alpha-Ketoisocaproate (BioDeep_00000897664)
代谢物信息卡片
alpha-Ketoisocaproate
化学式: C6H9O3- (129.05516640000002)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 31.25%
分子结构信息
SMILES: CC(C)CC(=O)C(=O)[O-]
InChI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
描述信息
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
PlantCyc(2)
代谢反应
36 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(9)
- superpathway of sterol biosynthesis:
4-methyl-2-oxopentanoate + NAD+ + coenzyme A ⟶ CO2 + NADH + isovaleryl-CoA - leucine degradation III:
2-oxoglutarate + leu ⟶ 4-methyl-2-oxopentanoate + glt - leucine degradation III:
4-methyl-2-oxopentanoate + H+ ⟶ 3-methylbutanal + CO2 - leucine degradation I:
4-methyl-2-oxopentanoate + NAD+ + coenzyme A ⟶ CO2 + NADH + isovaleryl-CoA - leucine degradation I:
2-oxoglutarate + leu ⟶ 4-methyl-2-oxopentanoate + glt - 3-methylbutanol biosynthesis (engineered):
3-methylbutanol + NAD+ ⟶ 3-methylbutanal + H+ + NADH - L-leucine degradation III:
3-methylbutanol + NAD+ ⟶ 3-methylbutanal + H+ + NADH - leucine degradation III:
2-oxoglutarate + leu ⟶ 4-methyl-2-oxopentanoate + glu - leucine degradation:
2-oxoglutarate + leu ⟶ 4-methyl-2-oxopentanoate + glu
Plant Reactome(0)
INOH(0)
PlantCyc(26)
- fatty acid α-oxidation I:
H+ + a 2(R)-hydroperoxy fatty acid ⟶ CO2 + H2O + a fatty aldehyde - fatty acid α-oxidation I:
H2O + NAD+ + a fatty aldehyde ⟶ H+ + NADH + a fatty acid - fatty acid α-oxidation I:
H2O + NAD+ + a fatty aldehyde ⟶ H+ + NADH + a fatty acid - fatty acid α-oxidation I:
H2O + NAD+ + a fatty aldehyde ⟶ H+ + NADH + a fatty acid - alkane oxidation:
H2O + NAD+ + a fatty aldehyde ⟶ H+ + NADH + a fatty acid - phospholipases:
H2O + a phosphatidylcholine ⟶ H+ + a 1,2-diacyl-sn-glycerol 3-phosphate + choline - phosphatidylcholine acyl editing:
a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA ⟶ a phosphatidylcholine + coenzyme A - phosphatidylcholine acyl editing:
ATP + a long-chain fatty acid + coenzyme A ⟶ AMP + a long-chain acyl-CoA + diphosphate - phospholipases:
H2O + a phosphatidylcholine ⟶ H+ + a 1,2-diacyl-sn-glycerol 3-phosphate + choline - phospholipases:
H2O + a phosphatidylcholine ⟶ H+ + a 1,2-diacyl-sn-glycerol 3-phosphate + choline - phosphatidylcholine acyl editing:
a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA ⟶ a phosphatidylcholine + coenzyme A - phospholipases:
H2O + a phosphatidylcholine ⟶ H+ + a 1,2-diacyl-sn-glycerol 3-phosphate + choline - phosphatidylcholine acyl editing:
a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA ⟶ a phosphatidylcholine + coenzyme A - phosphatidylcholine acyl editing:
H2O + a phosphatidylcholine ⟶ H+ + a 2-lysophosphatidylcholine + a fatty acid - phospholipases:
H2O + a phosphatidylcholine ⟶ H+ + a 2-lysophosphatidylcholine + a fatty acid - phospholipases:
H2O + a phosphatidylcholine ⟶ H+ + a 1,2-diacyl-sn-glycerol 3-phosphate + choline - phosphatidylcholine acyl editing:
ATP + a long-chain fatty acid + coenzyme A ⟶ AMP + a long-chain acyl-CoA + diphosphate - triacylglycerol degradation:
H2O + a 2-acylglycerol ⟶ H+ + a fatty acid + glycerol - triacylglycerol degradation:
H2O + a 2-acylglycerol ⟶ H+ + a fatty acid + glycerol - triacylglycerol degradation:
H2O + a 2-acylglycerol ⟶ H+ + a fatty acid + glycerol - Organic Nitrogen Assimilation:
H2O + O2 + urate ⟶ CO2 + allantoin + hydrogen peroxide - aliphatic glucosinolate biosynthesis, side chain elongation cycle:
2-[(2'-methylsulfanyl)propyl]maleate + H2O ⟶ 3-[(3'-methylsulfanyl)propyl]malate - triacylglycerol degradation:
H2O + a 2-acylglycerol ⟶ H+ + a fatty acid + glycerol - triacylglycerol degradation:
H2O + a 2-acylglycerol ⟶ H+ + a fatty acid + glycerol - triacylglycerol degradation:
H2O + a 2-acylglycerol ⟶ H+ + a fatty acid + glycerol - fatty acid α-oxidation I:
H+ + a 2(R)-hydroperoxy fatty acid ⟶ CO2 + H2O + a fatty aldehyde
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ângela Beatris Zemniaçak, Rafael Teixeira Ribeiro, Camila Vieira Pinheiro, Sâmela de Azevedo Cunha, Tailine Quevedo Tavares, Ediandra Tissot Castro, Guilhian Leipnitz, Moacir Wajner, Alexandre Umpierrez Amaral. In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury.
