acetyl-CoA(4-) (BioDeep_00000897810)

   


代谢物信息卡片


acetyl-CoA(4-)

化学式: C23H34N7O17P3S-4 (805.0944704000001)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 80%

分子结构信息

SMILES: CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)([O-])OP(=O)([O-])OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)([O-])[O-])O
InChI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1

描述信息

COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

1 个代谢物同义名

acetyl-CoA(4-)



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(83)

BioCyc(163)

PlantCyc(26)

代谢反应

1961 个相关的代谢反应过程信息。

Reactome(560)

BioCyc(373)

WikiPathways(1)

Plant Reactome(15)

INOH(0)

PlantCyc(1011)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mary T Doan, Michael D Neinast, Erika L Varner, Kenneth C Bedi, David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P Singh, Cholsoon Jang, J Eduardo Rame, Donita C Brady, Jordan L Meier, Kenneth B Marguiles, Zoltan Arany, Nathaniel W Snyder. Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species. Journal of lipid research. 2022 06; 63(6):100224. doi: 10.1016/j.jlr.2022.100224. [PMID: 35568254]
  • Chen Zhao, Youlin Wang, Hao Yang, Shupei Wang, Marie-Christine Tang, Denis Cyr, Fabienne Parente, Pierre Allard, Paula Waters, Alexandra Furtos, Gongshe Yang, Grant A Mitchell. Propionic acidemia in mice: Liver acyl-CoA levels and clinical course. Molecular genetics and metabolism. 2022 01; 135(1):47-55. doi: 10.1016/j.ymgme.2021.11.011. [PMID: 34896004]
  • Karine Mention, Marie Joncquel Chevalier Curt, Anne-Frédérique Dessein, Claire Douillard, Dries Dobbelaere, Joseph Vamecq. Citrin deficiency: Does the reactivation of liver aralar-1 come into play and promote HCC development?. Biochimie. 2021 Nov; 190(?):20-23. doi: 10.1016/j.biochi.2021.06.018. [PMID: 34228977]
  • Natalia Mast, Alexey M Petrov, Erin Prendergast, Ilya Bederman, Irina A Pikuleva. Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021 07; 18(3):2040-2060. doi: 10.1007/s13311-021-01079-6. [PMID: 34235635]
  • Inca A Dieterich, Yusi Cui, Megan M Braun, Alexis J Lawton, Nicklaus H Robinson, Jennifer L Peotter, Qing Yu, Jason C Casler, Benjamin S Glick, Anjon Audhya, John M Denu, Lingjun Li, Luigi Puglielli. Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Scientific reports. 2021 01; 11(1):2013. doi: 10.1038/s41598-021-81447-6. [PMID: 33479349]
  • Laurent Suissa, Pavel Kotchetkov, Jean-Marie Guigonis, Emilie Doche, Ophélie Osman, Thierry Pourcher, Sabine Lindenthal. Ingested Ketone Ester Leads to a Rapid Rise of Acetyl-CoA and Competes with Glucose Metabolism in the Brain of Non-Fasted Mice. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020524. [PMID: 33430235]
  • Yevgeniya I Shurubor, Arthur J L Cooper, Andrey B Krasnikov, Elena P Isakova, Yulia I Deryabina, M Flint Beal, Boris F Krasnikov. Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21238918. [PMID: 33255464]
  • Bjorn T Tam, Jessica Murphy, Natalie Khor, Jose A Morais, Sylvia Santosa. Acetyl-CoA Regulation, OXPHOS Integrity and Leptin Levels Are Different in Females With Childhood vs Adulthood Onset of Obesity. Endocrinology. 2020 11; 161(11):. doi: 10.1210/endocr/bqaa142. [PMID: 32808657]
