3-Hydroxy-3-methylbutanoate (BioDeep_00000897693)
代谢物信息卡片
3-Hydroxy-3-methylbutanoate
化学式: C5H9O3- (117.0552)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CC(=O)[O-])O
InChI: InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7)/p-1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Silvia Espina, Alejandro Sanz-Paris, Yolanda Gonzalez-Irazabal, Patricia Pérez-Matute, Fernando Andrade, Beatriz Garcia-Rodriguez, Christian Carpéné, Alexia Zakaroff, Vanesa Bernal-Monterde, Javier Fuentes-Olmo, Jose M Arbones-Mainar. Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients.
Nutrients.
2022 Jun; 14(11):. doi:
10.3390/nu14112344. [PMID: 35684144] - Hidehiko Nakano, Hideki Hashimoto, Masaki Mochizuki, Hiromu Naraba, Yuji Takahashi, Tomohiro Sonoo, Yujiro Matsuishi, Yasuhiro Ogawa, Nobutake Shimojo, Yoshiaki Inoue, Kensuke Nakamura. Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults.
Nutrients.
2021 Mar; 13(3):. doi:
10.3390/nu13030899. [PMID: 33802012] - Gabriella A M Ten Have, Lisa Jansen, Marieke G Schooneman, Marielle P K J Engelen, Nicolaas E P Deutz. Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and β-hydroxy β-methylbutyric acid across multiple organs in the pig.
American journal of physiology. Endocrinology and metabolism.
2021 03; 320(3):E629-E640. doi:
10.1152/ajpendo.00384.2020. [PMID: 33522397] - Jiram Torres-Ruiz, Alfredo Pérez-Fragoso, José Luis Maravillas-Montero, Luis Llorente, Nancy R Mejía-Domínguez, José Carlos Páez-Franco, Sandra Romero-Ramírez, Victor Andrés Sosa-Hernández, Rodrigo Cervantes-Díaz, Abdiel Absalón-Aguilar, Miroslava Nuñez-Aguirre, Guillermo Juárez-Vega, David Meza-Sánchez, Ari Kleinberg-Bid, Thierry Hernández-Gilsoul, Alfredo Ponce-de-León, Diana Gómez-Martín. Redefining COVID-19 Severity and Prognosis: The Role of Clinical and Immunobiotypes.
Frontiers in immunology.
2021; 12(?):689966. doi:
10.3389/fimmu.2021.689966. [PMID: 34566957] - L-N Peng, Y-C Cheng, P-C Yu, W-J Lee, M-H Lin, L-K Chen. Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial.
The journal of nutrition, health & aging.
2021; 25(6):767-773. doi:
10.1007/s12603-021-1621-7. [PMID: 34179932] - Hossein Shirvani, Saleh Rahmati-Ahmadabad, Elias Kowsari, Hillary Fry, Maryam Kazemi, Mojtaba Kaviani. Effects of 2-week HMB-FA supplementation with or without eccentric resistance exercise on expression of some genes related to muscle protein turnover and serum irisin and IGF-1 concentrations.
Gene.
2020 Nov; 760(?):145018. doi:
10.1016/j.gene.2020.145018. [PMID: 32758580] - Milan Holeček, Melita Vodeničarovová, Radana Fingrová. Dual Effects of Beta-Hydroxy-Beta-Methylbutyrate (HMB) on Amino Acid, Energy, and Protein Metabolism in the Liver and Muscles of Rats with Streptozotocin-Induced Type 1 Diabetes.
Biomolecules.
2020 10; 10(11):. doi:
10.3390/biom10111475. [PMID: 33114049] - Liang Hu, Niels Bastian Kristensen, Uffe Krogh, Peter Kappel Theil. Net Absorption and Metabolism of β-Hydroxy- β-Methyl Butyrate during Late Gestation in a Pig Model.
Nutrients.
2020 Feb; 12(2):. doi:
10.3390/nu12020561. [PMID: 32098129] - Casilda Olveira, Eva García-Escobar, Esperanza Doña, Francisco J Palenque, Nuria Porras, Antonio Dorado, Ana María Godoy, Elezahara Rubio-Martín, Francisco-Javier Bermúdez-Silva, Silvana Y Romero-Zerbo, Gemma Rojo Martínez, Rocío Martín-Valero, José Abuín Fernández, Gabriel Olveira. Oxidative and inflammatory effects of pulmonary rehabilitation in patients with bronchiectasis. A prospective, randomized study.
Nutricion hospitalaria.
2020 Feb; 37(1):6-13. doi:
10.20960/nh.02763. [PMID: 31960695] - You-Biao Ma, Feng-Dong Zhang, Jing Wang, Shu-Geng Wu, Guang-Hai Qi, Hai-Jun Zhang. Effect of in ovo feeding of β-hydroxy-β-methylbutyrate on hatchability, muscle growth and performance in prenatal and posthatch broilers.
