Azetidine-2-carboxylate (BioDeep_00000897325)
代谢物信息卡片
Azetidine-2-carboxylate
化学式: C4H7NO2 (101.0476762)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C[NH2+]C1C(=O)[O-]
InChI: InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xin Zhang, Ke Xiao, Suzhen Li, Jie Li, Jiaxing Huang, Rumei Chen, Sen Pang, Xiaojin Zhou. Genome-wide analysis of the NAAT, DMAS, TOM, and ENA gene families in maize suggests their roles in mediating iron homeostasis.
BMC plant biology.
2022 Jan; 22(1):37. doi:
10.1186/s12870-021-03422-7. [PMID: 35039017] - Fumiaki Nasu, Yutaro Obara, Yosuke Okamoto, Hiroaki Yamaguchi, Kazuya Kurakami, Ikuo Norota, Kuniaki Ishii. Azelnidipine treatment reduces the expression of Cav1.2 protein.
Life sciences.
2021 Mar; 269(?):119043. doi:
10.1016/j.lfs.2021.119043. [PMID: 33453240] - Motofumi Suzuki, Atsumi Urabe, Sayaka Sasaki, Ryo Tsugawa, Satoshi Nishio, Haruka Mukaiyama, Yoshiko Murata, Hiroshi Masuda, May Sann Aung, Akane Mera, Masaki Takeuchi, Keijo Fukushima, Michika Kanaki, Kaori Kobayashi, Yuichi Chiba, Binod Babu Shrestha, Hiromi Nakanishi, Takehiro Watanabe, Atsushi Nakayama, Hiromichi Fujino, Takanori Kobayashi, Keiji Tanino, Naoko K Nishizawa, Kosuke Namba. Development of a mugineic acid family phytosiderophore analog as an iron fertilizer.
Nature communications.
2021 03; 12(1):1558. doi:
10.1038/s41467-021-21837-6. [PMID: 33692352] - Ghaya Alchoubassi, Katarzyna Kińska, Katarzyna Bierla, Ryszard Lobinski, Joanna Szpunar. Speciation of essential nutrient trace elements in coconut water.
Food chemistry.
2021 Mar; 339(?):127680. doi:
10.1016/j.foodchem.2020.127680. [PMID: 32860999] - Yoshiko Murata, Masami Yoshida, Naho Sakamoto, Shiho Morimoto, Takehiro Watanabe, Kosuke Namba. Iron uptake mediated by the plant-derived chelator nicotianamine in the small intestine.
The Journal of biological chemistry.
2021 Jan; 296(?):100195. doi:
10.1074/jbc.ra120.015861. [PMID: 33334885] - Noura A Hassan, Hany M El Bassossy, Ahmed Fahmy, Mona F Mahmoud. Limonin alleviates macro- and micro-vascular complications of metabolic syndrome in rats: A comparative study with azelnidipine.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Apr; 43(?):92-102. doi:
10.1016/j.phymed.2018.03.044. [PMID: 29747759] - Takeshi Senoura, Emi Sakashita, Takanori Kobayashi, Michiko Takahashi, May Sann Aung, Hiroshi Masuda, Hiromi Nakanishi, Naoko K Nishizawa. The iron-chelate transporter OsYSL9 plays a role in iron distribution in developing rice grains.
Plant molecular biology.
2017 Nov; 95(4-5):375-387. doi:
10.1007/s11103-017-0656-y. [PMID: 28871478] - Priyabrata Das, Soma Mukhopadhyay, Nirmal Kumar Sarkar, Suvra Mandal, Manoj Kar, Ashis Mukhopadhyay. Mugineic acid, active ingredient of wheat grass: an oral novel hexadentate iron chelator in iron overloaded diseases.
Journal of biochemistry.
