(6R)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide (BioDeep_00000897464)
代谢物信息卡片
(6R)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
化学式: C56H98N16O13 (1202.7498898)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O
InChI: InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)/t32-,33-,34-,36+,37+,38+,39+,40+,41+,42+,43-,45+,46+/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui Li, Wenhui E, Dongying Zhao, Haiyang Liu, Jian Pei, Binghai Du, Kai Liu, Xueming Zhu, Chengqiang Wang. Response of Paenibacillus polymyxa SC2 to the stress of polymyxin B and a key ABC transporter YwjA involved.
Applied microbiology and biotechnology.
2024 Dec; 108(1):17. doi:
10.1007/s00253-023-12916-3. [PMID: 38170316] - Marie Burt, Georgia Angelidou, Christopher Nils Mais, Christian Preußer, Timo Glatter, Thomas Heimerl, Rüdiger Groß, Javier Serrania, Gowtham Boosarpu, Elke Pogge von Strandmann, Janis A Müller, Gert Bange, Anke Becker, Mareike Lehmann, Danny Jonigk, Lavinia Neubert, Hinrich Freitag, Nicole Paczia, Bernd Schmeck, Anna Lena Jung. Lipid A in outer membrane vesicles shields bacteria from polymyxins.
Journal of extracellular vesicles.
2024 May; 13(5):e12447. doi:
10.1002/jev2.12447. [PMID: 38766978] - Hui-Zhong Sun, Qing Li, Wei Shang, Bin Qiao, Qiu-Man Xu, Jing-Sheng Cheng. Combinatorial metabolic engineering of Bacillus subtilis for de novo production of polymyxin B.
Metabolic engineering.
2024 May; 83(?):123-136. doi:
10.1016/j.ymben.2024.04.001. [PMID: 38582143] - Nina Královič-Kanjaková, Ali Asi Shirazi, Lukáš Hubčík, Mária Klacsová, Atoosa Keshavarzi, Juan Carlos Martínez, Sophie Combet, José Teixeira, Daniela Uhríková. Polymyxin B-Enriched Exogenous Lung Surfactant: Thermodynamics and Structure.
Langmuir : the ACS journal of surfaces and colloids.
2024 Apr; 40(13):6847-6861. doi:
10.1021/acs.langmuir.3c03746. [PMID: 38501650] - Manon Janet-Maitre, Viviana Job, Maxime Bour, Mylène Robert-Genthon, Sabine Brugière, Pauline Triponney, David Cobessi, Yohann Couté, Katy Jeannot, Ina Attrée. Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxins.
mBio.
2024 Mar; 15(3):e0221123. doi:
10.1128/mbio.02211-23. [PMID: 38345374] - G L Xia, X Xu, X B You, X Wang, D D Feng, S Lei, R L Jiang. Efficacy and nephrotoxicity of polymyxin B in elderly patients with carbapenem resistant bacterial infection.
Annals of clinical microbiology and antimicrobials.
2023 Nov; 22(1):101. doi:
10.1186/s12941-023-00647-2. [PMID: 37968642] - Chunxia Hu, Jinyong Zhang, Ruiqin Cui, Shiyi Liu, Ying Huang, Huan Zeng, Shumin Cheng, Guibao Zhou, Jingli Li, Longqin Sun, Yan Zhao, Xiao Wang, Jianhua Liu, Quanming Zou, Wei Huang. The enhancement effect of small molecule Lyb24 reveals AzoR as a novel target of polymyxin B.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Nov; ?(?):115856. doi:
10.1016/j.biopha.2023.115856. [PMID: 37949698] - Melanie N Hurst, Connor J Beebout, Alexis Hollingsworth, Kirsten R Guckes, Alexandria Purcell, Tomas A Bermudez, Diamond Williams, Seth A Reasoner, M Stephen Trent, Maria Hadjifrangiskou. The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS.
mSphere.
2023 10; 8(5):e0005923. doi:
10.1128/msphere.00059-23. [PMID: 37676915] - Xiangfeng Lai, Seong Hoong Chow, Anton P Le Brun, Benjamin W Muir, Phillip J Bergen, Jacinta White, Heidi H Yu, Jiping Wang, Jill Danne, Jhih-Hang Jiang, Francesca L Short, Mei-Ling Han, Richard A Strugnell, Jiangning Song, Neil R Cameron, Anton Y Peleg, Jian Li, Hsin-Hui Shen. Polysaccharide-Targeting Lipid Nanoparticles to Kill Gram-Negative Bacteria.
Small (Weinheim an der Bergstrasse, Germany).
2023 Oct; ?(?):e2305052. doi:
10.1002/smll.202305052. [PMID: 37798622] - Meiling Yu, Hongyu Li, Boying Wang, Zhenxiang Wu, Sheng Wu, Guojun Jiang, Huaxue Wang, Yingying Huang. Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation.
