in human THP-1 macrophages.
Phytotherapy research : PTR.
2013 Mar; 27(3):357-61. doi:
10.1002/ptr.4713. [PMID: 22610793] - K Ried, O R Frank, N P Stocks. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial.
European journal of clinical nutrition.
2013 Jan; 67(1):64-70. doi:
10.1038/ejcn.2012.178. [PMID: 23169470] - Julio César Tobón-Velasco, Genaro Vázquez-Victorio, Marina Macías-Silva, Elvis Cuevas, Syed F Ali, Perla D Maldonado, María Eva González-Trujano, Antonio Cuadrado, José Pedraza-Chaverrí, Abel Santamaría. RETRACTED: S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades.
Free radical biology & medicine.
2012 09; 53(5):1024-40. doi:
10.1016/j.freeradbiomed.2012.06.040. [PMID: 22781654] - Ganapathy Saravanan, Ponnusamy Ponmurugan. Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2012 Sep; 64(6):639-44. doi:
10.1016/j.etp.2010.12.007. [PMID: 21216577] - Chan Wok Sohn, Hyunae Kim, Bo Ram You, Min Jee Kim, Hyo Jin Kim, Ji Yeon Lee, Dai-Eun Sok, Jin Hee Kim, Kun Jong Lee, Mee Ree Kim. High temperature- and high pressure-processed garlic improves lipid profiles in rats fed high cholesterol diets.
Journal of medicinal food.
2012 May; 15(5):435-40. doi:
10.1089/jmf.2011.1922. [PMID: 22404600] - Mohammad Ashafaq, Mohd Moshahid Khan, Syed Shadab Raza, Ajmal Ahmad, Gulrana Khuwaja, Hayate Javed, Andleeb Khan, Farah Islam, M Saeed Siddiqui, Mohammed M Safhi, Fakhrul Islam. S-allyl cysteine mitigates oxidative damage and improves neurologic deficit in a rat model of focal cerebral ischemia.
Nutrition research (New York, N.Y.).
2012 Feb; 32(2):133-43. doi:
10.1016/j.nutres.2011.12.014. [PMID: 22348462] - Samir Mandal, Sudip Mukherjee, Kaustav Dutta Chowdhury, Avik Sarkar, Kankana Basu, Soumosish Paul, Debasish Karmakar, Mahasweta Chatterjee, Tuli Biswas, Gobinda Chandra Sadhukhan, Gargi Sen. S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead.
Biochimica et biophysica acta.
2012 Jan; 1820(1):9-23. doi:
10.1016/j.bbagen.2011.09.019. [PMID: 22033380] - Ana L Colín-González, Ricardo A Santana, Carlos A Silva-Islas, Maria E Chánez-Cárdenas, Abel Santamaría, Perla D Maldonado. The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection.
Oxidative medicine and cellular longevity.
2012; 2012(?):907162. doi:
10.1155/2012/907162. [PMID: 22685624] - Patricia Rojas, Norma Serrano-García, Omar N Medina-Campos, José Pedraza-Chaverri, Perla D Maldonado, Elizabeth Ruiz-Sánchez. S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice.
The Journal of nutritional biochemistry.
2011 Oct; 22(10):937-44. doi:
10.1016/j.jnutbio.2010.08.005. [PMID: 21190833] - Balmiki Ray, Neelima B Chauhan, Debomoy K Lahiri. Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model.
Journal of neurochemistry.
2011 May; 117(3):388-402. doi:
10.1111/j.1471-4159.2010.07145.x. [PMID: 21166677] - B Ray, N B Chauhan, D K Lahiri. The "aged garlic extract:" (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD).
Current medicinal chemistry.
2011; 18(22):3306-13. doi:
10.2174/092986711796504664. [PMID: 21728972] - G Saravanan, P Ponmurugan, G P Senthil Kumar, T Rajarajan. Antidiabetic effect of S-allylcysteine: Effect on plasma and tissue glycoproteins in experimental diabetes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Dec; 17(14):1086-9. doi:
10.1016/j.phymed.2010.04.008. [PMID: 20576413] - Ganapathy Saravanan, Ponnusamy Ponmurugan. Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2010 Dec; 65(4):374-8. doi:
10.1007/s11130-010-0192-2. [PMID: 20839055] - S M Asdaq, M N Inamdar. Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Nov; 17(13):1016-26. doi:
10.1016/j.phymed.2010.07.012. [PMID: 20739164] - Feng-Yao Tang, En-Pei Chiang, Man-Hui Pai. Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model.
Journal of agricultural and food chemistry.
2010 Oct; 58(20):11156-64. doi:
10.1021/jf102539k. [PMID: 20866043] - Qian Wang, Xian-Li Wang, Hong-Rui Liu, Peter Rose, Yi-Zhun Zhu. Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production.
