Autoinducer-2 (BioDeep_00000897367)

 

Secondary id: BioDeep_00000011181


代谢物信息卡片


Autoinducer 2

化学式: C5H10BO7- (193.05195600000002)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: [B-]1(OC2(C(O1)(C(CO2)O)O)C)(O)O
InChI: InChI=1S/C5H10BO7/c1-4-5(8,3(7)2-11-4)13-6(9,10)12-4/h3,7-10H,2H2,1H3/q-1/t3-,4+,5+/m0/s1

描述信息

An organic anion that is a borate diester derived from a furanose and acts a universal signal molecule mediating intra- and interspecies communication among bacteria.

同义名列表

3 个代谢物同义名

Autoinducer 2; Autoinducer-2; AI-2



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yongming Duan, Min Han, Maja Grimm, Jessica Ponath, Michael Reichelt, Axel Mithöfer, Adam Schikora. Combination of bacterial N-acyl homoserine lactones primes Arabidopsis defenses via jasmonate metabolism. Plant physiology. 2023 Jan; ?(?):. doi: 10.1093/plphys/kiad017. [PMID: 36649188]
  • Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen, Lei Zhang. Exploring AI-2-mediated interspecies communications within rumen microbial communities. Microbiome. 2022 10; 10(1):167. doi: 10.1186/s40168-022-01367-z. [PMID: 36203182]
  • Radhika Khera, Ahmad R Mehdipour, Jani R Bolla, Joerg Kahnt, Sonja Welsch, Ulrich Ermler, Cornelia Muenke, Carol V Robinson, Gerhard Hummer, Hao Xie, Hartmut Michel. Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism. The EMBO journal. 2022 09; 41(18):e109990. doi: 10.15252/embj.2021109990. [PMID: 35698912]
  • Qin Xiong, Di Liu, Huihui Zhang, Xiaoyan Dong, Guishan Zhang, Yunpeng Liu, Ruifu Zhang. Quorum sensing signal autoinducer-2 promotes root colonization of Bacillus velezensis SQR9 by affecting biofilm formation and motility. Applied microbiology and biotechnology. 2020 Aug; 104(16):7177-7185. doi: 10.1007/s00253-020-10713-w. [PMID: 32621125]
  • Narendranath Bhokisham, Yi Liu, Adam D Brown, Gregory F Payne, James N Culver, William E Bentley. Transglutaminase-mediated assembly of multi-enzyme pathway onto TMV brush surfaces for synthesis of bacterial autoinducer-2. Biofabrication. 2020 07; 12(4):045017. doi: 10.1088/1758-5090/ab9e7a. [PMID: 32559753]
  • Yu V Zaitseva, V A Lipasova, V A Plyuta, O A Koksharova, I V Demidyuk, S V Kostrov, I A Khmel. Effect of inactivation of luxS gene on the properties of Serratia proteamaculans 94 strain. Folia microbiologica. 2019 May; 64(3):265-272. doi: 10.1007/s12223-018-0657-5. [PMID: 30361877]
  • Zujie Yao, Zhuang Guo, Yuqian Wang, Wanxin Li, Yuying Fu, Yuexu Lin, Wenxiong Lin, Xiangmin Lin. Integrated Succinylome and Metabolome Profiling Reveals Crucial Role of S-Ribosylhomocysteine Lyase in Quorum Sensing and Metabolism of Aeromonas hydrophila. Molecular & cellular proteomics : MCP. 2019 02; 18(2):200-215. doi: 10.1074/mcp.ra118.001035. [PMID: 30352804]
  • Xiaoka Wu, Xiaolong Lv, Jinye Lu, Shengqing Yu, Yawei Jin, Jiangang Hu, Jiakun Zuo, Rongsheng Mi, Yan Huang, Kezong Qi, Zhaoguo Chen, Xiangan Han. The role of the ptsI gene on AI-2 internalization and pathogenesis of avian pathogenic Escherichia coli. Microbial pathogenesis. 2017 Dec; 113(?):321-329. doi: 10.1016/j.micpath.2017.10.048. [PMID: 29111323]