2016 Sep; 160(3):163-76. doi:
10.1093/jb/mvw023. [PMID: 27008864] - Michio Fukuda, Yoshiaki Ogiyama, Ryo Sato, Toshiyuki Miura, Hidekatsu Fukuta, Masashi Mizuno, Ken Kiyono, Yoshiharu Yamamoto, Junichiro Hayano, Nobuyuki Ohte. L/T-type calcium channel blocker reduces non-Gaussianity of heart rate variability in chronic kidney disease patients under preceding treatment with ARB.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2016 Apr; 17(2):1470320316643905. doi:
10.1177/1470320316643905. [PMID: 27094219] - Norio Susa, Yayoi Nishida, Yoichi Yada, Tomohiro Nakayama, Satoshi Asai, Yasuo Takahashi. Comparative effect of fixed-dose combination tablets of candesartan cilexetil/amlodipine versus olmesartan medoxomil/azelnidipine on laboratory parameters in patients with hypertension: a retrospective cohort study.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2016; 38(2):173-9. doi:
10.3109/10641963.2015.1081214. [PMID: 26453437] - Adrian D Hobson, Christopher M Harris, Elizabeth L van der Kam, Sean C Turner, Ayome Abibi, Ana L Aguirre, Peter Bousquet, Tegest Kebede, Donald B Konopacki, Gary Gintant, Youngjae Kim, Kelly Larson, John W Maull, Nigel S Moore, Dan Shi, Anurupa Shrestha, Xiubo Tang, Peng Zhang, Kathy K Sarris. Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Journal of medicinal chemistry.
2015 Dec; 58(23):9154-70. doi:
10.1021/acs.jmedchem.5b00928. [PMID: 26509640] - Yanhui Gao, Baoqiu Li, Baomeng Zhu, Dongming Liu, Hengli Zhao, Zengjun Fang, Haisheng Wang, Hongxiang Lou. A liquid chromatography-tandem mass spectrometric assay for the antihypertensive agent azelnidipine in human plasma with application to clinical pharmacokinetics studies.
Biomedical chromatography : BMC.
2015 Jul; 29(7):970-4. doi:
10.1002/bmc.3399. [PMID: 25472837] - Hideki Kato, Takeshi Shiraishi, Shuko Ueda, Eiji Kubo, Tomoko Shima, Michito Nagura, Hirofumi Yano, Yuh Izumikawa, Masaru Shimada, Satoru Tomioka, Hitonari Nosaka, Kenichiro Kojima, Masayuki Tanemoto, Shunya Uchida. Blood pressure control and satisfaction of hypertensive patients following a switch to combined drugs of an angiotensin receptor blocker and a calcium channel blocker in clinical practice of nephrology.
Clinical and experimental nephrology.
2015 Jun; 19(3):465-73. doi:
10.1007/s10157-014-1017-7. [PMID: 25135635] - Hiroyasu Uzui, Tetsuji Morishita, Akira Nakano, Naoki Amaya, Yoshitomo Fukuoka, Kentaro Ishida, Kenichiro Arakawa, Jong-Dae Lee, Hiroshi Tada. Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension.
Journal of cardiovascular pharmacology and therapeutics.
2014 May; 19(3):304-9. doi:
10.1177/1074248413511692. [PMID: 24288395] - Satoshi Miyazaki, Toshihiro Hamada, Shigemasa Hirata, Akira Ohtahara, Einosuke Mizuta, Yasutaka Yamamoto, Masanari Kuwabara, Yoshihito Nosaka, Osamu Igawa, Kazuhide Ogino, Masahiko Kato, Akio Yoshida, Haruaki Ninomiya, Jidong Cheng, Yuji Moriwaki, Kazuhiro Yamamoto, Ichiro Hisatome. Effects of azelnidipine on uric acid metabolism in patients with essential hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2014; 36(7):447-53. doi:
10.3109/10641963.2013.846359. [PMID: 24433018] - Kazi Rafiq, Akira Nishiyama, Yoshio Konishi, Takashi Morikawa, Chizuko Kitabayashi, Masakazu Kohno, Tsutomu Masaki, Hirohito Mori, Hiroyuki Kobori, Masahito Imanishi. Regression of glomerular and tubulointerstitial injuries by dietary salt reduction with combination therapy of angiotensin II receptor blocker and calcium channel blocker in Dahl salt-sensitive rats.