  • Edward R Smith, Timothy D Hewitson. TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts. Scientific reports. 2020 10; 10(1):17914. doi: 10.1038/s41598-020-74919-8. [PMID: 33087819]
  • Martina Musutova, Martin Weiszenstein, Michal Koc, Jan Polak. Intermittent Hypoxia Stimulates Lipolysis, But Inhibits Differentiation and De Novo Lipogenesis in 3T3-L1 Cells. Metabolic syndrome and related disorders. 2020 04; 18(3):146-153. doi: 10.1089/met.2019.0112. [PMID: 31928504]
  • Rachel J Perry, Dongyan Zhang, Mateus T Guerra, Allison L Brill, Leigh Goedeke, Ali R Nasiri, Aviva Rabin-Court, Yongliang Wang, Liang Peng, Sylvie Dufour, Ye Zhang, Xian-Man Zhang, Gina M Butrico, Keshia Toussaint, Yuichi Nozaki, Gary W Cline, Kitt Falk Petersen, Michael H Nathanson, Barbara E Ehrlich, Gerald I Shulman. Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Nature. 2020 03; 579(7798):279-283. doi: 10.1038/s41586-020-2074-6. [PMID: 32132708]
  • Anna Michno, Katarzyna Grużewska, Hanna Bielarczyk, Marlena Zyśk, Andrzej Szutowicz. Inhibition of pyruvate dehydrogenase complex activity by 3-bromopyruvate affects blood platelets responses in type 2 diabetes. Pharmacological reports : PR. 2020 Feb; 72(1):225-237. doi: 10.1007/s43440-019-00005-0. [PMID: 32016856]
  • Cyril Corbet, Estelle Bastien, Joao Pedro Santiago de Jesus, Emeline Dierge, Ruben Martherus, Catherine Vander Linden, Bastien Doix, Charline Degavre, Céline Guilbaud, Laurenne Petit, Carine Michiels, Chantal Dessy, Yvan Larondelle, Olivier Feron. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nature communications. 2020 01; 11(1):454. doi: 10.1038/s41467-019-14262-3. [PMID: 31974393]
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  • Joost Schalkwijk, Erik L Allman, Patrick A M Jansen, Laura E de Vries, Julie M J Verhoef, Suzanne Jackowski, Peter N M Botman, Christien A Beuckens-Schortinghuis, Karin M J Koolen, Judith M Bolscher, Martijn W Vos, Karen Miller, Stacy A Reeves, Helmi Pett, Graham Trevitt, Sergio Wittlin, Christian Scheurer, Sibylle Sax, Christoph Fischli, Iñigo Angulo-Barturen, Mariá Belén Jiménez-Diaz, Gabrielle Josling, Taco W A Kooij, Roger Bonnert, Brice Campo, Richard H Blaauw, Floris P J T Rutjes, Robert W Sauerwein, Manuel Llinás, Pedro H H Hermkens, Koen J Dechering. Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Science translational medicine. 2019 09; 11(510):. doi: 10.1126/scitranslmed.aas9917. [PMID: 31534021]
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  • Salah Mohamed El Sayed, Hussam Baghdadi, Nagwa Sayed Ahmed, Hamdi H Almaramhy, Ahmed Al-Amir Mahmoud, Samer Ahmed El-Sawy, Mongi Ayat, Momen Elshazley, Wafaa Abdel-Aziz, Haitham Mahmoud Abdel-Latif, Walaa Ibrahim, Moutasem Salih Aboonq. Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis. Medical hypotheses. 2019 Jan; 122(?):206-209. doi: 10.1016/j.mehy.2018.11.012. [PMID: 30593413]
  • Lewin Small, Amanda E Brandon, Lake-Ee Quek, James R Krycer, David E James, Nigel Turner, Gregory J Cooney. Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake. American journal of physiology. Endocrinology and metabolism. 2018 08; 315(2):E258-E266. doi: 10.1152/ajpendo.00386.2017. [PMID: 29406780]