  • Marta Woźniak-Karczewska, Kamila Myszka, Agata Sznajdrowska, Alicja Szulc, Agnieszka Zgoła-Grześkowiak, Łukasz Ławniczak, Philippe F-X Corvini, Łukasz Chrzanowski. Isolation of rhamnolipids-producing cultures from faeces: Influence of interspecies communication on the yield of rhamnolipid congeners. New biotechnology. 2017 May; 36(?):17-25. doi: 10.1016/j.nbt.2016.12.008. [PMID: 28043869]
  • Lina Sheng, Barbara Rasco, Mei-Jun Zhu. Cinnamon Oil Inhibits Shiga Toxin Type 2 Phage Induction and Shiga Toxin Type 2 Production in Escherichia coli O157:H7. Applied and environmental microbiology. 2016 11; 82(22):6531-6540. doi: 10.1128/aem.01702-16. [PMID: 27590808]
  • Bohyun Yun, Seunghan Oh, Minyu Song, Young-Shick Hong, Sungsu Park, Dong-June Park, Mansel W Griffiths, Sejong Oh. Inhibitory Effect of Epigallocatechin Gallate on the Virulence of Clostridium difficile PCR Ribotype 027. Journal of food science. 2015 Dec; 80(12):M2925-31. doi: 10.1111/1750-3841.13145. [PMID: 26556797]
  • Yangcheng Ding, Huajun Feng, Wenkun Huang, Dongsheng Shen, Meizhen Wang. A sustainable method for effective regulation of anaerobic granular sludge: artificially increasing the concentration of signal molecules by cultivating a secreting strain. Bioresource technology. 2015 Nov; 196(?):273-8. doi: 10.1016/j.biortech.2015.07.066. [PMID: 26253911]
  • Yang Wang, Li Yi, Shaohui Wang, Hongjie Fan, Chan Ding, Xiang Mao, Chengping Lu. Crystal Structure and Identification of Two Key Amino Acids Involved in AI-2 Production and Biofilm Formation in Streptococcus suis LuxS. PloS one. 2015; 10(10):e0138826. doi: 10.1371/journal.pone.0138826. [PMID: 26484864]
  • O Priha, V Virkajärvi, R Juvonen, R Puupponen-Pimiä, L Nohynek, S Alakurtti, M Pirttimaa, E Storgårds. Quorum sensing signalling and biofilm formation of brewery-derived bacteria, and inhibition of signalling by natural compounds. Current microbiology. 2014 Nov; 69(5):617-27. doi: 10.1007/s00284-014-0627-3. [PMID: 24944110]
  • Nilesh Raut, Patrizia Pasini, Sylvia Daunert. Deciphering bacterial universal language by detecting the quorum sensing signal, autoinducer-2, with a whole-cell sensing system. Analytical chemistry. 2013 Oct; 85(20):9604-9. doi: 10.1021/ac401776k. [PMID: 24047052]
  • S M Nayeemul Bari, M Kamruzzaman Roky, M Mohiuddin, M Kamruzzaman, John J Mekalanos, Shah M Faruque. Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples. Proceedings of the National Academy of Sciences of the United States of America. 2013 Jun; 110(24):9926-31. doi: 10.1073/pnas.1307697110. [PMID: 23716683]
  • Clayton E Cox, Michael McClelland, Max Teplitski. Consequences of disrupting Salmonella AI-2 signaling on interactions within soft rots. Phytopathology. 2013 Apr; 103(4):352-61. doi: 10.1094/phyto-09-12-0237-fi. [PMID: 23324045]
  • Lee Põllumaa, Tiina Alamäe, Andres Mäe. Quorum sensing and expression of virulence in pectobacteria. Sensors (Basel, Switzerland). 2012; 12(3):3327-49. doi: 10.3390/s120303327. [PMID: 22737011]
  • Fabio Rezzonico, Theo H M Smits, Brion Duffy. Detection of AI-2 receptors in genomes of Enterobacteriaceae suggests a role of type-2 quorum sensing in closed ecosystems. Sensors (Basel, Switzerland). 2012; 12(5):6645-65. doi: 10.3390/s120506645. [PMID: 22778662]