Molecular neurobiology.
2023 Nov; ?(?):. doi:
10.1007/s12035-023-03718-9. [PMID: 37910283] - Tae Jun Park, Seung Yeon Park, Hyun Jung Lee, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung. α-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes.
Biochemical and biophysical research communications.
2022 05; 603(?):109-115. doi:
10.1016/j.bbrc.2022.03.010. [PMID: 35279461] - Xin Tang, Lulu Chang, Shujie Gu, Hao Zhang, Yong Q Chen, Haiqin Chen, Jianxin Zhao, Wei Chen. Role of beta-isopropylmalate dehydrogenase in lipid biosynthesis of the oleaginous fungus Mortierella alpina.
Fungal genetics and biology : FG & B.
2021 07; 152(?):103572. doi:
10.1016/j.fgb.2021.103572. [PMID: 34015432] - Gabriella A M Ten Have, Lisa Jansen, Marieke G Schooneman, Marielle P K J Engelen, Nicolaas E P Deutz. Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and β-hydroxy β-methylbutyric acid across multiple organs in the pig.
American journal of physiology. Endocrinology and metabolism.
2021 03; 320(3):E629-E640. doi:
10.1152/ajpendo.00384.2020. [PMID: 33522397] - Hémelin R Farias, Joice R Gabriel, Maria Laura Cecconi, Isabela S Lemos, Victoria L de Rezende, Letícia B Wessler, Mariane B Duarte, Giselli Scaini, Jade de Oliveira, Emilio L Streck. The metabolic effect of α-ketoisocaproic acid: in vivo and in vitro studies.
Metabolic brain disease.
2021 01; 36(1):185-192. doi:
10.1007/s11011-020-00626-y. [PMID: 33034842] - Yinzhao Zhong, Bo Song, Changbing Zheng, Fengna Li, Xiangfeng Kong, Yehui Duan, Jinping Deng. α-Ketoisocaproate and β-hydroxy-β-methyl butyrate regulate fatty acid composition and lipid metabolism in skeletal muscle of growing pigs.
Journal of animal physiology and animal nutrition.
2019 May; 103(3):846-857. doi:
10.1111/jpn.13077. [PMID: 30775808] - Yehui Duan, Lingyu Zhang, Fengna Li, Qiuping Guo, Cimin Long, Yulong Yin, Xiangfeng Kong, Mijun Peng, Wence Wang. β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs.
Food & function.
2018 Sep; 9(9):4836-4846. doi:
10.1039/c8fo00898a. [PMID: 30137075] - Claudia Grajeda-Iglesias, Oren Rom, Shadi Hamoud, Nina Volkova, Tony Hayek, Niroz Abu-Saleh, Michael Aviram. Leucine supplementation attenuates macrophage foam-cell formation: Studies in humans, mice, and cultured macrophages.
BioFactors (Oxford, England).
2018 May; 44(3):245-262. doi:
10.1002/biof.1415. [PMID: 29399895] - Giacomo Garibotto, Daniela Verzola, Monica Vettore, Paolo Tessari. The contribution of muscle, kidney, and splanchnic tissues to leucine transamination in humans.
Canadian journal of physiology and pharmacology.
