Glycodeoxycholate (BioDeep_00000898230)

   

Bile acids


代谢物信息卡片


Glycodeoxycholate

化学式: C26H42NO5- (448.30628220000006)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(bile_acids) 99.06%

分子结构信息

SMILES: CC(CCC(=O)NCC(=O)[O-])C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C26H43NO5/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-/m1/s1

描述信息

A N-acylglycinate that is the conjugate base of glycodeoxycholic acid.
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents

同义名列表

1 个代谢物同义名

Glycodeoxycholate



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Cuitong Wang, Bin Cheng, Wei Wei, Lanlan Gui, Wushuang Zeng, Yutong Wang, Yixuan Wang, Qi Chen, Liang Xu, Jia Miao, Ke Lan. Comparison of 1Beta- and 5Beta-hydroxylation of Deoxycholate and Glycodeoxycholate as In Vitro Index Reactions for Cytochrome P450 3A Activities. Drug metabolism and disposition: the biological fate of chemicals. 2024 Jan; 52(2):126-134. doi: 10.1124/dmd.123.001513. [PMID: 38050044]
  • Achmad Fauzi, Suhendro, Marcellus Simadibrata, Abdul Azis Rani, Dondin Sajuthi, Permanawati, Rosvitha Amanda, Dadang Makmun. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. Journal of medical primatology. 2022 06; 51(3):134-142. doi: 10.1111/jmp.12577. [PMID: 35306662]
  • Sławomira Drzymała-Czyż, Krzysztof Dziedzic, Artur Szwengiel, Patrycja Krzyżanowska-Jankowska, Jan K Nowak, Agata Nowicka, Raisa Aringazina, Sylwia Drzymała, Nataliya Kashirskaya, Jarosław Walkowiak. Serum bile acids in cystic fibrosis patients - glycodeoxycholic acid as a potential marker of liver disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2022 Jan; 54(1):111-117. doi: 10.1016/j.dld.2021.06.034. [PMID: 34305015]
  • Phylyne van Rijs, Vincenzo Fogliano. Roasting carob flour decreases the capacity to bind glycoconjugates of bile acids. Food & function. 2020 Jul; 11(7):5924-5932. doi: 10.1039/d0fo01158d. [PMID: 32638775]
  • S Ahlin, C Cefalo, I Bondia-Pons, E Capristo, L Marini, A Gastaldelli, G Mingrone, J J Nolan. Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity. The British journal of surgery. 2019 08; 106(9):1178-1186. doi: 10.1002/bjs.11208. [PMID: 31216062]
  • Brian Rago, Brendan Tierney, A David Rodrigues, Christopher L Holliman, Ragu Ramanathan. A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers. Bioanalysis. 2018 May; 10(9):645-657. doi: 10.4155/bio-2017-0274. [PMID: 29749252]
  • Cheng-Shi Wang, Shou-Hou Liu, Jin Peng, Chen Tang, Wei-Guo Zhu. Bile acids cycle disruption in patients with nasopharyngeal carcinoma promotes the elevation of interleukin-10 secretion. African health sciences. 2015 Dec; 15(4):1200-3. doi: 10.4314/ahs.v15i4.19. [PMID: 26958021]
  • Suzy A A Comhair, Jonathan McDunn, Carole Bennett, Jade Fettig, Serpil C Erzurum, Satish C Kalhan. Metabolomic Endotype of Asthma. Journal of immunology (Baltimore, Md. : 1950). 2015 Jul; 195(2):643-50. doi: 10.4049/jimmunol.1500736. [PMID: 26048149]
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  • Laura James, Ke Yan, Lisa Pence, Pippa Simpson, Sudeepa Bhattacharyya, Pritmohinder Gill, Lynda Letzig, Gregory Kearns, Richard Beger. Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PloS one. 2015; 10(7):e0131010. doi: 10.1371/journal.pone.0131010. [PMID: 26208104]
  • Benjamin L Woolbright, Mitchell R McGill, Vincent S Staggs, Robert D Winefield, Parviz Gholami, Mojtaba Olyaee, Matthew R Sharpe, Steven C Curry, William M Lee, Hartmut Jaeschke. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Dec; 142(2):436-44. doi: 10.1093/toxsci/kfu195. [PMID: 25239633]
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  • Li-Na Yang, Jing Wen, Yi Sun, Jia-Jia Liang, Wei-Hua Zheng, Li-Li Zhang, Yu-Jie Zhou, Zhi-Li Xiong. [Metabonomic study on the anti-liver injury effect of Si-Ni-San on rats by using UPLC-MS/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 Mar; 49(3):368-73. doi: NULL. [PMID: 24961109]
  • David R Taylor, Jamshid Alaghband-Zadeh, Gemma F Cross, Sohail Omar, Carel W le Roux, Royce P Vincent. Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2. PloS one. 2014; 9(4):e93540. doi: 10.1371/journal.pone.0093540. [PMID: 24736330]