Chemico-biological interactions.
2023 Sep; 382(?):110607. doi:
10.1016/j.cbi.2023.110607. [PMID: 37354967] - Jing Lu, Meiling Han, Heidi H Yu, Phillip J Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov. Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae.
Microbiology spectrum.
2023 Jul; ?(?):e0085223. doi:
10.1128/spectrum.00852-23. [PMID: 37432123] - Hongyu Li, Boying Wang, Sheng Wu, Shuying Dong, Guojun Jiang, Yingying Huang, Xuhui Tong, Meiling Yu. Ferroptosis is involved in polymyxin B-induced acute kidney injury via activation of p53.
Chemico-biological interactions.
2023 Jun; 378(?):110479. doi:
10.1016/j.cbi.2023.110479. [PMID: 37088170] - Alexandria B Purcell, Brent W Simpson, M Stephen Trent. Impact of the cAMP-cAMP Receptor Protein Regulatory Complex on Lipopolysaccharide Modifications and Polymyxin B Resistance in Escherichia coli.
Journal of bacteriology.
2023 Apr; ?(?):e0006723. doi:
10.1128/jb.00067-23. [PMID: 37070977] - Bradley Whitehead, Fabio Antennuci, Anders T Boysen, Peter Nejsum. Polymyxin B inhibits pro-inflammatory effects of E. coli outer membrane vesicles whilst increasing immune cell uptake and clearance.
The Journal of antibiotics.
2023 Apr; ?(?):. doi:
10.1038/s41429-023-00615-0. [PMID: 37016014] - Patrick O Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G Cess, Stacey D Finley, Phillip J Bergen, Tony Velkov, Jian Li, Gauri G Rao. Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae.
CPT: pharmacometrics & systems pharmacology.
2023 03; 12(3):387-400. doi:
10.1002/psp4.12923. [PMID: 36661181] - Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana E Adade, Dervla T D Kenna, Beverley C Millar, John E Moore, José Ramos Vivas, Antonio Molinaro, Miguel A Valvano. Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide.
Microbiology spectrum.
2023 Feb; 11(1):e0372922. doi:
10.1128/spectrum.03729-22. [PMID: 36519943] - Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T Tsuji, Darren J Creek, Tony Velkov, Jian Li. Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa.
Journal of biomedical science.
2022 Oct; 29(1):89. doi:
10.1186/s12929-022-00874-3. [PMID: 36310165] - Diship Srivastava, Niladri Patra. Self-Uptake Mechanism of Polymyxin-Based Lipopeptide against Gram-Negative Bacterial Membrane: Role of the First Adsorbed Lipopeptide.
The journal of physical chemistry. B.
2022 10; 126(41):8222-8232. doi:
10.1021/acs.jpcb.2c03827. [PMID: 36126341] - Lei Fu, Xiangyuan Li, Shan Zhang, Yi Dong, Weihai Fang, Lianghui Gao. Polymyxins induce lipid scrambling and disrupt the homeostasis of Gram-negative bacteria membrane.
Biophysical journal.
2022 09; 121(18):3486-3498. doi:
10.1016/j.bpj.2022.08.007. [PMID: 35964158] - Ting Huang, Mao Zeng, Huiyao Fu, Kelei Zhao, Tao Song, Yidong Guo, Jingyu Zhou, Longfei Zhai, Chaolan Liu, Balakrishnan Prithiviraj, Xinrong Wang, Yiwen Chu. A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains.
Annals of clinical microbiology and antimicrobials.
2022 Aug; 21(1):38. doi:
10.1186/s12941-022-00531-5. [PMID: 36038932] - Christopher Mullally, Keith A Stubbs, Van C Thai, Anandhi Anandan, Stephanie Bartley, Martin J Scanlon, Gary A Jarvis, Constance M John, Katherine Y L Lim, Courtney M Sullivan, Mitali Sarkar-Tyson, Alice Vrielink, Charlene M Kahler. Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.
The Journal of antimicrobial chemotherapy.
2022 08; 77(9):2441-2447. doi:
10.1093/jac/dkac204. [PMID: 35770844] - Taotao Lu, Xinyu Zheng, Fei Mao, Qiao Cao, Qin Cao, Jin Zhu, Xiaokang Li, Lefu Lan, Baoli Li, Jian Li. Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
European journal of medicinal chemistry.
2022 Jun; 236(?):114318. doi:
10.1016/j.ejmech.2022.114318. [PMID: 35398731] - Mingyeong Kang, Wonjae Kim, Jaebok Lee, Hye Su Jung, Che Ok Jeon, Woojun Park. 6-Bromo-2-naphthol from Silene armeria extract sensitizes Acinetobacter baumannii strains to polymyxin.
Scientific reports.
