(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoate (BioDeep_00000897458)
代谢物信息卡片
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoate
化学式: C10H13N2O4- (225.0875)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC(=C(C=C1)O)O)(C(=O)[O-])NN
InChI: InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/p-1/t10-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zhang Wenbo, Ma Zhigang, Zhang Jiren, Zhang Ce, Li Ting, Zhang Pinyuan, Wang Tian. Antinociceptive effects of carbidopa levodopa on normal rats and Parkinson's disease mice.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5):1489-1495. doi:
". [PMID: 37869925] - Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A Alananzeh, Mohd Nizam Mordi. Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.
Journal of ethnopharmacology.
2023 Jan; 300(?):115753. doi:
10.1016/j.jep.2022.115753. [PMID: 36162546] - Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Ming. Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Nov; 155(?):113718. doi:
10.1016/j.biopha.2022.113718. [PMID: 36152409] - Anthony T Olofinnade, Tolulope M Onaolapo, Samad Oladimeji, Adetunji M Fatoki, Covenant I Balogun, Adejoke Y Onaolapo, Olakunle J Onaolapo. An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice.
Central nervous system agents in medicinal chemistry.
2020; 20(1):13-25. doi:
10.2174/1871524920666200120142508. [PMID: 31987026] - Danique L M Radder, Andreas T Tiel Groenestege, Inge Boers, Eline W Muilwijk, Bastiaan R Bloem. Mucuna Pruriens Combined with Carbidopa in Parkinson's Disease: A Case Report.
Journal of Parkinson's disease.
2019; 9(2):437-439. doi:
10.3233/jpd-181500. [PMID: 30856121] - Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli. Daily intake of Mucuna pruriens in advanced Parkinson's disease: A 16-week, noninferiority, randomized, crossover, pilot study.
Parkinsonism & related disorders.
2018 04; 49(?):60-66. doi:
10.1016/j.parkreldis.2018.01.014. [PMID: 29352722] - Monica Colamartino, Guglielmo Duranti, Roberta Ceci, Stefania Sabatini, Antonella Testa, Renata Cozzi. A multi-biomarker analysis of the antioxidant efficacy of Parkinson's disease therapy.
Toxicology in vitro : an international journal published in association with BIBRA.
2018 Mar; 47(?):1-7. doi:
10.1016/j.tiv.2017.10.020. [PMID: 29080800] - Stephen Safe. Carbidopa: a selective Ah receptor modulator (SAhRM).
The Biochemical journal.
2017 11; 474(22):3763-3765. doi:
10.1042/bcj20170728. [PMID: 29109131] - Erin M Hill-Burns, Justine W Debelius, James T Morton, William T Wissemann, Matthew R Lewis, Zachary D Wallen, Shyamal D Peddada, Stewart A Factor, Eric Molho, Cyrus P Zabetian, Rob Knight, Haydeh Payami. Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome.
Movement disorders : official journal of the Movement Disorder Society.
2017 05; 32(5):739-749. doi:
10.1002/mds.26942. [PMID: 28195358] - Manuela Contin, Giovanna Lopane, Andrea Passini, Ferruccio Poli, Carmelina Iannello, Maria Guarino. Mucuna pruriens in Parkinson Disease: A Kinetic-Dynamic Comparison With Levodopa Standard Formulations.
Clinical neuropharmacology.
2015 Sep; 38(5):201-3. doi:
10.1097/wnf.0000000000000098. [PMID: 26366963] - Vandana S Nade, Laxman A Kawale, Shankar S Zambre, Amit B Kapure. Neuroprotective potential of Beta vulgaris L. in Parkinson's disease.
Indian journal of pharmacology.
2015 Jul; 47(4):403-8. doi:
10.4103/0253-7613.161263. [PMID: 26288473] - Sawsan A Zaitone, Lamiaa N Hammad, Noha E Farag. Antioxidant potential of melatonin enhances the response to L-dopa in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-parkinsonian mice.
Pharmacological reports : PR.
2013; 65(5):1213-26. doi:
10.1016/s1734-1140(13)71479-8. [PMID: 24399717] - Raquel Duran, Francisco J Barrero, Blas Morales, Juan D Luna, Manuel Ramirez, Francisco Vives. Oxidative stress and aminopeptidases in Parkinson's disease patients with and without treatment.
Neuro-degenerative diseases.
2011; 8(3):109-16. doi:
10.1159/000315404. [PMID: 20714110] - Ales Honzatko, Jiri Brichac, Matthew J Picklo. Quantification of trans-4-hydroxy-2-nonenal enantiomers and metabolites by LC-ESI-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 857(1):115-22. doi:
10.1016/j.jchromb.2007.07.004. [PMID: 17662675] - Ales Honzatko, Jiri Brichac, Tonya C Murphy, Alexander Reberg, Alena Kubátová, Irina P Smoliakova, Matthew J Picklo. Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria.
Free radical biology & medicine.
2005 Oct; 39(7):913-24. doi:
10.1016/j.freeradbiomed.2005.05.010. [PMID: 16140211] - Ken-ichi Tanaka, Norio Ogawa. Dopamine agonist cabergoline inhibits levodopa-induced caspase activation in 6-OHDA-lesioned mice.
Neuroscience research.
2005 Jan; 51(1):9-13. doi:
10.1016/j.neures.2004.09.002. [PMID: 15596235] - L Lyras, B-Y Zeng, G McKenzie, R K B Pearce, B Halliwell, P Jenner. Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys.
Journal of neural transmission (Vienna, Austria : 1996).
2002; 109(1):53-67. doi:
10.1007/s702-002-8236-2. [PMID: 11793162] - K R Larsen, E Z Dajani, N E Dajani, M T Dayton, J G Moore. Effects of tolcapone, a catechol-O-methyltransferase inhibitor, and Sinemet on intestinal electrolyte and fluid transport in conscious dogs.
Digestive diseases and sciences.
1998 Aug; 43(8):1806-13. doi:
10.1023/a:1018852223902. [PMID: 9724173] - J E Ahlskog, R J Uitti, P A Low, G M Tyce, K K Nickander, R C Petersen, E Kokmen. No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease.
Movement disorders : official journal of the Movement Disorder Society.
1995 Sep; 10(5):566-73. doi:
10.1002/mds.870100507. [PMID: 8552107] - J H Growdon, R R Young, B T Shahani. L-5-hydroxytryptophan in treatment of several different syndromes in which myoclonus is prominent.
Neurology.
1976 Dec; 26(12):1135-40. doi:
10.1212/wnl.26.12.1135. [PMID: 1086988]