  • Michiko E Taga, Karina B Xavier. Methods for analysis of bacterial autoinducer-2 production. Current protocols in microbiology. 2011 Nov; Chapter 1(?):Unit1C.1. doi: 10.1002/9780471729259.mc01c01s23. [PMID: 22045583]
  • Kang-Mu Lee, Jeesun Lim, Sunyoung Nam, Mi Young Yoon, Yong-Kuk Kwon, Byeong Yeal Jung, Yongjin Park, Sungsu Park, Sang Sun Yoon. Inhibitory effects of broccoli extract on Escherichia coli O157:H7 quorum sensing and in vivo virulence. FEMS microbiology letters. 2011 Aug; 321(1):67-74. doi: 10.1111/j.1574-6968.2011.02311.x. [PMID: 21592195]
  • Chen-Yu Tsao, Liang Wang, Yoshifumi Hashimoto, Hyunmin Yi, John C March, Matthew P DeLisa, Thomas K Wood, James J Valdes, William E Bentley. LuxS coexpression enhances yields of recombinant proteins in Escherichia coli in part through posttranscriptional control of GroEL. Applied and environmental microbiology. 2011 Mar; 77(6):2141-52. doi: 10.1128/aem.02347-10. [PMID: 21278275]
  • Yuping Wei, Gina T Ryan, Ana L Flores-Mireles, Esther D Costa, David J Schneider, Stephen C Winans. Saturation mutagenesis of a CepR binding site as a means to identify new quorum-regulated promoters in Burkholderia cenocepacia. Molecular microbiology. 2011 Feb; 79(3):616-32. doi: 10.1111/j.1365-2958.2010.07469.x. [PMID: 21255107]
  • Marijke Frederix, Allan J Downie. Quorum sensing: regulating the regulators. Advances in microbial physiology. 2011; 58(?):23-80. doi: 10.1016/b978-0-12-381043-4.00002-7. [PMID: 21722791]
  • Colin G Hebert, Apoorv Gupta, Rohan Fernandes, Chen-Yu Tsao, James J Valdes, William E Bentley. Biological nanofactories target and activate epithelial cell surfaces for modulating bacterial quorum sensing and interspecies signaling. ACS nano. 2010 Nov; 4(11):6923-31. doi: 10.1021/nn1013066. [PMID: 21028779]
  • Ping Kong, Bobby W K Lee, Zhaohui Sunny Zhou, Chuanxue Hong. Zoosporic plant pathogens produce bacterial autoinducer-2 that affects Vibrio harveyi quorum sensing. FEMS microbiology letters. 2010 Feb; 303(1):55-60. doi: 10.1111/j.1574-6968.2009.01861.x. [PMID: 20002192]
  • Gwendoline Kint, Kathleen Aj Sonck, Geert Schoofs, David De Coster, Jos Vanderleyden, Sigrid Cj De Keersmaecker. 2D proteome analysis initiates new insights on the Salmonella Typhimurium LuxS protein. BMC microbiology. 2009 Sep; 9(?):198. doi: 10.1186/1471-2180-9-198. [PMID: 19754952]
  • Paul M Gardner, Klaus Winzer, Benjamin G Davis. Sugar synthesis in a protocellular model leads to a cell signalling response in bacteria. Nature chemistry. 2009 Aug; 1(5):377-83. doi: 10.1038/nchem.296. [PMID: 21378891]
  • Rohan Fernandes, William E Bentley. AI-2 biosynthesis module in a magnetic nanofactory alters bacterial response via localized synthesis and delivery. Biotechnology and bioengineering. 2009 Feb; 102(2):390-9. doi: 10.1002/bit.22078. [PMID: 18949758]
  • Yan Gao, Junxian Song, Baishi Hu, Lei Zhang, Qianqian Liu, Fengquan Liu. The luxS gene is involved in AI-2 production, pathogenicity, and some phenotypes in Erwinia amylovora. Current microbiology. 2009 Jan; 58(1):1-10. doi: 10.1007/s00284-008-9256-z. [PMID: 18820970]
  • Catarina S Pereira, J Randall McAuley, Michiko E Taga, Karina B Xavier, Stephen T Miller. Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria. Molecular microbiology. 2008 Dec; 70(5):1223-35. doi: 10.1111/j.1365-2958.2008.06477.x. [PMID: 18990189]
