acetoacetyl-CoA(4-) (BioDeep_00000897828)
代谢物信息卡片
acetoacetyl-CoA(4-)
化学式: C25H36N7O18P3S-4 (847.105)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)([O-])OP(=O)([O-])OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)([O-])[O-])O
InChI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1
描述信息
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(7)
BioCyc(18)
- superpathway of tryptophan utilization
- 2-methylpropene degradation
- superpathway of L-lysine degradation
- L-lysine fermentation to acetate and butanoate
- isopropanol biosynthesis (engineered)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation
- pyruvate fermentation to acetone
- superpathway of Clostridium acetobutylicum solventogenic fermentation
- ketogenesis
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
- Methanobacterium thermoautotrophicum biosynthetic metabolism
- superpathway of ergosterol biosynthesis I
- superpathway of ergosterol biosynthesis
- ethylmalonyl-CoA pathway
- superpathway of Clostridium acetobutylicum acidogenic fermentation
- superpathway of cholesterol biosynthesis
- isoprene biosynthesis II (engineered)
- L-glutamate degradation VII (to butanoate)
代谢反应
113 个相关的代谢反应过程信息。
Reactome(106)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Ketone body metabolism:
HMG CoA ⟶ ACA + Ac-CoA - Synthesis of Ketone Bodies:
HMG CoA ⟶ ACA + Ac-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Ketone body metabolism:
HMG CoA ⟶ ACA + Ac-CoA - Synthesis of Ketone Bodies:
HMG CoA ⟶ ACA + Ac-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
3-oxopristanoyl-CoA + CoA-SH ⟶ 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Metabolism of lipids:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Ketone body metabolism:
ACA-CoA + Ac-CoA ⟶ CoA + HMG CoA - Synthesis of Ketone Bodies:
ACA-CoA + Ac-CoA ⟶ CoA + HMG CoA - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Metabolism of lipids:
ACA + H+ + NADH ⟶ NAD + bHBA - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Synthesis of Ketone Bodies:
ACA + H+ + NADH ⟶ NAD + bHBA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
(S)-3-hydroxypalmitoyl-CoA + NAD ⟶ 3-Oxopalmitoyl-CoA + H+ + NADH - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
ATP + BUT ⟶ AMP + BT-CoA + PPi - Beta oxidation of butanoyl-CoA to acetyl-CoA:
ATP + BUT ⟶ AMP + BT-CoA + PPi - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Mitochondrial Fatty Acid Beta-Oxidation:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
(S)-3-hydroxypalmitoyl-CoA + NAD ⟶ 3-Oxopalmitoyl-CoA + H+ + NADH - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Mitochondrial Fatty Acid Beta-Oxidation:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - mitochondrial fatty acid beta-oxidation of saturated fatty acids:
H+ + TPNH + tdec2-CoA ⟶ DEC-CoA + TPN - Beta oxidation of butanoyl-CoA to acetyl-CoA:
3HB-CoA + NAD ⟶ ACA-CoA + H+ + NADH - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
ACA + SUCC-CoA ⟶ ACA-CoA + SUCCA - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
ACA + SUCC-CoA ⟶ ACA-CoA + SUCCA - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH - Ketone body metabolism:
ACA + H+ + NADH ⟶ NAD + bHBA - Ketone body catabolism:
NAD + bHBA ⟶ ACA + H+ + NADH
BioCyc(6)
- superpathway of L-lysine degradation:
acetoacetate + butanoyl-CoA ⟶ acetoacetyl-CoA + butanoate - superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation:
H+ + acetoacetate ⟶ CO2 + acetone - pyruvate fermentation to acetone:
H+ + acetoacetate ⟶ CO2 + acetone - superpathway of Clostridium acetobutylicum solventogenic fermentation:
H+ + acetoacetate ⟶ CO2 + acetone - L-lysine fermentation to acetate and butanoate:
acetoacetate + butanoyl-CoA ⟶ acetoacetyl-CoA + butanoate - L-lysine fermentation to acetate and butanoate:
ATP + acetate ⟶ ADP + acetyl phosphate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(1)
- @COVID-19 Disease
Map["name"]:
2-Methyl-3-acetoacetyl-CoA + Coenzyme A ⟶ Acetyl-CoA + Propanoyl-CoA
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Martin F Kemper, Shireesh Srivastava, M Todd King, Kieran Clarke, Richard L Veech, Robert J Pawlosky. An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans.
Lipids.
2015 Dec; 50(12):1185-93. doi:
10.1007/s11745-015-4085-x. [PMID: 26498829] - Betty Su, Robert O Ryan. Metabolic biology of 3-methylglutaconic acid-uria: a new perspective.
Journal of inherited metabolic disease.
2014 May; 37(3):359-68. doi:
10.1007/s10545-013-9669-0. [PMID: 24407466] - R Miura, Y Nishina, S Fuji, K Shiga. C-NMR study on the interaction of medium-chain acyl-CoA dehydrogenase with acetoacetyl-CoA.
Journal of biochemistry.
1996 Mar; 119(3):512-9. doi:
10.1093/oxfordjournals.jbchem.a021271. [PMID: 8830047] - K L Peterson, E E Sergienko, Y Wu, N R Kumar, A W Strauss, A E Oleson, W W Muhonen, J B Shabb, D K Srivastava. Recombinant human liver medium-chain acyl-CoA dehydrogenase: purification, characterization, and the mechanism of interactions with functionally diverse C8-CoA molecules.
Biochemistry.
1995 Nov; 34(45):14942-53. doi:
10.1021/bi00045a039. [PMID: 7578106] - R Miura, Y Nishina, K Sato, S Fujii, K Kuroda, K Shiga. 13C- and 15N-NMR studies on medium-chain acyl-CoA dehydrogenase reconstituted with 13C- and 15N-enriched flavin adenine dinucleotide.
Journal of biochemistry.
1993 Jan; 113(1):106-13. doi:
10.1093/oxfordjournals.jbchem.a123992. [PMID: 8454567] - Y Nishina, K Sato, K Shiga, S Fujii, K Kuroda, R Miura. Resonance Raman study on complexes of medium-chain acyl-CoA dehydrogenase.
Journal of biochemistry.
1992 Jun; 111(6):699-706. doi:
10.1093/oxfordjournals.jbchem.a123822. [PMID: 1500413] - B Boyer, R Odessey. Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition.
The Biochemical journal.
1990 Oct; 271(2):523-8. doi:
10.1042/bj2710523. [PMID: 2241928] - B Middleton, K Bartlett, A Romanos, J Gomez Vazquez, C Conde, R A Cannon, M Lipson, L Sweetman, W L Nyhan. 3-Ketothiolase deficiency.
European journal of pediatrics.
1986 Apr; 144(6):586-9. doi:
10.1007/bf00496042. [PMID: 3709573] - J A Sharp, M R Edwards. Initial-velocity kinetics of succinoyl-coenzyme A-3-oxo acid coenzyme A-transferase from sheep kidney.
The Biochemical journal.
1983 Jul; 213(1):179-85. doi:
10.1042/bj2130179. [PMID: 6577858] - P S Brady, R F Scofield, S Ohgaku, W C Schumann, G E Bartsch, J M Margolis, K Kumaran, A Horvat, S Mann, B R Landau. Pathways of acetoacetate's formation in liver and kidney.
The Journal of biological chemistry.
1982 Aug; 257(16):9290-3. doi:
. [PMID: 6809735]
