N-formimidoyl-L-glutamate(1-) (BioDeep_00000898601)
代谢物信息卡片
N-formimidoyl-L-glutamate(1-)
化学式: C6H9N2O4- (173.0562)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C(CC(=O)[O-])C(C(=O)[O-])[NH+]=CN
InChI: InChI=1S/C6H10N2O4/c7-3-8-4(6(11)12)1-2-5(9)10/h3-4H,1-2H2,(H2,7,8)(H,9,10)(H,11,12)/p-1/t4-/m0/s1
描述信息
Conjugate base of N-formimidoyl-L-glutamic acid having both carboxy groups in anionic form and the imine nitrogen protonated.
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同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
11 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(11)
- L-histidine degradation I:
N-formimino-L-glutamate + H2O ⟶ formamide + glu - L-histidine degradation II:
N-formyl-L-glutamate + H2O ⟶ formate + glu - L-histidine degradation II:
his ⟶ ammonium + urocanate - L-histidine degradation II:
4-imidazolone-5-propanoate + H2O ⟶ N-formimino-L-glutamate - L-histidine degradation I:
4-imidazolone-5-propanoate + H2O ⟶ N-formimino-L-glutamate - histidine degradation I:
N-formimino-L-glutamate + H2O ⟶ formamide + glt - L-histidine degradation I:
N-formimino-L-glutamate + H2O ⟶ formamide + glt - L-histidine degradation I:
4-imidazolone-5-propanoate + H2O ⟶ N-formimino-L-glutamate - L-histidine degradation I:
4-imidazolone-5-propanoate + H2O ⟶ N-formimino-L-glutamate - histidine degradation I:
N-formimino-L-glutamate + H2O ⟶ formamide + glt - L-histidine degradation I:
4-imidazolone-5-propanoate + H2O ⟶ N-formimino-L-glutamate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Michael Jason Bishop, Brian S Crow, Kasey D Kovalcik, Joe George, James A Bralley. Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Apr; 848(2):303-10. doi:
10.1016/j.jchromb.2006.10.042. [PMID: 17118722] - S Yu, J G Morris. Folate requirement of growing kittens to prevent elevated formiminoglutamic acid excretion following histidine loading.
The Journal of nutrition.
1998 12; 128(12 Suppl):2606S-2608S. doi:
10.1093/jn/128.12.2606s. [PMID: 9868217] - K Narisawa. [Glutamate-formiminotransferase deficiency].
Ryoikibetsu shokogun shirizu.
1998; ?(19 Pt 2):204-6. doi:
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Sangre.
1997 Jun; 42(3):235-8. doi:
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Drug and chemical toxicology.
1995 Nov; 18(4):235-70. doi:
10.3109/01480549509014323. [PMID: 8586020] - P Gimsing, E Hippe. Cobalamin-dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine.
American journal of hematology.
1995 Jun; 49(2):121-30. doi:
10.1002/ajh.2830490205. [PMID: 7771463] - M Owada. [Formiminoglutamic acid (FIGLU)].
Nihon rinsho. Japanese journal of clinical medicine.
1995 Feb; 53 Su Pt 1(?):518-22. doi:
NULL. [PMID: 8753488] - A H van Gennip, N G Abeling, A A Nijenhuis, P A Voûte, H D Bakker. Formiminoglutamic/hydantoinpropionic aciduria in three patients with different tumours.
Journal of inherited metabolic disease.
1994; 17(5):642-3. doi:
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European journal of cancer (Oxford, England : 1990).
1994; 30A(11):1616-20. doi:
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Journal of inherited metabolic disease.
1993; 16(1):155-6. doi:
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Alcoholism, clinical and experimental research.
1991 Jun; 15(3):543-8. doi:
10.1111/j.1530-0277.1991.tb00557.x. [PMID: 1877742] - S W Thenen, S M Hwang, D E Blocker, C A Meadows. Folate deficiency and an abnormal lymphocyte deoxyuridine suppression test in monkeys.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
1991; 61(4):310-8. doi:
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Anesthesia and analgesia.
