NADPH(4-) (BioDeep_00000897199)
Metabolite Card
NADPH(4-)
Formula: C21H26N7O17P3-4 (741.0598)
Chinese Names:
Spectrum Hits:
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Molecular Structure
SMILES: C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O
InChI: InChI=1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/p-4/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
Cross Reference
Classification Terms
Related Pathways
Reactome(127)
- Metabolism
- Biological oxidations
- Aflatoxin activation and detoxification
- Phase I - Functionalization of compounds
- Metabolism of vitamins and cofactors
- Metabolism of fat-soluble vitamins
- Retinoid metabolism and transport
- Visual phototransduction
- Sensory Perception
- Metabolism of proteins
- Post-translational protein modification
- Disease
- Phase II - Conjugation of compounds
- Amino acid and derivative metabolism
- Diseases of signal transduction by growth factor receptors and second messengers
- FLT3 signaling in disease
- Drug ADME
- Asparagine N-linked glycosylation
- Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
- Synthesis of substrates in N-glycan biosythesis
- GDP-fucose biosynthesis
- Metabolism of lipids
- Metabolism of steroids
- Cholesterol biosynthesis
- Metabolism of cofactors
- Synthesis of Dolichyl-phosphate
- Diseases of metabolism
- Diseases of glycosylation
- Diseases associated with glycosylation precursor biosynthesis
- Transport of small molecules
- Urea cycle
- Cytochrome P450 - arranged by substrate type
- Signaling Pathways
- Signaling by Rho GTPases
- RHO GTPase Effectors
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3
- Immune System
- Innate Immune System
- ROS and RNS production in phagocytes
- Nucleotide metabolism
- Nucleotide catabolism
- Biosynthesis of specialized proresolving mediators (SPMs)
- Biosynthesis of EPA-derived SPMs
- Biosynthesis of E-series 18(R)-resolvins
- Fatty acid metabolism
- Metabolism of water-soluble vitamins and cofactors
- Tryptophan catabolism
- Bile acid and bile salt metabolism
- Synthesis of bile acids and bile salts
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Endogenous sterols
- Sterols are 12-hydroxylated by CYP8B1
- Metabolism of nitric oxide: NOS3 activation and regulation
- eNOS activation
- Signaling by Receptor Tyrosine Kinases
- Signaling by VEGF
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate NADPH Oxidases
- Cellular responses to stimuli
- Cellular responses to stress
- Detoxification of Reactive Oxygen Species
- Infectious disease
- Latent infection - Other responses of Mtb to phagocytosis
- Gene expression (Transcription)
- RNA Polymerase II Transcription
- Generic Transcription Pathway
- Transcriptional Regulation by TP53
- TP53 Regulates Transcription of Cell Death Genes
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- Infection with Mycobacterium tuberculosis
- Leishmania infection
- Killing mechanisms
- WNT5:FZD7-mediated leishmania damping
- Cellular response to chemical stress
- Cytoprotection by HMOX1
- Bacterial Infection Pathways
- Parasitic Infection Pathways
- Arachidonic acid metabolism
- Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
- Selenoamino acid metabolism
- Biosynthesis of electrophilic -3 PUFA oxo-derivatives
- Iron uptake and transport
- Carbohydrate metabolism
- Fatty acyl-CoA biosynthesis
- The citric acid (TCA) cycle and respiratory electron transport
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Pentose phosphate pathway
- Diseases of carbohydrate metabolism
- Sulfur amino acid metabolism
- Degradation of cysteine and homocysteine
- Porphyrin metabolism
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Hemostasis
- Sphingolipid metabolism
- Glutathione conjugation
- Defects in vitamin and cofactor metabolism
- APAP ADME
- Vitamin D (calciferol) metabolism
- Vitamins
- Metabolic disorders of biological oxidation enzymes
- Defective CYP27B1 causes VDDR1A
- Metabolism of amine-derived hormones
- Thyroxine biosynthesis
- Sphingolipid de novo biosynthesis
- Lipid metabolism
- Platelet homeostasis
- Nitric oxide stimulates guanylate cyclase
- VEGFR2 mediated vascular permeability
- Signaling by Nuclear Receptors
- ESR-mediated signaling
- Extra-nuclear estrogen signaling
- Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
- Cytosolic iron-sulfur cluster assembly
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Synthesis of bile acids and bile salts via 24-hydroxycholesterol
- Metabolism of steroid hormones
- Pregnenolone biosynthesis
- Glucocorticoid biosynthesis
- Mineralocorticoid biosynthesis
- Estrogen biosynthesis
- Metabolism of folate and pterines
- NADPH regeneration
- Heme degradation
- Eicosanoids
- Signaling by Retinoic Acid
- RA biosynthesis pathway
- Glutamate and glutamine metabolism
BioCyc(319)
- superpathway of pyrimidine ribonucleosides salvage
- superpathway of pyrimidine ribonucleosides degradation
- 4-hydroxyacetophenone degradation
- 4-nitrophenol degradation I
- alkylnitronates degradation
- O-antigen building blocks biosynthesis (E. coli)
- superpathway of L-phenylalanine biosynthesis
- patulin biosynthesis
- acetate and ATP formation from acetyl-CoA I
- superpathway of N-acetylneuraminate degradation
- superpathway of L-methionine biosynthesis (transsulfuration)
- superpathway of L-homoserine and L-methionine biosynthesis
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I
- superpathway of aromatic amino acid biosynthesis
- chorismate biosynthesis I
- chorismate biosynthesis from 3-dehydroquinate
- superpathway of bacteriochlorophyll a biosynthesis
- superpathway of L-tyrosine biosynthesis
- superpathway of hyoscyamine and scopolamine biosynthesis
- superpathway of chorismate metabolism
- gallate degradation III (anaerobic)
- aspartate superpathway
- superpathway of S-adenosyl-L-methionine biosynthesis
- superpathway of L-tryptophan biosynthesis
- gallate biosynthesis
- hyoscyamine and scopolamine biosynthesis
- kauralexin biosynthesis
- oryzalide A biosynthesis
- Amaryllidacea alkaloids biosynthesis
- plant sterol biosynthesis
- spinosyn A biosynthesis
- bacteriochlorophyll e biosynthesis
- superpathway of tryptophan utilization
- superpathway of diterpene resin acids biosynthesis
- superpathway of C28 brassinosteroid biosynthesis
- brassinosteroid biosynthesis I
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
- coumarin metabolism (to melilotic acid)
- protocatechuate degradation I (meta-cleavage pathway)
- glycolysis IV (plant cytosol)
- trans-4-hydroxy-L-proline degradation II
- bacteriochlorophyll c biosynthesis
- bacteriochlorophyll d biosynthesis
- pyrimidine deoxyribonucleotides de novo biosynthesis III
- L-lysine biosynthesis II
- L-lysine biosynthesis I
- glucosinolate biosynthesis from hexahomomethionine
- canavanine degradation
- nicotine degradation I (pyridine pathway)
- superpathway of arginine and polyamine biosynthesis
- clavulanate biosynthesis
- superpathway of L-citrulline metabolism
- L-citrulline biosynthesis
- L-Nδ-acetylornithine biosynthesis
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation
- superpathway of L-arginine and L-ornithine degradation
- superpathway of citrulline metabolism
- citrulline biosynthesis
- L-Nδ-acetylornithine biosynthesis
- superpathway of aromatic compound degradation
- nicotine degradation II
- formaldehyde oxidation I
- phosphopantothenate biosynthesis I
- morphine biosynthesis
- pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)
- superpathway of trimethylamine degradation
- trimethylamine degradation
- propane degradation II
- superpathway of coenzyme A biosynthesis I (bacteria)
- nicotine degradation IV
- ectoine biosynthesis
- formaldehyde assimilation I (serine pathway)
- dimethyl sulfide degradation II (oxidation)
- formaldehyde oxidation VII (THF pathway)
- colchicine biosynthesis
- formaldehyde oxidation V (tetrahydrofolate pathway)
- matairesinol biosynthesis
- justicidin B biosynthesis
- glucosinolate biosynthesis from dihomomethionine
- polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)
- phenylmercury acetate degradation
- superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)
- aurachin A, B, C and D biosynthesis
- L-arabinose degradation II
- superpathway of pentose and pentitol degradation
- pentachlorophenol degradation
- hentriaconta-3,6,9,12,15,19,22,25,28-nonaene biosynthesis
- anhydromuropeptides recycling I
- superpathway of pterocarpan biosynthesis (via daidzein)
- ubiquinol-10 biosynthesis
- ubiquinol-10 biosynthesis (eukaryotic)
- ubiquinol-10 biosynthesis (prokaryotic)
- superpathway of nicotine biosynthesis
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
- superpathay of heme b biosynthesis from glutamate
- TCA cycle I (prokaryotic)
- curcumin degradation
- superpathway of microbial D-galacturonate and D-glucuronate degradation
- mixed acid fermentation
- nicotine degradation II (pyrrolidine pathway)
- 1,3-propanediol biosynthesis (engineered)
- glycocholate metabolism (bacteria)
- superpathway of glyoxylate bypass and TCA
- tetrapyrrole biosynthesis I (from glutamate)
- superpathway of proto- and siroheme biosynthesis
- phenolphthiocerol biosynthesis
- 6-methylpretetramide biosynthesis
- superpathway of tetracycline and oxytetracycline biosynthesis
- bacteriochlorophyll a biosynthesis
- superpathway of testosterone and androsterone degradation
- 2,3-cis-flavanols biosynthesis
- plant sterol biosynthesis II
- bacteriochlorophyll b biosynthesis
- 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent)
- 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)
- heme degradation V
- superpathway of carotenoid biosynthesis in plants
- trans-lycopene biosynthesis II (oxygenic phototrophs and green sulfur bacteria)
- superpathway of carotenoid biosynthesis
- jasmonic acid biosynthesis
- superpathway of L-lysine degradation
- tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis and salvage
- N10-formyl-tetrahydrofolate biosynthesis
- superpathway of ergotamine biosynthesis
- ergotamine biosynthesis
- isopropanol biosynthesis (engineered)
- acetone degradation III (to propane-1,2-diol)
- acetone degradation I (to methylglyoxal)
- acetone degradation II (to acetoacetate)
- linear furanocoumarin biosynthesis
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation
- superpathway of Clostridium acetobutylicum solventogenic fermentation
- propane degradation I
- simple coumarins biosynthesis
- D-galactose degradation IV
- galactose degradation IV
- 2,4-dichlorophenoxyacetate degradation
- (-)-maackiain biosynthesis
- tetrahydroxyxanthone biosynthesis (from benzoate)
- tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)
- plumbagin biosynthesis
- superpathway of pterocarpan biosynthesis (via formononetin)
- superpathway of tetrahydroxyxanthone biosynthesis