2022 05; 12(1):8546. doi:
10.1038/s41598-022-11995-y. [PMID: 35595766] - Mousumi Ray, Ashwini Manjunath, Prakash M Halami. Prevalence of polymyxin resistance through the food chain, the global crisis.
The Journal of antibiotics.
2022 04; 75(4):185-198. doi:
10.1038/s41429-022-00502-0. [PMID: 35079146] - M Mohammed Atiyah, H Shnawa Jasim, H Mohammed Atiyah. Phytochemical Screening and Antibacterial Activities of Aqueous and Alcoholic Extracts of Averrhoa bilimbi Leaf against Bacteria Isolated from Oral Cavity.
Archives of Razi Institute.
2022 Apr; 77(2):923-928. doi:
10.22092/ari.2022.357207.1996. [PMID: 36284968] - Yuliang Sun, Zhixiong Deng, Xukai Jiang, Bing Yuan, Kai Yang. Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
Colloids and surfaces. B, Biointerfaces.
2022 Mar; 211(?):112288. doi:
10.1016/j.colsurfb.2021.112288. [PMID: 34942463] - Xiangfeng Lai, Mei-Ling Han, Yue Ding, Seong Hoong Chow, Anton P Le Brun, Chun-Ming Wu, Phillip J Bergen, Jhih-Hang Jiang, Hsien-Yi Hsu, Benjamin W Muir, Jacinta White, Jiangning Song, Jian Li, Hsin-Hui Shen. A polytherapy based approach to combat antimicrobial resistance using cubosomes.
Nature communications.
2022 01; 13(1):343. doi:
10.1038/s41467-022-28012-5. [PMID: 35039508] - Alice Goode, Vivien Yeh, Boyan B Bonev. Interactions of polymyxin B with lipopolysaccharide-containing membranes.
Faraday discussions.
2021 12; 232(0):317-329. doi:
10.1039/d1fd00036e. [PMID: 34550139] - Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.
Antimicrobial agents and chemotherapy.
2021 11; 65(12):e0106521. doi:
10.1128/aac.01065-21. [PMID: 34516251] - Cassandra E Nelson, Weiliang Huang, Emily M Zygiel, Elizabeth M Nolan, Maureen A Kane, Amanda G Oglesby. The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa.
Microbiology spectrum.
2021 10; 9(2):e0051921. doi:
10.1128/spectrum.00519-21. [PMID: 34549997] - Zhen Wang, Jiawei Wang, Jie Cheng, Xiaowen Yang, Hai Jiang, Qingmin Wu. Genome-Wide Analysis of the Response of Brucella melitensis NI to Polymyxin B.
Current pharmaceutical biotechnology.
2021 Oct; 22(14):1891-1899. doi:
10.2174/1389201021666201218125148. [PMID: 33342409] - Jibao Zhu, Chengfei Hu, Zizhen Zeng, Xiaoyu Deng, Lingbing Zeng, Saisai Xie, Yuanying Fang, Yi Jin, Valérie Alezra, Yang Wan. Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism.
European journal of medicinal chemistry.
2021 Oct; 221(?):113488. doi:
10.1016/j.ejmech.2021.113488. [PMID: 33991963] - G L Xia, R L Jiang. Efficacy and safety of polymyxin B in carbapenem-resistant gram-negative organisms infections.
BMC infectious diseases.
2021 Oct; 21(1):1034. doi:
10.1186/s12879-021-06719-y. [PMID: 34607561] - Yanli Shi, Yong He, Lvxia Zhang, Lin Wang, Zhifeng Fu. Dual-site recognition of Pseudomonas aeruginosa using polymyxin B and bacteriophage tail fiber protein.
Analytica chimica acta.
2021 Oct; 1180(?):338855. doi:
10.1016/j.aca.2021.338855. [PMID: 34538321] - Maizbha U Ahmed, Mohammad A K Azad, Mengyao Li, Darren J Creek, Meiling Han, Fanfan Zhou, Kim Chan, Qi Tony Zhou, Tony Velkov, Jian Li. Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0083521. doi:
10.1128/aac.00835-21. [PMID: 34228550] - Jaeeun Park, Misung Kim, Bora Shin, Mingyeong Kang, Jihye Yang, Tae Kwon Lee, Woojun Park. A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii.
eLife.
2021 06; 10(?):. doi:
10.7554/elife.66988. [PMID: 34180396] - Chui-Yoke Chin, Jinshi Zhao, Anna C Llewellyn, Igor Golovliov, Anders Sjöstedt, Pei Zhou, David S Weiss. Francisella FlmX broadly affects lipopolysaccharide modification and virulence.
Cell reports.
2021 06; 35(11):109247. doi:
10.1016/j.celrep.2021.109247. [PMID: 34133919] - Bruno C Borro, Marie S Toussaint, Saskia Bucciarelli, Martin Malmsten. Effects of charge contrast and composition on microgel formation and interactions with bacteria-mimicking liposomes.