2018 Apr; 96(4):382-387. doi:
10.1139/cjpp-2017-0439. [PMID: 28892650] - Caroline Hall, Ian Grayson. Genotoxicity and sub-chronic toxicity of MYOLUTION® (branched chain keto acids).
Regulatory toxicology and pharmacology : RTP.
2017 Nov; 90(?):133-143. doi:
10.1016/j.yrtph.2017.09.004. [PMID: 28888959] - Paolo Tessari. Leucine Transamination Is Lower in Middle-Aged Compared with Younger Adults.
The Journal of nutrition.
2017 11; 147(11):2025-2030. doi:
10.3945/jn.117.250852. [PMID: 28931590] - Luciane Taschetto, Giselli Scaini, Hugo G Zapelini, Ândrea C Ramos, Giulia Strapazzon, Vanessa M Andrade, Gislaine Z Réus, Monique Michels, Felipe Dal-Pizzol, João Quevedo, Patrícia F Schuck, Gustavo C Ferreira, Emilio L Streck. Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters and cognitive and noncognitive behaviors.
Metabolic brain disease.
2017 10; 32(5):1507-1518. doi:
10.1007/s11011-017-0035-z. [PMID: 28550500] - Edith Renguet, Audrey Ginion, Roselle Gélinas, Laurent Bultot, Julien Auquier, Isabelle Robillard Frayne, Caroline Daneault, Jean-Louis Vanoverschelde, Christine Des Rosiers, Louis Hue, Sandrine Horman, Christophe Beauloye, Luc Bertrand. Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake.
American journal of physiology. Heart and circulatory physiology.
2017 Aug; 313(2):H432-H445. doi:
10.1152/ajpheart.00738.2016. [PMID: 28646031] - Dillon K Walker, John J Thaden, Agata Wierzchowska-McNew, Marielle P K J Engelen, Nicolaas E P Deutz. Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jan; 1040(?):233-238. doi:
10.1016/j.jchromb.2016.11.010. [PMID: 27856194] - Davis S Sonnet, Monique N O'Leary, Mark A Gutierrez, Steven M Nguyen, Samiha Mateen, Yuehmei Hsu, Kylie P Mitchell, Antonio J Lopez, Jerry Vockley, Brian K Kennedy, Arvind Ramanathan. Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Scientific reports.
2016 07; 6(?):28775. doi:
10.1038/srep28775. [PMID: 27373929] - Sathyavageeswaran Shreeram, Subbarayan Ramesh, Jithesh K Puthan, Gayathri Balakrishnan, Ramachandran Subramanian, Murali Todime Reddy, Suzette L Pereira. Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
Experimental gerontology.
2016 07; 80(?):6-11. doi:
10.1016/j.exger.2016.03.021. [PMID: 27073170] - Miriam S W Wisniewski, Milena Carvalho-Silva, Lara M Gomes, Hugo G Zapelini, Patrícia F Schuck, Gustavo C Ferreira, Giselli Scaini, Emilio L Streck. Intracerebroventricular administration of α-ketoisocaproic acid decreases brain-derived neurotrophic factor and nerve growth factor levels in brain of young rats.
Metabolic brain disease.
2016 Apr; 31(2):377-83. doi:
10.1007/s11011-015-9768-8. [PMID: 26586008] - Katsumi Shibata, Chifumi Nakata, Tsutomu Fukuwatari. High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats.
Bioscience, biotechnology, and biochemistry.
2016; 80(2):304-12. doi:
10.1080/09168451.2015.1083395. [PMID: 26745680] - Katsumi Shibata, Momoka Sakamoto. Urinary Branched-Chain 2-Oxo Acids as a Biomarker for Function of B-Group Vitamins in Humans.
Journal of nutritional science and vitaminology.
2016; 62(4):220-228. doi:
10.3177/jnsv.62.220. [PMID: 27725406] - Kota Fukai, Sei Harada, Miho Iida, Ayako Kurihara, Ayano Takeuchi, Kazuyo Kuwabara, Daisuke Sugiyama, Tomonori Okamura, Miki Akiyama, Yuji Nishiwaki, Yuko Oguma, Asako Suzuki, Chizuru Suzuki, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Toru Takebayashi. Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men.
PloS one.