  • Guoyu Yu, Chien-Jui Cheng, Song-Chang Lin, Yu-Chen Lee, Daniel E Frigo, Li-Yuan Yu-Lee, Gary E Gallick, Mark A Titus, Leta K Nutt, Sue-Hwa Lin. Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II. Cancer research. 2018 05; 78(10):2490-2502. doi: 10.1158/0008-5472.can-17-2392. [PMID: 29535221]
  • Federica Gevi, Giuseppina Fanelli, Lello Zolla. Metabolic patterns in insulin-resistant male hypogonadism. Cell death & disease. 2018 04; 9(6):671. doi: 10.1038/s41419-018-0587-9. [PMID: 29867095]
  • Rachel J Perry, Liang Peng, Gary W Cline, Yongliang Wang, Aviva Rabin-Court, Joongyu D Song, Dongyan Zhang, Xian-Man Zhang, Yuichi Nozaki, Sylvie Dufour, Kitt Falk Petersen, Gerald I Shulman. Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes. Cell metabolism. 2018 01; 27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. [PMID: 29129786]
  • Yevgeniya I Shurubor, Marilena D'Aurelio, Joanne Clark-Matott, Elena P Isakova, Yulia I Deryabina, M Flint Beal, Arthur J L Cooper, Boris F Krasnikov. Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection. Molecules (Basel, Switzerland). 2017 Aug; 22(9):. doi: 10.3390/molecules22091388. [PMID: 28832533]
  • Laura B Gualdrón-Duarte, Michael S Allen. Increased anaplerosis of the tricarboxylic acid cycle decreased meal size and energy intake of cows in the postpartum period. Journal of dairy science. 2017 Jun; 100(6):4425-4434. doi: 10.3168/jds.2016-12104. [PMID: 28342606]
  • Suman K Samanta, Anuradha Sehrawat, Su-Hyeong Kim, Eun-Ryeong Hahm, Yongli Shuai, Ruchi Roy, Subrata K Pore, Krishna B Singh, Susan M Christner, Jan H Beumer, Nancy E Davidson, Shivendra V Singh. Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. Journal of the National Cancer Institute. 2017 06; 109(6):. doi: 10.1093/jnci/djw293. [PMID: 28040797]
  • Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J Kamphorst. Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation. Cell reports. 2017 01; 18(3):647-658. doi: 10.1016/j.celrep.2016.12.055. [PMID: 28099844]
  • Yan S Xu, Jinyuan J Liang, Yumei Wang, Xiang-Zhong J Zhao, Li Xu, Ye-Yang Xu, Quanli C Zou, Junxun M Zhang, Cheng-E Tu, Yan-Ge Cui, Wei-Hong Sun, Chao Huang, Jing-Hua Yang, Y Eugene Chin. STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism. Scientific reports. 2016 12; 6(?):39517. doi: 10.1038/srep39517. [PMID: 28004755]
  • Nikita Ikon, Robert O Ryan. On the origin of 3-methylglutaconic acid in disorders of mitochondrial energy metabolism. Journal of inherited metabolic disease. 2016 09; 39(5):749-756. doi: 10.1007/s10545-016-9933-1. [PMID: 27091556]
  • Shiu-Cheung Lung, Mee-Len Chye. Deciphering the roles of acyl-CoA-binding proteins in plant cells. Protoplasma. 2016 Sep; 253(5):1177-95. doi: 10.1007/s00709-015-0882-6. [PMID: 26340904]
  • Saori Kataoka, Yuuka Mukai, Mihoko Takebayashi, Megumi Kudo, Uson Rachael Acuram, Masaaki Kurasaki, Shin Sato. Melinjo (Gnetum gnemon) extract intake during lactation stimulates hepatic AMP-activated protein kinase in offspring of excessive fructose-fed pregnant rats. Reproductive biology. 2016 Jun; 16(2):165-73. doi: 10.1016/j.repbio.2016.01.002. [PMID: 27288341]