Biochimica et biophysica acta. General subjects.
2021 04; 1865(4):129485. doi:
10.1016/j.bbagen.2019.129485. [PMID: 31734459] - Amanda Castillo-Zeledón, Nazareth Ruiz-Villalobos, Pamela Altamirano-Silva, Carlos Chacón-Díaz, Elías Barquero-Calvo, Esteban Chaves-Olarte, Caterina Guzmán-Verri. A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence.
PloS one.
2021; 16(8):e0254568. doi:
10.1371/journal.pone.0254568. [PMID: 34388167] - Peile Wang, Qiwen Zhang, Zifei Qin, Han Xing, Min Xu, Hui Pei, Jing Yang, Xiaojian Zhang. A Simple and Robust Liquid Chromatography With Tandem Mass Spectrometry Analytical Method for Therapeutic Drug Monitoring of Plasma and Cerebrospinal Fluid Polymyxin B1 and B2.
Therapeutic drug monitoring.
2020 10; 42(5):716-723. doi:
10.1097/ftd.0000000000000754. [PMID: 32941397] - Jianguo Li, Roger Beuerman, Chandra S Verma. Mechanism of polyamine induced colistin resistance through electrostatic networks on bacterial outer membranes.
Biochimica et biophysica acta. Biomembranes.
2020 09; 1862(9):183297. doi:
10.1016/j.bbamem.2020.183297. [PMID: 32339485] - Christian Nehls, Arne Böhling, Rainer Podschun, Sabine Schubert, Joachim Grötzinger, Andra Schromm, Henning Fedders, Matthias Leippe, Jürgen Harder, Yani Kaconis, Sabine Gronow, Thomas Gutsmann. Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria.
Biochimica et biophysica acta. Biomembranes.
2020 08; 1862(8):183273. doi:
10.1016/j.bbamem.2020.183273. [PMID: 32171739] - Nusaibah Abdul Rahim, Soon-Ee Cheah, Matthew D Johnson, Yan Zhu, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Phillip J Bergen, Tony Velkov, Jian Li. Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.
International journal of antimicrobial agents.
2020 Aug; 56(2):106061. doi:
10.1016/j.ijantimicag.2020.106061. [PMID: 32574791] - Choongdeok Lee, Meong Il Kim, Jaewan Park, Junghun Kim, Hansol Oh, Yoeseph Cho, Junghyun Son, Bo-Young Jeon, Hakhyun Ka, Minsun Hong. Crystal structure of the Pseudomonas aeruginosa PA0423 protein and its functional implication in antibiotic sequestration.
Biochemical and biophysical research communications.
2020 07; 528(1):85-91. doi:
10.1016/j.bbrc.2020.05.023. [PMID: 32451086] - Maytham Hussein, Elena K Schneider-Futschik, Olivia K A Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Jian Li, Tony Velkov. Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline.
ACS infectious diseases.
2020 06; 6(6):1436-1450. doi:
10.1021/acsinfecdis.0c00108. [PMID: 32427476] - Prosenjit Samanta, Rahul Shubhra Mandal, Rudra Narayan Saha, Sreeja Shaw, Priyanka Ghosh, Shanta Dutta, Amit Ghosh, Daisuke Imamura, Masatomo Morita, Makoto Ohnishi, Thandavarayan Ramamurthy, Asish Kumar Mukhopadhyay. A Point Mutation in carR Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription.
Infection and immunity.
2020 04; 88(5):. doi:
10.1128/iai.00080-20. [PMID: 32094260] - Jiayuan Huang, Chen Li, Jiangning Song, Tony Velkov, Lushan Wang, Yan Zhu, Jian Li. Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB.
Future microbiology.
2020 04; 15(?):445-459. doi:
10.2217/fmb-2019-0322. [PMID: 32250173] - Fatma Ben Jeddou, Léna Falconnet, Alexandre Luscher, Thissa Siriwardena, Jean-Louis Reymond, Christian van Delden, Thilo Köhler. Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy.
2020 03; 64(4):. doi:
10.1128/aac.02040-19. [PMID: 32015046] - Sokunthearath Saem, Osama Shahid, Adree Khondker, Camila Moran-Hidalgo, Maikel C Rheinstädter, Jose Moran-Mirabal. Benchtop-fabricated lipid-based electrochemical sensing platform for the detection of membrane disrupting agents.
Scientific reports.
2020 03; 10(1):4595. doi:
10.1038/s41598-020-61561-7. [PMID: 32165701] - Lei Fu, Mingwei Wan, Shan Zhang, Lianghui Gao, Weihai Fang. Polymyxin B Loosens Lipopolysaccharide Bilayer but Stiffens Phospholipid Bilayer.
Biophysical journal.
