(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate (BioDeep_00000897923)
代谢物信息卡片
(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
化学式: C24H39O3- (375.2899)
中文名称:
谱图信息:
最多检出来源 not specific(lipidomics) 50%
分子结构信息
SMILES: CC(CCC(=O)[O-])C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
InChI: InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/p-1/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1
相关代谢途径
Reactome(7)
PlantCyc(0)
代谢反应
74 个相关的代谢反应过程信息。
Reactome(74)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
A1A4M6 + DCA + LCA ⟶ STARD5:DCA,LCA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
DCA + LCA + STARD5 ⟶ STARD5:DCA,LCA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
A0A5F4BPI8 + DCA + LCA ⟶ STARD5:DCA,LCA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
DCA + F1NPH6 + LCA ⟶ STARD5:DCA,LCA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
DCA + LCA + StAR-related lipid transfer protein 5 ⟶ STARD5:DCA,LCA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
DCA + LCA + Q9EPQ7 ⟶ STARD5:DCA,LCA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
D3ZN38 + DCA + LCA ⟶ STARD5:DCA,LCA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of steroids:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Recycling of bile acids and salts:
DCA + F1RID6 + LCA ⟶ STARD5:DCA,LCA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Recycling of bile acids and salts:
A0A6I8PZC4 + DCA + LCA ⟶ STARD5:DCA,LCA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Cytosolic sulfonation of small molecules:
H2O + PAP ⟶ AMP + Pi - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
PAPS + beta-estradiol ⟶ E2-SO4 + PAP - Cytosolic sulfonation of small molecules:
PAPS + beta-estradiol ⟶ E2-SO4 + PAP - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Song Chen, Zongren Hu, Jianbang Tang, Haipeng Zhu, Yuhua Zheng, Jiedong Xiao, Youhua Xu, Yao Wang, Yi Luo, Xiaoying Mo, Yalan Wu, Jianwen Guo, Yongliang Zhang, Huanhuan Luo. High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice.
Communications biology.
2024 Apr; 7(1):465. doi:
10.1038/s42003-024-06158-w. [PMID: 38632312] - Han-En Tsai, Chia-Ling Chen, Tzu-Ting Chang, Chih-Wei Fu, Wei-Chia Chen, Ser John Lynon P Perez, Pei-Wen Hsiao, Ming-Hong Tai, Wen-Shan Li. Development of a Novel, Potent, and Selective Sialyltransferase Inhibitor for Suppressing Cancer Metastasis.
International journal of molecular sciences.
2024 Apr; 25(8):. doi:
10.3390/ijms25084283. [PMID: 38673867] - Anita Wnętrzak, Dawid Szymczuk, Anna Chachaj-Brekiesz, Patrycja Dynarowicz-Latka, Dawid Lupa, Ewelina W Lipiec, Paulina Laszuk, Aneta D Petelska, Karolina H Markiewicz, Agnieszka Z Wilczewska. Lithocholic acid-based oligomers as drug delivery candidates targeting model of lipid raft.
Biochimica et biophysica acta. Biomembranes.
2024 Feb; ?(?):184294. doi:
10.1016/j.bbamem.2024.184294. [PMID: 38316379] - Ang Li, Fei Li, Wei Song, Zi-Li Lei, Qian-Qian Sha, Shao-Yuan Liu, Chang-Yin Zhou, Xue Zhang, Xiao-Zhen Li, Heide Schatten, Teng Zhang, Qing-Yuan Sun, Xiang-Hong Ou. Gut microbiota-bile acid-vitamin D axis plays an important role in determining oocyte quality and embryonic development.
Clinical and translational medicine.
2023 10; 13(10):e1236. doi:
10.1002/ctm2.1236. [PMID: 37846137] - Yue Li, Qian Wang, Jingyi Jin, Bo Tan, Jie Ren, Guochao Song, Bin Zou, Fengyi Weng, Dongming Yan, Furong Qiu. 15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation.
Toxicology letters.
2023 Feb; 377(?):62-70. doi:
10.1016/j.toxlet.2023.02.005. [PMID: 36804361] - Weijian Li, Zeyu Wang, Ruirong Lin, Shuai Huang, Huijie Miao, Lu Zou, Ke Liu, Xuya Cui, Ziyi Wang, Yijian Zhang, Chengkai Jiang, Shimei Qiu, Jiyao Ma, Wenguang Wu, Yingbin Liu. Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism.
Biochemical pharmacology.
2022 11; 205(?):115253. doi:
10.1016/j.bcp.2022.115253. [PMID: 36176239] - Priyanka Verma, Amit Arora, Kajal Rana, Devashish Mehta, Raunak Kar, Vikas Verma, C V Srikanth, Veena S Patil, Avinash Bajaj. Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4+ T cells.
Nanoscale.
2022 Oct; 14(39):14717-14731. doi:
10.1039/d1nr05644a. [PMID: 36169577] - Hajime Takei, Seiko Narushima, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Yuichiro Yamashiro, Hiroshi Nittono. Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces.
Journal of lipid research.