PloS one.
2014; 9(9):e107853. doi:
10.1371/journal.pone.0107853. [PMID: 25233358] - Ge Gao, Xiao-Cheng Liu, Wen-Bin Jing, Qin Yang, Guo-Wei He. Vasorelaxation induced by new third-generation dihydropyridine calcium antagonist azelnidipine in human internal mammary artery.
The Annals of thoracic surgery.
2013 Oct; 96(4):1316-1321. doi:
10.1016/j.athoracsur.2013.05.020. [PMID: 23895889] - Masayoshi Kojima, Setsuya Okubo, Ryuichi Mizubayashi, Naoki Isaka, Hirofumi Machida, Shinya Okamoto, Hisayoshi Hirota, Misao Takeuchi, Takuya Kato, Kaname Nakatani, Osamu Mizuno, Koichi Miyagawa, Katsutoshi Makino, Takanobu Okura, Yasuaki Dohi, Masaaki Ito, Genjiro Kimura. Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a randomized study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Jul; 28(7):1802-10. doi:
10.1093/ndt/gft034. [PMID: 23535223] - Matsuda Sanae, Aoyagi Yasuo. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats.
Journal of agricultural and food chemistry.
2013 Jun; 61(23):5520-5. doi:
10.1021/jf3041066. [PMID: 23647085] - Tadashi Uramatsu, Tomoya Nishino, Yoko Obata, Yohei Sato, Akira Furusu, Takehiko Koji, Toru Miyazaki, Shigeru Kohno. Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine.
Biological & pharmaceutical bulletin.
2013; 36(8):1271-7. doi:
10.1248/bpb.b12-00965. [PMID: 23902971] - Kazuki Noda, Maki Hosoya, Sota Nakajima, Junko Ohashi, Yoshihiro Fukumoto, Hiroaki Shimokawa. Anti-atherogenic effects of the combination therapy with olmesartan and azelnidipine in diabetic apolipoprotein E-deficient mice.
The Tohoku journal of experimental medicine.
2012 12; 228(4):305-15. doi:
10.1620/tjem.228.305. [PMID: 23124103] - Ikuo Saito, Toshio Kushiro, Natsuko Zenimura, Yasuyuki Matsushita, Kei Sagawa, Katsutoshi Hiramatsu, Fumie Yamaguchi. Olmesartan medoxomil and azelnidipine therapy in patients with hypertension and chronic kidney disease in Japan.
Journal of nephrology.
2012 Sep; 25(5):699-708. doi:
10.5301/jn.5000043. [PMID: 22020401] - Hajime Nagasu, Minoru Satoh, Sohachi Fujimoto, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara. Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Mar; 35(3):348-55. doi:
10.1038/hr.2011.184. [PMID: 22072106] - Ulrich Deinlein, Michael Weber, Holger Schmidt, Stefan Rensch, Aleksandra Trampczynska, Thomas H Hansen, Søren Husted, Jan K Schjoerring, Ina N Talke, Ute Krämer, Stephan Clemens. Elevated nicotianamine levels in Arabidopsis halleri roots play a key role in zinc hyperaccumulation.
The Plant cell.
2012 Feb; 24(2):708-23. doi:
10.1105/tpc.111.095000. [PMID: 22374395] - Tsuneo Takenaka, Takeru Seto, Mika Okayama, Eriko Kojima, Yuka Nodaira, Keita Sueyoshi, Tomohiro Kikuta, Yusuke Watanabe, Tsutomu Inoue, Hiroshi Takane, Yoichi Ohno, Hiromichi Suzuki. Long-term effects of calcium antagonists on augmentation index in hypertensive patients with chronic kidney disease: a randomized controlled study.
American journal of nephrology.
