gamma-Aminobutyrylhistidine (BioDeep_00000897315)

   


代谢物信息卡片


gamma-Aminobutyrylhistidine

化学式: C10H16N4O3 (240.12223459999998)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(NC=N1)CC(C(=O)[O-])NC(=O)CCC[NH3+]
InChI: InChI=1S/C10H16N4O3/c11-3-1-2-9(15)14-8(10(16)17)4-7-5-12-6-13-7/h5-6,8H,1-4,11H2,(H,12,13)(H,14,15)(H,16,17)/t8-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

gamma-Aminobutyrylhistidine



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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Francesco Bellia, Graziella Vecchio, Enrico Rizzarelli. Carnosinases, their substrates and diseases. Molecules (Basel, Switzerland). 2014 Feb; 19(2):2299-329. doi: 10.3390/molecules19022299. [PMID: 24566305]
  • Giuseppa I Grasso, Giuseppe Arena, Francesco Bellia, Enrico Rizzarelli, Graziella Vecchio. Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound. Journal of inorganic biochemistry. 2014 Feb; 131(?):56-63. doi: 10.1016/j.jinorgbio.2013.10.020. [PMID: 24246303]
  • Verena Peters, Claus P Schmitt, Johannes Zschocke, Marie-Luise Gross, Kerstin Brismar, Elisabete Forsberg. Carnosine treatment largely prevents alterations of renal carnosine metabolism in diabetic mice. Amino acids. 2012 Jun; 42(6):2411-6. doi: 10.1007/s00726-011-1046-4. [PMID: 21833769]
  • Verena Peters, Moustafa Kebbewar, Erwin W Jansen, Cornelis Jakobs, Eva Riedl, Hannes Koeppel, Dirk Frey, Katja Adelmann, Kristina Klingbeil, Matthias Mack, Georg F Hoffmann, Bart Janssen, Johannes Zschocke, Benito A Yard. Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity. Amino acids. 2010 May; 38(5):1607-15. doi: 10.1007/s00726-009-0367-z. [PMID: 19915793]
  • Kristen J Skvorak, Elizabeth J Hager, Erland Arning, Teodoro Bottiglieri, Harbhajan S Paul, Stephen C Strom, Gregg E Homanics, Qin Sun, Erwin E W Jansen, Cornelis Jakobs, William J Zinnanti, K Michael Gibson. Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochimica et biophysica acta. 2009 Oct; 1792(10):1004-10. doi: 10.1016/j.bbadis.2009.08.006. [PMID: 19699299]
  • Giulio Vistoli, Alessandro Pedretti, Matteo Cattaneo, Giancarlo Aldini, Bernard Testa. Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate. Journal of medicinal chemistry. 2006 Jun; 49(11):3269-77. doi: 10.1021/jm0602099. [PMID: 16722645]
  • Erwin E W Jansen, K Michael Gibson, Yosuke Shigematsu, Cornelis Jakobs, Nanda M Verhoeven. A novel, quantitative assay for homocarnosine in cerebrospinal fluid using stable-isotope dilution liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(2):196-200. doi: 10.1016/j.jchromb.2005.10.053. [PMID: 16309980]
  • Phillip L Pearl, K Michael Gibson. Clinical aspects of the disorders of GABA metabolism in children. Current opinion in neurology. 2004 Apr; 17(2):107-13. doi: 10.1097/00019052-200404000-00005. [PMID: 15021235]
  • Jung Hoon Kang, Kyung Sik Kim, Soo Young Choi, Hyeok Yil Kwon, Moo Ho Won, Tae-Cheon Kang. Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification. Molecules and cells. 2002 Jun; 13(3):498-502. doi: . [PMID: 12132593]
  • Rinat Tabakman, Philip Lazarovici, Ron Kohen. Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. Journal of neuroscience research. 2002 May; 68(4):463-9. doi: 10.1002/jnr.10228. [PMID: 11992473]
  • Jung Hoon Kang, Kyung Sik Kim, Soo Young Choi, Hyeok Yil Kwon, Moo Ho Won, Tae-Cheon Kang. Protection by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin modification. Molecules and cells. 2002 Feb; 13(1):107-12. doi: . [PMID: 11911459]