  • Kotaro Shirakawa, Lan Wang, Na Man, Jasna Maksimoska, Alexander W Sorum, Hyung W Lim, Intelly S Lee, Tadahiro Shimazu, John C Newman, Sebastian Schröder, Melanie Ott, Ronen Marmorstein, Jordan Meier, Stephen Nimer, Eric Verdin. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. eLife. 2016 05; 5(?):. doi: 10.7554/elife.11156. [PMID: 27244239]
  • P Piantoni, C M Ylioja, M S Allen. Feed intake is related to changes in plasma nonesterified fatty acid concentration and hepatic acetyl CoA content following feeding in lactating dairy cows. Journal of dairy science. 2015 Oct; 98(10):6839-47. doi: 10.3168/jds.2014-9085. [PMID: 26210272]
  • Rachel J Perry, Sangwon Lee, Lie Ma, Dongyan Zhang, Joseph Schlessinger, Gerald I Shulman. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature communications. 2015 Apr; 6(?):6980. doi: 10.1038/ncomms7980. [PMID: 25916467]
  • Satoru Yuzawa, Sachiko Kamakura, Junya Hayase, Hideki Sumimoto. Structural basis of cofactor-mediated stabilization and substrate recognition of the α-tubulin acetyltransferase αTAT1. The Biochemical journal. 2015 Apr; 467(1):103-13. doi: 10.1042/bj20141193. [PMID: 25602620]
  • E I Kalenikova, E V Kharitonova, E A Gorodetskaya, O G Tokareva, O S Medvedev. [Hplc estimation of coenzyme Q(10) redox status in plasma after intravenous coenzyme Q(10) administration]. Biomeditsinskaia khimiia. 2015 Jan; 61(1):125-31. doi: 10.18097/pbmc20156101125. [PMID: 25762606]
  • Dai Hatakeyama, Masaki Shoji, Seiya Yamayoshi, Takenori Hirota, Monami Nagae, Shin Yanagisawa, Masahiro Nakano, Naho Ohmi, Takeshi Noda, Yoshihiro Kawaoka, Takashi Kuzuhara. A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication. The Journal of biological chemistry. 2014 Sep; 289(36):24980-94. doi: 10.1074/jbc.m114.559708. [PMID: 25063805]
  • Gopinath Sutendra, Adam Kinnaird, Peter Dromparis, Roxane Paulin, Trevor H Stenson, Alois Haromy, Kyoko Hashimoto, Nancy Zhang, Eric Flaim, Evangelos D Michelakis. A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation. Cell. 2014 Jul; 158(1):84-97. doi: 10.1016/j.cell.2014.04.046. [PMID: 24995980]
  • Laura Strittmatter, Yang Li, Nathan J Nakatsuka, Sarah E Calvo, Zenon Grabarek, Vamsi K Mootha. CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity. Human molecular genetics. 2014 May; 23(9):2313-23. doi: 10.1093/hmg/ddt624. [PMID: 24334609]
  • Betty Su, Robert O Ryan. Metabolic biology of 3-methylglutaconic acid-uria: a new perspective. Journal of inherited metabolic disease. 2014 May; 37(3):359-68. doi: 10.1007/s10545-013-9669-0. [PMID: 24407466]
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  • S E Stocks, M S Allen. Effects of lipid and propionic acid infusions on feed intake of lactating dairy cows. Journal of dairy science. 2014; 97(4):2297-304. doi: 10.3168/jds.2013-7066. [PMID: 24534511]
  • Isaac Marin-Valencia, Levi B Good, Qian Ma, Craig R Malloy, Juan M Pascual. Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013 Feb; 33(2):175-82. doi: 10.1038/jcbfm.2012.151. [PMID: 23072752]
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  • Katsumi Shibata, Takumi Nakai, Tsutomu Fukuwatari. Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats. Analytical biochemistry. 2012 Nov; 430(2):151-5. doi: 10.1016/j.ab.2012.08.010. [PMID: 22922385]
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