2012; 35(5):416-23. doi:
10.1159/000338132. [PMID: 22517217] - Sichul Lee, Daniel P Persson, Thomas H Hansen, Søren Husted, Jan K Schjoerring, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Yusuke Kakei, Hiroshi Masuda, Naoko K Nishizawa, Gynheung An. Bio-available zinc in rice seeds is increased by activation tagging of nicotianamine synthase.
Plant biotechnology journal.
2011 Oct; 9(8):865-73. doi:
10.1111/j.1467-7652.2011.00606.x. [PMID: 21426477] - Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki, Hiroyuki Daida. Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).
Cardiovascular diabetology.
2011 Sep; 10(?):79. doi:
10.1186/1475-2840-10-79. [PMID: 21906391] - Masanori Abe, Noriaki Maruyama, Kazuyoshi Okada, Shiro Matsumoto, Koichi Matsumoto, Masayoshi Soma. Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Aug; 34(8):935-41. doi:
10.1038/hr.2011.67. [PMID: 21654755] - Katsuyuki Ando, Masakazu Haneda, Sadayoshi Ito, Naoki Kashihara, Koichi Node, Masaomi Nangaku, Tatsuo Shimosawa, Junji Kishimoto, Toshiro Fujita. Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria.
Cardiovascular drugs and therapy.
2011 Aug; 25(4):341-7. doi:
10.1007/s10557-011-6309-5. [PMID: 21637969] - Koichi Hayashi. L-/T-type Ca channel blockers for kidney protection: ready for sophisticated use of Ca channel blockers.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Aug; 34(8):910-2. doi:
10.1038/hr.2011.74. [PMID: 21753772] - Tsukasa Nakamura, Eiichi Sato, Nobuharu Fujiwara, Yasuhiro Kawagoe, Hikaru Koide, Yoshihiko Ueda, Masayoshi Takeuchi, Sho-ichi Yamagishi. Calcium channel blocker inhibition of AGE and RAGE axis limits renal injury in nondiabetic patients with stage I or II chronic kidney disease.
Clinical cardiology.
2011 Jun; 34(6):372-7. doi:
10.1002/clc.20885. [PMID: 21432860] - Yoshio Matsui, Kazuo Eguchi, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario. Urinary albumin excretion during angiotensin II receptor blockade: comparison of combination treatment with a diuretic or a calcium-channel blocker.
American journal of hypertension.
2011 Apr; 24(4):466-73. doi:
10.1038/ajh.2010.240. [PMID: 21164498] - Yoshio Matsui, Kazuo Eguchi, Michael F O'Rourke, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario. Association between aldosterone induced by antihypertensive medication and arterial stiffness reduction: the J-CORE study.
Atherosclerosis.
2011 Mar; 215(1):184-8. doi:
10.1016/j.atherosclerosis.2010.12.022. [PMID: 21241987] - Hajime Nagasu, Minoru Satoh, Daisuke Yorimitsu, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara. Comparison of combination therapy of olmesartan plus azelnidipine or hydrochlorothiazide on renal and vascular damage in SHR/NDmcr-cp rats.
Kidney & blood pressure research.
2011; 34(2):87-96. doi:
10.1159/000323535. [PMID: 21273789] - Takeshi Yamamoto, Jun Matsuda, Hiroyuki Kadoya, Tomoko Namba, Masanobu Takeji, Atsushi Yamauchi. Azelnidipine-induced chyloperitoneum in a patient with microscopic polyangiitis.
Clinical and experimental nephrology.
2010 Oct; 14(5):496-500. doi:
10.1007/s10157-010-0302-3. [PMID: 20556459] - Heng-Hsuan Chu, Jeff Chiecko, Tracy Punshon, Antonio Lanzirotti, Brett Lahner, David E Salt, Elsbeth L Walker. Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures.
Plant physiology.
