L-Palmitoyloxycarnitine (BioDeep_00000897333)
代谢物信息卡片
L-Palmitoyloxycarnitine
化学式: C23H46NO4+ (400.34266560000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C
InChI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/p+1/t21-/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cuong H Le, Jun Han, Christoph H Borchers. Dithranol as a MALDI matrix for tissue imaging of lipids by Fourier transform ion cyclotron resonance mass spectrometry.
Analytical chemistry.
2012 Oct; 84(19):8391-8. doi:
10.1021/ac301901s. [PMID: 22931516] - Ilka Haferkamp, Stephan Schmitz-Esser. The plant mitochondrial carrier family: functional and evolutionary aspects.
Frontiers in plant science.
2012; 3(?):2. doi:
10.3389/fpls.2012.00002. [PMID: 22639632] - Young Ahn Yoon, Dong Hwan Lee, Chang-Seok Ki, Soo-Youn Lee, Jong-Won Kim, Yong-Wha Lee, Hyung-Doo Park. SLC22A5 mutations in a patient with systemic primary carnitine deficiency: the first Korean case confirmed by biochemical and molecular investigation.
Annals of clinical and laboratory science.
2012; 42(4):424-8. doi:
. [PMID: 23090741] - Xiao-Jun Zhang, Noe A Rodriguez, Lijian Wang, Demidmaa Tuvdendorj, Zhanpin Wu, Alai Tan, David N Herndon, Robert R Wolfe. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate.
Journal of lipid research.
2012 Jan; 53(1):119-25. doi:
10.1194/jlr.m019901. [PMID: 21934122] - Noelle N Gronroos, Alanna M Chamberlain, Aaron R Folsom, Elsayed Z Soliman, Sunil K Agarwal, Jennifer A Nettleton, Alvaro Alonso. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study.
PloS one.
2012; 7(5):e36686. doi:
10.1371/journal.pone.0036686. [PMID: 22570739] - Xudong Wang, Gail J Mick, Edmund Maser, Kenneth McCormick. Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11β-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration.
The Biochemical journal.
2011 Jul; 437(1):109-15. doi:
10.1042/bj20102069. [PMID: 21492096] - Christopher M Jenkins, Jingyue Yang, Harold F Sims, Richard W Gross. Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism.
The Journal of biological chemistry.
2011 Apr; 286(14):11937-50. doi:
10.1074/jbc.m110.203661. [PMID: 21258134] - Zarazuela Zolkipli, Christina B Pedersen, Anne-Marie Lamhonwah, Niels Gregersen, Ingrid Tein. Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants.
PloS one.
2011 Apr; 6(4):e17534. doi:
10.1371/journal.pone.0017534. [PMID: 21483766] - Nolwenn Brandhonneur, Gilles Dollo, Maja Ratajczak-Enselme, Anne Laure Deniau, François Chevanne, Jean Pierre Estèbe, Alain Legrand, Pascal Le Corre. Ex vivo and in vivo diffusion of ropivacaine through spinal meninges: influence of absorption enhancers.
International journal of pharmaceutics.
2011 Feb; 404(1-2):36-41. doi:
10.1016/j.ijpharm.2010.10.049. [PMID: 21056096] - C Lawrence Kien, Karen I Everingham, Robert D Stevens, Naomi K Fukagawa, Deborah M Muoio. Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.
Obesity (Silver Spring, Md.).
2011 Feb; 19(2):305-11. doi:
10.1038/oby.2010.135. [PMID: 20559306] - Nobuyuki Doi, Mikio Tomita, Masahiro Hayashi. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers.
Drug metabolism and pharmacokinetics.
2011; 26(2):162-70. doi:
10.2133/dmpk.dmpk-10-rg-071. [PMID: 21206134] - Ronald J A Wanders, Jos P N Ruiter, Lodewijk IJLst, Hans R Waterham, Sander M Houten. The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results.
Journal of inherited metabolic disease.
2010 Oct; 33(5):479-94. doi:
10.1007/s10545-010-9104-8. [PMID: 20490924] - Eric D Bruder, Hershel Raff. Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats.
Lipids in health and disease.
2010 Jan; 9(?):3. doi:
10.1186/1476-511x-9-3. [PMID: 20070908] - Julie H Rennison, Tracy A McElfresh, Xiaoqin Chen, Vijay R Anand, Brian D Hoit, Charles L Hoppel, Margaret P Chandler. Prolonged exposure to high dietary lipids is not associated with lipotoxicity in heart failure.
Journal of molecular and cellular cardiology.
2009 Jun; 46(6):883-90. doi:
10.1016/j.yjmcc.2009.02.019. [PMID: 19265702] - A Lombardi, P de Lange, E Silvestri, R A Busiello, A Lanni, F Goglia, M Moreno. 3,5-Diiodo-L-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement.
American journal of physiology. Endocrinology and metabolism.
2009 Mar; 296(3):E497-502. doi:
10.1152/ajpendo.90642.2008. [PMID: 19116374] - Jean-Paul Bonnefont, Jean Bastin, Anthony Behin, Fatima Djouadi. Bezafibrate for an inborn mitochondrial beta-oxidation defect.
