1D-myo-inositol 1,4,5-trisphosphate(6-) (BioDeep_00000897453)

   


代谢物信息卡片


1D-myo-inositol 1,4,5-trisphosphate(6-)

化学式: C6H9O15P3-6 (413.9154)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)([O-])[O-])O)OP(=O)([O-])[O-])OP(=O)([O-])[O-])O)O
InChI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

1D-myo-inositol 1,4,5-trisphosphate(6-)



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(25)

BioCyc(6)

PlantCyc(3)

代谢反应

71 个相关的代谢反应过程信息。

Reactome(45)

BioCyc(5)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(21)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Filip Vasilev, Yulia Ezhova, Jong Tai Chun. Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane. International journal of molecular sciences. 2021 Sep; 22(19):. doi: 10.3390/ijms221910366. [PMID: 34638705]
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  • Yi Xiao, Anja Rabien, René Buschow, Vyacheslav Amtislavskiy, Jonas Busch, Ergin Kilic, Sonia L Villegas, Bernd Timmermann, Moritz Schütte, Thorsten Mielke, Marie-Laure Yaspo, Klaus Jung, David Meierhofer. Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma. Cancer research. 2020 12; 80(24):5491-5501. doi: 10.1158/0008-5472.can-20-1998. [PMID: 33115803]
  • Jingyuan Zhang, Xiaohui Lu, Mei Liu, Hanlu Fan, Han Zheng, Shanshan Zhang, Nafis Rahman, Sławomir Wołczyński, Adam Kretowski, Xiangdong Li. Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension. Cardiovascular research. 2020 11; 116(13):2156-2169. doi: 10.1093/cvr/cvz312. [PMID: 31774487]
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  • Fulin Xing, Songyue Qu, Junfang Liu, Jianyu Yang, Fen Hu, Irena Drevenšek-Olenik, Leiting Pan, Jingjun Xu. Intercellular Bridge Mediates Ca2+ Signals between Micropatterned Cells via IP3 and Ca2+ Diffusion. Biophysical journal. 2020 03; 118(5):1196-1204. doi: 10.1016/j.bpj.2020.01.006. [PMID: 32023438]
  • Mengyang Xu, Biying Zhu, Xiuye Cao, Shannai Li, Dan Li, Huihao Zhou, Vesa M Olkkonen, Wenbin Zhong, Jun Xu, Daoguang Yan. OSBP-Related Protein 5L Maintains Intracellular IP3/Ca2+ Signaling and Proliferation in T Cells by Facilitating PIP2 Hydrolysis. Journal of immunology (Baltimore, Md. : 1950). 2020 03; 204(5):1134-1145. doi: 10.4049/jimmunol.1900671. [PMID: 31953353]
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  • Xianqiong Huang, Zhaoyang Li, Renshan Sun. High-dose levocetirizine for the treatment of refractory chronic spontaneous urticaria and the effect on the serum inositol triphosphate level. The Journal of international medical research. 2019 Sep; 47(9):4374-4379. doi: 10.1177/0300060519857768. [PMID: 31342821]
  • David L Prole, Colin W Taylor. Structure and Function of IP3 Receptors. Cold Spring Harbor perspectives in biology. 2019 04; 11(4):. doi: 10.1101/cshperspect.a035063. [PMID: 30745293]
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  • Ilari Pulli, Taru Lassila, Guoping Pan, Daoguang Yan, Vesa M Olkkonen, Kid Törnquist. Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments. Cell calcium. 2018 06; 72(?):62-69. doi: 10.1016/j.ceca.2018.03.001. [PMID: 29748134]
  • Mitchell Y Sun, Melissa Geyer, Yulia A Komarova. IP3 receptor signaling and endothelial barrier function. Cellular and molecular life sciences : CMLS. 2017 11; 74(22):4189-4207. doi: 10.1007/s00018-017-2624-8. [PMID: 28803370]
  • Michael V Keebler, Colin W Taylor. Endogenous signalling pathways and caged IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites. Journal of cell science. 2017 Nov; 130(21):3728-3739. doi: 10.1242/jcs.208520. [PMID: 28893841]
  • Jian Shi, Francesc Miralles, Jean-Pierre Kinet, Lutz Birnbaumer, William A Large, Anthony P Albert. Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells. Channels (Austin, Tex.). 2017 Jul; 11(4):329-339. doi: 10.1080/19336950.2017.1303025. [PMID: 28301277]