  • Fabio Rezzonico, Brion Duffy. Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria. BMC microbiology. 2008 Sep; 8(?):154. doi: 10.1186/1471-2180-8-154. [PMID: 18803868]
  • Chengru Zhu, Shuzhang Feng, Venessa Sperandio, Zhuolu Yang, Timothy E Thate, James B Kaper, Edgar C Boedeker. The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli. Veterinary microbiology. 2007 Dec; 125(3-4):313-22. doi: 10.1016/j.vetmic.2007.05.030. [PMID: 17643872]
  • Fabio Rezzonico, Brion Duffy. The role of luxS in the fire blight pathogen Erwinia amylovora is limited to metabolism and does not involve quorum sensing. Molecular plant-microbe interactions : MPMI. 2007 Oct; 20(10):1284-97. doi: 10.1094/mpmi-20-10-1284. [PMID: 17918630]
  • Anne M L Barnard, Steven D Bowden, Tom Burr, Sarah J Coulthurst, Rita E Monson, George P C Salmond. Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2007 Jul; 362(1483):1165-83. doi: 10.1098/rstb.2007.2042. [PMID: 17360277]
  • Mojtaba Mohammadi, Klaus Geider. Autoinducer-2 of the fire blight pathogen Erwinia amylovora and other plant-associated bacteria. FEMS microbiology letters. 2007 Jan; 266(1):34-41. doi: 10.1111/j.1574-6968.2006.00510.x. [PMID: 17092294]
  • Eve Laasik, Liis Andresen, Andres Mäe. Type II quorum sensing regulates virulence in Erwinia carotovora ssp. carotovora. FEMS microbiology letters. 2006 May; 258(2):227-34. doi: 10.1111/j.1574-6968.2006.00222.x. [PMID: 16640578]
  • Sigrid C J De Keersmaecker, Kathleen Sonck, Jos Vanderleyden. Let LuxS speak up in AI-2 signaling. Trends in microbiology. 2006 Mar; 14(3):114-9. doi: 10.1016/j.tim.2006.01.003. [PMID: 16459080]
  • Sigrid C J De Keersmaecker, Csaba Varszegi, Nadja van Boxel, Lothar W Habel, Kristine Metzger, Ruth Daniels, Kathleen Marchal, Dirk De Vos, Jos Vanderleyden. Chemical synthesis of (S)-4,5-dihydroxy-2,3-pentanedione, a bacterial signal molecule precursor, and validation of its activity in Salmonella typhimurium. The Journal of biological chemistry. 2005 May; 280(20):19563-8. doi: 10.1074/jbc.m412660200. [PMID: 15790567]
  • Jibin Sun, Rolf Daniel, Irene Wagner-Döbler, An-Ping Zeng. Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways. BMC evolutionary biology. 2004 Sep; 4(?):36. doi: 10.1186/1471-2148-4-36. [PMID: 15456522]
  • Sigrid C J DeKeersmaecker, Jos Vanderleyden. Constraints on detection of autoinducer-2 (AI-2) signalling molecules using Vibrio harveyi as a reporter. Microbiology (Reading, England). 2003 Aug; 149(Pt 8):1953-1956. doi: 10.1099/mic.0.c0117-0. [PMID: 12904534]
  • David S Blehert, Robert J Palmer, Joao B Xavier, Jonas S Almeida, Paul E Kolenbrander. Autoinducer 2 production by Streptococcus gordonii DL1 and the biofilm phenotype of a luxS mutant are influenced by nutritional conditions. Journal of bacteriology. 2003 Aug; 185(16):4851-60. doi: 10.1128/jb.185.16.4851-4860.2003. [PMID: 12897005]
  • M Graessmann, A Graessmann. Regulation mechanism of simian virus 40 late gene expression in primary kidney cells and simian virus 40 transformed 3T3 cells. Virology. 1975 Jun; 65(2):591-4. doi: 10.1016/0042-6822(75)90066-5. [PMID: 165627]