Journal of the science of food and agriculture.
2020 Jan; 100(2):755-763. doi:
10.1002/jsfa.10080. [PMID: 31605375] - Milan Holeček, Melita Vodeničarovová. Effects of beta-hydroxy-beta-methylbutyrate supplementation on skeletal muscle in healthy and cirrhotic rats.
International journal of experimental pathology.
2019 06; 100(3):175-183. doi:
10.1111/iep.12322. [PMID: 31321841] - Hossein Shirvani, Saleh Rahmati-Ahmadabad, David Robert Broom, Reza Mirnejad. Eccentric resistance training and β-hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin in rats.
The Journal of experimental biology.
2019 05; 222(Pt 10):. doi:
10.1242/jeb.198424. [PMID: 31085594] - Monika Hułas-Stasiak, Joanna Jakubowicz-Gil, Piotr Dobrowolski, Ewa Tomaszewska, Siemowit Muszyński. Maternal β-hydroxy-β-methylbutyrate (HMB) supplementation during pregnancy affects early folliculogenesis in the ovary of newborn piglets.
Theriogenology.
2019 Apr; 128(?):91-100. doi:
10.1016/j.theriogenology.2019.02.003. [PMID: 30743108] - Irene De Biase, Marzia Pasquali, Alexander Asamoah. Unusual Metabolites in a Patient with Isovaleric Acidemia.
Clinical chemistry.
2019 04; 65(4):595-597. doi:
10.1373/clinchem.2018.300558. [PMID: 30923063] - D J Wilkinson, T Hossain, M C Limb, B E Phillips, J Lund, J P Williams, M S Brook, J Cegielski, A Philp, S Ashcroft, J A Rathmacher, N J Szewczyk, K Smith, P J Atherton. Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism.
Clinical nutrition (Edinburgh, Scotland).
2018 12; 37(6 Pt A):2068-2075. doi:
10.1016/j.clnu.2017.09.024. [PMID: 29097038] - M Holeček, M Vodeničarovová. Effects of beta-hydroxy-beta-methylbutyrate in partially hepatectomized rats.
Physiological research.
2018 11; 67(5):741-751. doi:
10.33549/physiolres.933861. [PMID: 30044108] - Song-Gyu Ra, Teruo Miyazaki, Ryo Kojima, Shoichi Komine, Keisuke Ishikura, Kentaro Kawanaka, Akira Honda, Yasushi Matsuzaki, Hajime Ohmori. Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: a pilot placebo-controlled double-blind study.
The Journal of sports medicine and physical fitness.
2018 Nov; 58(11):1582-1591. doi:
10.23736/s0022-4707.17.07638-1. [PMID: 28944645] - Yehui Duan, Lingyu Zhang, Fengna Li, Qiuping Guo, Cimin Long, Yulong Yin, Xiangfeng Kong, Mijun Peng, Wence Wang. β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs.
Food & function.
2018 Sep; 9(9):4836-4846. doi:
10.1039/c8fo00898a. [PMID: 30137075] - Mohammad Hossein Rahimi, Hamed Mohammadi, Hesam Eshaghi, Gholamreza Askari, Maryam Miraghajani. The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis.
Journal of the American College of Nutrition.
2018 Sep; 37(7):640-649. doi:
10.1080/07315724.2018.1451789. [PMID: 29676656] - Noriko Wada, Yukinori Kurokawa, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Tsuyoshi Takahashi, Hiroshi Wada, Makoto Yamasaki, Makoto Yamasaki, Kiyokazu Nakajima, Hidetoshi Eguchi, Shuji Takiguchi, Masaki Mori, Yuichiro Doki. Perioperative Nutritional Support With Beta-hydroxy-beta-methylbutyrate, Arginine, and Glutamine in Surgery for Abdominal Malignancies.
Wounds : a compendium of clinical research and practice.
2018 Sep; 30(9):251-256. doi:
NULL. [PMID: 30256751] - Galit Tal, Dalit E Dar, Anna Idin, Stanley H Korman, Elena Dumin. Argininemia, Hyperornithinemia, and 3-Hydroxyisovaleric Aciduria.
Clinical chemistry.
2018 06; 64(6):978-980. doi:
10.1373/clinchem.2018.286617. [PMID: 29844061] - Hafsa Majid, Lena Jafri, Aysha Habib Khan, Zeba Zulfiqar Ali, Azeema Jamil, Nasir Yusufzai, Midhat Fatimah, Bushra Afroze. Diagnostic dilemma of patients with methylmalonic aciduria: Experience from a tertiary care centre in Pakistan.
JPMA. The Journal of the Pakistan Medical Association.