1990 Dec; 71(6):610-7. doi:
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Nihon rinsho. Japanese journal of clinical medicine.
1989 Dec; 48 Suppl(?):428-31. doi:
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The Journal of nutrition.
1989 Mar; 119(3):416-24. doi:
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The Journal of nutrition.
1988 Sep; 118(9):1089-96. doi:
10.1093/jn/118.9.1089. [PMID: 3418416] - M Lato, A Minelli, M Ghebregzabher, A M Martelli, S Rufini. Erythrocyte formimino glutamate transferase in FIGLU aciduria.
La Pediatria medica e chirurgica : Medical and surgical pediatrics.
1986 Nov; 8(6):855-8. doi:
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Journal of chromatography.
1986 Sep; 381(2):401-5. doi:
10.1016/s0378-4347(00)83606-3. [PMID: 3760095] - R S Stebbings, G Lewis. Cobalt deficiency and urinary formiminoglutamic acid in lambs.
The British veterinary journal.
1986 May; 142(3):270-4. doi:
10.1016/0007-1935(86)90071-0. [PMID: 3594157] - Y S Shin, S Reiter, O Zelger, I Brünstler, A von Rücker. Orotic aciduria, homocystinuria, formiminoglutamic aciduria and megaloblastosis associated with the formiminotransferase/cyclodeaminase deficiency.
Advances in experimental medicine and biology.
1986; 195 Pt A(?):71-6. doi:
10.1007/978-1-4684-5104-7_11. [PMID: 3728187] - R E Davis. Clinical chemistry of folic acid.
Advances in clinical chemistry.
1986; 25(?):233-94. doi:
10.1016/s0065-2423(08)60127-4. [PMID: 3087140] - G P Xue, A M Snoswell, W B Runciman. Perturbation of methionine metabolism in sheep with nitrous-oxide-induced inactivation of cobalamin.
Biochemistry international.
1986 Jan; 12(1):61-9. doi:
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Clinics in haematology.
1985 Oct; 14(3):629-41. doi:
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Acta anthropogenetica.
1985; 9(1-3):117-21. doi:
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Clinical genetics.
1983 Sep; 24(3):153-5. doi:
10.1111/j.1399-0004.1983.tb02231.x. [PMID: 6627717] - J G Skinner. Urinary formininoglutamic acid in lambs.
The Veterinary record.
1983 May; 112(20):487. doi:
10.1136/vr.112.20.487. [PMID: 6868328] - A J Russel, A Whitelaw. Urinary formiminoglutamic acid in lambs.
The Veterinary record.
1983 Apr; 112(17):418. doi:
10.1136/vr.112.17.418. [PMID: 6868303] - R S Stebbings, G Lewis. Urinary formiminoglutamic acid in lambs.
The Veterinary record.
1983 Apr; 112(14):328. doi:
10.1136/vr.112.14.328. [PMID: 6857970] - D Fell, R D Steele. Effect of methionine on in vivo histidine metabolism in rats.
The Journal of nutrition.
1983 Apr; 113(4):860-6. doi:
10.1093/jn/113.4.860. [PMID: 6131952] - R Deacon, J Perry, M Lumb, I Chanarin. Increased urinary excretion of formiminoglutamic acid in nitrous-oxide-treated rats and its reduction by methionine.
European journal of biochemistry.
1983 Jan; 129(3):627-8. doi:
10.1111/j.1432-1033.1983.tb07095.x. [PMID: 6825678] - I Matsuda, K Matsuo, F Endo, I Uehara, N Nagata, Y Jinno, S Chikazawa, T Miyakita, H Miura. Skin histidase activity and urine formiminoglutamic acid (FIGLU) in patients with histidinemia found by screening newborn infants.
Clinica chimica acta; international journal of clinical chemistry.
1982 Mar; 119(3):319-28. doi:
10.1016/0009-8981(82)90345-x. [PMID: 7067128] - D Fell, R D Steele. Enhancement of histidine and one-carbon metabolism in rats fed high levels of retinol.
