Novobiocin(1-) (BioDeep_00000897234)
代谢物信息卡片
Novobiocin(1-)
化学式: C31H35N2O11- (611.224074)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2[O-])NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O
InChI: InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/p-1/t23-,25+,26-,29-/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
An organic anion that is the conjugate base of novobiocin.
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinxin Zhang, Lixia Liu, Yan Li, Yaling Huang, Senbo Xiao, Zihao Deng, Zhenming Zheng, Jieyou Li, Manfeng Liang, Guantai Xie, Xiao Chen, Yaotang Deng, Wenchong Tan, Hairou Su, Guibing Wu, Chunqing Cai, Xuemei Chen, Fei Zou. HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma.
Neoplasia (New York, N.Y.).
2023 Sep; 44(?):100935. doi:
10.1016/j.neo.2023.100935. [PMID: 37717471] - Kazushige Sasaki, Hisashi Takada, Chigusa Hayashi, Kouhei Ohya, Yuko Yamaguchi, Yoshiaki Takahashi, Masayuki Igarashi, Masakatsu Shibasaki. Synthesis of novobiocin derivatives and evaluation of their antigonococcal activity and pharmacokinetics.
Bioorganic & medicinal chemistry.
2023 09; 92(?):117381. doi:
10.1016/j.bmc.2023.117381. [PMID: 37506559] - Sameera Firdous, Showkat H Bhat, Safeena Aziz, Muneeza Jehangir, Sobiya Syeed, Zainab Iqra, Mohammad Abrar Ahmad, Shahid Rasool, Aadil Khursheed, Aabid Hussain Shalla, Arsheed A Ganaie, Manzoor A Rather. Antibacterial potential of Thymus linearis essential oil collected from Wasturwan mountain: A combination of experimental and theoretical studies involving in silico molecular docking simulation of the major compounds against Novobiocin-resistant mutant of DNA Gyrase-B.
Microbial pathogenesis.
2023 Aug; ?(?):106280. doi:
10.1016/j.micpath.2023.106280. [PMID: 37541555] - Yinghui Gao, Huanhuan Wang, Yazhuo Hu, JianHua Li, Weihao Xu, LiBo Zhao, Xiaofeng Su, Jiming Han, Tianzhi Li, Xiangqun Fang, Lin Liu. Whole-genome metagenomic analysis of the oral microbiota in patients with obstructive sleep apnea.
Sleep & breathing = Schlaf & Atmung.
2023 08; 27(4):1383-1398. doi:
10.1007/s11325-022-02732-w. [PMID: 36401059] - Mohamed Abdel-Monem El-Sakhawy. Combinational Effect of Selected Medicinal Plants and Antibiotics Against Pathogenic Bacteria.
Pakistan journal of biological sciences : PJBS.
2023 Feb; 26(3):108-118. doi:
10.3923/pjbs.2023.108.118. [PMID: 37480267] - Rongrong Li, Bin Yin, Deyu Zeng, Zhenyang Liu. A novobiocin derivative, XN4, triggers ferroptosis in gastric cancer cells via the activation of NOX4.
Pharmaceutical biology.
2022 Dec; 60(1):1449-1457. doi:
10.1080/13880209.2022.2099431. [PMID: 35938505] - Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
ACS infectious diseases.
2022 10; 8(10):2187-2197. doi:
10.1021/acsinfecdis.2c00357. [PMID: 36098580] - Jing Han, Caiyu Li, Zhi Dai, Juanhui Duan, Wen Cai, Yong Wang, Youcai Zhang. Yinzhihuang Oral Liquid Ameliorates Hyperbilirubinemia Induced by δ-Aminolevulinic Acid and Novobiocin in Neonatal Rats.
Chemistry & biodiversity.
2021 Aug; 18(8):e2100222. doi:
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2020 Sep; 50(9):1121-1127. doi:
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2019 09; 9(10):. doi:
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Nature chemical biology.
2018 12; 14(12):1109-1117. doi:
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2018 Dec; 41(6):902-911. doi:
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Scientific reports.
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Carbohydrate research.
2017 Nov; 452(?):116-121. doi:
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Microbial pathogenesis.
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Marine environmental research.
2016 Dec; 122(?):169-177. doi:
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Biophysical journal.
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Ecotoxicology and environmental safety.
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Ecotoxicology and environmental safety.
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BMC complementary and alternative medicine.
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Plant signaling & behavior.
2011 Mar; 6(3):327-9. doi:
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Biological chemistry.
2010 Sep; 391(9):1067-77. doi:
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International journal of antimicrobial agents.
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Molecular bioSystems.
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International journal of pharmaceutics.
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Drug metabolism and disposition: the biological fate of chemicals.
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Journal of neurochemistry.
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