2022 10; 63(10):100275. doi:
10.1016/j.jlr.2022.100275. [PMID: 36089004] - Jae Won Lee, Elise S Cowley, Patricia G Wolf, Heidi L Doden, Tsuyoshi Murai, Kelly Yovani Olivos Caicedo, Lindsey K Ly, Furong Sun, Hajime Takei, Hiroshi Nittono, Steven L Daniel, Isaac Cann, H Rex Gaskins, Karthik Anantharaman, João M P Alves, Jason M Ridlon. Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes.
Gut microbes.
2022 Jan; 14(1):2132903. doi:
10.1080/19490976.2022.2132903. [PMID: 36343662] - Heidi L Doden, Patricia G Wolf, H Rex Gaskins, Karthik Anantharaman, João M P Alves, Jason M Ridlon. Completion of the gut microbial epi-bile acid pathway.
Gut microbes.
2021 Jan; 13(1):1-20. doi:
10.1080/19490976.2021.1907271. [PMID: 33938389] - Ya-Ru Xue, Sheng Yao, Qian Liu, Zhao-Liang Peng, Qiang-Qiang Deng, Bo Liu, Zheng-Hua Ma, Le Wang, Hu Zhou, Yang Ye, Guo-Yu Pan. Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver.
Acta pharmacologica Sinica.
2020 Nov; 41(11):1433-1445. doi:
10.1038/s41401-020-0406-6. [PMID: 32404983] - Qiong Li, Meng Li, Fenghua Li, Wenjun Zhou, Yanqi Dang, Li Zhang, Guang Ji. Qiang-Gan formula extract improves non-alcoholic steatohepatitis via regulating bile acid metabolism and gut microbiota in mice.
Journal of ethnopharmacology.
2020 Aug; 258(?):112896. doi:
10.1016/j.jep.2020.112896. [PMID: 32325178] - Susbin Raj Wagle, Daniel Walker, Bozica Kovacevic, Ahmed Gedawy, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Hani Al-Salami. Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies.
Scientific reports.
2020 05; 10(1):7715. doi:
10.1038/s41598-020-64355-z. [PMID: 32382021] - Dong-Shun Li, Quan-Fei Huang, Li-Huan Guan, Hui-Zhen Zhang, Xi Li, Kai-Li Fu, Yi-Xin Chen, Jian-Bo Wan, Min Huang, Hui-Chang Bi. Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Schisandra sphenanthera extract) against LCA-induced cholestasis.
Chinese journal of natural medicines.
2020 Mar; 18(3):211-218. doi:
10.1016/s1875-5364(20)30023-6. [PMID: 32245591] - Shicheng Fan, Conghui Liu, Yiming Jiang, Yue Gao, Yixin Chen, Kaili Fu, Xinpeng Yao, Min Huang, Huichang Bi. Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice.
Journal of ethnopharmacology.
2019 Dec; 245(?):112103. doi:
10.1016/j.jep.2019.112103. [PMID: 31336134] - Mari Takahara, Rie Wakabayashi, Naoki Fujimoto, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya. Enzymatic Cell-Surface Decoration with Proteins using Amphiphilic Lipid-Fused Peptide Substrates.
Chemistry (Weinheim an der Bergstrasse, Germany).
2019 May; 25(30):7315-7321. doi:
10.1002/chem.201900370. [PMID: 30840777] - Bin Huang, Qiang Zhao, Jing-Hui Zhou, Gang Xu. Enhanced activity and substrate tolerance of 7α-hydroxysteroid dehydrogenase by directed evolution for 7-ketolithocholic acid production.
Applied microbiology and biotechnology.
2019 Mar; 103(6):2665-2674. doi:
10.1007/s00253-019-09668-4. [PMID: 30734123] - Adel Qlayel Alkhedaide. Preventive effect of Juniperus procera extract on liver injury induced by lithocholic acid.
Cellular and molecular biology (Noisy-le-Grand, France).
2018 Oct; 64(13):63-68. doi:
. [PMID: 30403597] - Stefanie Staats, Gerald Rimbach, Axel Kuenstner, Simon Graspeuntner, Jan Rupp, Hauke Busch, Christian Sina, Ignacio R Ipharraguerre, Anika E Wagner. Lithocholic Acid Improves the Survival of Drosophila Melanogaster.
Molecular nutrition & food research.
2018 10; 62(20):e1800424. doi:
10.1002/mnfr.201800424. [PMID: 30051966] - Dan Wang, Li Bie, Yanbin Su, Haoran Xu, Fengrong Zhang, Yanwen Su, Bo Zhang. Effect of lithocholic acid on biologically active α,β-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment.
International journal of molecular medicine.
2018 Jun; 41(6):3195-3202. doi:
10.3892/ijmm.2018.3530. [PMID: 29512691] - Trang H Luu, Jean-Marie Bard, Delphine Carbonnelle, Chloé Chaillou, Jean-Michel Huvelin, Christine Bobin-Dubigeon, Hassan Nazih. Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells.
Cellular oncology (Dordrecht).
2018 Feb; 41(1):13-24. doi:
10.1007/s13402-017-0353-5. [PMID: 28993998] - Takuya Kuno, Mio Hirayama-Kurogi, Shingo Ito, Sumio Ohtsuki. Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels.