The New England journal of medicine.
2009 Feb; 360(8):838-40. doi:
10.1056/nejmc0806334. [PMID: 19228633] - Bridget Wilcken. Disorders of the carnitine cycle and detection by newborn screening.
Annals of the Academy of Medicine, Singapore.
2008 Dec; 37(12 Suppl):71-3. doi:
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Rapid communications in mass spectrometry : RCM.
2008 Nov; 22(21):3434-42. doi:
10.1002/rcm.3755. [PMID: 18837479] - Undurti N Das. Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules.
Lipids in health and disease.
2008 Oct; 7(?):37. doi:
10.1186/1476-511x-7-37. [PMID: 18922179] - Muhammad A Abdul-Ghani, Florian L Muller, Yuhong Liu, Alberto O Chavez, Bogdan Balas, Pengou Zuo, Zhi Chang, Devjit Tripathy, Rucha Jani, Marjorie Molina-Carrion, Adriana Monroy, Franco Folli, Holly Van Remmen, Ralph A DeFronzo. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
American journal of physiology. Endocrinology and metabolism.
2008 Sep; 295(3):E678-85. doi:
10.1152/ajpendo.90287.2008. [PMID: 18593850] - Paul E Minkler, Maria S K Stoll, Stephen T Ingalls, Shuming Yang, Janos Kerner, Charles L Hoppel. Quantification of carnitine and acylcarnitines in biological matrices by HPLC electrospray ionization-mass spectrometry.
Clinical chemistry.
2008 Sep; 54(9):1451-62. doi:
10.1373/clinchem.2007.099226. [PMID: 18678604] - Julie H Rennison, Tracy A McElfresh, Isidore C Okere, Hiral V Patel, Amy B Foster, Kalpana K Patel, Maria S Stoll, Paul E Minkler, Hisashi Fujioka, Brian D Hoit, Martin E Young, Charles L Hoppel, Margaret P Chandler. Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure.
Cardiovascular research.
2008 Jul; 79(2):331-40. doi:
10.1093/cvr/cvn066. [PMID: 18339649] - Hiromutsu Tominaga, Hideki Katoh, Keiichi Odagiri, Yasuyo Takeuchi, Hirotaka Kawashima, Masao Saotome, Tsuyoshi Urushida, Hiroshi Satoh, Hideharu Hayashi. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H105-12. doi:
10.1152/ajpheart.01307.2007. [PMID: 18469143] - John J Lehman, Sihem Boudina, Natasha Hausler Banke, Nandakumar Sambandam, Xianlin Han, Deanna M Young, Teresa C Leone, Richard W Gross, E Douglas Lewandowski, E Dale Abel, Daniel P Kelly. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.
American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H185-96. doi:
10.1152/ajpheart.00081.2008. [PMID: 18487436] - Sonja Primassin, Frank Ter Veld, Ertan Mayatepek, Ute Spiekerkoetter. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine.
Pediatric research.
2008 Jun; 63(6):632-7. doi:
10.1203/pdr.0b013e31816ff6f0. [PMID: 18317232] - O Galbès, L Goret, C Caillaud, J Mercier, P Obert, R Candau, G Py. Combined effects of hypoxia and endurance training on lipid metabolism in rat skeletal muscle.
Acta physiologica (Oxford, England).
2008 Jun; 193(2):163-73. doi:
10.1111/j.1748-1716.2007.01794.x. [PMID: 18081885] - K M Bushma. [The role of the functional state of kidney mitochondria in predisposition of hydronephrotic rabits to gentamicin nephrotoxicity].
Eksperimental'naia i klinicheskaia farmakologiia.
2008 May; 71(3):26-30. doi:
NULL. [PMID: 18652252] - Timothy K Tippin, Dhiren R Thakker. Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers.
Journal of pharmaceutical sciences.
2008 May; 97(5):1977-92. doi:
10.1002/jps.21118. [PMID: 17724658] - Gino Boily, Erin L Seifert, Lisa Bevilacqua, Xiao Hong He, Guillaume Sabourin, Carmen Estey, Cynthia Moffat, Sean Crawford, Sarah Saliba, Karen Jardine, Jian Xuan, Meredith Evans, Mary-Ellen Harper, Michael W McBurney. SirT1 regulates energy metabolism and response to caloric restriction in mice.
PloS one.
2008 Mar; 3(3):e1759. doi:
10.1371/journal.pone.0001759. [PMID: 18335035] - Fu Yang, Shikai Yan, Fang Wang, Ying He, Yingjun Guo, Qi Zhou, Yue Wang, Xiaoying Zhang, Weidong Zhang, Shuhan Sun. DNA immunization perturbs lipid metabolites and increases risk of atherogenesis.
Journal of proteome research.
2008 Feb; 7(2):741-8. doi:
10.1021/pr700663q. [PMID: 18166009] - Olga Jáuregui, Adriana Y Sierra, Patricia Carrasco, Esther Gratacós, Fausto G Hegardt, Núria Casals. A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.