- superpathway of formononetin derivative biosynthesis
- superpathway of glycolysis and the Entner-Doudoroff pathway
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
- Entner-Doudoroff pathway I
- pentose phosphate pathway
- NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)
- superpathway NAD/NADP - NADH/NADPH interconversion (yeast)
- gluconeogenesis I
- L-arginine biosynthesis II (acetyl cycle)
- superpathway NAD/NADP - NADH/NADPH interconversion
- NAD/NADP-NADH/NADPH cytosolic interconversion
- 1,8-cineole degradation
- oleandomycin biosynthesis
- D-galactose degradation I (Leloir pathway)
- menthol biosynthesis
- phenol degradation I (aerobic)
- diphenyl ethers degradation
- glucosinolate biosynthesis from pentahomomethionine
- juvenile hormone III biosynthesis I
- juvenile hormone III biosynthesis II
- brassinosteroid biosynthesis II
- glutamate and glutamine biosynthesis
- tryptophan degradation III (eukaryotic)
- uracil degradation II (reductive)
- arginine biosynthesis IV
- purine nucleotides degradation IV (anaerobic)
- folate transformations II (plants)
- tetrapyrrole biosynthesis I
- superpathway of glutamate biosynthesis
- leucine degradation IV
- isoleucine degradation III
- suberin biosynthesis
- heme biosynthesis I
- TCA cycle VI (obligate autotrophs)
- tryptophan degradation X (mammalian, via tryptamine)
- glutamine biosynthesis III
- tetracycline and oxytetracycline biosynthesis
- Methanobacterium thermoautotrophicum biosynthetic metabolism
- 2,4,6-trinitrophenol and 2,4-dinitrophenol degradation
- superpathway of ergosterol biosynthesis I
- ergosterol biosynthesis I
- superpathway of ergosterol biosynthesis
- ergosterol biosynthesis
- superpathway of cholesterol degradation II (cholesterol dehydrogenase)
- superpathway of cholesterol degradation I (cholesterol oxidase)
- limonene degradation II (L-limonene)
- L-lysine degradation IV
- Spodoptera littoralis pheromone biosynthesis
- phenylpropanoid biosynthesis
- lysine degradation I (saccharopine pathway)
- secologanin and strictosidine biosynthesis
- fumigaclavine biosynthesis
- UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)
- UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)
- 2-nitrobenzoate degradation I
- ammonia assimilation cycle III
- ethylmalonyl-CoA pathway
- ethylene glycol biosynthesis (engineered)
- methylaspartate cycle
- colanic acid building blocks biosynthesis
- suberin monomers biosynthesis
- L-glutamine degradation II
- crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)
- TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
- (4S)-carvone biosynthesis
- geraniol and geranial biosynthesis
- Entner-Doudoroff pathway II (non-phosphorylative)
- L-lysine degradation XI (mammalian)
- superpathway of Clostridium acetobutylicum acidogenic fermentation
- grixazone biosynthesis
- L-glutamate and L-glutamine biosynthesis
- L-carnitine degradation III
- D-galactose detoxification
- reductive TCA cycle I
- 4-hydroxymandelate degradation
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate
- 4-hydroxyphenylacetate degradation
- purine nucleobases degradation II (anaerobic)
- superpathway of aromatic compound degradation via 3-oxoadipate
- UDP-sugars interconversion
- norspermidine biosynthesis
- peptidoglycan biosynthesis I (meso-diaminopimelate containing)
- peptidoglycan biosynthesis II (staphylococci)
- superpathway of polyamine biosynthesis III
- superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP)
- taxadiene biosynthesis (engineered)
- superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis
- superpathway of rifamycin B biosynthesis
- novobiocin biosynthesis
- L-valine biosynthesis
- superpathway of CDP-glucose-derived O-antigen building blocks biosynthesis
- phosphinothricin tripeptide biosynthesis
- L-arginine biosynthesis I (via L-ornithine)
- 2-nitrophenol degradation
- artemisinin biosynthesis
- L-rhamnose degradation II
- L-ornithine biosynthesis I
- androstenedione degradation
- Entner-Doudoroff pathway III (semi-phosphorylative)
- mandelate degradation to acetyl-CoA
- methylerythritol phosphate pathway I
- methylerythritol phosphate pathway II
- ubiquinol-8 biosynthesis (prokaryotic)
- L-ascorbate biosynthesis IV
- superpathway of phylloquinol biosynthesis
- superpathway of ubiquinol-8 biosynthesis (prokaryotic)
- superpathway of L-threonine metabolism
- sphingolipid biosynthesis (plants)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
- erythro-tetrahydrobiopterin biosynthesis I
- zymosterol biosynthesis
- cholesterol biosynthesis I
- cholesterol biosynthesis III (via desmosterol)
- superpathway of cholesterol biosynthesis
- epoxypseudoisoeugenol-2-methylbutanoate biosynthesis
- (+)-pisatin biosynthesis
- pyrrolnitrin biosynthesis
- ethanolamine utilization
- versicolorin B biosynthesis
- 1,2-propanediol biosynthesis from lactate (engineered)
- superpathway of pyrimidine nucleobases salvage
- 2,4-xylenol degradation to protocatechuate
- t-anethole biosynthesis
- hyperxanthone E biosynthesis
- phylloquinol biosynthesis
- ascorbate glutathione cycle
- superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
- polyacyltrehalose biosynthesis
- resorcinol degradation
- citrulline-nitric oxide cycle
- nitric oxide biosynthesis II (mammals)
- nitric oxide biosynthesis I (plants)
- L-citrulline-nitric oxide cycle
- nitric oxide biosynthesis (plants)
- coelimycin P1 biosynthesis
- salicortin biosynthesis
- benzoate biosynthesis I (CoA-dependent, β-oxidative)
- stipitatate biosynthesis
- pinitol biosynthesis II
- cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
- bisphenol A degradation
- isoprene biosynthesis II (engineered)
- isoprene biosynthesis I
- γ-coniciene and coniine biosynthesis
- 7-dehydroporiferasterol biosynthesis
- pyruvate fermentation to isobutanol (engineered)
- nylon-6 oligomer degradation
- tetracenomycin C biosynthesis
- L-glutamate degradation VII (to butanoate)
- L-ascorbate degradation IV
- superpathway of erythromycin biosynthesis
- superpathway of megalomicin A biosynthesis
- erythromycin D biosynthesis
- superpathway of erythromycin biosynthesis (without sugar biosynthesis)
- phaseollin biosynthesis
- detoxification of reactive carbonyls in chloroplasts
- neurosporaxanthin biosynthesis
- superpathway of seleno-compound metabolism
- L-homoserine biosynthesis
- superpathway of L-threonine biosynthesis
- superpathway of L-isoleucine biosynthesis I
- 2,3-trans-flavanols biosynthesis
- cardenolide biosynthesis
- vestitol and sativan biosynthesis
- polybrominated dihydroxylated diphenyl ethers biosynthesis
- spongiadioxin C biosynthesis
- ajmaline and sarpagine biosynthesis
- dTDP-L-daunosamine biosynthesis
- leucopelargonidin and leucocyanidin biosynthesis
- glucosinolate biosynthesis from tetrahomomethionine
- androgen biosynthesis
- superpathway of gibberellin biosynthesis
- uracil degradation I (reductive)
PlantCyc(98)
- superpathway of hyoscyamine and scopolamine biosynthesis
- hyoscyamine and scopolamine biosynthesis
- superpathway of isoflavonoids (via naringenin)
- oryzalide A biosynthesis
- kauralexin biosynthesis
- superpathway of diterpene resin acids biosynthesis
- brassinolide biosynthesis II
- brassinolide biosynthesis I
- brassinosteroid biosynthesis I
- superpathway of C28 brassinosteroid biosynthesis
- glycolysis IV (plant cytosol)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
- coumarin metabolism (to melilotic acid)
- leucodelphinidin biosynthesis
- luteolinidin 5-O-glucoside biosynthesis
- leucopelargonidin and leucocyanidin biosynthesis
- superpathway of L-citrulline metabolism
- canavanine degradation
- L-citrulline biosynthesis
- L-Nδ-acetylornithine biosynthesis
- superpathway of hyoscyamine (atropine) and scopolamine biosynthesis
- formaldehyde oxidation VII (THF pathway)
- colchicine biosynthesis
- morphine biosynthesis
- superpathway of pterocarpan biosynthesis (via daidzein)
- polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)
- superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)
- ajmaline and sarpagine biosynthesis
- phytosterol biosynthesis (plants)
- NAD/NADH phosphorylation and dephosphorylation
- superpathway of gibberellin biosynthesis
- gibberellin biosynthesis II (early C-3 hydroxylation)
- ubiquinol-10 biosynthesis (eukaryotic)
- ubiquinol-10 biosynthesis (late decarboxylation)
- superpathway of proto- and siroheme biosynthesis
- superpathway of nicotine biosynthesis
- 2,3-cis-flavanols biosynthesis
- 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)
- superpathway of carotenoid biosynthesis in plants
- vindoline, vindorosine and vinblastine biosynthesis
- capsaicin biosynthesis
- linear furanocoumarin biosynthesis
- tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)
- superpathway of tetrahydroxyxanthone biosynthesis
- (-)-maackiain biosynthesis
- superpathway of pterocarpan biosynthesis (via formononetin)
- plumbagin biosynthesis
- tetrahydroxyxanthone biosynthesis (from benzoate)
- superpathway of formononetin derivative biosynthesis
- calystegine biosynthesis
- tropane alkaloids biosynthesis
- menthol biosynthesis
- glucosinolate biosynthesis from pentahomomethionine
- juvenile hormone III biosynthesis I
- L-lysine degradation I
- superpathway of photosynthetic hydrogen production
- photosynthesis light reactions
- brassinosteroid biosynthesis II
- L-glutamate biosynthesis I
- matairesinol biosynthesis
- phenylpropanoid biosynthesis
- superpathway of phylloquinol biosynthesis
- (4S)-carvone biosynthesis
- suberin monomers biosynthesis
- geraniol and geranial biosynthesis
- sphingolipid biosynthesis (plants)
- artemisinin and arteannuin B biosynthesis
- chorismate biosynthesis I
- cholesterol biosynthesis I
- zymosterol biosynthesis
- superpathway of seleno-compound metabolism
- selenate reduction
- epoxypseudoisoeugenol-2-methylbutanoate biosynthesis
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II
- t-anethole biosynthesis
- hyperxanthone E biosynthesis
- ascorbate glutathione cycle
- (-)-glycinol biosynthesis
- jasmonic acid biosynthesis
- Amaryllidacea alkaloids biosynthesis
- pinitol biosynthesis II
- L-ascorbate biosynthesis VI (plants, myo-inositol pathway)
- cholesterol biosynthesis (plants)
- cholesterol biosynthesis (plants, early side-chain reductase)
- isoprene biosynthesis II (engineered)
- isoprene biosynthesis I
- L-ascorbate degradation IV
- phylloquinol biosynthesis
- detoxification of reactive carbonyls in chloroplasts
- botryococcenes and methylated squalene biosynthesis
- justicidin B biosynthesis
- 2,3-trans-flavanols biosynthesis
- proanthocyanidins biosynthesis from flavanols
- cardenolide biosynthesis
- vestitol and sativan biosynthesis
- glucosinolate biosynthesis from tetrahomomethionine
- fatty acid β-oxidation IV (unsaturated, even number)
Biological Process
9434 related biological process reactions.
