Novobiocin(1-) (BioDeep_00000897234)
代谢物信息卡片
Novobiocin(1-)
化学式: C31H35N2O11- (611.2241)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2[O-])NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O
InChI: InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/p-1/t23-,25+,26-,29-/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
An organic anion that is the conjugate base of novobiocin.
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jinxin Zhang, Lixia Liu, Yan Li, Yaling Huang, Senbo Xiao, Zihao Deng, Zhenming Zheng, Jieyou Li, Manfeng Liang, Guantai Xie, Xiao Chen, Yaotang Deng, Wenchong Tan, Hairou Su, Guibing Wu, Chunqing Cai, Xuemei Chen, Fei Zou. HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma.
Neoplasia (New York, N.Y.).
2023 Sep; 44(?):100935. doi:
10.1016/j.neo.2023.100935. [PMID: 37717471] - Kazushige Sasaki, Hisashi Takada, Chigusa Hayashi, Kouhei Ohya, Yuko Yamaguchi, Yoshiaki Takahashi, Masayuki Igarashi, Masakatsu Shibasaki. Synthesis of novobiocin derivatives and evaluation of their antigonococcal activity and pharmacokinetics.
Bioorganic & medicinal chemistry.
2023 09; 92(?):117381. doi:
10.1016/j.bmc.2023.117381. [PMID: 37506559] - Sameera Firdous, Showkat H Bhat, Safeena Aziz, Muneeza Jehangir, Sobiya Syeed, Zainab Iqra, Mohammad Abrar Ahmad, Shahid Rasool, Aadil Khursheed, Aabid Hussain Shalla, Arsheed A Ganaie, Manzoor A Rather. Antibacterial potential of Thymus linearis essential oil collected from Wasturwan mountain: A combination of experimental and theoretical studies involving in silico molecular docking simulation of the major compounds against Novobiocin-resistant mutant of DNA Gyrase-B.
Microbial pathogenesis.
2023 Aug; ?(?):106280. doi:
10.1016/j.micpath.2023.106280. [PMID: 37541555] - Yinghui Gao, Huanhuan Wang, Yazhuo Hu, JianHua Li, Weihao Xu, LiBo Zhao, Xiaofeng Su, Jiming Han, Tianzhi Li, Xiangqun Fang, Lin Liu. Whole-genome metagenomic analysis of the oral microbiota in patients with obstructive sleep apnea.
Sleep & breathing = Schlaf & Atmung.
2023 08; 27(4):1383-1398. doi:
10.1007/s11325-022-02732-w. [PMID: 36401059] - Mohamed Abdel-Monem El-Sakhawy. Combinational Effect of Selected Medicinal Plants and Antibiotics Against Pathogenic Bacteria.
Pakistan journal of biological sciences : PJBS.
2023 Feb; 26(3):108-118. doi:
10.3923/pjbs.2023.108.118. [PMID: 37480267] - Rongrong Li, Bin Yin, Deyu Zeng, Zhenyang Liu. A novobiocin derivative, XN4, triggers ferroptosis in gastric cancer cells via the activation of NOX4.
Pharmaceutical biology.
2022 Dec; 60(1):1449-1457. doi:
10.1080/13880209.2022.2099431. [PMID: 35938505] - Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
ACS infectious diseases.
2022 10; 8(10):2187-2197. doi:
10.1021/acsinfecdis.2c00357. [PMID: 36098580] - Jing Han, Caiyu Li, Zhi Dai, Juanhui Duan, Wen Cai, Yong Wang, Youcai Zhang. Yinzhihuang Oral Liquid Ameliorates Hyperbilirubinemia Induced by δ-Aminolevulinic Acid and Novobiocin in Neonatal Rats.
Chemistry & biodiversity.
2021 Aug; 18(8):e2100222. doi:
10.1002/cbdv.202100222. [PMID: 34085382] - Kei Suzuki, Kazuhiro Taniyama, Takao Aoyama, Yoshiaki Watanabe. Usefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Sep; 50(9):1121-1127. doi:
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Biomolecules.
2019 09; 9(10):. doi:
10.3390/biom9100522. [PMID: 31547634] - Yu-Ming M Huang, Jason Munguia, Yinglong Miao, Victor Nizet, J Andrew McCammon. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria.
Chemical biology & drug design.