2020 01; 118(1):138-150. doi:
10.1016/j.bpj.2019.11.008. [PMID: 31812355] - Hui Su, Han-Yuan Liu, Anna-Maria Pappa, Tania Cecilia Hidalgo, Priscila Cavassin, Sahika Inal, Róisín M Owens, Susan Daniel. Facile Generation of Biomimetic-Supported Lipid Bilayers on Conducting Polymer Surfaces for Membrane Biosensing.
ACS applied materials & interfaces.
2019 Nov; 11(47):43799-43810. doi:
10.1021/acsami.9b10303. [PMID: 31659897] - Sue C Nang, Mei-Ling Han, Heidi H Yu, Jiping Wang, Von Vergel L Torres, Chongshan Dai, Tony Velkov, Marina Harper, Jian Li. Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1.
The Journal of antimicrobial chemotherapy.
2019 11; 74(11):3190-3198. doi:
10.1093/jac/dkz314. [PMID: 31365098] - Sreenu Madhumanchi, Roongnapa Suedee, Titpawan Nakpheng, Kittiya Tinpun, Pornvichai Temboot, Teerapol Srichana. Binding interactions of bacterial lipopolysaccharides to polymyxin B in an amphiphilic carrier 'sodium deoxycholate sulfate'.
Colloids and surfaces. B, Biointerfaces.
2019 Oct; 182(?):110374. doi:
10.1016/j.colsurfb.2019.110374. [PMID: 31330430] - Elise Gasiorowski, Rodolphe Auger, Xudong Tian, Samia Hicham, Chantal Ecobichon, Sophie Roure, Martin V Douglass, M Stephen Trent, Dominique Mengin-Lecreulx, Thierry Touzé, Ivo Gomperts Boneca. HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach.
PLoS pathogens.
2019 09; 15(9):e1007972. doi:
10.1371/journal.ppat.1007972. [PMID: 31487328] - Lis Marie Monteiro, Raimar Löbenberg, Nikoletta Fotaki, Gabriel Lima Barros de Araújo, Paulo Cesar Cotrim, Nádia Bou-Chacra. Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment.
Journal of global antimicrobial resistance.
2019 09; 18(?):279-283. doi:
10.1016/j.jgar.2019.06.006. [PMID: 31202979] - Nekane Reta, Andrew Michelmore, Christopher P Saint, Beatriz Prieto-Simon, Nicolas H Voelcker. Label-Free Bacterial Toxin Detection in Water Supplies Using Porous Silicon Nanochannel Sensors.
ACS sensors.
2019 06; 4(6):1515-1523. doi:
10.1021/acssensors.8b01670. [PMID: 31140789] - Miranda E Pitt, Minh Duc Cao, Mark S Butler, Soumya Ramu, Devika Ganesamoorthy, Mark A T Blaskovich, Lachlan J M Coin, Matthew A Cooper. Octapeptin C4 and polymyxin resistance occur via distinct pathways in an epidemic XDR Klebsiella pneumoniae ST258 isolate.
The Journal of antimicrobial chemotherapy.
2019 03; 74(3):582-593. doi:
10.1093/jac/dky458. [PMID: 30445429] - Hanae Kobayashi-Tsukumo, Kanami Oiji, Dan Xie, Yuka Sawada, Kunihiko Yamashita, Shinichi Ogata, Hajime Kojima, Hiroshi Itagaki. Eliminating the contribution of lipopolysaccharide to protein allergenicity in the human cell-line activation test (h-CLAT).
The Journal of toxicological sciences.
2019; 44(4):283-297. doi:
10.2131/jts.44.283. [PMID: 30944281] - Yih-Ling Tzeng, Zachary Berman, Evelyn Toh, Jose A Bazan, Abigail Norris Turner, Adam C Retchless, Xin Wang, David E Nelson, David S Stephens. Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon.
Molecular microbiology.
2019 01; 111(1):254-268. doi:
10.1111/mmi.14153. [PMID: 30338585] - Adree Khondker, Alexander K Dhaliwal, Sokunthearath Saem, Ahmad Mahmood, Cécile Fradin, Jose Moran-Mirabal, Maikel C Rheinstädter. Membrane charge and lipid packing determine polymyxin-induced membrane damage.
Communications biology.
2019; 2(?):67. doi:
10.1038/s42003-019-0297-6. [PMID: 30793045] - Ronald Domalaon, Liam Berry, Quinn Tays, George G Zhanel, Frank Schweizer. Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component.
Bioorganic chemistry.
2018 10; 80(?):639-648. doi:
10.1016/j.bioorg.2018.07.018. [PMID: 30053708] - Charalampos Pitsalidis, Anna-Maria Pappa, Mintu Porel, Christine M Artim, Gregorio C Faria, Duc D Duong, Christopher A Alabi, Susan Daniel, Alberto Salleo, Róisín M Owens. Biomimetic Electronic Devices for Measuring Bacterial Membrane Disruption.