Reactome(1479)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Glutathione conjugation:
CysGly + H2O ⟶ Gly + L-Cys - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Biological oxidations:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Biological oxidations:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
PAPS + beta-estradiol ⟶ E2-SO4 + PAP - Glutathione conjugation:
CysGly + H2O ⟶ Gly + L-Cys - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Glutathione conjugation:
GSH + H2O ⟶ CysGly + L-Glu - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
3-oxopristanoyl-CoA + CoA-SH ⟶ 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H2O + lysoPC ⟶ GPCho + LCFA(-) - Fatty acid metabolism:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Fatty acyl-CoA biosynthesis:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Fatty acid metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Fatty acyl-CoA biosynthesis:
ATP + Ac-CoA + HCO3- ⟶ ADP + Mal-CoA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
AA + ATP + CoA-SH ⟶ AA-CoA + AMP + H2O + PPi - Metabolism of lipids:
ACA + H+ + NADH ⟶ NAD + bHBA - Fatty acid metabolism:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
AA + ATP + CoA-SH ⟶ AA-CoA + AMP + H2O + PPi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Endogenous sterols:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of steroids:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
B12r + NADH ⟶ B12s + H+ + NAD - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Metabolism of folate and pterines:
FOLA + Q0VCN9 ⟶ FOLR2:FOLA - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Metabolism of folate and pterines:
A0A5F4C041 + FOLA ⟶ FOLR2:FOLA - Metabolism of folate and pterines:
FOLA + folr ⟶ FOLR2:FOLA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Metabolism of folate and pterines:
FOLA + FOLR2_HUMAN ⟶ FOLR2:FOLA - Metabolism of folate and pterines:
FOLA + Folr2 ⟶ FOLR2:FOLA - Metabolism of folate and pterines:
D4A4S5 + FOLA ⟶ FOLR2:FOLA - Metabolism of folate and pterines:
A0A5G2QLX9 + FOLA ⟶ FOLR2:FOLA - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Plasmalogen biosynthesis:
GO3P + H+ + TPNH ⟶ HXDG3P + TPN - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
GO3P + H+ + TPNH ⟶ HXDG3P + TPN - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
GO3P + H+ + TPNH ⟶ HXDG3P + TPN - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Plasmalogen biosynthesis:
HXOL + Palmitoylglycerone phosphate ⟶ GO3P + PALM - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Cholesterol biosynthesis:
7-dehydroCHOL + H+ + TPNH ⟶ CHOL + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + STAR - Metabolism of steroid hormones:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Pregnenolone biosynthesis:
H+ + ISCAL + TPNH ⟶ MePeOH + TPN - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + STAR - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + star - Metabolism of steroids:
H+ + TPNH + estrone ⟶ EST17b + TPN - Metabolism of steroid hormones:
H+ + TPNH + estrone ⟶ EST17b + TPN - Pregnenolone biosynthesis:
H+ + ISCAL + TPNH ⟶ MePeOH + TPN - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of steroid hormones:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Pregnenolone biosynthesis:
H+ + ISCAL + TPNH ⟶ MePeOH + TPN - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + STAR - Metabolism of steroid hormones:
11-deoxycortisol ⟶ 11DCORT - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + STAR - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + Star - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + Star - Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroid hormones:
EST17b + TPN ⟶ H+ + TPNH + estrone - Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroid hormones:
H+ + TPNH + estrone ⟶ EST17b + TPN - Pregnenolone biosynthesis:
H+ + ISCAL + TPNH ⟶ MePeOH + TPN - Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Pregnenolone biosynthesis:
H+ + ISCAL + TPNH ⟶ MePeOH + TPN - Metabolism of steroid hormones:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Pregnenolone biosynthesis:
STAR:CHOL ⟶ CHOL + STAR - Pregnenolone biosynthesis:
H+ + ISCAL + TPNH ⟶ MePeOH + TPN - Signaling Pathways:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
E2QW22 + E2RPT1 + ESR1:ER:PGR:P4 + F6UTY3 + J9P0C0 ⟶ ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + F8W2D1 + HSP90:HSP90 + Pi + Q7SZQ8 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
E9QD41 + atRA ⟶ SUMO-CRABP1:atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Retinoic Acid:
H+ + TPNH + atRAL ⟶ TPN + atROL - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Q9VH95 + Q9VL78 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
atRA + fabp ⟶ SUMO-CRABP1:atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
CRABP1 + atRA ⟶ SUMO-CRABP1:atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
11cROL + TPN ⟶ 11cRAL + H+ + TPNH - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Immunophilin FKBP52 + Pi + cPGES - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + Fkbp4 + HSP90:HSP90 + Pi + Q9R0Q7 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Ptges3 + Q9QVC8 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Visual phototransduction:
H+ + TPNH + atRAL ⟶ TPN + atROL - The canonical retinoid cycle in rods (twilight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Retinoic Acid:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - RA biosynthesis pathway:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Retinoic Acid:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - RA biosynthesis pathway:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The retinoid cycle in cones (daylight vision):
F6T9Q4 + atROL ⟶ RLBP1:atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ A0A310SUH5 + ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Q5U4Z0 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
H+ + TPNH + atRAL ⟶ TPN + atROL - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 - The canonical retinoid cycle in rods (twilight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Metabolism of fat-soluble vitamins:
TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism of fat-soluble vitamins:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism of fat-soluble vitamins:
Homologues of TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Metabolism of fat-soluble vitamins:
TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
BIL:ALB + O2.- ⟶ ALB + BV - Cellular responses to stress:
BIL:ALB + O2.- ⟶ ALB + BV - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme degradation:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Iron uptake and transport:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Porphyrin metabolism:
BV + TPNH ⟶ BIL + TPN - Heme degradation:
BV + TPNH ⟶ BIL + TPN - Cellular responses to stimuli:
BV + TPNH ⟶ BIL + TPN - Cellular responses to stress:
BV + TPNH ⟶ BIL + TPN - Transport of small molecules:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Iron uptake and transport:
CIT ⟶ ISCIT - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
BV + TPNH ⟶ BIL + TPN - Cytoprotection by HMOX1:
BV + TPNH ⟶ BIL + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cytoprotection by HMOX1:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
BIL:ALB + O2.- ⟶ ALB + BV - Cytoprotection by HMOX1:
BIL:ALB + O2.- ⟶ ALB + BV - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
25(S) THCA-CoA + Oxygen ⟶ H2O2 + THCA-CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
H2O + choloyl-CoA ⟶ CoA-SH + cholate - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
4CHOL7a,12aDONE + H+ + TPNH ⟶ 5beta-cholesten-7alpha, 12alpha-diol-3-one + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Androgen biosynthesis:
ANDST + H+ + TPNH ⟶ TEST + TPN - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Cytochrome P450 - arranged by substrate type:
ANDST + H+ + Oxygen + TPNH ⟶ H2O + HCOOH + TPN + estrone - Endogenous sterols:
ANDST + H+ + Oxygen + TPNH ⟶ H2O + HCOOH + TPN + estrone - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Androgen biosynthesis:
ANDST + H+ + TPNH ⟶ TEST + TPN - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Cytochrome P450 - arranged by substrate type:
ANDST + H+ + Oxygen + TPNH ⟶ H2O + HCOOH + TPN + estrone - Endogenous sterols:
ANDST + H+ + Oxygen + TPNH ⟶ H2O + HCOOH + TPN + estrone - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Metabolism of steroids:
H+ + TEST + TPNH ⟶ DHTEST + TPN - Metabolism of steroid hormones:
H+ + TEST + TPNH ⟶ DHTEST + TPN - Androgen biosynthesis:
H+ + TEST + TPNH ⟶ DHTEST + TPN - Androgen biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 17aHPROG + H2O + TPN - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Androgen biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 17aHPROG + H2O + TPN - Estrogen biosynthesis:
EST17b + TPN ⟶ H+ + TPNH + estrone - Androgen biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 17aHPROG + H2O + TPN - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN - Cholesterol biosynthesis:
H+ + LAN + Oxygen + TPNH ⟶ 4,4DMCHtOL + H2O + HCOOH + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Cholesterol biosynthesis:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Gene expression (Transcription):
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - RNA Polymerase II Transcription:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Generic Transcription Pathway:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Gene expression (Transcription):
H2O2 + Homologues of TXN ⟶ H2O + Homologues of 2xHC-TXN - RNA Polymerase II Transcription:
H2O2 + Homologues of TXN ⟶ H2O + Homologues of 2xHC-TXN - Generic Transcription Pathway:
H2O2 + Homologues of TXN ⟶ H2O + Homologues of 2xHC-TXN - Transcriptional Regulation by TP53:
H2O2 + Homologues of TXN ⟶ H2O + Homologues of 2xHC-TXN - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c-Fe2+ + H+ + Oxygen ⟶ Cytochrome c-Fe3+ + H+ + H2O - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
H2O2 + TXN ⟶ F6ZMN7 + H2O - TP53 Regulates Transcription of Cell Death Genes:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain:
1,2-Naphthoquinone + H+ + TPNH ⟶ TPN + semiquinone - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene C4 ⟶ L-Glu + leukotriene D4 - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biosynthesis of specialized proresolving mediators (SPMs):
DHA + Oxygen ⟶ 17-HDHA - Biosynthesis of electrophilic -3 PUFA oxo-derivatives:
DHA + Oxygen ⟶ 17-HDHA - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
7-dehydroCHOL + H+ + TPNH ⟶ CHOL + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin M1 - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ H2O + TPN + aflatoxin Q1 - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
L-gulonate + NAD ⟶ 3-dehydro-L-gulonate + H+ + NADH - Formation of xylulose-5-phosphate:
L-gulonate + NAD ⟶ 3-dehydro-L-gulonate + H+ + NADH - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
L-gulonate + NAD ⟶ 3-dehydro-L-gulonate + H+ + NADH - Formation of xylulose-5-phosphate:
L-gulonate + NAD ⟶ 3-dehydro-L-gulonate + H+ + NADH - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
ATP + PYR + carbon dioxide ⟶ ADP + OAA + Pi - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Formation of xylulose-5-phosphate:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Metabolism of nitric oxide: NOS3 activation and regulation:
ADMA + H2O ⟶ DMA + L-Cit - eNOS activation:
ADMA + H2O ⟶ DMA + L-Cit - Signaling by Receptor Tyrosine Kinases:
H2O + cAMP ⟶ AMP - Signaling by VEGF:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFA-VEGFR2 Pathway:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling Pathways:
H2O + cAMP ⟶ AMP - Signaling by Receptor Tyrosine Kinases:
H2O + cAMP ⟶ AMP - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Receptor Tyrosine Kinases:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling by Receptor Tyrosine Kinases:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - eNOS activation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFA-VEGFR2 Pathway:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFR2 mediated vascular permeability:
PAK1,2,3 dimer + p-VAV family:PIP3:RAC1:GTP ⟶ 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H2O + Hydrouracil ⟶ H+ + UPROP - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
ATP + Thy-dRib ⟶ ADP + TMP - Nucleotide catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
Ade + PRPP ⟶ AMP + PPi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H+ + TPNH + Ura ⟶ Hydrouracil + TPN - Nucleotide metabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Nucleotide catabolism:
AMP + H2O ⟶ Ade-Rib + Pi - Pyrimidine catabolism:
H2O + Hydrouracil ⟶ H+ + UPROP - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
4CHOL7a,12a,27TONE + H+ + TPNH ⟶ 5beta-cholestan-7alpha,12alpha,27-triol-3-one + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
4CHOL7a,12a,27TONE + H+ + TPNH ⟶ 5beta-cholestan-7alpha,12alpha,27-triol-3-one + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
27HCHOL + H+ + Oxygen + TPNH ⟶ 7alpha,26-dihydroxycholesterol + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
4CHOL7a,12a,27TONE + H+ + TPNH ⟶ 5beta-cholestan-7alpha,12alpha,27-triol-3-one + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
4CHOL7a,12a,27TONE + H+ + TPNH ⟶ 5beta-cholestan-7alpha,12alpha,27-triol-3-one + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
5beta-cholestan-7alpha,12alpha,27-triol-3-one + H+ + TPNH ⟶ 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Thyroxine biosynthesis:
Iodine + L-Tyr ⟶ HI + MIT - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Regulation of thyroid hormone activity:
H+ + TPNH + Thyroxine ⟶ 3,5,3'-triiodothyronine + I- + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - eNOS activation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Eicosanoids:
H+ + Oxygen + TPNH + Trioxilin A3 ⟶ 20OH-TrXA3 + H2O + TPN - Eicosanoids:
prostaglandin H2 ⟶ Prostacyclin - Eicosanoids:
prostaglandin H2 ⟶ Prostacyclin - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Eicosanoids:
prostaglandin H2 ⟶ Prostacyclin - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Arachidonic acid metabolism:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
prostaglandin H2 ⟶ prostaglandin D2 - Arachidonic acid metabolism:
H2O + leukotriene A4 ⟶ leukotriene B4 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
prostaglandin H2 ⟶ prostaglandin D2 - Arachidonic acid metabolism:
prostaglandin H2 ⟶ prostaglandin E2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
prostaglandin H2 ⟶ prostaglandin E2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Arachidonic acid metabolism:
H2O + leukotriene A4 ⟶ leukotriene B4 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
prostaglandin H2 ⟶ prostaglandin E2 - Arachidonic acid metabolism:
H2O + leukotriene A4 ⟶ leukotriene B4 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + TPNH + prostaglandin D2 ⟶ 11epi-PGF2a + TPN - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN - Estrogen biosynthesis:
EST17b + TPN ⟶ H+ + TPNH + estrone - Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Metabolism of folate and pterines:
F1N9X0 + FOLA ⟶ FOLR2:FOLA - Metabolism of vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of folate and pterines:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Metabolism of vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Selenoamino acid metabolism:
H2O + SeMet ⟶ 2OBUTA + MeSeH + ammonia - Metabolism of ingested H2SeO4 and H2SeO3 into H2Se:
H+ + PAPSe + TPNH ⟶ H2O + PAP + SeO3(2-) + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
7-dehydroCHOL ⟶ calciol - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Fructose metabolism:
GA + H2O + NAD ⟶ DGA + H+ + NADH - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
GA + H2O + NAD ⟶ DGA + H+ + NADH - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
GA + H2O + NAD ⟶ DGA + H+ + NADH - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
ATP + DGA ⟶ 3PDGA + ADP + H+ - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Carbohydrate metabolism:
H2O + Heparan(3)-PGs ⟶ CH3COO- + Heparan(4)-PGs - Fructose metabolism:
GA + H2O + NAD ⟶ DGA + H+ + NADH - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
GA + H2O + NAD ⟶ DGA + H+ + NADH - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
GA + H2O + NAD ⟶ DGA + H+ + NADH - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Carbohydrate metabolism:
ATP + PYR + carbon dioxide ⟶ ADP + OAA + Pi - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Carbohydrate metabolism:
ATP + PYR + carbon dioxide ⟶ ADP + OAA + Pi - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose metabolism:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - Fructose biosynthesis:
Glc + H+ + TPNH ⟶ D-sorbitol + TPN - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
11-deoxycortisol ⟶ 11DCORT - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Glucocorticoid biosynthesis:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Synthesis of Lipoxins (LX):
NAD + lipoxin A4 ⟶ 15k-LXA4 + H+ + NADH - Biosynthesis of EPA-derived SPMs:
18(R)-HpEPE + GSH ⟶ 18(R)-HEPE + GSSG + H2O - Biosynthesis of E-series 18(R)-resolvins:
18(R)-HpEPE + GSH ⟶ 18(R)-HEPE + GSSG + H2O - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
alpha-Fuc ⟶ beta-Fuc - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
alpha-Fuc ⟶ beta-Fuc - Metabolism of proteins:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Post-translational protein modification:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH + Q9GU68 - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH + Q9GU68 - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Metabolism of proteins:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Post-translational protein modification:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
alpha-Fuc ⟶ beta-Fuc - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
alpha-Fuc ⟶ beta-Fuc - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
TPNH + pPNOL ⟶ DCHOL + TPN - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