2019 04; 93(4):647-652. doi:
10.1111/cbdd.13462. [PMID: 30570806] - Min Yang, Charlie Fehl, Karen V Lees, Eng-Kiat Lim, Wendy A Offen, Gideon J Davies, Dianna J Bowles, Matthew G Davidson, Stephen J Roberts, Benjamin G Davis. Functional and informatics analysis enables glycosyltransferase activity prediction.
Nature chemical biology.
2018 12; 14(12):1109-1117. doi:
10.1038/s41589-018-0154-9. [PMID: 30420693] - Fazul Nabi, Muhammad K Iqbal, Hui Zhang, Mujeeb Ur Rehman, Muhammad Shahzad, Shucheng Huang, Zhaoqing Han, Khalid Mehmood, Nisar Ahmed, Bahram Chachar, Muhammad A Arain, Jiakui Li. Clinical efficiency and safety of Hsp90 inhibitor Novobiocin in avian tibial dyschondroplasia.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):902-911. doi:
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Scientific reports.
2018 02; 8(1):3620. doi:
10.1038/s41598-018-21866-0. [PMID: 29483524] - Guoxuan Sun, Pedro Ernesto de Resende, Paul Stapleton, Martyna Kuta, Xiangtao Wang, Shozeb Haider, Min Yang. Regioselective glycosylation of novobiocin alters activity.
Carbohydrate research.
2017 Nov; 452(?):116-121. doi:
10.1016/j.carres.2017.10.011. [PMID: 29096184] - Aida Lahmar, Ahmed Bedoui, Imen Mokdad-Bzeouich, Zaineb Dhaouifi, Zahar Kalboussi, Imed Cheraif, Kamel Ghedira, Leila Chekir-Ghedira. Reversal of resistance in bacteria underlies synergistic effect of essential oils with conventional antibiotics.
Microbial pathogenesis.
2017 May; 106(?):50-59. doi:
10.1016/j.micpath.2016.10.018. [PMID: 27815129] - Lucas Buruaem Moreira, Luciane Alves Maranho, Rosa María Baena-Nogueras, Pablo Antonio Lara-Martín, Maria Laura Martín-Díaz. Effects of novobiocin and methotrexate on the benthic amphipod Ampelisca brevicornis exposed to spiked sediments.
Marine environmental research.
2016 Dec; 122(?):169-177. doi:
10.1016/j.marenvres.2016.11.003. [PMID: 27829510] - Thanyaluck Siriyong, Sasitorn Chusri, Potjanee Srimanote, Varomyalin Tipmanee, Supayang Piyawan Voravuthikunchai. Holarrhena antidysenterica Extract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-Resistant Acinetobacter baumannii.
Microbial drug resistance (Larchmont, N.Y.).
2016 Jun; 22(4):273-82. doi:
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Ecotoxicology and environmental safety.
2016 Feb; 124(?):18-31. doi:
10.1016/j.ecoenv.2015.09.031. [PMID: 26436477] - Thatyane M Nobre, Michael W Martynowycz, Konstantin Andreev, Ivan Kuzmenko, Hiroshi Nikaido, David Gidalevitz. Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin.
Biophysical journal.
2015 Dec; 109(12):2537-2545. doi:
10.1016/j.bpj.2015.10.013. [PMID: 26682812] - Mariusz Grinholc, Aleksandra Rodziewicz, Katarzyna Forys, Aleksandra Rapacka-Zdonczyk, Anna Kawiak, Anna Domachowska, Grzegorz Golunski, Christiane Wolz, Lili Mesak, Karsten Becker, Krzysztof P Bielawski. Fine-tuning recA expression in Staphylococcus aureus for antimicrobial photoinactivation: importance of photo-induced DNA damage in the photoinactivation mechanism.
Applied microbiology and biotechnology.
2015 Nov; 99(21):9161-76. doi:
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Ecotoxicology and environmental safety.
2015 Oct; 120(?):142-54. doi:
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International journal of molecular sciences.
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PloS one.
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Biochemical and biophysical research communications.
2014 Jun; 448(3):255-60. doi:
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Environmental microbiology.
2014 Jun; 16(6):1779-92. doi:
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Microbiological research.
2014 May; 169(5-6):417-24. doi:
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Marine drugs.
2014 Mar; 12(3):1495-511. doi:
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PloS one.