2016; 11(10):e0164877. doi:
10.1371/journal.pone.0164877. [PMID: 27741291] - Andrew D James, Waseema Patel, Zohra Butt, Magretta Adiamah, Raga Dakhel, Ayse Latif, Carolina Uggenti, Eileithyia Swanton, Hiromi Imamura, Ajith K Siriwardena, Jason I E Bruce. The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.
The Journal of biological chemistry.
2015 Oct; 290(41):24760-71. doi:
10.1074/jbc.m115.668707. [PMID: 26294767] - Anthony J Lee, David W A Beno, Xiaolin Zhang, Robin Shapiro, Mark Mason, Tanita Mason-Bright, Bruce Surber, Neilé K Edens. A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite.
Amino acids.
2015 May; 47(5):917-24. doi:
10.1007/s00726-015-1920-6. [PMID: 25618754] - Xiaoya Huang, Yuan Zhong, Zhongping Huang, Chen Jin, Lili Wang, Zaifa Pan. [Simultaneous determination of five active components of compound α-ketoacid tablet in human urine by ion-pair reversed-phase high performance liquid chromatography].
Se pu = Chinese journal of chromatography.
2015 Feb; 33(2):169-73. doi:
10.3724/sp.j.1123.2014.10024. [PMID: 25989690] - Donald F Stec, Suwan Wang, Cody Stothers, Josh Avance, Deon Denson, Raymond Harris, Paul Voziyan. Alterations of urinary metabolite profile in model diabetic nephropathy.
Biochemical and biophysical research communications.
2015 Jan; 456(2):610-4. doi:
10.1016/j.bbrc.2014.12.003. [PMID: 25499815] - Hester Vlaardingerbroek, Jorine A Roelants, Denise Rook, Kristien Dorst, Henk Schierbeek, Andras Vermes, Marijn J Vermeulen, Johannes B van Goudoever, Chris H P van den Akker. Adaptive regulation of amino acid metabolism on early parenteral lipid and high-dose amino acid administration in VLBW infants - a randomized, controlled trial.
Clinical nutrition (Edinburgh, Scotland).
2014 Dec; 33(6):982-90. doi:
10.1016/j.clnu.2014.01.002. [PMID: 24461877] - Hiroyuki Hachiya, Yoshikazu Miura, Ken-Ichi Inoue, Kyung Hwa Park, Masayoshi Takeuchi, Keiichi Kubota. Advanced glycation end products impair glucose-induced insulin secretion from rat pancreatic β-cells.
Journal of hepato-biliary-pancreatic sciences.
2014 Feb; 21(2):134-41. doi:
10.1002/jhbp.12. [PMID: 23798335] - Rajavel Elango, Karen Chapman, Mahroukh Rafii, Ronald O Ball, Paul B Pencharz. Determination of the tolerable upper intake level of leucine in acute dietary studies in young men.
The American journal of clinical nutrition.
2012 Oct; 96(4):759-67. doi:
10.3945/ajcn.111.024471. [PMID: 22952178] - Alexandros Pechlivanis, Sarantos Kostidis, Ploutarchos Saraslanidis, Anatoli Petridou, George Tsalis, Vassilis Mougios, Helen G Gika, Emmanuel Mikros, Georgios A Theodoridis. (1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine.
Journal of proteome research.
2010 Dec; 9(12):6405-16. doi:
10.1021/pr100684t. [PMID: 20932058] - Jeffery Escobar, Jason W Frank, Agus Suryawan, Hanh V Nguyen, Cynthia G Van Horn, Susan M Hutson, Teresa A Davis. Leucine and alpha-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs.
The Journal of nutrition.
2010 Aug; 140(8):1418-24. doi:
10.3945/jn.110.123042. [PMID: 20534881] - William S Crim, Runpei Wu, Jeffrey D Carter, Banumathi K Cole, Anthony P Trace, Raghavendra G Mirmira, Charles Kunsch, Jerry L Nadler, Craig S Nunemaker. AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
Molecular and cellular endocrinology.
2010 Jul; 323(2):246-55. doi:
10.1016/j.mce.2010.02.041. [PMID: 20211684] - Alexandre Umpierrez Amaral, Guilhian Leipnitz, Carolina Gonçalves Fernandes, Bianca Seminotti, Patrícia Fernanda Schuck, Moacir Wajner. Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain.
Brain research.
2010 Apr; 1324(?):75-84. doi:
10.1016/j.brainres.2010.02.018. [PMID: 20153737] - Hideki Matsumoto, Keiichi Akita, Ryosei Sakai, Yoshiharu Shimomura. Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate.