The Journal of nutrition.
1982 Mar; 112(3):474-9. doi:
10.1093/jn/112.3.474. [PMID: 6121019] - A M Shojania. Oral contraceptives: effect of folate and vitamin B12 metabolism.
Canadian Medical Association journal.
1982 Feb; 126(3):244-7. doi:
. [PMID: 7037144] - M Duran, D Ketting, P K de Bree, F J van Sprang, S K Wadman, T J Penders, R H Wilms. A case of formiminoglutamic aciduria. Clinical and biochemical studies.
European journal of pediatrics.
1981 Jul; 136(3):319-23. doi:
10.1007/bf00443002. [PMID: 7262105] - B Beck, E Christensen, N J Brandt, M Pedersen. Formiminoglutamic aciduria in a slightly retarded boy with chronic obstructive lung disease.
Journal of inherited metabolic disease.
1981; 4(4):225-8. doi:
10.1007/bf02263657. [PMID: 6796776] - Z Kalafatic, K Lipovac, Z Jezerinac, D Juretic, M Dumic, B Zurga, L Res. A liver urocanase deficiency.
Metabolism: clinical and experimental.
1980 Oct; 29(11):1013-9. doi:
10.1016/0026-0495(80)90209-7. [PMID: 6107814] - M M Chan, E L Stokstad. Metabolic responses of folic acid and related compounds to thyroxine in rats.
Biochimica et biophysica acta.
1980 Oct; 632(2):244-53. doi:
10.1016/0304-4165(80)90082-3. [PMID: 7417525] - E R Farnworth, D C Hill. Utilization of administered folacin derivatives by rats fed a diet low in methionine and folacin.
Canadian journal of physiology and pharmacology.
1980 Aug; 58(8):988-91. doi:
10.1139/y80-150. [PMID: 7225935] - K Pietrzik, G Urban, D Hötzel. [Biochemical and hematological parameters for the estimation of folate status in man. 3. Importance of formiminoglutamic acid excretion in the urine in comparison to other measurements].
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
1980; 50(3):261-6. doi:
. [PMID: 7429754] - K K Batra, J E Watson, E L Stokstad. Effect of dietary thyroid powder on urinary excretion of formiminoglutamic acid and methylmalonic acid.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1979 Sep; 161(4):589-93. doi:
10.3181/00379727-161-40602. [PMID: 482295] - T J Rising. Effects of hepatic microsomal enzyme inducers of the endogenous substrates vitamin D3 and folate in rat.
Biochemical pharmacology.
1979; 28(1):63-7. doi:
10.1016/0006-2952(79)90271-5. [PMID: 215168] - Y Shapira, A B Zvi, M Statter. Folic acid deficiency: a reversible cause of infantile hypotonia.
The Journal of pediatrics.
1978 Dec; 93(6):984-6. doi:
10.1016/s0022-3476(78)81229-3. [PMID: 722448] - O P Hansen. Bone marrow studies in myelomatosis.
Scandinavian journal of haematology.
1978 Sep; 21(3):265-72. doi:
10.1111/j.1600-0609.1978.tb00362.x. [PMID: 715378] - P Gimsing, E Hippe. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast.
Scandinavian journal of haematology.
1978 Sep; 21(3):243-9. doi:
10.1111/j.1600-0609.1978.tb00359.x. [PMID: 715376] - S W Thenen. Blood and liver folacin activity, formiminoglutamic acid excretion, growth and hematology in guinea pigs fed a folacin deficient diet with and without sulfonamides.
The Journal of nutrition.
1978 May; 108(5):836-42. doi:
10.1093/jn/108.5.836. [PMID: 641599] - A Russell, M Statter, S Abzug-Horowitz. Methionine dependent glutamic acid formiminotransferase deficiency: human and experimental studies in its therapy.
Monographs in human genetics.