Advanced materials (Deerfield Beach, Fla.).
2018 Sep; 30(39):e1803130. doi:
10.1002/adma.201803130. [PMID: 30117203] - Raad Jasim, Mei-Ling Han, Yan Zhu, Xiaohan Hu, Maytham H Hussein, Yu-Wei Lin, Qi Tony Zhou, Charlie Yao Da Dong, Jian Li, Tony Velkov. Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates.
International journal of molecular sciences.
2018 Aug; 19(8):. doi:
10.3390/ijms19082356. [PMID: 30103446] - Nicolò Paracini, Luke A Clifton, Maximilian W A Skoda, Jeremy H Lakey. Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility.
Proceedings of the National Academy of Sciences of the United States of America.
2018 08; 115(32):E7587-E7594. doi:
10.1073/pnas.1803975115. [PMID: 30037998] - Takehiro Sugawara, Sakura Onoue, Hiroaki Takimoto, Kazuyoshi Kawahara. Modification of lipid A structure and activity by the introduction of palmitoyltransferase gene to the acyltransferase-knockout mutant of Escherichia coli.
Microbiology and immunology.
2018 Aug; 62(8):497-506. doi:
10.1111/1348-0421.12631. [PMID: 29932223] - Maros Kolomaznik, Gilda Liskayova, Nina Kanjakova, Lukas Hubcik, Daniela Uhrikova, Andrea Calkovska. The Perturbation of Pulmonary Surfactant by Bacterial Lipopolysaccharide and Its Reversal by Polymyxin B: Function and Structure.
International journal of molecular sciences.
2018 Jul; 19(7):. doi:
10.3390/ijms19071964. [PMID: 29976869] - Mei-Ling Han, Yan Zhu, Darren J Creek, Yu-Wei Lin, Dovile Anderson, Hsin-Hui Shen, Brian Tsuji, Alina D Gutu, Samuel M Moskowitz, Tony Velkov, Jian Li. Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy.
2018 06; 62(6):. doi:
10.1128/aac.02656-17. [PMID: 29632014] - Xinyu Hong, H Deborah Chen, Eduardo A Groisman. Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.
Science signaling.
2018 05; 11(529):. doi:
10.1126/scisignal.aar7921. [PMID: 29739882] - Jae Seung Yang, Jun Ho Jeon, Mi Seon Jang, Seok-Seong Kang, Ki Bum Ahn, Manki Song, Cheol-Heui Yun, Seung Hyun Han. Vibrio cholerae OmpU induces IL-8 expression in human intestinal epithelial cells.
Molecular immunology.
2018 01; 93(?):47-54. doi:
10.1016/j.molimm.2017.11.005. [PMID: 29145158] - Adree Khondker, Richard J Alsop, Alexander Dhaliwal, Sokunthearath Saem, Jose M Moran-Mirabal, Maikel C Rheinstädter. Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogs.
Biophysical journal.
2017 Nov; 113(9):2016-2028. doi:
10.1016/j.bpj.2017.09.013. [PMID: 29117525] - Jenna Covelli, Donna Ruszaj, Robert Straubinger, Jian Li, Gauri G Rao. The development and validation of a simple liquid chromatography-tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Oct; 1065-1066(?):112-118. doi:
10.1016/j.jchromb.2017.09.031. [PMID: 28961485] - Denys E S Santos, Laércio Pol-Fachin, Roberto D Lins, Thereza A Soares. Polymyxin Binding to the Bacterial Outer Membrane Reveals Cation Displacement and Increasing Membrane Curvature in Susceptible but Not in Resistant Lipopolysaccharide Chemotypes.
Journal of chemical information and modeling.
2017 09; 57(9):2181-2193. doi:
10.1021/acs.jcim.7b00271. [PMID: 28805387] - Patrícia Severino, Elisânia F Silveira, Kahynna Loureiro, Marco V Chaud, Danilo Antonini, Marcelo Lancellotti, Victor Hugo Sarmento, Classius F da Silva, Maria Helena A Santana, Eliana B Souto. Antimicrobial activity of polymyxin-loaded solid lipid nanoparticles (PLX-SLN): Characterization of physicochemical properties and in vitro efficacy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Aug; 106(?):177-184. doi:
10.1016/j.ejps.2017.05.063. [PMID: 28576561] - Mei-Ling Han, Hsin-Hui Shen, Karl A Hansford, Elena K Schneider, Sivashangarie Sivanesan, Kade D Roberts, Philip E Thompson, Anton P Le Brun, Yan Zhu, Marc-Antoine Sani, Frances Separovic, Mark A T Blaskovich, Mark A Baker, Samuel M Moskowitz, Matthew A Cooper, Jian Li, Tony Velkov. Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.