Antioxidants & redox signaling.
2010 May; 12(10):1155-65. doi:
10.1089/ars.2009.2947. [PMID: 19842912] - Diana Elinos-Calderón, Yolanda Robledo-Arratia, Verónica Pérez-De La Cruz, Perla D Maldonado, Sonia Galván-Arzate, José Pedraza-Chaverrí, Abel Santamaría. Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine.
Journal of neural transmission (Vienna, Austria : 1996).
2010 Jan; 117(1):35-44. doi:
10.1007/s00702-009-0299-5. [PMID: 19866339] - Hiroji Shinkawa, Shigekazu Takemura, Yukiko Minamiyama, Shintaro Kodai, Takuma Tsukioka, Mayuko Osada-Oka, Shoji Kubo, Shigeru Okada, Shigefumi Suehiro. S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats.
Osaka city medical journal.
2009 Dec; 55(2):61-9. doi:
NULL. [PMID: 20088405] - Vinayagam Magendiramani, Syed Umesalma, Srinivasan Kalayarasan, Ponnuraj Nagendraprabhu, Jagadeesan Arunkumar, Ganapasam Sudhandiran. S-allylcysteine attenuates renal injury by altering the expressions of iNOS and matrix metallo proteinase-2 during cyclosporine-induced nephrotoxicity in Wistar rats.
Journal of applied toxicology : JAT.
2009 Aug; 29(6):522-30. doi:
10.1002/jat.1437. [PMID: 19391111] - Fahim Atif, Seema Yousuf, Sandeep Kumar Agrawal. S-allyl L-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus.
Brain research.
2009 Apr; 1265(?):128-37. doi:
10.1016/j.brainres.2008.12.077. [PMID: 19401183] - Kanchan Bhatia, Firoz Ahmad, Hina Rashid, Sheikh Raisuddin. Protective effect of S-allylcysteine against cyclophosphamide-induced bladder hemorrhagic cystitis in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Nov; 46(11):3368-74. doi:
10.1016/j.fct.2008.08.011. [PMID: 18786597] - Esperanza Garcia, Daniel Limon, Veronica Perez-De La Cruz, Magda Giordano, Mauricio Diaz-Muñoz, Perla D Maldonado, Maria Nieves Herrera-Mundo, Jose Pedraza-Chaverri, Abel Santamaria. Lipid peroxidation, mitochondrial dysfunction and neurochemical and behavioural deficits in different neurotoxic models: protective role of S-allylcysteine.
Free radical research.
2008 Oct; 42(10):892-902. doi:
10.1080/10715760802506356. [PMID: 18985488] - Srinivasan Kalayarasan, Narayanan Sriram, Ananthasadagopan Sureshkumar, Ganapasam Sudhandiran. Chromium (VI)-induced oxidative stress and apoptosis is reduced by garlic and its derivative S-allylcysteine through the activation of Nrf2 in the hepatocytes of Wistar rats.
Journal of applied toxicology : JAT.
2008 Oct; 28(7):908-19. doi:
10.1002/jat.1355. [PMID: 18548744] - Amichand Dairam, Ronen Fogel, Santy Daya, Janice L Limson. Antioxidant and iron-binding properties of curcumin, capsaicin, and S-allylcysteine reduce oxidative stress in rat brain homogenate.
Journal of agricultural and food chemistry.
2008 May; 56(9):3350-6. doi:
10.1021/jf0734931. [PMID: 18422331] - Sivapatham Sundaresan, Perumal Subramanian. Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine.
Molecular and cellular biochemistry.
2008 Mar; 310(1-2):209-14. doi:
10.1007/s11010-007-9682-4. [PMID: 18185914] - Ganapathy Ekambaram, Peramaiyan Rajendran, Venkataraman Magesh, Dhanapal Sakthisekaran. Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.
Nutrition research (New York, N.Y.).
2008 Feb; 28(2):106-12. doi:
10.1016/j.nutres.2007.12.002. [PMID: 19083396] - Shin Chet Chuah, Philip K Moore, Yi Zhun Zhu. S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway.
American journal of physiology. Heart and circulatory physiology.
2007 Nov; 293(5):H2693-701. doi:
10.1152/ajpheart.00853.2007. [PMID: 17766469] - Göksel Sener, Abdullah Sakarcan, Berrak C Yegen. Role of garlic in the prevention of ischemia-reperfusion injury.
Molecular nutrition & food research.
2007 Nov; 51(11):1345-52. doi:
10.1002/mnfr.200700078. [PMID: 17966137] - Cristino Cruz, Ricardo Correa-Rotter, Dolores Javier Sánchez-González, Rogelio Hernández-Pando, Perla D Maldonado, Claudia María Martínez-Martínez, Omar Noel Medina-Campos, Edilia Tapia, Diana Aguilar, Yolanda I Chirino, José Pedraza-Chaverri. Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats.