2010 Sep; 154(1):197-210. doi:
10.1104/pp.110.159103. [PMID: 20625001] - Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Shigeshi Kamikawa, Shinichi Usui, Youko Kaji, Kosuke Sakane, Hiroko Ogawa, Yoshifumi Ninomiya, Shozo Kusachi. Combination therapy of calcium channel blocker and angiotensin II receptor blocker reduces augmentation index in hypertensive patients.
The American journal of the medical sciences.
2010 May; 339(5):433-9. doi:
10.1097/maj.0b013e3181d658c4. [PMID: 20234301] - Tomomichi Ishizaka, Akira Takahara, Hiroshi Iwasaki, Yoshitaka Mitsumori, Hiroaki Kise, Yuji Nakamura, Atsushi Sugiyama. Cardiovascular effects of azelnidipine in comparison with those of amlodipine assessed in the halothane-anaesthetized dog.
Basic & clinical pharmacology & toxicology.
2010 Feb; 106(2):135-43. doi:
10.1111/j.1742-7843.2009.00478.x. [PMID: 19906049] - Tatsuya Kondo, Rieko Goto, Kazuhiro Sonoda, Takeomi Yasuda, Kaoru Ono, Yuki Takaki, Riichiro Yatsuda, Nobuhiro Miyamura, Eiichi Araki. Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine, in hypertensive patients.
Internal medicine (Tokyo, Japan).
2010; 49(7):637-43. doi:
10.2169/internalmedicine.49.2749. [PMID: 20371952] - Yukiko Inoue, Tatsuyuki Kakuma, Yoshisuke Nonaka, Shunichiro Sumi, Keisuke Okamura, Sunao Kodama, Chie Ando, Hideya Niimura, Kei Miyoshi, Yoshihiro Tsuchiya, Yoshio Yamanouchi, Hidenori Urata. Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010 Jan; 32(1):21-8. doi:
10.3109/10641960902960516. [PMID: 20144069] - Hiroshi Komoda, Teruo Inoue, Koichi Node. Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010 Jan; 32(2):121-8. doi:
10.3109/10641960903254414. [PMID: 20374186] - Sohachi Fujimoto, Minoru Satoh, Hajime Nagasu, Hideyuki Horike, Tamaki Sasaki, Naoki Kashihara. Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Dec; 24(12):3651-8. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2009 Nov; 32(11):962-8. doi:
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American journal of hypertension.
2009 Oct; 22(10):1101-6. doi:
10.1038/ajh.2009.148. [PMID: 19730414] - Yu-Yan Fan, Masakazu Kohno, Daisuke Nakano, Hirofumi Hitomi, Yukiko Nagai, Yoshihide Fujisawa, Xiao-Mei Lu, Hua Fu, Jun Du, Koji Ohmori, Naohisa Hosomi, Shoji Kimura, Hideyasu Kiyomoto, Akira Nishiyama. Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats.
Journal of hypertension.
2009 Sep; 27(9):1855-62. doi:
10.1097/hjh.0b013e32832dda6f. [PMID: 19633569] - Takahiro Aoyama, Takanori Kobayashi, Michiko Takahashi, Seiji Nagasaka, Kanako Usuda, Yusuke Kakei, Yasuhiro Ishimaru, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints.
Plant molecular biology.
2009 Aug; 70(6):681-92. doi:
10.1007/s11103-009-9500-3. [PMID: 19468840] - Haruhiko Inoue, Takanori Kobayashi, Tomoko Nozoye, Michiko Takahashi, Yusuke Kakei, Kazumasa Suzuki, Mikio Nakazono, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Rice OsYSL15 is an iron-regulated iron(III)-deoxymugineic acid transporter expressed in the roots and is essential for iron uptake in early growth of the seedlings.
The Journal of biological chemistry.
2009 Feb; 284(6):3470-9. doi:
10.1074/jbc.m806042200. [PMID: 19049971] - Yutaka Haitani, Maiko Nakata, Toshiya Sasaki, Akiko Uchida, Hiroshi Takagi. Engineering of the yeast ubiquitin ligase Rsp5: isolation of a new variant that induces constitutive inactivation of the general amino acid permease Gap1.