ACS infectious diseases.
2017 08; 3(8):606-619. doi:
10.1021/acsinfecdis.7b00065. [PMID: 28695731] - Sylvia L Hanna, Jenny L Huang, Alana J Swinton, Gregory A Caputo, Timothy D Vaden. Synergistic effects of polymyxin and ionic liquids on lipid vesicle membrane stability and aggregation.
Biophysical chemistry.
2017 08; 227(?):1-7. doi:
10.1016/j.bpc.2017.05.002. [PMID: 28526567] - Xiao-Xiao Lu, Yi-Fan Jiang, Hong Li, Ying-Ye Ou, Zhi-De Zhang, Hong-Ye DI, Dao-Feng Chen, Yun-Yi Zhang. Polymyxin B as an inhibitor of lipopolysaccharides contamination of herb crude polysaccharides in mononuclear cells.
Chinese journal of natural medicines.
2017 Jul; 15(7):487-494. doi:
10.1016/s1875-5364(17)30074-2. [PMID: 28807222] - Kim H Hee, Yee K J Leaw, Jun L Ong, Lawrence S Lee. Development and validation of liquid chromatography tandem mass spectrometry method quantitative determination of polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1 in human plasma and its application in clinical studies.
Journal of pharmaceutical and biomedical analysis.
2017 Jun; 140(?):91-97. doi:
10.1016/j.jpba.2017.03.018. [PMID: 28343078] - Li-Hang Hsu, Hsuan-Fu Wang, Pei-Lun Sun, Fung-Rong Hu, Ying-Lien Chen. The antibiotic polymyxin B exhibits novel antifungal activity against Fusarium species.
International journal of antimicrobial agents.
2017 Jun; 49(6):740-748. doi:
10.1016/j.ijantimicag.2017.01.029. [PMID: 28433743] - Martti Vaara, Timo Vaara, Jonathan M Tyrrell. Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity.
Peptides.
2017 05; 91(?):8-12. doi:
10.1016/j.peptides.2017.03.002. [PMID: 28300674] - Javier Salazar, Mackarenna Alarcón, Jaime Huerta, Belén Navarro, Daniel Aguayo. Phosphoethanolamine addition to the Heptose I of the Lipopolysaccharide modifies the inner core structure and has an impact on the binding of Polymyxin B to the Escherichia coli outer membrane.
Archives of biochemistry and biophysics.
2017 04; 620(?):28-34. doi:
10.1016/j.abb.2017.03.008. [PMID: 28342805] - Sivashangarie Sivanesan, Kade Roberts, Jiping Wang, Soon-Ee Chea, Philip E Thompson, Jian Li, Roger L Nation, Tony Velkov. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.
Journal of natural products.
2017 01; 80(1):225-229. doi:
10.1021/acs.jnatprod.6b01176. [PMID: 28080060] - Jyl S Matson, Jonathan Livny, Victor J DiRita. A putative Vibrio cholerae two-component system controls a conserved periplasmic protein in response to the antimicrobial peptide polymyxin B.
PloS one.
2017; 12(10):e0186199. doi:
10.1371/journal.pone.0186199. [PMID: 29020117] - Muhammad Osama Alam, Ejaz Mohiuddin, - Shahab-Ud-Din, Muhammad Daniyal, Khan Usmanghani. Clinical efficacy and safety of herbal medicine Dermidoc in the management of atopic dermatitis versus allopathic medicine PolymixinB-bacitrin ointment.
Pakistan journal of pharmaceutical sciences.
2016 Nov; 29(6 Suppl):2287-2291. doi:
". [PMID: 28167467] - Yogita Patil-Sen, Sarah R Dennison, Timothy J Snape. Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation.
Bioorganic & medicinal chemistry.
2016 09; 24(18):4241-4245. doi:
10.1016/j.bmc.2016.07.017. [PMID: 27427397] - Kata R Mikuláss, Krisztina Nagy, Balázs Bogos, Zsolt Szegletes, Etelka Kovács, Attila Farkas, György Váró, Éva Kondorosi, Attila Kereszt. Antimicrobial nodule-specific cysteine-rich peptides disturb the integrity of bacterial outer and inner membranes and cause loss of membrane potential.
Annals of clinical microbiology and antimicrobials.
2016 Jul; 15(1):43. doi:
10.1186/s12941-016-0159-8. [PMID: 27465344] - Anita Umerska, Nada Matougui, Anne-Claire Groo, Patrick Saulnier. Understanding the adsorption of salmon calcitonin, antimicrobial peptide AP114 and polymyxin B onto lipid nanocapsules.
International journal of pharmaceutics.
2016 Jun; 506(1-2):191-200. doi:
10.1016/j.ijpharm.2016.04.028. [PMID: 27113868] - X Li, R H Müller, C M Keck, N A Bou-Chacra. Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion--novel combinatorial formulation concept.