Analytical biochemistry.
2010 Apr; 399(1):1-6. doi:
10.1016/j.ab.2009.12.017. [PMID: 20018161] - William J Zinnanti, Jelena Lazovic, Kathleen Griffin, Kristen J Skvorak, Harbhajan S Paul, Gregg E Homanics, Maria C Bewley, Keith C Cheng, Kathryn F Lanoue, John M Flanagan. Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.
Brain : a journal of neurology.
2009 Apr; 132(Pt 4):903-18. doi:
10.1093/brain/awp024. [PMID: 19293241] - A B Crujeiras, D Parra, E Goyenechea, I Abete, P González-Muniesa, J A Martínez. Energy restriction in obese subjects impact differently two mitochondrial function markers.
Journal of physiology and biochemistry.
2008 Sep; 64(3):211-9. doi:
10.1007/bf03178844. [PMID: 19244935] - Michael J MacDonald, Scott W Stoker, Noaman M Hasan. Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria.
Molecular and cellular biochemistry.
2008 Jun; 313(1-2):195-202. doi:
10.1007/s11010-008-9757-x. [PMID: 18414997] - K Nakashima, Y Yakabe, A Ishida, M Yamazaki, H Abe. Suppression of myofibrillar proteolysis in chick skeletal muscles by alpha-ketoisocaproate.
Amino acids.
2007 Sep; 33(3):499-503. doi:
10.1007/s00726-006-0404-0. [PMID: 16998714] - André Wajner, Cristiane Bürger, Carlos Severo Dutra-Filho, Moacir Wajner, Angela Terezinha de Souza Wyse, Clóvis Milton Duval Wannmacher. Synaptic plasma membrane Na(+), K (+)-ATPase activity is significantly reduced by the alpha-keto acids accumulating in maple syrup urine disease in rat cerebral cortex.
Metabolic brain disease.
2007 Mar; 22(1):77-88. doi:
10.1007/s11011-007-9046-5. [PMID: 17295076] - M Fex, M Dekker Nitert, N Wierup, F Sundler, C Ling, H Mulder. Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
Diabetologia.
2007 Jan; 50(1):74-83. doi:
10.1007/s00125-006-0464-4. [PMID: 17093947] - Michael J Toth, Cynthia K Sites, Dwight E Matthews. Role of ovarian hormones in the regulation of protein metabolism in women: effects of menopausal status and hormone replacement therapy.
American journal of physiology. Endocrinology and metabolism.
2006 Sep; 291(3):E639-46. doi:
10.1152/ajpendo.00050.2006. [PMID: 16684855] - Berrin Oguzhan, Ying Zhang, Karim Louchami, Philippe Courtois, Laurence Portois, Jean-Michel Chardigny, Willy J Malaisse, Yvon A Carpentier, Abdullah Sener. Pancreatic islet function in omega3 fatty acid-depleted rats: Glucose metabolism and nutrient-stimulated insulin release.
Endocrine.
2006 Jun; 29(3):457-66. doi:
10.1385/endo:29:3:457. [PMID: 16943585] - S Patterson, P R Flatt, L Brennan, P Newsholme, N H McClenaghan. Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.
The Journal of endocrinology.
2006 May; 189(2):301-10. doi:
10.1677/joe.1.06537. [PMID: 16648297] - Cláudia Funchal, Patrícia Fernanda Schuck, André Quincozes Dos Santos, Maria Caroline Jacques-Silva, Carmem Gottfried, Regina Pessoa-Pureur, Moacir Wajner. Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.
Cellular and molecular neurobiology.
2006 Feb; 26(1):67-79. doi:
10.1007/s10571-006-9098-9. [PMID: 16633902] - Cláudia Funchal, Ariane Zamoner, André Quincozes dos Santos, Maria Beatriz Moretto, João B T Rocha, Moacir Wajner, Regina Pessoa-Pureur. Evidence that intracellular Ca2+ mediates the effect of alpha-ketoisocaproic acid on the phosphorylating system of cytoskeletal proteins from cerebral cortex of immature rats.
Journal of the neurological sciences.
2005 Nov; 238(1-2):75-82. doi:
10.1016/j.jns.2005.06.013. [PMID: 16111708] - Benjamin F Miller, Jens L Olesen, Mette Hansen, Simon Døssing, Regina M Crameri, Rasmus J Welling, Henning Langberg, Allan Flyvbjerg, Michael Kjaer, John A Babraj, Kenneth Smith, Michael J Rennie. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise.