2018 Apr; 68(4):510-514. doi:
NULL. [PMID: 29808036] - Grant M Tinsley, Amy H Givan, Austin J Graybeal, Michael I Villarreal, Austin G Cross. β-Hydroxy β-methylbutyrate free acid alters cortisol responses, but not myofibrillar proteolysis, during a 24-h fast.
The British journal of nutrition.
2018 03; 119(5):517-526. doi:
10.1017/s0007114517003907. [PMID: 29508695] - Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, Yasuyoshi Ouchi, Masahiro Akishita. Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy.
PloS one.
2018; 13(1):e0191318. doi:
10.1371/journal.pone.0191318. [PMID: 29351340] - Yftach Gepner, Jay R Hoffman, Elad Shemesh, Jeffrey R Stout, David D Church, Alyssa N Varanoske, Hila Zelicha, Ilan Shelef, Yacov Chen, Hagai Frankel, Ishay Ostfeld. Combined effect of Bacillus coagulans GBI-30, 6086 and HMB supplementation on muscle integrity and cytokine response during intense military training.
Journal of applied physiology (Bethesda, Md. : 1985).
2017 Jul; 123(1):11-18. doi:
10.1152/japplphysiol.01116.2016. [PMID: 28408697] - Subramanian Ramachandran, Stefan Ehling, Sathyavageeswaran Shreeram, Todime M Reddy. The development and validation of a high-throughput LC-MS/MS method for the analysis of endogenous β-hydroxy-β-methylbutyrate in human plasma.
Biomedical chromatography : BMC.
2017 Jul; 31(7):. doi:
10.1002/bmc.3904. [PMID: 27882562] - Tao Sun, Ying Wu, Xueping Wu, Haifeng Ma. Metabolomic profiles investigation on athletes' urine 35 minutes after an 800-meter race.
The Journal of sports medicine and physical fitness.
2017 Jun; 57(6):839-849. doi:
10.23736/s0022-4707.17.06254-5. [PMID: 26699119] - Dominique Roland, Patrice Jissendi-Tchofo, Gilbert Briand, Joseph Vamecq, Monique Fontaine, Vincent Ultré, Cécile Acquaviva-Bourdain, Karine Mention, Dries Dobbelaere. Coupled brain and urine spectroscopy - in vivo metabolomic characterization of HMG-CoA lyase deficiency in 5 patients.
Molecular genetics and metabolism.
2017 06; 121(2):111-118. doi:
10.1016/j.ymgme.2017.03.006. [PMID: 28396157] - Michael Munroe, Yair Pincu, Jennifer Merritt, Adam Cobert, Ryan Brander, Tor Jensen, Justin Rhodes, Marni D Boppart. Impact of β-hydroxy β-methylbutyrate (HMB) on age-related functional deficits in mice.
Experimental gerontology.
2017 01; 87(Pt A):57-66. doi:
10.1016/j.exger.2016.11.010. [PMID: 27887984] - Dillon K Walker, John J Thaden, Agata Wierzchowska-McNew, Marielle P K J Engelen, Nicolaas E P Deutz. Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jan; 1040(?):233-238. doi:
10.1016/j.jchromb.2016.11.010. [PMID: 27856194] - Peter J Fitschen, Annabel Biruete, Jinny Jeong, Kenneth R Wilund. Efficacy of beta-hydroxy-beta-methylbutyrate supplementation in maintenance hemodialysis patients.
Hemodialysis international. International Symposium on Home Hemodialysis.
2017 01; 21(1):107-116. doi:
10.1111/hdi.12440. [PMID: 27302563] - Gabriel Olveira, Casilda Olveira, Esperanza Doña, Francisco Javier Palenque, Nuria Porras, Antonio Dorado, Ana M Godoy, Elehazara Rubio-Martínez, Gemma Rojo-Martínez, Rocío Martín-Valero. Oral supplement enriched in HMB combined with pulmonary rehabilitation improves body composition and health related quality of life in patients with bronchiectasis (Prospective, Randomised Study).
Clinical nutrition (Edinburgh, Scotland).
2016 10; 35(5):1015-22. doi:
10.1016/j.clnu.2015.10.001. [PMID: 26522923] - Rebecca Kuriyan, Deepa P Lokesh, Sumithra Selvam, J Jayakumar, Mamatha G Philip, Sathyavageeswaran Shreeram, Anura V Kurpad. The relationship of endogenous plasma concentrations of β-Hydroxy β-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans.
Experimental gerontology.
2016 08; 81(?):13-8. doi:
10.1016/j.exger.2016.04.013. [PMID: 27108182] - Sathyavageeswaran Shreeram, Subbarayan Ramesh, Jithesh K Puthan, Gayathri Balakrishnan, Ramachandran Subramanian, Murali Todime Reddy, Suzette L Pereira. Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
Experimental gerontology.