1978; 9(?):65-74. doi:
NULL. [PMID: 732853] - S C Wang, M S Fong, P H Chen, W K Ting. Estimation of formiminoglutamic acid and urocanic acid in urine of the Chinese.
Modern medicine of Asia.
1977 Nov; 13(11):16-8. doi:
. [PMID: 600247] - S Friedman, A Shachter, B Eckerling, F Eichhorn, A Rutenberg. Fromino-glutamic acid (Figlu) excretion and abortion.
Panminerva medica.
1977 Jul; 19(4):271-4. doi:
NULL. [PMID: 593704] - I F Tagbo, D C Hill. Effect of folic acid deficiency on pregnant rats and their offspring.
Canadian journal of physiology and pharmacology.
1977 Jun; 55(3):427-33. doi:
10.1139/y77-060. [PMID: 884600] - W A Petri, L A Poirier. A methionine-reversible folate deficiency in rats following the acute administration of diethylnitrosamine and alpha-naphthylisothiocyanate.
Chemico-biological interactions.
1977 Apr; 17(1):1-7. doi:
10.1016/0009-2797(77)90066-7. [PMID: 872264] - F Chiao, E L Stokstad. Effect of methionine on the metabolism of formate and histidine by rats fed folate/vitamin B-12-methionine-deficient diet.
Biochimica et biophysica acta.
1977 Mar; 497(1):225-33. doi:
10.1016/0304-4165(77)90155-6. [PMID: 849479] - J Hilgertová, J Sonka. Formiminoglutamate excretion in rat urine after whole body irradiation, histidine administration, starvation and stress.
Physiologia Bohemoslovaca.
1977; 26(6):565-72. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1976 Nov; 73(1):39-43. doi:
10.1016/0009-8981(76)90301-6. [PMID: 1000838] - E H Reynolds. Neurological aspects of folate and vitamin B12 metabolism.
Clinics in haematology.
1976 Oct; 5(3):661-96. doi:
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The Tohoku journal of experimental medicine.
1976 Aug; 119(4):297-303. doi:
10.1620/tjem.119.297. [PMID: 960096] - J Sonka, A Ostrá-Rosenauerová, J Hilgertová, J Beneś. [Urinary formiminoglutamate in irradiated patients with cancer].
Sbornik lekarsky.
1976 Jun; 78(6):156-61. doi:
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Pediatric research.
1976 Apr; 10(4):215-9. doi:
10.1203/00006450-197604000-00002. [PMID: 1272625] - S Serra, V Bonavita. [Clinical and metabolic study of 3 cases of homocystinuria].
Acta neurologica.
1975 Sep; 30(5):515-29. doi:
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The Journal of nuclear biology and medicine.
1975 Jan; 19(1):1-4. doi:
NULL. [PMID: 1141992] - R C Siddons, J A Spence, A D Dayan. Experimental vitamin B12 deficiency in the baboon.
Advances in neurology.
1975; 10(?):239-52. doi:
NULL. [PMID: 1146647] - D P ROSE. VALUE OF DETECTION OF FORMIMINOGLUTAMIC ACID IN URINE FOR THE DIAGNOSIS OF MALABSORPTION STATES.
British medical journal.
1965 Apr; 1(5441):1031-4. doi:
10.1136/bmj.1.5441.1031. [PMID: 14262194] - G ACEVEDO, A M MAUER. THE EFFECT OF LARGE INTRAVENOUS DOSES OF METHOTREXATE ON URINARY FORMIMINOGLUTAMIC ACID EXCRETION.
The Journal of pediatrics.
1965 Apr; 66(?):753-7. doi:
10.1016/s0022-3476(65)80011-7. [PMID: 14271367] - T ARAKAWA, K OHARA, M FUJII, H HIRONO. A SIMPLE METHOD FOR DETECTION OF FORMIMINOGLUTAMIC ACID IN URINE.
The Tohoku journal of experimental medicine.
1965 Mar; 85(?):178-80. doi:
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Lancet (London, England).