American journal of physiology. Renal physiology.
2007 Nov; 293(5):F1691-8. doi:
10.1152/ajprenal.00235.2007. [PMID: 17686953] - Dipak K Das. Hydrogen sulfide preconditioning by garlic when it starts to smell.
American journal of physiology. Heart and circulatory physiology.
2007 Nov; 293(5):H2629-30. doi:
10.1152/ajpheart.00996.2007. [PMID: 17873010] - Sheng-lei Yan, Mei-chin Yin. Protective and alleviative effects from 4 cysteine-containing compounds on ethanol-induced acute liver injury through suppression of oxidation and inflammation.
Journal of food science.
2007 Sep; 72(7):S511-5. doi:
10.1111/j.1750-3841.2007.00449.x. [PMID: 17995665] - Muhammad Saeed Ahmad, Monika Pischetsrieder, Nessar Ahmed. Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts.
European journal of pharmacology.
2007 Apr; 561(1-3):32-8. doi:
10.1016/j.ejphar.2007.01.041. [PMID: 17321518] - Shintaro Kodai, Shigekazu Takemura, Yukiko Minamiyama, Seikan Hai, Satoshi Yamamoto, Shoji Kubo, Yasukazu Yoshida, Etsuo Niki, Shigeru Okada, Kazuhiro Hirohashi, Shigefumi Suehiro. S-allyl cysteine prevents CCl(4)-induced acute liver injury in rats.
Free radical research.
2007 Apr; 41(4):489-97. doi:
10.1080/10715760601118361. [PMID: 17454131] - José Pedraza-Chaverrí, Omar Noel Medina-Campos, Sabina Segoviano-Murillo. Effect of heating on peroxynitrite scavenging capacity of garlic.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2007 Apr; 45(4):622-7. doi:
10.1016/j.fct.2006.10.010. [PMID: 17126976] - Neelima B Chauhan. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576.
Journal of ethnopharmacology.
2006 Dec; 108(3):385-94. doi:
10.1016/j.jep.2006.05.030. [PMID: 16842945] - María N Herrera-Mundo, Daniela Silva-Adaya, Perla D Maldonado, Sonia Galván-Arzate, Leticia Andrés-Martínez, Verónica Pérez-De La Cruz, José Pedraza-Chaverrí, Abel Santamaría. S-Allylcysteine prevents the rat from 3-nitropropionic acid-induced hyperactivity, early markers of oxidative stress and mitochondrial dysfunction.
Neuroscience research.
2006 Sep; 56(1):39-44. doi:
10.1016/j.neures.2006.04.018. [PMID: 16806549] - Takefumi Katsuki, Keiji Hirata, Hideki Ishikawa, Nariaki Matsuura, Shin-ichiro Sumi, Hideaki Itoh. Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats.
The Journal of nutrition.
2006 03; 136(3 Suppl):847S-851S. doi:
10.1093/jn/136.3.847s. [PMID: 16484578] - Verónica Pérez-De La Cruz, Carolina González-Cortés, José Pedraza-Chaverrí, Perla D Maldonado, Leticia Andrés-Martínez, Abel Santamaría. Protective effect of S-allylcysteine on 3-nitropropionic acid-induced lipid peroxidation and mitochondrial dysfunction in rat brain synaptosomes.
Brain research bulletin.
2006 Jan; 68(5):379-83. doi:
10.1016/j.brainresbull.2005.09.013. [PMID: 16377446] - Lip Yong Chung. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide.
Journal of medicinal food.
2006; 9(2):205-13. doi:
10.1089/jmf.2006.9.205. [PMID: 16822206] - Shinjiro Mizuguchi, Shigekazu Takemura, Yukiko Minamiyama, Shintaro Kodai, Takuma Tsukioka, Kiyotoshi Inoue, Shigeru Okada, Shigefumi Suehiro. S-allyl cysteine attenuated CCl4-induced oxidative stress and pulmonary fibrosis in rats.
BioFactors (Oxford, England).
2006; 26(1):81-92. doi:
10.1002/biof.5520260108. [PMID: 16614485] - Marco A Velasco-Velázquez, Perla D Maldonado, Diana Barrera, Víctor Torres, Alejandro Zentella-Dehesa, José Pedraza-Chaverrí. Aged garlic extract induces proliferation and ameliorates gentamicin-induced toxicity in LLC-PK1 cells.
Phytotherapy research : PTR.
2006 Jan; 20(1):76-8. doi:
10.1002/ptr.1780. [PMID: 16397848] - Perla D Maldonado, María Elena Chánez-Cárdenas, José Pedraza-Chaverrí. Aged garlic extract, garlic powder extract, S-allylcysteine, diallyl sulfide and diallyl disulfide do not interfere with the antibiotic activity of gentamicin.