2016 07; 80(?):6-11. doi:
10.1016/j.exger.2016.03.021. [PMID: 27073170] - Maha H Sharawy, Mohammed S El-Awady, Nirmeen Megahed, Nariman M Gameil. The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver.
Canadian journal of physiology and pharmacology.
2016 May; 94(5):488-97. doi:
10.1139/cjpp-2015-0385. [PMID: 26871756] - Haifeng Wan, Jiatao Zhu, Guoqi Su, Yan Liu, Lun Hua, Liang Hu, Caimei Wu, Ruinan Zhang, Pan Zhou, Yong Shen, Yan Lin, Shengyu Xu, Zhengfeng Fang, Lianqiang Che, Bin Feng, De Wu. Dietary supplementation with β-hydroxy-β-methylbutyrate calcium during the early postnatal period accelerates skeletal muscle fibre growth and maturity in intra-uterine growth-retarded and normal-birth-weight piglets.
The British journal of nutrition.
2016 04; 115(8):1360-9. doi:
10.1017/s0007114516000465. [PMID: 26917333] - Minayuki Shirato, Yosuke Tsuchiya, Teruyuki Sato, Saki Hamano, Takeshi Gushiken, Naoto Kimura, Eisuke Ochi. Effects of combined β-hydroxy-β-methylbutyrate (HMB) and whey protein ingestion on symptoms of eccentric exercise-induced muscle damage.
Journal of the International Society of Sports Nutrition.
2016; 13(?):7. doi:
10.1186/s12970-016-0119-x. [PMID: 26933398] - John C Fuller, Rick L Sharp, Hector F Angus, Paul Y Khoo, John A Rathmacher. Comparison of availability and plasma clearance rates of β-hydroxy-β-methylbutyrate delivery in the free acid and calcium salt forms.
The British journal of nutrition.
2015 Nov; 114(9):1403-9. doi:
10.1017/s0007114515003050. [PMID: 26373270] - Y Ogura, N Yuki, A Sukegane, T Nishi, Y Miyake, H Sato, C Miyamoto, C Mihara. Treatment of pressure ulcers in patients with declining renal function using arginine, glutamine and ß-hydroxy-ß-methylbutyrate.
Journal of wound care.
2015 Oct; 24(10):478-82. doi:
10.12968/jowc.2015.24.10.478. [PMID: 26488739] - A Santos-Fandila, P Bueno-Vargas, A Zafra-Gómez, J M López-Pedrosa, M Ramírez. Quantification of β-hydroxymethylbutyrate and leucine by ultrahigh performance liquid chromatography tandem mass spectrometry at different situations and stages of a rodent life.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jul; 995-996(?):54-63. doi:
10.1016/j.jchromb.2015.05.013. [PMID: 26025886] - Anthony J Lee, David W A Beno, Xiaolin Zhang, Robin Shapiro, Mark Mason, Tanita Mason-Bright, Bruce Surber, Neilé K Edens. A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite.
Amino acids.
2015 May; 47(5):917-24. doi:
10.1007/s00726-015-1920-6. [PMID: 25618754] - Michael A Puskarich, Michael A Finkel, Alla Karnovsky, Alan E Jones, Julie Trexel, Brooke N Harris, Kathleen A Stringer. Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock.
Annals of the American Thoracic Society.
2015 Jan; 12(1):46-56. doi:
10.1513/annalsats.201409-415oc. [PMID: 25496487] - Ai Tsuji, Toshinobu Nakamura, Katsumi Shibata. Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes.
Bioscience, biotechnology, and biochemistry.
2015; 79(2):292-9. doi:
10.1080/09168451.2014.968090. [PMID: 25301108] - Cydne A Perry, Allyson A West, Antoinette Gayle, Lauren K Lucas, Jian Yan, Xinyin Jiang, Olga Malysheva, Marie A Caudill. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
The Journal of nutrition.
2014 Dec; 144(12):1977-84. doi:
10.3945/jn.114.194472. [PMID: 25122647] - Sathyavageeswaran Shreeram, Paul W Johns, Swaminathan Subramaniam, Subbarayan Ramesh, Vadakkanchery Vaidyanathan, Jithesh K Puthan, Shibajee Mandal, Vijay Kumar Mamidi, Richard W Gelling. The relative bioavailability of the calcium salt of β-hydroxy-β-methylbutyrate is greater than that of the free fatty acid form in rats.
The Journal of nutrition.
2014 Oct; 144(10):1549-55. doi:
10.3945/jn.114.196527. [PMID: 25143371] - C Y Yonamine, S S Teixeira, R S Campello, F Gerlinger-Romero, C F Rodrigues, L Guimarães-Ferreira, U F Machado, M T Nunes. Beta hydroxy beta methylbutyrate supplementation impairs peripheral insulin sensitivity in healthy sedentary Wistar rats.