FEMS yeast research.
2009 Feb; 9(1):73-86. doi:
10.1111/j.1567-1364.2008.00460.x. [PMID: 19054125] - Chiaki Tanifuji, Yusuke Suzuki, Wong Mu Geot, Satoshi Horikoshi, Hisahide Takahashi, Yasuhiko Tomino. Beneficial effects of combination therapy with olmesartan and azelnidipine in murine polycystic kidneys.
Kidney & blood pressure research.
2009; 32(4):239-49. doi:
10.1159/000238821. [PMID: 19752573] - Eiji Nakamura, Hidetoshi Akashi, Shinichi Hiromatsu, Atsuhisa Tanaka, Seiji Onitsuka, Shigeaki Aoyagi. Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair.
The Kurume medical journal.
2009; 56(1-2):25-32. doi:
10.2739/kurumemedj.56.25. [PMID: 20103998] - Yusuke Tanigawara, Kazutaka Yoshihara, Kizuku Kuramoto, Kikuo Arakawa. Comparative pharmacodynamics of olmesartan and azelnidipine in patients with hypertension: a population pharmacokinetic/pharmacodynamic analysis.
Drug metabolism and pharmacokinetics.
2009; 24(4):376-88. doi:
10.2133/dmpk.24.376. [PMID: 19745564] - Tomomi Kurashige, Katsushige Abe, Akira Furusu, Masanobu Miyazaki, Yoko Obata, Zihyin Xia, Masayuki Nakazawa, Yuka Nakazawa, Satoshi Funakoshi, Takashi Harada, Takehiko Koji, Shigeru Kohno. Renoprotective effect of azelnidipine in rats.
Biological & pharmaceutical bulletin.
2008 Dec; 31(12):2237-44. doi:
10.1248/bpb.31.2237. [PMID: 19043206] - Satomi Konno, Yoshitaka Hirooka, Shuichiro Araki, Yasuaki Koga, Takuya Kishi, Kenji Sunagawa. Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
2008 Dec; 52(6):555-60. doi:
10.1097/fjc.0b013e318192690e. [PMID: 19057394] - Eleftherios Sachlos, Debra T Auguste. Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation.
Biomaterials.
2008 Dec; 29(34):4471-80. doi:
10.1016/j.biomaterials.2008.08.012. [PMID: 18793799] - T Nakamura, T Inoue, N Fujiwara, Y Kawagoe, T Sugaya, Y Ueda, H Koide, K Node. Additional renoprotective effects of azelnidipine combined with angiotensin receptor blockers in patients with diabetic nephropathy.
Clinical nephrology.
2008 Nov; 70(5):385-92. doi:
10.5414/cnp70385. [PMID: 19000538] - Jian-Jun Zou, Hong-Jian Ji, Xiao-Hua Zhou, Yu-Bin Zhu, Hong-Wei Fan, Da-Wei Xiao, Qin Hu. Determination of azelnidipine by LC-ESI-MS and its application to a pharmacokinetic study in healthy Chinese volunteers.
Die Pharmazie.
2008 Aug; 63(8):568-70. doi:
NULL. [PMID: 18771003] - Aki Hirayama, Atsushi Ueda, Takaaki Oteki, Sohji Nagase, Kazumasa Aoyagi, Akio Koyama. In vivo imaging of renal redox status during azelnidipine treatment.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Aug; 31(8):1643-50. doi:
10.1291/hypres.31.1643. [PMID: 18971540] - Shigehiro Katayama, Ryuzo Kawamori, Yasuhiko Iwamoto, Ikuo Saito, Kizuku Kuramoto. In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diabetes (ATTEST) study.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Aug; 31(8):1499-508. doi:
10.1291/hypres.31.1499. [PMID: 18971523] - Susumu Ogawa, Takefumi Mori, Kazuhiro Nako, Sadayoshi Ito. Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jun; 31(6):1147-55. doi:
10.1291/hypres.31.1147. [PMID: 18716362] - Jiko Yamada, Hirofumi Tomiyama, Chisa Matsumoto, Masanobu Yoshida, Kazuki Shiina, Akira Yamashina. Effects of azelnidipine on the autonomic functions and its influence on arterial stiffness and endothelial functions.