  • Arif Burak Cekic, Etem Alhan, Arif Usta, Serdar Türkyılmaz, Birgül Vanizor Kural, Cengiz Erçin. Effects of clotrimazol on the acute necrotizing pancreatitis in rats. Inflammation. 2013 Dec; 36(6):1576-83. doi: 10.1007/s10753-013-9702-3. [PMID: 23892997]
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  • Yong Zhou, Elizabeth J Dial, Rand Doyen, Lenard M Lichtenberger. Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs. American journal of physiology. Gastrointestinal and liver physiology. 2010 May; 298(5):G722-31. doi: 10.1152/ajpgi.00387.2009. [PMID: 20203063]
  • Oliver Mann, Wolf-Jonas Tiefenbacher, Jussuf Kaifi, Claus Schneider, Dirk Kluth, Christian Bloechle, Emre Yekebas, Jakob R Izbicki, Tim Strate. Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. Pancreas. 2009 Jan; 38(1):58-64. doi: 10.1097/mpa.0b013e3181841845. [PMID: 18695628]
  • Femke Lutgendorff, Lena M Trulsson, L Paul van Minnen, Ger T Rijkers, Harro M Timmerman, Lennart E Franzén, Hein G Gooszen, Louis M A Akkermans, Johan D Söderholm, Per A Sandström. Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis. American journal of physiology. Gastrointestinal and liver physiology. 2008 Nov; 295(5):G1111-21. doi: 10.1152/ajpgi.00603.2007. [PMID: 18832452]
  • Serdar Turkyilmaz, Etem Alhan, Cengiz Ercin, Birgul Kural Vanizor, Nese Kaklikkaya, Burhan Ates, Selim Erdogan, Serdar Topaloglu. Effects of caffeic acid phenethyl ester on pancreatitis in rats. The Journal of surgical research. 2008 Mar; 145(1):19-24. doi: 10.1016/j.jss.2007.04.019. [PMID: 18028950]
  • Serdar Turkyilmaz, Etem Alhan, Cengiz Ercin, Birgul Kural Vanizor. Effects of enalaprilat on acute necrotizing pancreatitis in rats. Inflammation. 2007 Dec; 30(6):205-12. doi: 10.1007/s10753-007-9038-y. [PMID: 17653597]
  • Frank Axel Wenger, Maik Kilian, Ina Heukamp, Thomas Foitzik, Christoph Andreas Jacobi, Hans Guski, Ingolf Schimke, Joachim Michael Müller. Effects of octreotide in acute hemorrhagic necrotizing pancreatitis in rats. Journal of gastroenterology and hepatology. 2007 Nov; 22(11):1872-6. doi: 10.1111/j.1440-1746.2006.04627.x. [PMID: 17914962]
  • Nuri I Kalyoncu, Etem Alhan, Cengiz Ercin, Birgul Vanizor Kural. Effects of dual inhibitor of cyclooxygenase and 5-lipoxygenase on acute necrotizing pancreatitis in rats. Hepato-gastroenterology. 2006 Jul; 53(70):597-602. doi: . [PMID: 16995470]
  • Gerhard Dongowski, Bertram Fritzsch, Jochen Giessler, Albert Härtl, Olaf Kuhlmann, Reinhard H H Neubert. The influence of bile salts and mixed micelles on the pharmacokinetics of quinine in rabbits. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2005 May; 60(1):147-51. doi: 10.1016/j.ejpb.2005.01.003. [PMID: 15848066]
  • S Mumcu, E Alhan, S Türkyilmaz, B V Kural, C Erçin, N I Kalyoncu. Effects of N-acetylcysteine on acute necrotizing pancreatitis in rats. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 2005 May; 37(3):173-8. doi: 10.1159/000085965. [PMID: 16088183]
  • Damian J Mole, Mark A Taylor, Neil V McFerran, Thomas Diamond. The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2005; 5(4-5):475-85. doi: 10.1159/000086614. [PMID: 15985775]
  • Etem Alhan, Nuri I Kalyoncu, Cengiz Ercin, Birgul Vanizor Kural. Effects of the celecoxib on the acute necrotizing pancreatitis in rats. Inflammation. 2004 Oct; 28(5):303-9. doi: 10.1007/s10753-004-6055-x. [PMID: 16134005]
  • E Alhan, N Kaklikkaya, O Deger, C Erçin. Effects of combined nutritional therapy on acute necrotizing pancreatitis in rats in the early phase of the disease. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 2004 Jan; 36(1):33-8. doi: 10.1159/000075072. [PMID: 14730221]
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  • H M Chen, M H Shyr, S W Ueng, M F Chen. Hyperbaric oxygen therapy attenuates pancreatic microcirculatory derangement and lung edema in an acute experimental pancreatitis model in rats. Pancreas. 1998 Jul; 17(1):44-9. doi: 10.1097/00006676-199807000-00005. [PMID: 9667519]
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  • A J Hoogstraate, J Coos Verhoef, A Pijpers, L A van Leengoed, J H Verheijden, H E Junginger, H E Boddé. In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs. Pharmaceutical research. 1996 Aug; 13(8):1233-7. doi: 10.1023/a:1016024606221. [PMID: 8865318]
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