Acta physiologica (Oxford, England).
2014 Sep; 212(1):62-74. doi:
10.1111/apha.12336. [PMID: 24962220] - Scott M Wheatley, Samer W El-Kadi, Agus Suryawan, Claire Boutry, Renán A Orellana, Hanh V Nguyen, Steven R Davis, Teresa A Davis. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of β-hydroxy-β-methylbutyrate.
American journal of physiology. Endocrinology and metabolism.
2014 Jan; 306(1):E91-9. doi:
10.1152/ajpendo.00500.2013. [PMID: 24192287] - Jacob M Wilson, Ryan P Lowery, Jordan M Joy, Joe A Walters, Shawn M Baier, John C Fuller, Jeffrey R Stout, Layne E Norton, Eric M Sikorski, Stephanie M C Wilson, Nevine M Duncan, Nelo E Zanchi, John Rathmacher. β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men.
The British journal of nutrition.
2013 Aug; 110(3):538-44. doi:
10.1017/s0007114512005387. [PMID: 23286834] - D J Wilkinson, T Hossain, D S Hill, B E Phillips, H Crossland, J Williams, P Loughna, T A Churchward-Venne, L Breen, S M Phillips, T Etheridge, J A Rathmacher, K Smith, N J Szewczyk, P J Atherton. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism.
The Journal of physiology.
2013 Jun; 591(11):2911-23. doi:
10.1113/jphysiol.2013.253203. [PMID: 23551944] - X Qiao, H J Zhang, S G Wu, H Y Yue, J J Zuo, D Y Feng, G H Qi. Effect of β-hydroxy-β-methylbutyrate calcium on growth, blood parameters, and carcass qualities of broiler chickens.
Poultry science.
2013 Mar; 92(3):753-9. doi:
10.3382/ps.2012-02341. [PMID: 23436526] - Parag Deshpande, Zhang Jie, Ramesh Subbarayan, Vijay Kumar Mamidi, Raja Haranadha Babu Chunduri, Tapas Das, Sathyavageeswaran Shreeram. Development and validation of LC-MS/MS method for the estimation of β-hydroxy-β-methylbutyrate in rat plasma and its application to pharmacokinetic studies.
Biomedical chromatography : BMC.
2013 Feb; 27(2):142-7. doi:
10.1002/bmc.2758. [PMID: 22623082] - Savas Sipahi, Ozkan Gungor, Mehmet Gunduz, Mehmet Cilci, Mustafa Cahit Demirci, Ali Tamer. The effect of oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine on wound healing: a retrospective analysis of diabetic haemodialysis patients.
BMC nephrology.
2013 Jan; 14(?):8. doi:
10.1186/1471-2369-14-8. [PMID: 23311725] - C Flummer, P K Theil. Effect of β-hydroxy β-methyl butyrate supplementation of sows in late gestation and lactation on sow production of colostrum and milk and piglet performance.
Journal of animal science.
2012 Dec; 90 Suppl 4(?):372-4. doi:
10.2527/jas.53971. [PMID: 23365383] - Paula B M Luís, Jos P Ruiter, Lodewijk IJlst, Luísa Diogo, Paula Garcia, Isabel Tavares de Almeida, Marinus Duran, Ronald J Wanders, Margarida F B Silva. Inhibition of 3-methylcrotonyl-CoA carboxylase explains the increased excretion of 3-hydroxyisovaleric acid in valproate-treated patients.
Journal of inherited metabolic disease.
2012 May; 35(3):443-9. doi:
10.1007/s10545-011-9423-4. [PMID: 22189597] - Thomas D Horvath, Nell I Matthews, Shawna L Stratton, Donald M Mock, Gunnar Boysen. Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS.
Analytical and bioanalytical chemistry.
2011 Nov; 401(9):2805-10. doi:
10.1007/s00216-011-5356-x. [PMID: 21892638] - Donald M Mock, Shawna L Stratton, Thomas D Horvath, Anna Bogusiewicz, Nell I Matthews, Cindy L Henrich, Amanda M Dawson, Horace J Spencer, Suzanne N Owen, Gunnar Boysen, Jeffery H Moran. Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.
The Journal of nutrition.
2011 Nov; 141(11):1925-30. doi:
10.3945/jn.111.146126. [PMID: 21918059] - Dong OuYang, Jingjing Xu, Heguang Huang, Zhong Chen. Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis.
Applied biochemistry and biotechnology.
2011 Sep; 165(1):148-54. doi:
10.1007/s12010-011-9240-0. [PMID: 21505807] - F Gerlinger-Romero, L Guimarães-Ferreira, G Giannocco, M T Nunes. Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
2011 Apr; 21(2):57-62. doi:
10.1016/j.ghir.2010.12.006. [PMID: 21237681] - John C Fuller, Rick L Sharp, Hector F Angus, Shawn M Baier, John A Rathmacher. Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt.
