Anhydroleucovorin (BioDeep_00000897978)
代谢物信息卡片
Anhydroleucovorin
化学式: C20H22N7O6+ (456.1631492)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90%
分子结构信息
SMILES: C1C2CN(C=[N+]2C3=C(N1)N=C(NC3=O)N)C4=CC=C(C=C4)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p+1/t12-,13+/m1/s1
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
16 个相关的代谢反应过程信息。
Reactome(12)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + Homologues of FOLR2 ⟶ FOLR2:FOLA
BioCyc(3)
- folate metabolism:
H+ + ser + tetrahydrofolate ⟶ 5,10-methylene-THF + H2O + gly - formylTHF biosynthesis II:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia - formylTHF biosynthesis I:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tanja Göbel, Stefan Reisbacher, Alfred Batschauer, Richard Pokorny. Flavin Adenine Dinucleotide and N5 ,N10 -Methenyltetrahydrofolate are the in planta Cofactors of Arabidopsis thaliana Cryptochrome 3.
Photochemistry and photobiology.
2017 01; 93(1):355-362. doi:
10.1111/php.12622. [PMID: 27463507] - Christine M Pfeiffer, Maya R Sternberg, Zia Fazili, David A Lacher, Mindy Zhang, Clifford L Johnson, Heather C Hamner, Regan L Bailey, Jeanne I Rader, Sedigheh Yamini, R J Berry, Elizabeth A Yetley. Folate status and concentrations of serum folate forms in the US population: National Health and Nutrition Examination Survey 2011-2.
The British journal of nutrition.
2015 Jun; 113(12):1965-77. doi:
10.1017/s0007114515001142. [PMID: 25917925] - Patrick Scheerer, Fan Zhang, Jacqueline Kalms, David von Stetten, Norbert Krauß, Inga Oberpichler, Tilman Lamparter. The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways.
The Journal of biological chemistry.
2015 May; 290(18):11504-14. doi:
10.1074/jbc.m115.637868. [PMID: 25784552] - Zia Fazili, Ralph D Whitehead, Neelima Paladugula, Christine M Pfeiffer. A high-throughput LC-MS/MS method suitable for population biomonitoring measures five serum folate vitamers and one oxidation product.
Analytical and bioanalytical chemistry.
2013 May; 405(13):4549-60. doi:
10.1007/s00216-013-6854-9. [PMID: 23462981] - Mara L Becker, Leon van Haandel, Roger Gaedigk, Bradley Thomas, Mark F Hoeltzel, Andrew Lasky, Hongying Dai, John Stobaugh, James S Leeder. Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.
Pharmacogenetics and genomics.
2012 Apr; 22(4):236-46. doi:
10.1097/fpc.0b013e3283500202. [PMID: 22344247] - Julia Moldt, Richard Pokorny, Christian Orth, Uwe Linne, Yann Geisselbrecht, Mohamed A Marahiel, Lars-Oliver Essen, Alfred Batschauer. Photoreduction of the folate cofactor in members of the photolyase family.
The Journal of biological chemistry.
2009 Aug; 284(32):21670-83. doi:
10.1074/jbc.m109.018697. [PMID: 19531478] - Aymeric Goyer, Eva Collakova, Rocío Díaz de la Garza, Eoin P Quinlivan, Jerry Williamson, Jesse F Gregory, Yair Shachar-Hill, Andrew D Hanson. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves.
The Journal of biological chemistry.
2005 Jul; 280(28):26137-42. doi:
10.1074/jbc.m503106200. [PMID: 15888445] - J E Baggott, T Tamura. Bioactivity of orally administered unnatural isomers, [6R]-5-formyltetrahydrofolate and [6S]-5,10-methenyltetrahydrofolate, in humans.
Biochimica et biophysica acta.
1999 Oct; 1472(1-2):323-32. doi:
10.1016/s0304-4165(99)00135-x. [PMID: 10572954] - R Ghosh, S Biswas, S Roy. An apyrase from Mimosa pudica contains N5,N10-methenyl tetrahydrofolate and is stimulated by light.
European journal of biochemistry.
1998 Dec; 258(3):1009-13. doi:
10.1046/j.1432-1327.1998.2581009.x. [PMID: 9990319] - J A Houghton, L G Williams, S K Loftin, P J Cheshire, C L Morton, P J Houghton, A Dayan, J Jolivet. Factors that influence the therapeutic activity of 5-fluorouracil [6RS]leucovorin combinations in colon adenocarcinoma xenografts.
Cancer chemotherapy and pharmacology.
1992; 30(6):423-32. doi:
10.1007/bf00685592. [PMID: 1394798] - J L Johnson, S Hamm-Alvarez, G Payne, G B Sancar, K V Rajagopalan, A Sancar. Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate.
Proceedings of the National Academy of Sciences of the United States of America.
1988 Apr; 85(7):2046-50. doi:
10.1073/pnas.85.7.2046. [PMID: 2895469]