THYMIDINE 5-MONOPHOSPHATE (BioDeep_00000897236)

   


代谢物信息卡片


THYMIDINE 5-MONOPHOSPHATE

化学式: C10H13N2O8P-2 (320.041)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 71.29%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)([O-])[O-])O
InChI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1

描述信息

同义名列表

1 个代谢物同义名

THYMIDINE 5-MONOPHOSPHATE



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(12)

PlantCyc(1)

代谢反应

749 个相关的代谢反应过程信息。

Reactome(44)

BioCyc(51)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(652)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Marina Giralt, Sara Chocron, Roser Ferrer, Gema Ariceta. Plasma intact fibroblast growth factor 23 level is a useful tool for diagnostic approach of renal hypophosphatemia. Pediatric nephrology (Berlin, Germany). 2021 04; 36(4):1025-1028. doi: 10.1007/s00467-020-04906-8. [PMID: 33492457]
  • Morse Faria, Matthew S Halquist, Erick Kindt, Wenlin Li, H Thomas Karnes, Peter J O'Brien. Liquid chromatography-tandem mass spectrometry method for quantification of thymidine kinase activity in human serum by monitoring the conversion of 3'-deoxy-3'-fluorothymidine to 3'-deoxy-3'-fluorothymidine monophosphate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):13-20. doi: 10.1016/j.jchromb.2012.08.024. [PMID: 22995377]
  • Fatih M Uckun, Pedro Cahn, Sanjive Qazi, Osmond D'Cruz. Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS. Expert opinion on investigational drugs. 2012 Apr; 21(4):489-500. doi: 10.1517/13543784.2012.664635. [PMID: 22360744]
  • Zafar Rasheed, Hani A Al-Shobaili, Ahmad A Al Robaee, Abdullateef A Alzolibani, Walid I A Wadi, Muhammad Ismail Khan, Hamad A Al-Hamed. Preferential recognition of peroxynitrite damaged thymidine-monophosphate by anti-DNA autoantibodies in systemic lupus erythematosus. Nucleosides, nucleotides & nucleic acids. 2012; 31(10):736-51. doi: 10.1080/15257770.2012.724135. [PMID: 23067125]
  • Juan Sun, Yanxin Hu, Shanping Cao, Guozhong Zhang, Lun-Quan Sun, Ming Wang. Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent. Journal of biomedicine & biotechnology. 2010; 2010(?):. doi: 10.1155/2010/362524. [PMID: 20706607]
  • Salim Khiati, Nathalie Pierre, Soahary Andriamanarivo, Mark W Grinstaff, Nessim Arazam, Frédéric Nallet, Laurence Navailles, Philippe Barthélémy. Anionic nucleotide--lipids for in vitro DNA transfection. Bioconjugate chemistry. 2009 Sep; 20(9):1765-72. doi: 10.1021/bc900163s. [PMID: 19711898]
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  • Giovanna Pontarin, Paola Ferraro, Maria L Valentino, Michio Hirano, Peter Reichard, Vera Bianchi. Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. The Journal of biological chemistry. 2006 Aug; 281(32):22720-8. doi: 10.1074/jbc.m604498200. [PMID: 16774911]
  • Fatih M Uckun, Barbara Waurzyniak, Heather Tibbles, Taracad K Venkatachalam, Doug Erbeck. In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats. Arzneimittel-Forschung. 2006 Feb; 56(2A):176-92. doi: 10.1055/s-0031-1296805. [PMID: 16570826]
  • Osmond J D'Cruz, Peter Samuel, Barbara Waurzyniak, Fatih M Uckun. Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Biology of reproduction. 2003 Dec; 69(6):1843-51. doi: 10.1095/biolreprod.103.019182. [PMID: 12890726]
  • Fatih M Uckun, Chun-Lin Chen, Elizabeth Lisowski, Greg C Mitcheltree, Taracad K Venkatachalam, Douglas Erbeck, Hao Chen, Barbara Waurzyniak. Toxicity and pharmacokinetics of stampidine in mice and rats. Arzneimittel-Forschung. 2003; 53(5):357-67. doi: 10.1055/s-0031-1297120. [PMID: 12854363]
  • Chun-Lin Chen, Gengli Yu, T K Venkatachalam, Fatih M Uckun. Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats. Drug metabolism and disposition: the biological fate of chemicals. 2002 Dec; 30(12):1523-31. doi: 10.1124/dmd.30.12.1523. [PMID: 12433828]
  • Fatih M Uckun, Sanjive Qazi, Sharon Pendergrass, Elizabeth Lisowski, Barbara Waurzyniak, Chun-Lin Chen, T K Venkatachalam. In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice. Antimicrobial agents and chemotherapy. 2002 Nov; 46(11):3428-36. doi: 10.1128/aac.46.11.3428-3436.2002. [PMID: 12384347]
  • Alex V Birk, Darya Bubman, M Johan Broekman, Hugh D Robertson, Joan H F Drosopoulos, Aaron J Marcus, Hazel H Szeto. Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology. The Journal of laboratory and clinical medicine. 2002 Feb; 139(2):116-24. doi: 10.1067/mlc.2002.121334. [PMID: 11919550]
  • C Rampazzo, L Gallinaro, E Milanesi, E Frigimelica, P Reichard, V Bianchi. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease. Proceedings of the National Academy of Sciences of the United States of America. 2000 Jul; 97(15):8239-44. doi: 10.1073/pnas.97.15.8239. [PMID: 10899995]
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  • O J D'Cruz, M J Shih, S H Yiv, C L Chen, F M Uckun. Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities. Molecular human reproduction. 1999 May; 5(5):421-32. doi: 10.1093/molehr/5.5.421. [PMID: 10338365]
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  • J Balzarini, H Egberink, K Hartmann, D Cahard, T Vahlenkamp, H Thormar, E De Clercq, C McGuigan. Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324. Molecular pharmacology. 1996 Nov; 50(5):1207-13. doi: NULL. [PMID: 8913352]
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  • M Neuburger, F Rébeillé, A Jourdain, S Nakamura, R Douce. Mitochondria are a major site for folate and thymidylate synthesis in plants. The Journal of biological chemistry. 1996 Apr; 271(16):9466-72. doi: 10.1074/jbc.271.16.9466. [PMID: 8621617]
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