The British journal of nutrition.
2011 Feb; 105(3):367-72. doi:
10.1017/s0007114510003582. [PMID: 21134325] - Lan-Chi Hsieh, Chau-Jen Chow, Wen-Chou Chang, Tsung-Han Liu, Chen-Kang Chang. Effect of beta-hydroxy-beta-methylbutyrate on protein metabolism in bed-ridden elderly receiving tube feeding.
Asia Pacific journal of clinical nutrition.
2010; 19(2):200-8. doi:
NULL. [PMID: 20460233] - W L Nyhan, M Willis, B A Barshop, J Gangoiti. Positive newborn screen in the biochemically normal infant of a mother with treated holocarboxylase synthetase deficiency.
Journal of inherited metabolic disease.
2009 Dec; 32 Suppl 1(?):S79-82. doi:
10.1007/s10545-009-1062-7. [PMID: 19357990] - M R Tatara. Effect of β-hydroxy-β-methylbutyrate (HMB) administration on volumetric bone mineral density, and morphometric and mechanical properties of tibia in male turkeys.
Journal of animal physiology and animal nutrition.
2009 Dec; 93(6):669-77. doi:
10.1111/j.1439-0396.2008.00854.x. [PMID: 18700848] - Eva Morava, Ulrike Steuerwald, Rosalba Carrozzo, Leo A J Kluijtmans, Frodi Joensen, René Santer, Carlo Dionisi-Vici, Ron A Wevers. Dystonia and deafness due to SUCLA2 defect; Clinical course and biochemical markers in 16 children.
Mitochondrion.
2009 Nov; 9(6):438-42. doi:
10.1016/j.mito.2009.08.003. [PMID: 19666145] - J Buyse, Q Swennen, F Vandemaele, K C Klasing, T A Niewold, M Baumgartner, B M Goddeeris. Dietary β-hydroxy-β-methylbutyrate supplementation influences performance differently after immunization in broiler chickens.
Journal of animal physiology and animal nutrition.
2009 Aug; 93(4):512-9. doi:
10.1111/j.1439-0396.2008.00833.x. [PMID: 18522686] - Heidi M T Kunttu, E Tellervo Valtonen, Lotta-Riina Suomalainen, Jouni Vielma, Ilmari E Jokinen. The efficacy of two immunostimulants against Flavobacterium columnare infection in juvenile rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology.
2009 Jun; 26(6):850-7. doi:
10.1016/j.fsi.2009.03.013. [PMID: 19344871] - Reut Kornasio, Ingo Riederer, Gillian Butler-Browne, Vincent Mouly, Zehava Uni, Orna Halevy. Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways.
Biochimica et biophysica acta.
2009 May; 1793(5):755-63. doi:
10.1016/j.bbamcr.2008.12.017. [PMID: 19211028] - F Tuba Eminoglu, Aysima A Ozcelik, Ilyas Okur, Leyla Tumer, Gursel Biberoglu, Ercan Demir, Alev Hasanoglu, Matthias R Baumgartner. 3-Methylcrotonyl-CoA carboxylase deficiency: phenotypic variability in a family.
Journal of child neurology.
2009 Apr; 24(4):478-81. doi:
10.1177/0883073808324536. [PMID: 19339287] - M Holecek, T Muthny, M Kovarik, L Sispera. Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Jan; 47(1):255-9. doi:
10.1016/j.fct.2008.11.021. [PMID: 19056452] - Toshiaki Watanabe, Yoshiko Nagai, Ayumi Taniguchi, Shuhei Ebara, Sachiko Kimura, Toru Fukui. Effects of biotin deficiency on embryonic development in mice.
Nutrition (Burbank, Los Angeles County, Calif.).
2009 Jan; 25(1):78-84. doi:
10.1016/j.nut.2008.06.031. [PMID: 18752930] - Marcin R Tatara, Ewa Sliwa, Witold Krupski, Marta Worzakowska. 3-Hydroxy-3-methylbutyrate administration diminishes fundectomy-induced osteopenia of the lumbar spine in pigs.
Nutrition (Burbank, Los Angeles County, Calif.).
2008 Jul; 24(7-8):753-60. doi:
10.1016/j.nut.2008.03.009. [PMID: 18490141] - Guilhian Leipnitz, Bianca Seminotti, Alexandre U Amaral, Giorgia de Bortoli, Alexandre Solano, Patrícia F Schuck, Angela T S Wyse, Clóvis M D Wannmacher, Alexandra Latini, Moacir Wajner. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats.
Life sciences.