  • Raphaël Courjaret, Maya Dib, Khaled Machaca. Store-Operated Ca2+ Entry in Oocytes Modulate the Dynamics of IP3 -Dependent Ca2+ Release From Oscillatory to Tonic. Journal of cellular physiology. 2017 05; 232(5):1095-1103. doi: 10.1002/jcp.25513. [PMID: 27504787]
  • Rachel Escue, Kathirvel Kandasamy, Kaushik Parthasarathi. Thrombin Induces Inositol Trisphosphate-Mediated Spatially Extensive Responses in Lung Microvessels. The American journal of pathology. 2017 Apr; 187(4):921-935. doi: 10.1016/j.ajpath.2016.12.014. [PMID: 28188112]
  • Gleb P Tolstykh, Melissa Tarango, Caleb C Roth, Bennett L Ibey. Nanosecond pulsed electric field induced dose dependent phosphatidylinositol-4,5-bisphosphate signaling and intracellular electro-sensitization. Biochimica et biophysica acta. Biomembranes. 2017 03; 1859(3):438-445. doi: 10.1016/j.bbamem.2017.01.003. [PMID: 28064021]
  • Wei Huang, Matthew C Cane, Rajarshi Mukherjee, Peter Szatmary, Xiaoying Zhang, Victoria Elliott, Yulin Ouyang, Michael Chvanov, Diane Latawiec, Li Wen, David M Booth, Andrea C Haynes, Ole H Petersen, Alexei V Tepikin, David N Criddle, Robert Sutton. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release. Gut. 2017 02; 66(2):301-313. doi: 10.1136/gutjnl-2015-309363. [PMID: 26642860]
  • László Pecze, Walter Blum, Thomas Henzi, Beat Schwaller. Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations. Biochimica et biophysica acta. 2016 12; 1863(12):2905-2915. doi: 10.1016/j.bbamcr.2016.09.013. [PMID: 27663071]
  • Shamshad Cockcroft, Padinjat Raghu. Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap. The Biochemical journal. 2016 Dec; 473(23):4289-4310. doi: 10.1042/bcj20160514c. [PMID: 27888240]
  • Ariane Scoumanne, Patricia Molina-Ortiz, Daniel Monteyne, David Perez-Morga, Christophe Erneux, Stéphane Schurmans. Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice. Advances in biological regulation. 2016 09; 62(?):1-10. doi: 10.1016/j.jbior.2016.03.001. [PMID: 27036498]
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  • Zoltan Machaty. Signal transduction in mammalian oocytes during fertilization. Cell and tissue research. 2016 Jan; 363(1):169-183. doi: 10.1007/s00441-015-2291-8. [PMID: 26453398]
  • Patricia Reuquén, María L Oróstica, Israel Rojas, Patricia Díaz, Alexis Parada-Bustamante, Pedro A Orihuela. Estradiol increases IP3 by a nongenomic mechanism in the smooth muscle cells from the rat oviduct. Reproduction (Cambridge, England). 2015 Oct; 150(4):331-41. doi: 10.1530/rep-15-0137. [PMID: 26159830]
  • Qing He, Yan Zhu, Braden A Corbin, Antonius Plagge, Murat Bastepe. The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo. Science signaling. 2015 Aug; 8(391):ra84. doi: 10.1126/scisignal.aaa9953. [PMID: 26307011]
  • Amarjeet Singh, Nikita Bhatnagar, Amita Pandey, Girdhar K Pandey. Plant phospholipase C family: Regulation and functional role in lipid signaling. Cell calcium. 2015 Aug; 58(2):139-46. doi: 10.1016/j.ceca.2015.04.003. [PMID: 25933832]
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  • Pengcheng Liu, Hong-Juan Peng, Jinsong Zhu. Juvenile hormone-activated phospholipase C pathway enhances transcriptional activation by the methoprene-tolerant protein. Proceedings of the National Academy of Sciences of the United States of America. 2015 Apr; 112(15):E1871-9. doi: 10.1073/pnas.1423204112. [PMID: 25825754]
  • Alan V Smrcka. Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes. Journal of cardiovascular pharmacology. 2015 Mar; 65(3):203-10. doi: 10.1097/fjc.0000000000000195. [PMID: 25658460]
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