Die Pharmazie.
2016 Jun; 71(6):327-33. doi:
. [PMID: 27455551] - Kiichiro Yamaguchi, Kentaro Ono, Suzuro Hitomi, Misa Ito, Tomotaka Nodai, Tetsuya Goto, Nozomu Harano, Seiji Watanabe, Hiromasa Inoue, Kanako Miyano, Yasuhito Uezono, Motohiro Matoba, Kiyotoshi Inenaga. Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Pain.
2016 May; 157(5):1004-1020. doi:
10.1097/j.pain.0000000000000498. [PMID: 26808144] - Zulfaquar Ahmad Arfi, Stephan Hellwig, Jürgen Drossard, Rainer Fischer, Johannes Felix Buyel. Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins.
Biotechnology journal.
2016 Mar; 11(4):507-18. doi:
10.1002/biot.201500271. [PMID: 26632519] - Petar Knezevic, Verica Aleksic, Natasa Simin, Emilija Svircev, Aleksandra Petrovic, Neda Mimica-Dukic. Antimicrobial activity of Eucalyptus camaldulensis essential oils and their interactions with conventional antimicrobial agents against multi-drug resistant Acinetobacter baumannii.
Journal of ethnopharmacology.
2016 Feb; 178(?):125-36. doi:
10.1016/j.jep.2015.12.008. [PMID: 26671210] - Domenica Carnicelli, Valentina Arfilli, Francesca Ricci, Claudio Velati, Pier Luigi Tazzari, Maurizio Brigotti. The Antibiotic Polymyxin B Impairs the Interactions between Shiga Toxins and Human Neutrophils.
Journal of immunology (Baltimore, Md. : 1950).
2016 Feb; 196(3):1177-85. doi:
10.4049/jimmunol.1500671. [PMID: 26695372] - Jagoda Kicielińska, Agnieszka Szczygieł, Joanna Rossowska, Natalia Anger, Katarzyna Kempińska, Marta Świtalska, Marta Kaszowska, Joanna Wietrzyk, Janusz Boratyński, Elżbieta Pajtasz-Piasecka. Oral Administration of Polymyxin B Modulates the Activity of Lipooligosaccharide E. coli B against Lung Metastases in Murine Tumor Models.
PloS one.
2016; 11(2):e0148156. doi:
10.1371/journal.pone.0148156. [PMID: 26829479] - Chui-Yoke Chin, Kelsey A Gregg, Brooke A Napier, Robert K Ernst, David S Weiss. A PmrB-Regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii.
Antimicrobial agents and chemotherapy.
2015 Dec; 59(12):7911-4. doi:
10.1128/aac.00515-15. [PMID: 26459891] - Henrietta Abodakpi, Jie Gohlke, Kai-Tai Chang, Diana S-L Chow, Vincent H Tam. Analytical and functional determination of polymyxin B protein binding in serum.
Antimicrobial agents and chemotherapy.
2015 Nov; 59(11):7121-3. doi:
10.1128/aac.01815-15. [PMID: 26324262] - P Severino, E F Silveira, M Vazzana, M V Chaud, M H A Santana, E B Souto. Validation of an UV spectrophotometric assay for the quantification of polymyxin B in solid lipid nanoparticles.
Die Pharmazie.
2015 Nov; 70(11):693-7. doi:
". [PMID: 26790184] - Patrícia Severino, Marco V Chaud, Andrea Shimojo, Danilo Antonini, Marcelo Lancelloti, Maria Helena A Santana, Eliana B Souto. Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies.
Colloids and surfaces. B, Biointerfaces.
2015 May; 129(?):191-7. doi:
10.1016/j.colsurfb.2015.03.049. [PMID: 25863712] - Erica J Rubin, Carmen M Herrera, Alexander A Crofts, M Stephen Trent. PmrD is required for modifications to escherichia coli endotoxin that promote antimicrobial resistance.
Antimicrobial agents and chemotherapy.
2015 Apr; 59(4):2051-61. doi:
10.1128/aac.05052-14. [PMID: 25605366] - Kivanc Bilecen, Jiunn C N Fong, Andrew Cheng, Christopher J Jones, David Zamorano-Sánchez, Fitnat H Yildiz. Polymyxin B resistance and biofilm formation in Vibrio cholerae are controlled by the response regulator CarR.
Infection and immunity.
2015 Mar; 83(3):1199-209. doi:
10.1128/iai.02700-14. [PMID: 25583523] - T W Cullen, W B Schofield, N A Barry, E E Putnam, E A Rundell, M S Trent, P H Degnan, C J Booth, H Yu, A L Goodman. Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation.
Science (New York, N.Y.).
2015 Jan; 347(6218):170-5. doi:
10.1126/science.1260580. [PMID: 25574022]