2008 Mar; 82(11-12):652-62. doi:
10.1016/j.lfs.2007.12.024. [PMID: 18261750] - Nayeli Rodríguez-Fuentes, Itzel López-Rosas, Gabriela Román-Cisneros, Antonio Velázquez-Arellano. Biotin deficiency affects both synthesis and degradation of pyruvate carboxylase in rat primary hepatocyte cultures.
Molecular genetics and metabolism.
2007 Nov; 92(3):222-8. doi:
10.1016/j.ymgme.2007.06.021. [PMID: 17720579] - Marcin R Tatara, Ewa Sliwa, Witold Krupski. Prenatal programming of skeletal development in the offspring: effects of maternal treatment with beta-hydroxy-beta-methylbutyrate (HMB) on femur properties in pigs at slaughter age.
Bone.
2007 Jun; 40(6):1615-22. doi:
10.1016/j.bone.2007.02.018. [PMID: 17433802] - G Ferreira, W P Weiss, L B Willett. Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin.
Journal of dairy science.
2007 Mar; 90(3):1452-9. doi:
10.3168/jds.s0022-0302(07)71630-2. [PMID: 17297118] - Shawna L Stratton, Anna Bogusiewicz, Matthew M Mock, Nell I Mock, Amanda M Wells, Donald M Mock. Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans.
The American journal of clinical nutrition.
2006 Aug; 84(2):384-8. doi:
10.1093/ajcn/84.1.384. [PMID: 16895887] - S Wortmann, R J T Rodenburg, M Huizing, F J Loupatty, T de Koning, L A J Kluijtmans, U Engelke, R Wevers, J A M Smeitink, E Morava. Association of 3-methylglutaconic aciduria with sensori-neural deafness, encephalopathy, and Leigh-like syndrome (MEGDEL association) in four patients with a disorder of the oxidative phosphorylation.
Molecular genetics and metabolism.
2006 May; 88(1):47-52. doi:
10.1016/j.ymgme.2006.01.013. [PMID: 16527507] - Udo F H Engelke, Berry Kremer, Leo A J Kluijtmans, Marinette van der Graaf, Eva Morava, Ference J Loupatty, Ronald J A Wanders, Detlef Moskau, Sandra Loss, Erik van den Bergh, Ron A Wevers. NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism.
NMR in biomedicine.
2006 Apr; 19(2):271-8. doi:
10.1002/nbm.1018. [PMID: 16541463] - L Pinto, P Zen, R Rosa, G Paskulin, A Perla, L Barea, M R Baumgartner, M F Dantas, B Fowler, R Giugliani, C Vargas, M Wajner, C Graziadio. Isolated 3-methylcrotonyl-coenzyme A carboxylase deficiency in a child with metabolic stroke.
Journal of inherited metabolic disease.
2006 Feb; 29(1):205-6. doi:
10.1007/s10545-006-0188-0. [PMID: 16601894] - Eric T Payne, Nobuo Yasuda, Jacqueline M Bourgeois, Michaela C Devries, M Christine Rodriguez, Junaid Yousuf, Mark A Tarnopolsky. Nutritional therapy improves function and complements corticosteroid intervention in mdx mice.
Muscle & nerve.
2006 Jan; 33(1):66-77. doi:
10.1002/mus.20436. [PMID: 16149047] - Ken A van Someren, Adam J Edwards, Glyn Howatson. Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.
International journal of sport nutrition and exercise metabolism.
2005 Aug; 15(4):413-24. doi:
10.1123/ijsnem.15.4.413. [PMID: 16286672] - Toshiaki Watanabe, Ken-Ichi Oguchi, Shuhei Ebara, Toru Fukui. Measurement of 3-hydroxyisovaleric acid in urine of biotin-deficient infants and mice by HPLC.
The Journal of nutrition.
2005 Mar; 135(3):615-8. doi:
10.1093/jn/135.3.615. [PMID: 15735103] - T Baykal, G Huner Gokcay, Z Ince, M F Dantas, B Fowler, M R Baumgartner, F Demir, G Can, M Demirkol. Consanguineous 3-methylcrotonyl-CoA carboxylase deficiency: early-onset necrotizing encephalopathy with lethal outcome.
Journal of inherited metabolic disease.
2005; 28(2):229-33. doi:
10.1007/s10545-005-4559-8. [PMID: 15877210] - Toru Fukui, Kazunari Kumasaka. [Biotin (vitamin H)].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Dec; 62 Suppl 12(?):194-7. doi:
NULL. [PMID: 15658298] - Matthias R Baumgartner, M Fernanda Dantas, Terttu Suormala, Shlomo Almashanu, Cecilia Giunta, Dolores Friebel, Boris Gebhardt, Brian Fowler, Georg F Hoffmann, E Regula Baumgartner, David Valle. Isolated 3-methylcrotonyl-CoA carboxylase deficiency: evidence for an allele-specific dominant negative effect and responsiveness to biotin therapy.
American journal of human genetics.