  • G G Kramarenko, E D Markova, I A Ivanova-Smolenskaya, A A Boldyrev. Peculiarities of carnosine metabolism in a patient with pronounced homocarnosinemia. Bulletin of experimental biology and medicine. 2001 Oct; 132(4):996-9. doi: 10.1023/a:1013687832424. [PMID: 11782804]
  • A W Goddard, G F Mason, A Almai, D L Rothman, K L Behar, O A Petroff, D S Charney, J H Krystal. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Archives of general psychiatry. 2001 Jun; 58(6):556-61. doi: 10.1001/archpsyc.58.6.556. [PMID: 11386984]
  • N Hamajima, Y Wada. [Serum carnosinase deficiency and homocarnosinosis]. Ryoikibetsu shokogun shirizu. 1998; ?(18 Pt 1):252-4. doi: NULL. [PMID: 9590040]
  • N I Uskova, A V Lysenko, A M Mendzheritskii. [Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide]. Vestnik Rossiiskoi akademii meditsinskikh nauk. 1996; ?(9):27-30. doi: NULL. [PMID: 8983406]
  • M C Jackson, D M Scollard, R J Mack, J F Lenney. Localization of a novel pathway for the liberation of GABA in the human CNS. Brain research bulletin. 1994; 33(4):379-85. doi: 10.1016/0361-9230(94)90280-1. [PMID: 8124577]
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  • L R Gjessing, H A Lunde, L Mørkrid, J F Lenney, O Sjaastad. Inborn errors of carnosine and homocarnosine metabolism. Journal of neural transmission. Supplementum. 1990; 29(?):91-106. doi: 10.1007/978-3-7091-9050-0_10. [PMID: 2358806]
  • H A Lunde, J F Lenney, S Halvorsen, L Gjessing. Serum carnosinase in blood and homocarnosine in CSF of patients with Følling's disease (PKU). Journal of the Oslo city hospitals. 1987 Apr; 37(4):29-33. doi: . [PMID: 3598759]
  • H A Lunde, L R Gjessing, O Sjaastad. Homocarnosinosis: influence of dietary restriction of histidine. Neurochemical research. 1986 Jun; 11(6):825-38. doi: 10.1007/bf00965207. [PMID: 3736769]
  • J F Lenney. Carnosinase and homocarnosinosis. Journal of the Oslo city hospitals. 1985 Feb; 35(2-3):27-40. doi: NULL. [PMID: 3891936]
  • J Jaeken, P Casaer, P de Cock, L Corbeel, R Eeckels, E Eggermont, P J Schechter, J M Brucher. Gamma-aminobutyric acid-transaminase deficiency: a newly recognized inborn error of neurotransmitter metabolism. Neuropediatrics. 1984 Aug; 15(3):165-9. doi: 10.1055/s-2008-1052362. [PMID: 6148708]
  • O Ziesler, K Hole, I Haugan, A L Børresen, L R Gjessing, O Sjaastad. Transport and distribution of homocarnosine after intracerebroventricular and intravenous injection in the rat. Neurochemical research. 1984 May; 9(5):637-48. doi: 10.1007/bf00964510. [PMID: 6472567]
  • R Mitchell, G Grieve, R Dow, G Fink. Endogenous GABA receptor ligands in hypophysial portal blood. Neuroendocrinology. 1983 Sep; 37(3):169-76. doi: 10.1159/000123539. [PMID: 6312354]
  • J F Lenney, S C Peppers, C M Kucera, O Sjaastad. Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine. Clinica chimica acta; international journal of clinical chemistry. 1983 Aug; 132(2):157-65. doi: 10.1016/0009-8981(83)90243-7. [PMID: 6616870]
  • J F Lenney, R P George, A M Weiss, C M Kucera, P W Chan, G S Rinzler. Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. Clinica chimica acta; international journal of clinical chemistry. 1982 Aug; 123(3):221-31. doi: 10.1016/0009-8981(82)90166-8. [PMID: 7116644]
  • H Lunde, O Sjaastad, L Gjessing. Homocarnosinosis: hypercarnosinuria. Journal of neurochemistry. 1982 Jan; 38(1):242-5. doi: 10.1111/j.1471-4159.1982.tb10876.x. [PMID: 7108529]