2014; 9(3):e92004. doi:
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Ecotoxicology and environmental safety.
2013 Nov; 97(?):47-58. doi:
10.1016/j.ecoenv.2013.07.002. [PMID: 23916015] - Niccole Carner, Zachary S Carroll, Sharon C Long. A comparison of rapid bacterial methods to U.S. EPA-approved methods for biosolids.
Water environment research : a research publication of the Water Environment Federation.
2013 Jul; 85(7):643-9. doi:
10.2175/106143013x13596524515942. [PMID: 23944146] - Pinanong Na Phatthalung, Sasitorn Chusri, Supayang P Voravuthikunchai. Thai ethnomedicinal plants as resistant modifying agents for combating Acinetobacter baumannii infections.
BMC complementary and alternative medicine.
2012 Apr; 12(?):56. doi:
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Letters in applied microbiology.
2012 Mar; 54(3):247-54. doi:
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Plant signaling & behavior.
2011 Mar; 6(3):327-9. doi:
10.4161/psb.6.3.13355. [PMID: 21336027] - María González, María Jose Gude, Cristina Seral, Maria Pilar Abad, Sonia Algarate, F Javier Castillo. [Comparasion of two methods for recovery of Aeromonas spp. in feces from agar CIN (Cefsulodin-Irgasan-Novobiocin)].
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.
2010 Dec; 23(4):217-8. doi:
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Journal of bacteriology.
2010 Sep; 192(18):4776-85. doi:
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Biological chemistry.
2010 Sep; 391(9):1067-77. doi:
10.1515/bc.2010.102. [PMID: 20536386] - Violeta Rodríguez-Cerrato, Gema Del Prado, Lorena Huelves, Plínio Naves, Vicente Ruiz, Ernesto García, Carmen Ponte, Francisco Soriano. Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta-lactam-susceptible and highly resistant pneumococci.
International journal of antimicrobial agents.
2010 Jun; 35(6):544-9. doi:
10.1016/j.ijantimicag.2010.02.007. [PMID: 20303716] - Jeffrey J Lin, Charles S Hemenway. Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.
The Journal of biological chemistry.
2010 Apr; 285(16):11966-73. doi:
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The Journal of antimicrobial chemotherapy.
2009 Dec; 64(6):1203-11. doi:
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Molecular bioSystems.
2009 Dec; 5(12):1904-12. doi:
10.1039/b903022k. [PMID: 19763333] - A Y Abaut, F Chevanne, P Le Corre. Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.
International journal of pharmaceutics.
2009 Aug; 378(1-2):80-5. doi:
10.1016/j.ijpharm.2009.05.068. [PMID: 19508886] - Peng Duan, Guofeng You. Novobiocin is a potent inhibitor for human organic anion transporters.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Jun; 37(6):1203-10. doi:
10.1124/dmd.109.026880. [PMID: 19282394] - Keri A Barksdale, Gautam N Bijur. The basal flux of Akt in the mitochondria is mediated by heat shock protein 90.
Journal of neurochemistry.
2009 Mar; 108(5):1289-99. doi:
10.1111/j.1471-4159.2009.05878.x. [PMID: 19187436] - Koichi Inoue, Sachiko Nitta, Tomoaki Hino, Hisao Oka. LC-MS/MS and centrifugal ultrafiltration method for the determination of novobiocin in chicken, fish tissues, milk and human serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Journal of applied microbiology.
2007 Sep; 103(3):650-6. doi:
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FEMS microbiology letters.
2006 Oct; 263(2):163-8. doi:
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2006 Jun; 143(2):179-86. doi:
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Biochemical Society transactions.
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Cellular and molecular biology (Noisy-le-Grand, France).
2004 Jul; 50(5):605-12. doi:
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International journal of cancer.
2004 Jan; 108(1):146-51. doi:
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Journal of microbiological methods.
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Infection and immunity.
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Journal of mass spectrometry : JMS.
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The Plant cell.
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Cellular microbiology.
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Molecular microbiology.
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Infection and immunity.
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Glycoconjugate journal.
2001 Oct; 18(10):779-87. doi:
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The Journal of antibiotics.
2001 May; 54(5):441-7. doi:
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Cancer journal (Sudbury, Mass.).
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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2000; 6(3A):335-43. doi:
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