Journal of cardiology.
2008 Apr; 51(2):114-20. doi:
10.1016/j.jjcc.2008.01.005. [PMID: 18522784] - Nan Wang, Ling Ye, Fangfei Yan, Ren Xu. Spectroscopic studies on the interaction of azelnidipine with bovine serum albumin.
International journal of pharmaceutics.
2008 Mar; 351(1-2):55-60. doi:
10.1016/j.ijpharm.2007.09.016. [PMID: 18029121] - Atsumi Hayashi, Koichi Kimoto. Nicotianamine preferentially inhibits Angiotensin I-converting enzyme.
Journal of nutritional science and vitaminology.
2007 Aug; 53(4):331-6. doi:
10.3177/jnsv.53.331. [PMID: 17934238] - Kiyoshi Kawabata, Naozumi Samata, Yoko Urasaki, Ichiro Fukazawa, Naoki Uchida, Eiji Uchida, Hajime Yasuhara. Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):389-97. doi:
10.1016/j.jchromb.2007.01.050. [PMID: 17350354] - Tsukasa Nakamura, Takeshi Sugaya, Yasuhiro Kawagoe, Tsukasa Suzuki, Yoshihiko Ueda, Hikaru Koide, Teruo Inoue, Koichi Node. Azelnidipine reduces urinary protein excretion and urinary liver-type fatty acid binding protein in patients with hypertensive chronic kidney disease.
The American journal of the medical sciences.
2007 Jun; 333(6):321-6. doi:
10.1097/maj.0b013e318065c254. [PMID: 17570983] - Li Ding, Li Li, Pengcheng Ma. Determination of azelnidipine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2007 Jan; 43(2):575-9. doi:
10.1016/j.jpba.2006.07.011. [PMID: 16920318] - Yoshikuni Kimura, Yoshitaka Hirooka, Yoji Sagara, Kenji Sunagawa. Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2007 Jan; 29(1):13-21. doi:
10.1080/10641960601096745. [PMID: 17190727] - Teru Nada, Masahiro Nomura, Kunihiko Koshiba, Tomohito Kawano, Jyunichi Mikawa, Susumu Ito. Clinical study with azelnidipine in patients with essential hypertension. Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity.
Arzneimittel-Forschung.
2007; 57(11):698-704. doi:
10.1055/s-0031-1296670. [PMID: 18193691] - Masarsu Iwai, Huan-Sheng Li, Rui Chen, Tetsuya Shiuchi, Lan Wu, Li-Juan Min, Jian-Mei Li, Masahiro Tsuda, Jun Suzuki, Yumiko Tomono, Hirokazu Tomochika, Masaki Mogi, Masatsugu Horiuchi. Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan.
The Journal of pharmacology and experimental therapeutics.
2006 Dec; 319(3):1081-7. doi:
10.1124/jpet.106.108894. [PMID: 16990512] - Kiyoshi Kawabata, Yoko Urasaki. Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 844(1):45-52. doi:
10.1016/j.jchromb.2006.06.031. [PMID: 16854634] - Estelle Bakkaus, Richard N Collins, Jean-Louis Morel, Barbara Gouget. Anion exchange liquid chromatography--inductively coupled plasma-mass spectrometry detection of the Co2+, Cu2+, Fe3+ and Ni2+ complexes of mugineic and deoxymugineic acid.
Journal of chromatography. A.