2004 Nov; 75(5):790-800. doi:
10.1086/425181. [PMID: 15359379] - Wendy M Sealey, April M Teague, Shawna L Stratton, Donald M Mock. Smoking accelerates biotin catabolism in women.
The American journal of clinical nutrition.
2004 Oct; 80(4):932-5. doi:
10.1093/ajcn/80.4.932. [PMID: 15447901] - Sabine Illsinger, Thomas Lücke, Johannes Zschocke, Kenneth M Gibson, Anibh M Das. 3-methylglutaconic aciduria type I in a boy with fever-associated seizures.
Pediatric neurology.
2004 Mar; 30(3):213-5. doi:
10.1016/j.pediatrneurol.2003.09.016. [PMID: 15033206] - R Santer, H Muhle, T Suormala, E R Baumgartner, M Duran, X Yang, Y Aoki, Y Suzuki, U Stephani. Partial response to biotin therapy in a patient with holocarboxylase synthetase deficiency: clinical, biochemical, and molecular genetic aspects.
Molecular genetics and metabolism.
2003 Jul; 79(3):160-6. doi:
10.1016/s1096-7192(03)00091-x. [PMID: 12855220] - Melissa J Crowe, Donna M O'Connor, Joann E Lukins. The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on indices of health in highly trained athletes.
International journal of sport nutrition and exercise metabolism.
2003 Jun; 13(2):184-97. doi:
10.1123/ijsnem.13.2.184. [PMID: 12945829] - Donald M Mock, Cindy L Henrich, Nadine Carnell, Nell I Mock. Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge.
The American journal of clinical nutrition.
2002 Nov; 76(5):1061-8. doi:
10.1093/ajcn/76.5.1061. [PMID: 12399279] - Jeremy Z Williams, Naji Abumrad, Adrian Barbul. Effect of a specialized amino acid mixture on human collagen deposition.
Annals of surgery.
2002 Sep; 236(3):369-74; discussion 374. doi:
10.1097/00000658-200209000-00013. [PMID: 12192323] - Rebecca Mardach, Janos Zempleni, Barry Wolf, Martin J Cannon, Michael L Jennings, Sally Cress, Jane Boylan, Susan Roth, Stephen Cederbaum, Donald M Mock. Biotin dependency due to a defect in biotin transport.
The Journal of clinical investigation.
2002 Jun; 109(12):1617-23. doi:
10.1172/jci13138. [PMID: 12070309] - Donald M Mock, J Gerald Quirk, Nell I Mock. Marginal biotin deficiency during normal pregnancy.
The American journal of clinical nutrition.
2002 Feb; 75(2):295-9. doi:
10.1093/ajcn/75.2.295. [PMID: 11815321] - R M Helm, N I Mock, P Simpson, D M Mock. Certain immune markers are not good indicators of mild to moderate biotin deficiency in rats.
The Journal of nutrition.
2001 Dec; 131(12):3231-6. doi:
10.1093/jn/131.12.3231. [PMID: 11739872] - M F Silva, J Selhorst, H Overmars, A H van Gennip, M Maya, R J Wanders, I T de Almeida, M Duran. Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS.
Clinical biochemistry.
2001 Nov; 34(8):635-8. doi:
10.1016/s0009-9120(01)00272-7. [PMID: 11849623] - E Jówko, P Ostaszewski, M Jank, J Sacharuk, A Zieniewicz, J Wilczak, S Nissen. Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program.
Nutrition (Burbank, Los Angeles County, Calif.).
2001 Jul; 17(7-8):558-66. doi:
10.1016/s0899-9007(01)00540-8. [PMID: 11448573] - P M Gallagher, J A Carrithers, M P Godard, K E Schulze, S W Trappe. Beta-hydroxy-beta-methylbutyrate ingestion, Part I: effects on strength and fat free mass.
Medicine and science in sports and exercise.
2000 Dec; 32(12):2109-15. doi:
10.1097/00005768-200012000-00022. [PMID: 11128859] - P M Gallagher, J A Carrithers, M P Godard, K E Schulze, S W Trappe. Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function.
Medicine and science in sports and exercise.
2000 Dec; 32(12):2116-9. doi:
10.1097/00005768-200012000-00023. [PMID: 11128860] - L B Panton, J A Rathmacher, S Baier, S Nissen. Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance training.
Nutrition (Burbank, Los Angeles County, Calif.).
2000 Sep; 16(9):734-9. doi:
10.1016/s0899-9007(00)00376-2. [PMID: 10978853] - R Ensenauer, C B Müller, K O Schwab, K M Gibson, M Brandis, W Lehnert. 3-Methylglutaconyl-CoA hydratase deficiency: a new patient with speech retardation as the leading sign.
Journal of inherited metabolic disease.
2000 Jun; 23(4):341-4. doi:
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