Scientific reports.
2018 01; 8(1):1253. doi:
10.1038/s41598-018-19545-1. [PMID: 29352187] - Vedagopuram Sreekanth, Nihal Medatwal, Sanjay Pal, Sandeep Kumar, Sagar Sengupta, Avinash Bajaj. Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability.
Molecular pharmaceutics.
2017 08; 14(8):2649-2659. doi:
10.1021/acs.molpharmaceut.7b00105. [PMID: 28665132] - Anna Leonov, Anthony Arlia-Ciommo, Simon D Bourque, Olivia Koupaki, Pavlo Kyryakov, Paméla Dakik, Mélissa McAuley, Younes Medkour, Karamat Mohammad, Tamara Di Maulo, Vladimir I Titorenko. Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.
Oncotarget.
2017 May; 8(19):30672-30691. doi:
10.18632/oncotarget.16766. [PMID: 28410198] - Runbin Sun, Na Yang, Bo Kong, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Jingqiu Huang, Jianliang Shen, Pei Wang, Siqi Feng, Fei Fei, Jiahua Guo, Jun He, Nan Aa, Qiang Chen, Yang Pan, Justin D Schumacher, Chung S Yang, Grace L Guo, Jiye Aa, Guangji Wang. Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway.
Molecular pharmacology.
2017 Feb; 91(2):110-122. doi:
10.1124/mol.116.106617. [PMID: 27932556] - Stefanie Baldofski, Holger Hoffmann, Andreas Lehmann, Stefan Breitfeld, Leif-Alexander Garbe, Rudolf J Schneider. Enzyme-linked immunosorbent assay (ELISA) for the anthropogenic marker isolithocholic acid in water.
Journal of environmental management.
2016 Nov; 182(?):612-619. doi:
10.1016/j.jenvman.2016.08.023. [PMID: 27544648] - Krzysztof Dziedzic, Artur Szwengiel, Danuta Górecka, Elżbieta Gujska, Joanna Kaczkowska, Agnieszka Drożdżyńska, Jarosław Walkowiak. Effect of Wheat Dietary Fiber Particle Size during Digestion In Vitro on Bile Acid, Faecal Bacteria and Short-Chain Fatty Acid Content.
Plant foods for human nutrition (Dordrecht, Netherlands).
2016 Jun; 71(2):151-7. doi:
10.1007/s11130-016-0537-6. [PMID: 26924312] - Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang, Huichang Bi. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.
Drug metabolism and disposition: the biological fate of chemicals.
2016 Mar; 44(3):337-42. doi:
10.1124/dmd.115.066969. [PMID: 26658429] - F-Nora Vögtle, Michael Keller, Asli A Taskin, Susanne E Horvath, Xue Li Guan, Claudia Prinz, Magdalena Opalińska, Carina Zorzin, Martin van der Laan, Markus R Wenk, Rolf Schubert, Nils Wiedemann, Martin Holzer, Chris Meisinger. The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.
The Journal of cell biology.
2015 Sep; 210(6):951-60. doi:
10.1083/jcb.201506085. [PMID: 26347140] - Xianxie Zhang, Zengchun Ma, Qiande Liang, Xianglin Tang, Donghua Hu, Canglong Liu, Hongling Tan, Chengrong Xiao, Boli Zhang, Yuguang Wang, Yue Gao. Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor.
Journal of ethnopharmacology.
2015 Apr; 164(?):357-67. doi:
10.1016/j.jep.2015.01.047. [PMID: 25660334] - Antoni Caimari, Francesc Puiggròs, Manuel Suárez, Anna Crescenti, Sirle Laos, Juan Antonio Ruiz, Virginia Alonso, Josep Moragas, Josep Maria Del Bas, Lluís Arola. The intake of a hazelnut skin extract improves the plasma lipid profile and reduces the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in hamsters fed a high-fat diet.
Food chemistry.
2015 Jan; 167(?):138-44. doi:
10.1016/j.foodchem.2014.06.072. [PMID: 25148970] - Jing-Chun Han, Jian Yu, Ya-Jie Gao. Lipidomics investigation of reversal effect of glycyrrhizin (GL) towards lithocholic acid (LCA)-induced alteration of phospholipid profiles.
Pharmaceutical biology.
2014 Dec; 52(12):1624-8. doi:
10.3109/13880209.2014.900810. [PMID: 25289528] - Anthony Arlia-Ciommo, Amanda Piano, Veronika Svistkova, Sadaf Mohtashami, Vladimir I Titorenko. Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid.
International journal of molecular sciences.
2014 Sep; 15(9):16522-43. doi:
10.3390/ijms150916522. [PMID: 25238416] - Jie Cheng, Zhong-Ze Fang, Jung-Hwan Kim, Kristopher W Krausz, Naoki Tanaka, John Y L Chiang, Frank J Gonzalez. Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.
Journal of lipid research.
2014 Mar; 55(3):455-65. doi:
10.1194/jlr.m044420. [PMID: 24343899] - Michelle T Burstein, Vladimir I Titorenko. A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology.
Redox biology.
2014; 2(?):305-7. doi:
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