2006 Oct; 1129(2):208-15. doi:
10.1016/j.chroma.2006.07.004. [PMID: 16876808] - Tetsuya Nakamura, Yuichiro Saito, Tomoko Saito, Masahiko Kurabayashi. Azelnidipine down-regulates renal angiotensin-converting enzyme and mineralocorticoid receptor mRNA in diabetic hypertensive rats.
Journal of pharmacological sciences.
2006 Oct; 102(2):239-42. doi:
10.1254/jphs.sc0060064. [PMID: 17031066] - Kaku Nakano, Kensuke Egashira, Hideo Tada, Yoshiro Kohjimoto, Yasuhiko Hirouchi, Shun-ichi Kitajima, Yasuhisa Endo, Xiao-Hang Li, Kenji Sunagawa. A third-generation, long-acting, dihydropyridine calcium antagonist, azelnidipine, attenuates stent-associated neointimal formation in non-human primates.
Journal of hypertension.
2006 Sep; 24(9):1881-9. doi:
10.1097/01.hjh.0000242414.96277.95. [PMID: 16915039] - Hiroo Kumagai, Toshiko Onami, Chie Takimoto, Kamon Iigaya, Koichi Hayashi. [Novel actions of calcium channel blockers].
Nihon rinsho. Japanese journal of clinical medicine.
2006 Aug; 64 Suppl 6(?):311-7. doi:
NULL. [PMID: 16983770] - Naoki Kondo, Hideyasu Kiyomoto, Tokunori Yamamoto, Akira Miyatake, Guang-Ping Sun, Matlubur Rahman, Hirofumi Hitomi, Kumiko Moriwaki, Taiga Hara, Shoji Kimura, Youichi Abe, Masakazu Kohno, Akira Nishiyama. Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats.
The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1047-52. doi:
10.1124/jpet.105.095331. [PMID: 16319305] - Stéphane Mari, Delphine Gendre, Katia Pianelli, Laurent Ouerdane, Ryszard Lobinski, Jean-François Briat, Michel Lebrun, Pierre Czernic. Root-to-shoot long-distance circulation of nicotianamine and nicotianamine-nickel chelates in the metal hyperaccumulator Thlaspi caerulescens.
Journal of experimental botany.
2006; 57(15):4111-22. doi:
10.1093/jxb/erl184. [PMID: 17079698] - Hiromichi Suzuki, Tsutomu Inoue, Kazuhiro Kobayashi, Junko Shoda, Hidetomo Nakamoto. The newly developed calcium antagonist, azelnidipine, increases drain volume in continuous ambulatory peritoneal dialysis patients.
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.
2006; 22(?):18-23. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2005 Dec; 28(12):1017-23. doi:
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Medical hypotheses.
2005; 65(1):155-7. doi:
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International journal of tissue reactions.
2005; 27(3):137-43. doi:
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The Journal of biological chemistry.
2004 Dec; 279(53):55051-9. doi:
10.1074/jbc.m410287200. [PMID: 15485863] - Shokei Kim-Mitsuyama, Yasukatsu Izumi, Yasuhiro Izumiya, Kaoru Yoshida, Minoru Yoshiyama, Hiroshi Iwao. Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Oct; 27(10):771-9. doi:
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The Plant journal : for cell and molecular biology.
2004 Aug; 39(3):403-14. doi:
10.1111/j.1365-313x.2004.02128.x. [PMID: 15255869] - Shintaro Koike, Haruhiko Inoue, Daichi Mizuno, Michiko Takahashi, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem.
The Plant journal : for cell and molecular biology.
2004 Aug; 39(3):415-24. doi:
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Journal of gastroenterology and hepatology.
2004 Apr; 19(4):413-7. doi:
10.1111/j.1440-1746.2003.03315.x. [PMID: 15012778] - Shinji Takamizawa, Yojiro Maehata, Katsuyuki Imai, Haruki Senoo, Sadao Sato, Ryu-Ichiro Hata. Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells.
Cell biology international.
2004; 28(4):255-65. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2003 12; 122(6):539-47. doi:
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2003 Mar; 26(3):201-8. doi:
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