The Journal of physiology.
2005 Sep; 567(Pt 3):1021-33. doi:
10.1113/jphysiol.2005.093690. [PMID: 16002437] - Cláudia Funchal, André Quincozes Dos Santos, Maria Caroline Jacques-Silva, Ariane Zamoner, Carmem Gottfried, Moacir Wajner, Regina Pessoa-Pureur. Branched-chain alpha-keto acids accumulating in maple syrup urine disease induce reorganization of phosphorylated GFAP in C6-glioma cells.
Metabolic brain disease.
2005 Sep; 20(3):205-17. doi:
10.1007/s11011-005-7208-x. [PMID: 16167198] - Cláudia Funchal, Ariane Zamoner, André Quincozes dos Santos, Samanta Oliveira Loureiro, Moacir Wajner, Regina Pessoa-Pureur. Alpha-ketoisocaproic acid increases phosphorylation of intermediate filament proteins from rat cerebral cortex by mechanisms involving Ca2+ and cAMP.
Neurochemical research.
2005 Sep; 30(9):1139-46. doi:
10.1007/s11064-005-7709-3. [PMID: 16292507] - Ken A van Someren, Adam J Edwards, Glyn Howatson. Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.
International journal of sport nutrition and exercise metabolism.
2005 Aug; 15(4):413-24. doi:
10.1123/ijsnem.15.4.413. [PMID: 16286672] - Raquel Bridi, César A Braun, Giovanni K Zorzi, Clóvis M D Wannmacher, Moacir Wajner, Eduardo G Lissi, Carlos Severo Dutra-Filho. alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats.
Metabolic brain disease.
2005 Jun; 20(2):155-67. doi:
10.1007/s11011-005-4152-8. [PMID: 15938133] - Kaori Matsuzaki, Hisanori Kato, Ryosei Sakai, Sakino Toue, Michiko Amao, Takeshi Kimura. Transcriptomics and metabolomics of dietary leucine excess.
The Journal of nutrition.
2005 06; 135(6 Suppl):1571S-5S. doi:
10.1093/jn/135.6.1571s. [PMID: 15930471] - Daniel Cuthbertson, Kenneth Smith, John Babraj, Graham Leese, Tom Waddell, Philip Atherton, Henning Wackerhage, Peter M Taylor, Michael J Rennie. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2005 Mar; 19(3):422-4. doi:
10.1096/fj.04-2640fje. [PMID: 15596483] - Cláudia Funchal, Carmem Gottfried, Lúcia Maria Vieira De Almeida, Moacir Wajner, Regina Pessoa-Pureur. Evidence that the branched-chain alpha-keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex.
Glia.
2004 Nov; 48(3):230-40. doi:
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American journal of physiology. Endocrinology and metabolism.
2004 Jul; 287(1):E160-5. doi:
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American journal of physiology. Cell physiology.
2004 Jun; 286(6):C1474-8. doi:
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Journal of the American Society of Nephrology : JASN.
2004 Jun; 15(6):1606-15. doi:
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Pharmacology, biochemistry, and behavior.
2004 Jan; 77(1):183-90. doi:
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The Journal of pediatrics.
2004 Jan; 144(1):75-80. doi:
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Biochimica et biophysica acta.
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Metabolism: clinical and experimental.
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American journal of physiology. Endocrinology and metabolism.
2003 Jul; 285(1):E54-62. doi:
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The Journal of biological chemistry.
2003 Jun; 278(25):22956-63. doi:
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Metabolism: clinical and experimental.
2003 Apr; 52(4):463-7. doi:
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Pediatric research.
2003 Feb; 53(2):281-7. doi:
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Pediatric research.
2003 Feb; 53(2):320-4. doi:
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Brain research. Developmental brain research.
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Drug metabolism and disposition: the biological fate of chemicals.
2002 Dec; 30(12):1436-40. doi:
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American journal of physiology. Renal physiology.
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Kidney international.
2002 Oct; 62(4):1408-16. doi:
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The Journal of clinical endocrinology and metabolism.
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Critical care medicine.
2002 Jan; 30(1):65-70. doi:
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American journal of physiology. Endocrinology and metabolism.
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