Analytica chimica acta.
2007 Sep; 599(1):1-6. doi:
10.1016/j.aca.2007.07.066. [PMID: 17765057] - Katarzyna A Nałecz, Dorota Szczepankowska, Magdalena Czeredys, Natalia Kulikova, Stanisław Grześkiewicz. Palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP-43.
FEBS letters.
2007 Aug; 581(21):3950-4. doi:
10.1016/j.febslet.2007.07.027. [PMID: 17662726] - Jon V Busto, Jesús Sot, Félix M Goñi, Faustino Mollinedo, Alicia Alonso. Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine).
Biochimica et biophysica acta.
2007 Jul; 1768(7):1855-60. doi:
10.1016/j.bbamem.2007.04.025. [PMID: 17543274] - Kristen L King, Martin E Young, Janos Kerner, Hazel Huang, Karen M O'Shea, Stefan E H Alexson, Charles L Hoppel, William C Stanley. Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.
Journal of lipid research.
2007 Jul; 48(7):1511-7. doi:
10.1194/jlr.m600364-jlr200. [PMID: 17438340] - Ronald N Cortright, Kimberly M Sandhoff, Jessica L Basilio, Jason R Berggren, Robert C Hickner, Matthew W Hulver, G Lynis Dohm, Joseph A Houmard. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training.
Obesity (Silver Spring, Md.).
2006 Jul; 14(7):1201-10. doi:
10.1038/oby.2006.137. [PMID: 16899801] - Arne C Rufer, Ralf Thoma, Jörg Benz, Martine Stihle, Bernard Gsell, Elodie De Roo, David W Banner, Francis Mueller, Odile Chomienne, Michael Hennig. The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
Structure (London, England : 1993).
2006 Apr; 14(4):713-23. doi:
10.1016/j.str.2006.01.008. [PMID: 16615913] - Dayong Sun, Melanie G Cree, Xiao-Jun Zhang, Elisabet Bøersheim, Robert R Wolfe. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS.
Journal of lipid research.
2006 Feb; 47(2):431-9. doi:
10.1194/jlr.d500026-jlr200. [PMID: 16301738] - H M Dann, J K Drackley. Carnitine palmitoyltransferase I in liver of periparturient dairy cows: effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders.
Journal of dairy science.
2005 Nov; 88(11):3851-9. doi:
10.3168/jds.s0022-0302(05)73070-8. [PMID: 16230690] - Alexandra Meynier, Agnès Andre, Jeanine Lherminier, André Grandgirard, Luc Demaison. Dietary oxysterols induce in vivo toxicity of coronary endothelial and smooth muscle cells.
European journal of nutrition.
2005 Oct; 44(7):393-405. doi:
10.1007/s00394-005-0539-x. [PMID: 15668746] - E B Taylor, W J Ellingson, J D Lamb, D G Chesser, W W Winder. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.
American journal of physiology. Endocrinology and metabolism.
2005 Jun; 288(6):E1055-61. doi:
10.1152/ajpendo.00516.2004. [PMID: 15644453] - E Silvestri, M Moreno, A Lombardi, M Ragni, P de Lange, S E H Alexson, A Lanni, F Goglia. Thyroid-hormone effects on putative biochemical pathways involved in UCP3 activation in rat skeletal muscle mitochondria.
FEBS letters.
2005 Mar; 579(7):1639-45. doi:
10.1016/j.febslet.2005.02.022. [PMID: 15757654] - Paul E Minkler, Stephen T Ingalls, Charles L Hoppel. Strategy for the isolation, derivatization, chromatographic separation, and detection of carnitine and acylcarnitines.
Analytical chemistry.
2005 Mar; 77(5):1448-57. doi:
10.1021/ac0487810. [PMID: 15732930] - Paul E Minkler, Janos Kerner, Kathryn N North, Charles L Hoppel. Quantitation of long-chain acylcarnitines by HPLC/fluorescence detection: application to plasma and tissue specimens from patients with carnitine palmitoyltransferase-II deficiency.
Clinica chimica acta; international journal of clinical chemistry.
2005 Feb; 352(1-2):81-92. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2003 Nov; 337(1-2):103-13. doi:
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The Journal of biological chemistry.
2003 Oct; 278(40):38796-802. doi:
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FEBS letters.
2003 Jun; 544(1-3):138-42. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Jun; 17(9):1112-4. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
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Molecular and cellular biochemistry.
2003 Jan; 243(1-2):55-64. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2003 Jan; 327(1-2):47-57. doi:
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Analytical and bioanalytical chemistry.
2003 Jan; 375(2):200-10. doi:
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Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2002 Aug; 85 Suppl 2(?):S710-9. doi:
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Journal of inherited metabolic disease.
2002 Feb; 25(1):17-27. doi:
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Archives of medical research.
2001 Sep; 32(5):394-9. doi:
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Molecular and cellular biochemistry.
2001 Aug; 224(1-2):103-16. doi:
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Molecular and cellular biochemistry.
2001 Apr; 220(1-2):169-75. doi:
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