1964 Nov; 2(7370):1146-9. doi:
10.1016/s0140-6736(64)92668-6. [PMID: 14213572] - J C EDOZIEN, J A MODIE. DETERMINATION OF FORMIMINOGLUTAMIC ACID BY ION-EXCHANGE CHROMATOGRAPHY.
Lancet (London, England).
1964 Nov; 2(7370):1149-50. doi:
10.1016/s0140-6736(64)92669-8. [PMID: 14213573] - M MEISS, D P PEYSER, A MILLER. AN ENZYMATIC METHOD FOR THE ASSAY OF GLUTAMIN AND FORMIMINOGLUTAMIC ACID.
The Journal of laboratory and clinical medicine.
1964 Sep; 64(?):512-8. doi:
NULL. [PMID: 14215468] - I W DYMOCK. ABNORMAL URINARY EXCRETION OF UROCANIC ACID AND FORMIMINOGLUTAMIC ACID IN NEOPLASTIC DISEASE.
Lancet (London, England).
1964 Jul; 2(7351):114-5. doi:
10.1016/s0140-6736(64)90123-0. [PMID: 14160540] - J KOHN. QUANTITATIVE ESTIMATION OF FORMIMINOGLUTAMIC ACID IN URINE.
Journal of clinical pathology.
1964 Jul; 17(?):466-7. doi:
10.1136/jcp.17.4.466. [PMID: 14195636] - R W CAREY, G P BRENA, M J KRANT. URINARY FORMIMINOGLUTAMIC ACID EXCRETION IN PATIENTS WITH NEOPLASTIC DISEASE.
Cancer.
1964 Jun; 17(?):713-22. doi:
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Proceedings of the Royal Society of Medicine.
1964 May; 57(?):384-8. doi:
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Nederlands tijdschrift voor geneeskunde.
1964 Mar; 108(?):452-8. doi:
NULL. [PMID: 14142095] - J FREZAL, J REY, H JARLIER, M LAMY. [THE EXCRETION OF FORMIMINOGLUTAMIC ACID (FIGLU) IN THE "NORMAL" INFANT AND IN STEATORRHEA CAUSED BY DISORDER OF INTESTINAL ABSORPTION].
Revue francaise d'etudes cliniques et biologiques.
1964 Jan; 9(?):38-48. doi:
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The Australian journal of experimental biology and medical science.
1963 Oct; 41(?):499-504. doi:
10.1038/icb.1963.39. [PMID: 14074099] - A V TRUFANOV, G M KIULIAN. [EFFECT OF ANTI-VITAMIN B12 ON THE EXCRETION OF FORMIMINOGLUTAMIC ACID IN GUINEA PIGS AND MONKEYS].
Biokhimiia (Moscow, Russia).
1963 Sep; 28(?):753-8. doi:
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Blood.
1962 Jul; 20(?):33-40. doi:
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The Journal of clinical investigation.
1962 Jul; 41(?):1472-83. doi:
10.1172/jci104602. [PMID: 14472889] - F J LEWIS, G R MOORE. Detection of formiminoglutamic acid in urine without histidine loading.
Lancet (London, England).
1962 Feb; 1(7224):305-6. doi:
10.1016/s0140-6736(62)91249-7. [PMID: 14464859] - M R FOX, W J LUDWIG. Excretion of formiminoglutamic acid as an index of vitamin B12, folic acid, and methionine deficiencies.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1961 Dec; 108(?):703-6. doi:
10.3181/00379727-108-27041. [PMID: 13894386] - R GRASBECK, F BJORKSTEN, W NYBERG. [Formiminoglutamic acid in the urine in folic acid deficiency].
Nordisk medicin.
1961 Sep; 66(?):1343-8. doi:
NULL. [PMID: 13901184] - J KOHN, D L MOLLIN, L M ROSENBACH. Conventional voltage electrophoresis for formiminoglutamic-acid determination in folic acid deficiency.
Journal of clinical pathology.
1961 Jul; 14(?):345-50. doi:
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Archives of internal medicine.
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