Phytotherapy research : PTR.
2005 Mar; 19(3):252-4. doi:
10.1002/ptr.1674. [PMID: 15934032] - B Velmurugan, S Nagini. Combination chemoprevention of experimental gastric carcinogenesis by s-allylcysteine and lycopene: modulatory effects on glutathione redox cycle antioxidants.
Journal of medicinal food.
2005; 8(4):494-501. doi:
10.1089/jmf.2005.8.494. [PMID: 16379561] - Naoaki Morihara, Nagatoshi Ide, Isao Sumioka, Eikai Kyo. Aged garlic extract inhibits peroxynitrite-induced hemolysis.
Redox report : communications in free radical research.
2005; 10(3):159-65. doi:
10.1179/135100005x57364. [PMID: 16156955] - Francisca Pérez-Severiano, Mayra Rodríguez-Pérez, José Pedraza-Chaverrí, Perla D Maldonado, Omar N Medina-Campos, Alma Ortíz-Plata, Aurora Sánchez-García, Juana Villeda-Hernández, Sonia Galván-Arzate, Penélope Aguilera, Abel Santamaría. S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats.
Neurochemistry international.
2004 Dec; 45(8):1175-83. doi:
10.1016/j.neuint.2004.06.008. [PMID: 15380627] - Michel Demeule, Mathieu Brossard, Sandra Turcotte, Anthony Regina, Julie Jodoin, Richard Béliveau. Diallyl disulfide, a chemopreventive agent in garlic, induces multidrug resistance-associated protein 2 expression.
Biochemical and biophysical research communications.
2004 Nov; 324(2):937-45. doi:
10.1016/j.bbrc.2004.09.141. [PMID: 15474518] - Francisca Pérez-Severiano, Raquel Salvatierra-Sánchez, Mayra Rodríguez-Pérez, Elvis Y Cuevas-Martínez, Jorge Guevara, Daniel Limón, Perla D Maldonado, Omar N Medina-Campos, José Pedraza-Chaverrí, Abel Santamaría. S-Allylcysteine prevents amyloid-beta peptide-induced oxidative stress in rat hippocampus and ameliorates learning deficits.
European journal of pharmacology.
2004 Apr; 489(3):197-202. doi:
10.1016/j.ejphar.2004.03.001. [PMID: 15087243] - Cheng-chin Hsu, Chien-ning Huang, Yu-chuan Hung, Mei-chin Yin. Five cysteine-containing compounds have antioxidative activity in Balb/cA mice.
The Journal of nutrition.
2004 Jan; 134(1):149-52. doi:
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Free radical biology & medicine.
2003 Aug; 35(3):317-24. doi:
10.1016/s0891-5849(03)00312-5. [PMID: 12885594] - Sivapatham Sundaresan, Perumal Subramanian. S-allylcysteine inhibits circulatory lipid peroxidation and promotes antioxidants in N-nitrosodiethylamine-induced carcinogenesis.
Polish journal of pharmacology.
2003 Jan; 55(1):37-42. doi:
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Asia Pacific journal of clinical nutrition.
2003; 12(4):488-94. doi:
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Cell biochemistry and function.
2002 Sep; 20(3):263-8. doi:
10.1002/cbf.967. [PMID: 12125104] - Qiaoling Peng, Amber R Buz'Zard, Benjamin H S Lau. Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro.
Medical science monitor : international medical journal of experimental and clinical research.
2002 Aug; 8(8):BR328-37. doi:
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Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB).
2002 Feb; 6(1):13-6. doi:
10.1080/10258140290010160. [PMID: 12186777] - N Gupta, T D Porter. Garlic and garlic-derived compounds inhibit human squalene monooxygenase.
The Journal of nutrition.
2001 Jun; 131(6):1662-7. doi:
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The Journal of nutrition.
2001 03; 131(3s):968S-71S. doi:
10.1093/jn/131.3.968s. [PMID: 11238798] - Y Y Yeh, L Liu. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies.
The Journal of nutrition.
2001 03; 131(3s):989S-93S. doi:
10.1093/jn/131.3.989s. [PMID: 11238803] - S T Ohnishi, T Ohnishi. In vitro effects of aged garlic extract and other nutritional supplements on sickle erythrocytes.
The Journal of nutrition.
2001 Mar; 131(3s):1085S-92S. doi:
10.1093/jn/131.3.1085s. [PMID: 11238822] - Y Numagami, S T Ohnishi. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia.
The Journal of nutrition.
2001 03; 131(3s):1100S-5S. doi:
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The Journal of nutrition.
2001 03; 131(3s):1020S-6S. doi:
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