alpha-Fuc ⟶ beta-Fuc - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
GlcNGc-6-P + H2O ⟶ CCA + GlcN6P - GDP-fucose biosynthesis:
alpha-Fuc ⟶ beta-Fuc - Metabolism of proteins:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Post-translational protein modification:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - GDP-fucose biosynthesis:
GDP-KDGal + H+ + TPNH ⟶ GDP-Fuc + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala - Glutamate and glutamine metabolism:
Glu + L-Glu5S ⟶ 2OG + L-Orn - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Metabolism of cofactors:
ISCIT + TPN ⟶ 2OG + H+ + TPNH + carbon dioxide - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
GTP + H2O ⟶ DHNTP + HCOOH - Metabolism of cofactors:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of cofactors:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Q9VH95 + Q9VL78 - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Immunophilin FKBP52 + Pi + cPGES - ESR-mediated signaling:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + Fkbp4 + HSP90:HSP90 + Pi + Q9R0Q7 - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Ptges3 + Q9QVC8 - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ESR-mediated signaling:
SPG ⟶ S1P - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
SPG ⟶ S1P - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Extra-nuclear estrogen signaling:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Biosynthesis of E-series 18(S)-resolvins:
EPA + H+ + Oxygen + TPNH ⟶ 18(S)-HpEPE + TPN - Metabolism:
H2O + PBG ⟶ HMBL + ammonia - Lipid metabolism:
PALM-CoA + Ser ⟶ 3-ketosphinganine + CoA-SH + carbon dioxide - Sphingolipid metabolism:
PALM-CoA + Ser ⟶ 3-ketosphinganine + CoA-SH + carbon dioxide - Synthesis of bile acids and bile salts via 27-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 27OH-CHOL + H2O + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Cytochrome P450 - arranged by substrate type:
EtOH + H+ + Oxygen + TPNH ⟶ CH3CHO + H2O + TPN - Endogenous sterols:
H+ + LAN + Oxygen + TPNH ⟶ 4,4DMCHtOL + H2O + HCOOH + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Mineralocorticoid biosynthesis:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Mineralocorticoid biosynthesis:
pregn-5-ene-3,20-dione ⟶ progesterone - Cytochrome P450 - arranged by substrate type:
H+ + LAN + Oxygen + TPNH ⟶ 4,4DMCHtOL + H2O + HCOOH + TPN - Endogenous sterols:
H+ + LAN + Oxygen + TPNH ⟶ 4,4DMCHtOL + H2O + HCOOH + TPN - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Cytochrome P450 - arranged by substrate type:
H+ + LAN + Oxygen + TPNH ⟶ 4,4DMCHtOL + H2O + HCOOH + TPN - Endogenous sterols:
H+ + LAN + Oxygen + TPNH ⟶ 4,4DMCHtOL + H2O + HCOOH + TPN - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Aflatoxin activation and detoxification:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Aflatoxin activation and detoxification:
AFXBO-NAC,AFNBO-NAC + H2O ⟶ AFXBO-C,AFNBO-C + CH3COO- - Synthesis of bile acids and bile salts via 24-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Glucocorticoid biosynthesis:
CORT + TPN ⟶ COR + H+ + TPNH - Glucocorticoid biosynthesis:
CORT + TPN ⟶ COR + H+ + TPNH - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Kandutsch-Russell pathway:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Vitamins:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamins:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamins:
H+ + Oxygen + TPNH + atRA ⟶ 4OH-atRA + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamins:
CTL + H+ + Oxygen + TPNH ⟶ CTLA + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamin D (calciferol) metabolism:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Vitamins:
H+ + Oxygen + TPNH + calciol ⟶ CDL + H2O + TPN - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Arachidonic acid metabolism:
prostaglandin H2 ⟶ prostaglandin E2 - Synthesis of Prostaglandins (PG) and Thromboxanes (TX):
prostaglandin H2 ⟶ prostaglandin E2 - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET):
AA + H+ + Oxygen + TPNH ⟶ 5,6-EET + H2O + TPN - Fatty acyl-CoA biosynthesis:
ATP + CIT + CoA-SH ⟶ ADP + Ac-CoA + OA + Pi - Synthesis of very long-chain fatty acyl-CoAs:
Mal-CoA + PALM-CoA ⟶ 3OOD-CoA + CoA-SH + carbon dioxide - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Androgen biosynthesis:
DHEA + NAD ⟶ ANDST + H+ + NADH - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Bloch pathway:
CHdOL + H+ + Oxygen + TPNH ⟶ 7dhDESOL + H2O + TPN - Bloch pathway:
DESMOL + H+ + TPNH ⟶ CHOL + TPN - Drug ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
AMP + abacavir ⟶ Ade-Rib + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - APAP ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Glucocorticoid biosynthesis:
17aHPREG + NAD ⟶ H+ + NADH + pregn-5-ene-3,20-dione-17-ol - Synthesis of 5-eicosatetraenoic acids:
5S-HpETE + GSH ⟶ 5S-HETE + GSSG + H2O - Selenoamino acid metabolism:
Sec ⟶ H2Se + L-Ala - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Selenoamino acid metabolism:
Sec ⟶ H2Se + L-Ala - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Selenoamino acid metabolism:
Sec ⟶ H2Se + L-Ala - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Selenoamino acid metabolism:
Sec ⟶ H2Se + L-Ala - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Selenoamino acid metabolism:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Selenoamino acid metabolism:
Sec ⟶ H2Se + L-Ala - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Metabolism of ingested MeSeO2H into MeSeH:
H+ + MeSeO2H + TPNH ⟶ H2O + MeSeOH + TPN - Wax and plasmalogen biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Wax biosynthesis:
H+ + PALM-CoA + TPNH ⟶ CoA-SH + HXOL + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Hemostasis:
2AG + H2O ⟶ AA + Glycerol + H+ - Platelet homeostasis:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Immune System:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Hemostasis:
3AG + H2O ⟶ AA + Glycerol + H+ - Platelet homeostasis:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - ROS and RNS production in phagocytes:
H+ + O2.- ⟶ H2O2 - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Hemostasis:
3AG + H2O ⟶ AA + Glycerol + H+ - Platelet homeostasis:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Innate Immune System:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - ROS and RNS production in phagocytes:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Hemostasis:
2AG + H2O ⟶ AA + Glycerol + H+ - Platelet homeostasis:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
H2O + PC ⟶ Cho + PA - Innate Immune System:
H2O + PC ⟶ Cho + PA - ROS and RNS production in phagocytes:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Immune System:
H2O + PC ⟶ Cho + PA - Innate Immune System:
H2O + PC ⟶ Cho + PA - ROS and RNS production in phagocytes:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Nitric oxide stimulates guanylate cyclase:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
TPNH + pPNOL ⟶ DCHOL + TPN - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Synthesis of substrates in N-glycan biosythesis:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Synthesis of Dolichyl-phosphate:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Bloch pathway:
CHdOL + H+ + Oxygen + TPNH ⟶ 7dhDESOL + H2O + TPN - Bloch pathway:
CHdOL + H+ + Oxygen + TPNH ⟶ 7dhDESOL + H2O + TPN - Cholesterol biosynthesis:
ATP + MVA5PP ⟶ ADP + IPPP + Pi + carbon dioxide - Biosynthesis of DHA-derived SPMs:
17(S)-Hp-DHA + TPN ⟶ 16S,17S-epoxy-DHA + TPNH - Biosynthesis of maresins:
14(S)-HDHA + H+ + Oxygen + TPNH ⟶ 14(S),22-diHDHA + H2O + TPN - Biosynthesis of maresin-like SPMs:
14(S)-HDHA + H+ + Oxygen + TPNH ⟶ 14(S),22-diHDHA + H2O + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - Disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Diseases of signal transduction by growth factor receptors and second messengers:
H+ + Oxygen + TPNH ⟶ H2O2 + TPN - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Factors involved in megakaryocyte development and platelet production:
Oxygen + TPNH ⟶ H2O2 + TPN - FLT3 signaling in disease:
H+ + Oxygen + TPNH ⟶ H2O2 + TPN - Signaling by FLT3 ITD and TKD mutants:
H+ + Oxygen + TPNH ⟶ H2O2 + TPN - STAT5 activation downstream of FLT3 ITD mutants:
H+ + Oxygen + TPNH ⟶ H2O2 + TPN - Signaling by FLT3 fusion proteins:
H+ + Oxygen + TPNH ⟶ H2O2 + TPN - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Ade + PRPP ⟶ AMP + PPi - Purine salvage:
Ade + PRPP ⟶ AMP + PPi - Nucleotide salvage:
Gua + R1P, dRibP ⟶ G, dG + Pi - Purine salvage:
Gua + R1P, dRibP ⟶ G, dG + Pi - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Signaling by Rho GTPases:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - RHO GTPase Effectors:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - RHO GTPases Activate NADPH Oxidases:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + Homologues of KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + Homologues of KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Cellular responses to stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Detoxification of Reactive Oxygen Species:
H+ + O2.- ⟶ H2O2 + Oxygen - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Infectious disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + Kdm4c + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + Kdm4c + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A ⟶ CH2O + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A ⟶ CH2O + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Cellular responses to stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + KDM4C + SUCCA + carbon dioxide + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - ROS and RNS production in phagocytes:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Rho GTPases:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + SUCCA + carbon dioxide + kdm4b + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPase Effectors:
2OG + Oxygen + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C ⟶ CH2O + SUCCA + carbon dioxide + kdm4b + p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 - RHO GTPases Activate NADPH Oxidases:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Leishmania infection:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Killing mechanisms:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - WNT5:FZD7-mediated leishmania damping:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Cellular response to chemical stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular response to chemical stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Signaling by Rho GTPases, Miro GTPases and RHOBTB3:
NOX2 complex:RAC2:GTP + S100A8:S100A9:AA:Ca2+ ⟶ NOX2 complex:S100A8:S100A9:Ca2+ - Parasitic Infection Pathways:
Adenylate cyclase (Mg2+ cofactor) + Gs:GTP ⟶ Gs-activated adenylate cyclase - TP53 Regulates Metabolic Genes:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
GSH + H2O2 ⟶ GSSG + H2O - TP53 Regulates Metabolic Genes:
GSH + H2O2 ⟶ GSSG + H2O - TP53 Regulates Metabolic Genes:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - TP53 Regulates Metabolic Genes:
H2O2 + Homologues of TXN ⟶ H2O + Homologues of 2xHC-TXN - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Metabolic Genes:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - TP53 Regulates Metabolic Genes:
Cytochrome c-Fe2+ + H+ + Oxygen ⟶ Cytochrome c-Fe3+ + H+ + H2O - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Metabolic Genes:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Carbohydrate metabolism:
Glu + OAA ⟶ 2OG + L-Asp - Pentose phosphate pathway:
G6P + TPN ⟶ 6-Phospho-D-glucono-1,5-lactone + H+ + TPNH - Gene expression (Transcription):
GSSG + H+ + TPNH ⟶ GSH + TPN - RNA Polymerase II Transcription:
GSSG + H+ + TPNH ⟶ GSH + TPN - Generic Transcription Pathway:
GSSG + H+ + TPNH ⟶ GSH + TPN - Transcriptional Regulation by TP53:
GSSG + H+ + TPNH ⟶ GSH + TPN - TP53 Regulates Metabolic Genes:
GSSG + H+ + TPNH ⟶ GSH + TPN - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Gene expression (Transcription):
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - RNA Polymerase II Transcription:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Generic Transcription Pathway:
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 + H2O ⟶ BRD2 homodimer + CH3COO- + RUNX3:CBFB:CCND1:HDAC4 - Transcriptional Regulation by TP53:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Metabolic Genes:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - Gene expression (Transcription):
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - RNA Polymerase II Transcription:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - Generic Transcription Pathway:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - Transcriptional Regulation by TP53:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - TP53 Regulates Metabolic Genes:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Gene expression (Transcription):
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - RNA Polymerase II Transcription:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - Generic Transcription Pathway:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - Transcriptional Regulation by TP53:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - TP53 Regulates Metabolic Genes:
H2O2 + PRDX1 dimer ⟶ H2O + HOOS-C52-PRDX1 dimer - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - TP53 Regulates Metabolic Genes:
Cytochrome c (reduced) + H+ + Oxygen ⟶ Cytochrome c (oxidised) + H+ + H2O - TP53 Regulates Metabolic Genes:
H2O2 + TXN ⟶ F6ZMN7 + H2O - Pentose phosphate pathway:
PDG + TPN ⟶ H+ + RU5P + TPNH + carbon dioxide - Diseases of metabolism:
2OG + H+ + TPNH ⟶ 2HG + TPN - Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate:
2OG + H+ + TPNH ⟶ 2HG + TPN
BioCyc(1017)
- acetone degradation I (to methylglyoxal):
H+ + acetoacetate ⟶ CO2 + acetone - isopropanol biosynthesis (engineered):
NADP+ + propan-2-ol ⟶ H+ + NADPH + acetone - acetone degradation III (to propane-1,2-diol):
NADP+ + propan-2-ol ⟶ H+ + NADPH + acetone - acetone degradation I (to methylglyoxal):
NADP+ + propan-2-ol ⟶ H+ + NADPH + acetone - acetone degradation II (to acetoacetate):
NADP+ + propan-2-ol ⟶ H+ + NADPH + acetone - propane degradation I:
NAD+ + propan-2-ol ⟶ H+ + NADH + acetone - sanguinarine and macarpine biosynthesis:
H+ + NADPH + O2 + S-cheilanthifoline ⟶ H2O + NADP+ + S-stylopine - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of formononetin derivative biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of chorismate metabolism:
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - superpathway of chorismate metabolism:
2-oxoglutarate + phe ⟶ 3-phenyl-2-oxopropanoate + glu - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - superpathway of chorismate metabolism:
2-oxoglutarate + H+ + isochorismate ⟶ 2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2 - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - superpathway of chorismate metabolism:
2-oxoglutarate + H+ + isochorismate ⟶ 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2 - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ ⟶ 2-octaprenylphenol + CO2 - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 ⟶ 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol + H2O + NADP+ - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 ⟶ 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol + H2O + NADP+ - superpathway of chorismate metabolism:
2-oxoglutarate + H+ + isochorismate ⟶ 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2 - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenyl-6-methoxyphenol + H+ + NADPH + O2 ⟶ 2-octaprenyl-6-methoxyquinol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of chorismate metabolism:
2-oxoglutarate + tyr ⟶ 4-hydroxyphenylpyruvate + glt - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of chorismate metabolism:
2-oxoglutarate + H+ + isochorismate ⟶ 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2 - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of chorismate metabolism:
2-oxoglutarate + tyr ⟶ 4-hydroxyphenylpyruvate + glt - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-octaprenylphenol + H+ + NADPH + O2 ⟶ 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ - ubiquinol-8 biosynthesis (prokaryotic):
2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 ⟶ 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol + H2O + NADP+ - superpathway of ubiquinol-8 biosynthesis (prokaryotic):
2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 ⟶ 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol + H2O + NADP+ - daunorubicin biosynthesis:
ε-rhodomycinone + dTDP-L-daunosamine ⟶ H+ + dTDP + rhodomycinone D - ecdysteroid metabolism (arthropods):
3-dehydroecdysone + H+ + NADPH ⟶ 3-epiecdysone + NADP+ - ethionamide activation:
H+ + NADPH + O2 + ethionamide S-oxide ⟶ (2-ethylpyridin-4-yl)(imino)methanesulfinate + H2O + NADP+ - ethionamide activation:
H+ + NADPH + O2 + ethionamide S-oxide ⟶ (2-ethylpyridin-4-yl)(imino)methanesulfinate + H2O + NADP+ - bile acid biosynthesis, neutral pathway:
(25R)-3α,7α-dihydroxy-5-β-cholestanate + ATP + coenzyme A ⟶ (25R)-3α,7α-dihydroxy-5β-cholestanoyl-CoA + AMP + diphosphate - limonene degradation I (D-limonene):
(1S,2S,4R)-limonene-1,2-diol + oxidized DCPIP ⟶ (1S,4R)-1-hydroxymenth-8-en-2-one + H+ + reduced DCPIP - ferulate and sinapate biosynthesis:
H2O + NADP+ + sinapaldehyde ⟶ H+ + NADPH + sinapate - phenylpropanoid biosynthesis:
5-hydroxy-coniferaldehyde + SAM ⟶ H+ + SAH + sinapaldehyde - phenylpropanoid biosynthesis:
5-hydroxy-coniferaldehyde + SAM ⟶ H+ + SAH + sinapaldehyde - ferulate and sinapate biosynthesis:
5-hydroxy-coniferaldehyde + SAM ⟶ H+ + SAH + sinapaldehyde - phenol degradation I (aerobic):
H+ + NADPH + O2 + phenol ⟶ H2O + NADP+ + catechol - 2-nitrophenol degradation:
2-nitrophenol + H+ + NADPH + O2 ⟶ H2O + NADP+ + catechol + nitrite - phenol degradation I (aerobic):
H+ + NADPH + O2 + phenol ⟶ H2O + NADP+ + catechol - phenol degradation I (aerobic):
H+ + NADPH + O2 + phenol ⟶ H2O + NADP+ + catechol - phenol degradation I (aerobic):
H+ + NADPH + O2 + phenol ⟶ H2O + NADP+ + catechol - superpathway of aromatic compound degradation:
O2 + protocatechuate ⟶ 3-carboxy-cis,cis-muconate + H+ - camalexin biosynthesis:
2-(cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + NADP+ ⟶ H+ + NADPH + dihydrocamalexate + hydrogen cyanide - albaflavenone biosynthesis:
(5R)-albaflavenol + H+ + NADPH + O2 ⟶ H2O + NADP+ + albaflavenone - albaflavenone biosynthesis:
(+)-epi-isozizaene + H+ + NADPH + O2 ⟶ (5S)-albaflavenol + H2O + NADP+ - t-anethole biosynthesis:
trans-anol + SAM ⟶ t-anethole + H+ + SAH - epoxypseudoisoeugenol-2-methylbutanoate biosynthesis:
2-methylbutanoate + pseudoisoeugenol ⟶ epoxypseudoisoeugenol-2-methylbutanoate - matairesinol biosynthesis:
(-)-secoisolariciresinol + NAD+ ⟶ (3R,4R)-3,4-bis(4-hydroxy-3-methoxybenzyl)tetrahydro-2-furanol + H+ + NADH - justicidin B biosynthesis:
NAD+ + collinusin ⟶ H+ + NADH + justicidin B - matairesinol biosynthesis:
(+)-lariciresinol + H+ + NADPH ⟶ (-)-secoisolariciresinol + NADP+ - superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation:
H+ + acetoacetate ⟶ CO2 + acetone - superpathway of Clostridium acetobutylicum solventogenic fermentation:
H+ + acetoacetate ⟶ CO2 + acetone - detoxification of reactive carbonyls in chloroplasts:
(Z)-but-2-enal + H+ + NADPH ⟶ NADP+ + butan-1-al - glycerol degradation to butanol:
NAD+ + butan-1-ol ⟶ H+ + NADH + butan-1-al - pyruvate fermentation to butanol I:
NAD+ + butan-1-ol ⟶ H+ + NADH + butan-1-al - detoxification of reactive carbonyls in chloroplasts:
(Z)-but-2-enal + H+ + NADPH ⟶ NADP+ + butan-1-al - glycerol degradation to butanol:
NAD+ + glycerol ⟶ H+ + NADH + dihydroxyacetone - glycerol degradation to butanol:
NAD+ + glycerol ⟶ H+ + NADH + dihydroxyacetone - glycerol degradation to butanol:
NAD+ + glycerol ⟶ H+ + NADH + dihydroxyacetone - dimethyl sulfide degradation II (oxidation):
H+ + NADPH + O2 + dimethyl sulfide ⟶ H2O + NADP+ + dimethyl sulfoxide - superpathway of cholesterol biosynthesis:
H+ + O2 + a ferrocytochrome b5 + lathosterol ⟶ 7-dehydrocholesterol + H2O + a ferricytochrome b5 - cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
H+ + O2 + a ferrocytochrome b5 + lathosterol ⟶ 7-dehydrocholesterol + H2O + a ferricytochrome b5 - cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
24,25-dihydrolanosterol + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 4,4-dimethyl-14α-hydroxymethyl-5α-cholesta-8-en-3β-ol + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of cholesterol biosynthesis:
24,25-dihydrolanosterol + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 4,4-dimethyl-14α-hydroxymethyl-5α-cholesta-8-en-3β-ol + H2O + an oxidized [NADPH-hemoprotein reductase] - 2,4-xylenol degradation to protocatechuate:
4-hydroxy-3-methylbenzaldehyde + H2O + NADP+ ⟶ 4-hydroxy-3-methylbenzoate + H+ + NADPH - dTDP-L-daunosamine biosynthesis:
2-oxoglutarate + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-β-L-glucose ⟶ dTDP-3,4-didehydro-2,6-dideoxy-β-L-glucose + glu - senecionine N-oxide biosynthesis:
H+ + NADPH + O2 + senecionine ⟶ H2O + NADP+ + senecionine N-oxide - erythritol degradation I:
D-erythrulose 1-phosphate ⟶ L-erythrulose 1-phosphate - superpathway of ubiquinol-6 biosynthesis (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - ubiquinol-6 bypass biosynthesis (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - ubiquinol-6 bypass biosynthesis:
3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + SAM ⟶ 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ + SAH - ubiquinol-6 biosynthesis (eukaryotic):
3-hexaprenyl-4-hydroxybenzoate + H+ + NADPH + O2 ⟶ 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NADP+ - ubiquinol-6 biosynthesis (eukaryotic):
3-hexaprenyl-4-hydroxybenzoate + H+ + NADPH + O2 ⟶ 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NADP+ - kauralexin biosynthesis:
(-)-ent-copalyl diphosphate ⟶ ent-kaurene + diphosphate - GA12 biosynthesis:
ent-kaurene + H+ + NADPH + O2 ⟶ ent-kaurenol + H2O + NADP+ - (4S)-carveol and (4S)-dihydrocarveol degradation:
(4S,6S)-cis-carveol + oxidized DCPIP ⟶ (+)-carvone + H+ + reduced DCPIP - pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin):
(-)-maackiain + H+ + NAD(P)H + O2 ⟶ 1α-hydroxy-maackiain + H2O + NAD(P)+ - retinol biosynthesis:
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - the visual cycle I (vertebrates):
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - retinol biosynthesis:
H2O + a dietary all-trans-retinyl ester ⟶ all-trans-retinol + H+ + a fatty acid - the visual cycle I (vertebrates):
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - retinol biosynthesis:
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - superpathway of C28 brassinosteroid biosynthesis:
3-dehydro-6-deoxoteasterone + A ⟶ (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + A(H2) - brassinosteroid biosynthesis I:
6-deoxoteasterone + A ⟶ 3-dehydro-6-deoxoteasterone + A(H2) - brassinosteroid biosynthesis II:
3-dehydro-6-deoxoteasterone + A ⟶ (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + A(H2) - L-galactose degradation:
L-galactopyranose + NADP+ ⟶ H+ + L-galactono-1,5-lactone + NADPH - lycopadiene biosynthesis:
A(H2) + lycopaoctaene ⟶ (2E6E,10E,14E,18E,22E)-lycopahexaene + A - aflatoxins B1 and G1 biosynthesis:
8-O-methylsterigmatocystin + H+ + NADPH + O2 ⟶ CO2 + H2O + NADP+ + aflatoxin B1 + methanol - aflatoxins B2 and G2 biosynthesis:
H+ + NADPH + O2 + dihydro-O-methylsterigmatocystin ⟶ CO2 + H2O + NADP+ + aflatoxin B2 + methanol - (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene biosynthesis:
(E,E)-geranyllinalool + H+ + NADPH + O2 ⟶ H2O + NADP+ + TMTT + but-1-en-3-one - (4S)-carvone biosynthesis:
(+)-trans-carveol + NAD+ ⟶ (+)-carvone + H+ + NADH - reductive acetyl coenzyme A pathway I (homoacetogenic bacteria):
CO + H2O + an oxidized ferredoxin [iron-sulfur] cluster ⟶ CO2 + H+ + a reduced ferredoxin [iron-sulfur] cluster - carbon tetrachloride degradation II:
A(H2) + carbon tetrachloride ⟶ A + H+ + chloride + trichloromethyl radical - cyclohexanol degradation:
H+ + NADPH + O2 + cyclohexanone ⟶ ε-caprolactone + H2O + NADP+ - oleandomycin biosynthesis:
(S)-methylmalonyl-CoA + H+ + NADPH + acetyl-CoA ⟶ 8,8a-deoxyoleandolide + CO2 + H2O + NADP+ + coenzyme A - ajmaline and sarpagine biosynthesis:
H2O + polyneuridine aldehyde ⟶ 16-epivellosimine + CO2 + MeOH - ethene and chloroethene degradation:
H+ + NADH + O2 + ethene ⟶ H2O + NAD+ + ethylene oxide - sesamin biosynthesis:
coniferyl alcohol + hydrogen peroxide ⟶ H2O + coniferyl alcohol radical - androgen biosynthesis:
17-α-hydroxypregnenolone + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 3-β-hydroxyandrost-5-en-17-one + H+ + H2O + acetate + an oxidized [NADPH-hemoprotein reductase] - androgen biosynthesis:
NADP+ + testosterone ⟶ H+ + NADPH + androst-4-ene-3,17-dione - mithramycin biosynthesis:
dTDP-α-D-olivose + premithramycin A3 ⟶ 3A-deolivosylpremithramycin B + H+ + dTDP - superpathway of C28 brassinosteroid biosynthesis:
6-deoxotyphasterol + A ⟶ 3-dehydro-6-deoxoteasterone + A(H2) - brassinosteroid biosynthesis II:
6-deoxotyphasterol + A ⟶ 3-dehydro-6-deoxoteasterone + A(H2) - ursolate biosynthesis:
H+ + NADPH + O2 + uvaol ⟶ H2O + NADP+ + ursolic aldehyde - pentachlorophenol degradation:
2,3,5,6-tetrachlorohydroquinone + H+ + NAD+ ⟶ 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH - plant sterol biosynthesis:
4α-formyl-ergosta-7,24(241)-dien-3β-ol + H+ + O2 + a ferrocytochrome b5 ⟶ 4α-carboxy-ergosta-7,24(241)-dien-3β-ol + H2O + a ferricytochrome b5 - juvenile hormone III biosynthesis I:
(2E,6E)-farnesol + NADP+ ⟶ (2E,6E)-farnesal + H+ + NADPH - juvenile hormone III biosynthesis II:
(2E,6E)-farnesol + NADP+ ⟶ (2E,6E)-farnesal + H+ + NADPH - farnesylcysteine salvage pathway:
(2E,6E)-farnesol + NADP+ ⟶ (2E,6E)-farnesal + H+ + NADPH - farnesylcysteine salvage pathway:
(2E,6E)-farnesol + NADP+ ⟶ (2E,6E)-farnesal + H+ + NADPH - juvenile hormone III biosynthesis I:
(2E,6E)-farnesol + NADP+ ⟶ (2E,6E)-farnesal + H+ + NADPH - juvenile hormone III biosynthesis II:
(2E,6E)-farnesol + NADP+ ⟶ (2E,6E)-farnesal + H+ + NADPH - cardenolide biosynthesis:
5-α-pregnane-3,20-dione + NADP+ ⟶ H+ + NADPH + progesterone - cardenolide biosynthesis:
NADP+ + allopregnanolone ⟶ 5-α-pregnane-3,20-dione + H+ + NADPH - selenate reduction:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - Amaryllidacea alkaloids biosynthesis:
4'-O-methylnorbelladine + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ (4aS,10bR)-noroxomaritidine + H2O + an oxidized [NADPH-hemoprotein reductase] - methyl tert-butyl ether degradation:
H+ + NADH + O2 + methyl tert-butyl ether ⟶ tert-butoxymethanol + H2O + NAD+ - TCA cycle variation I:
2-oxoglutarate + H+ ⟶ CO2 + succinate semialdehyde - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutyrate ⟶ glt + succinate semialdehyde - superpathway of 4-aminobutyrate degradation:
2-oxoglutarate + 4-aminobutyrate ⟶ glt + succinate semialdehyde - eugenol and isoeugenol biosynthesis:
acetyl-CoA + coniferyl alcohol ⟶ coenzyme A + coniferyl acetate - eugenol and isoeugenol biosynthesis:
acetyl-CoA + coniferyl alcohol ⟶ coenzyme A + coniferyl acetate - diadinoxanthin and diatoxanthin interconversion:
H+ + NADPH + O2 + diatoxanthin ⟶ H2O + NADP+ + diadinoxanthin - leucodelphinidin biosynthesis:
(2R,3S,4S)-leucodelphinidin + NADP+ ⟶ (+)-dihydromyricetin + H+ + NADPH - 2,3-trans-flavanols biosynthesis:
(+)-gallocatechin + H2O + NADP+ ⟶ (2R,3S,4S)-leucodelphinidin + H+ + NADPH - cocaine biosynthesis:
NADP+ + ecgonine methyl ester ⟶ H+ + NADPH + methyl ecgonone - cholesterol biosynthesis III (via desmosterol):
H+ + NADPH + desmosterol ⟶ NADP+ + cholesterol - zymosterol biosynthesis:
4α-carboxy-5α-cholesta-8,24-dien-3β-ol + NAD(P)+ ⟶ CO2 + NAD(P)H + zymosterone - cholesterol biosynthesis I:
H+ + O2 + a ferrocytochrome b5 + lathosterol ⟶ 7-dehydrocholesterol + H2O + a ferricytochrome b5 - superpathway of ergosterol biosynthesis I:
(3S)-2,3-epoxy-2,3-dihydrosqualene ⟶ lanosterol - zymosterol biosynthesis:
NADP+ + zymosterol ⟶ H+ + NADPH + zymosterone - cholesterol biosynthesis I:
(3S)-2,3-epoxy-2,3-dihydrosqualene ⟶ lanosterol - cholesterol biosynthesis III (via desmosterol):
(3S)-2,3-epoxy-2,3-dihydrosqualene ⟶ lanosterol - superpathway of ergosterol biosynthesis:
NADP+ + ergosterol ⟶ H+ + NADPH + ergosta-5,7,22,24(28)-tetraen-3-β-ol - zymosterol biosynthesis:
4α-carboxy-5α-cholesta-8,24-dien-3β-ol + NAD(P)+ ⟶ CO2 + NAD(P)H + zymosterone - zymosterol biosynthesis:
H+ + NADPH + O2 + lanosterol ⟶ 14-demethyllanosterol + H2O + NADP+ + formate - phosphopantothenate biosynthesis II:
β-alanine + (R)-pantolactone ⟶ (R)-pantothenate + H+ - aurachin RE biosynthesis:
H+ + NADPH + O2 + aurachin D ⟶ 9'-hydroxy-aurachin D + H2O + NADP+ - aurachin A, B, C and D biosynthesis:
aurachin B epoxide ⟶ aurachin A - very long chain fatty acid biosynthesis:
NADP+ + a (3R)-3-hydroxyacyl-CoA ⟶ H+ + NADPH + a 3-oxoacyl-CoA - 1,2-propanediol biosynthesis from lactate (engineered):
(S)-propane-1,2-diol + NADP+ ⟶ (S)-lactaldehyde + H+ + NADPH - galactose degradation IV:
D-galactitol + NAD+ ⟶ H+ + L-xylo-3-hexulose + NADH - D-glucuronate degradation:
L-gulonate + NADP+ ⟶ aldehydo-D-glucuronate + H+ + NADPH - L-arabinose degradation II:
NADP+ + xylitol ⟶ H+ + L-xylulose + NADPH - D-xylose degradation II:
NADP+ + xylitol ⟶ D-xylopyranose + H+ + NADPH - D-glucuronate degradation I:
NADP+ + xylitol ⟶ H+ + L-xylulose + NADPH - superpathway of pentose and pentitol degradation:
H2O + L-arabinono-1,4-lactone ⟶ H+ + L-arabinonate - xylose degradation II:
NADP+ + xylitol ⟶ D-xylopyranose + H+ + NADPH - yatein biosynthesis II:
O4,O5--dimethylthujaplicatin + H+ + NADPH + O2 ⟶ (-)-yatein + H2O + NADP+ - paspaline biosynthesis:
10,11-epoxy-3-geranylgeranylindole ⟶ emindole-SB - superpathway of trimethylamine degradation:
H+ + NADPH + O2 + dimethylamine ⟶ H2O + NADP+ + formaldehyde + methylamine - trimethylamine degradation:
H+ + NADPH + O2 + dimethylamine ⟶ H2O + NADP+ + formaldehyde + methylamine - colchicine biosynthesis:
O-methylandrocymbine + O2 ⟶ H2O + N-formyldemecolcine - nitrobenzene degradation I:
N-phenylhydroxylamine ⟶ 2-aminophenol - nitrobenzene degradation I:
N-phenylhydroxylamine ⟶ 2-aminophenol - 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent):
3,8-divinyl chlorophyllide a + NADP+ ⟶ 3,8-divinyl protochlorophyllide a + H+ + NADPH + hν - 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent):
131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 ⟶ 3,8-divinyl protochlorophyllide a + H2O + NADP+ - menthol biosynthesis:
(-)-menthone + NADP+ ⟶ (+)-pulegone + H+ + NADPH - canavanine degradation:
H+ + L-canaline + NADPH ⟶ L-homoserine + NADP+ + ammonia - coumestrol biosynthesis:
H+ + NADPH + daidzein ⟶ (S)-dihydrodaidzein + NADP+ - daidzin and daidzein degradation:
(3R,4S)-tetrahydrodaidzein + A(H2) ⟶ (S)-equol + A + H2O - plant sterol biosynthesis:
4α-hydroxymethyl-ergosta-7,24(241)-dien-3β-ol + H+ + NADH + O2 ⟶ 4α-formyl-ergosta-7,24(241)-dien-3β-ol + H2O + NAD+ - (3E)-4,8-dimethylnona-1,3,7-triene biosynthesis I:
(3R,6E)-nerolidol + H+ + NADPH + O2 ⟶ (3E)-4,8-dimethylnona-1,3,7-triene + H2O + NADP+ + but-3-en-2-one - (3E)-4,8-dimethylnona-1,3,7-triene biosynthesis:
(2E,6E)-farnesyl diphosphate + H2O ⟶ (3R,6E)-nerolidol + diphosphate - tetracycline and oxytetracycline biosynthesis:
4-dedimethylamino-4-oxoanhydrotetracycline + an aminated amino group donor ⟶ 4-amino-4-de(dimethylamino)anhydrotetracycline + a deaminated amino group donor - superpathway of tetracycline and oxytetracycline biosynthesis:
nonaketamide tricyclic intermediate-[OxyC acyl-carrier protein] ⟶ H+ + OxyC acyl-carrier protein + pretetramide - chlorophyll a biosynthesis II:
NADP+ + chlorophyll a ⟶ H+ + NADPH + tetrahydrogeranylgeranyl chlorophyll a - chlorophyll a biosynthesis I:
H+ + chlorophyllide a + phytyl diphosphate ⟶ chlorophyll a + diphosphate - superpathway of bacteriochlorophyll a biosynthesis:
131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + SAM ⟶ 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + H+ + met - bacteriochlorophyll e biosynthesis:
(31R)-8-ethyl-12-methylbacteriochlorophyllide d ⟶ 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + H2O - bacteriochlorophyll c biosynthesis:
(31R)-8-ethyl-12-methylbacteriochlorophyllide d ⟶ 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + H2O - bacteriochlorophyll d biosynthesis:
(31R)-8-ethyl-12-methylbacteriochlorophyllide d ⟶ 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + H2O - bacteriochlorophyll a biosynthesis:
an oxidized ferredoxin [iron-sulfur] cluster + chlorophyllide a ⟶ 3,8-divinyl chlorophyllide a + H+ + a reduced ferredoxin [iron-sulfur] cluster - 1,3-propanediol biosynthesis (engineered):
1,3-propanediol + NADP+ ⟶ 3-hydroxypropionaldehyde + H+ + NADPH - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - androgen biosynthesis:
NAD+ + dehydroepiandrosterone ⟶ 5-androstene-3,17-dione + H+ + NADH - elloramycin biosynthesis:
8-demethyl-8-(2-O-methyl-α-L-rhamnosyl)-tetracenomycin C + SAM ⟶ 8-demethyl-8-(2,3-O-dimethyl-α-L-rhamnosyl)-tetracenomycin C + H+ + SAH - morphine biosynthesis:
2-oxoglutarate + O2 + codeine ⟶ CO2 + formaldehyde + morphine + succinate - morphine biosynthesis:
2-oxoglutarate + O2 + codeine ⟶ CO2 + formaldehyde + morphine + succinate - lutein biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + zeinoxanthin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + lutein - superpathway of carotenoid biosynthesis in plants:
γ-carotene ⟶ β-carotene - 3-hydroxypropanoate/4-hydroxybutanate cycle:
NADP+ + propanoyl-CoA ⟶ H+ + NADPH + acryloyl-CoA - TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - chorismate biosynthesis from 3-dehydroquinate:
NADP+ + shikimate ⟶ 3-dehydroshikimate + H+ + NADPH - chorismate biosynthesis II (archaea):
NADP+ + shikimate ⟶ 3-dehydroshikimate + H+ + NADPH - glyoxylate assimilation:
NADP+ + propanoyl-CoA ⟶ H+ + NADPH + acryloyl-CoA - D-arabinose degradation III:
D-arabinofuranose + NADP+ ⟶ D-arabinono-1,4-lactone + H+ + NADPH - mixed acid fermentation:
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - superpathway of ergosterol biosynthesis II:
(3S)-2,3-epoxy-2,3-dihydrosqualene ⟶ cycloartenol - ergosterol biosynthesis I:
SAM + zymosterol ⟶ H+ + SAH + fecosterol - ergosterol biosynthesis II:
(3S)-2,3-epoxy-2,3-dihydrosqualene ⟶ cycloartenol - ergosterol biosynthesis:
NADP+ + ergosterol ⟶ H+ + NADPH + ergosta-5,7,22,24(28)-tetraen-3-β-ol - betulinate biosynthesis:
H+ + NADPH + O2 + lupeol ⟶ H2O + NADP+ + betulin - α-tocopherol degradation:
α-tocopherol + H+ + NADPH + O2 ⟶ 13'-hydroxy-α-tocopherol + H2O + NADP+ - tryptophan degradation via tryptamine:
H2O + O2 + tryptamine ⟶ (indol-3-yl)acetaldehyde + ammonium + hydrogen peroxide - superpathway of tryptophan utilization:
N-formylkynurenine + H2O ⟶ H+ + L-kynurenine + formate - L-tryptophan degradation X (mammalian, via tryptamine):
(indol-3-yl)acetaldehyde + H+ + NADPH ⟶ NADP+ + indole-3-ethanol - tryptophan degradation X (mammalian, via tryptamine):
H2O + O2 + tryptamine ⟶ H+ + ammonia + hydrogen peroxide + indole acetaldehyde - (4R)-carvone biosynthesis:
geranyl diphosphate ⟶ (4S)-limonene + diphosphate - ubiquinol-10 biosynthesis:
3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H+ ⟶ 6-(all-trans-decaprenyl)-2-methoxy-phenol + CO2 - ubiquinol-10 biosynthesis (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H+ ⟶ 6-(all-trans-decaprenyl)-2-methoxy-phenol + CO2 - ubiquinol-10 biosynthesis (prokaryotic):
6-(all-trans-decaprenyl)-2-methoxy-phenol + H+ + NADPH + O2 ⟶ all trans-decaprenyl-2-methoxy-6-1,4-benzoquinol + H2O + NADP+ - pyrimidine ribonucleosides degradation:
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation:
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
3-ureidopropanoate + H+ + H2O ⟶ β-alanine + CO2 + ammonium - superpathway of pyrimidine ribonucleosides degradation:
5,6-dihydrouracil + H2O ⟶ 3-ureidopropanoate + H+ - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + H2O ⟶ 3-ureidopropionate + H+ - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + H2O ⟶ 3-ureidopropanoate + H+ - uracil degradation II (reductive):
3-ureidopropionate + H2O + H+ ⟶ β-alanine + CO2 + ammonia - uracil degradation I (reductive):
5,6-dihydrouracil + H2O ⟶ 3-ureidopropanoate + H+ - uracil degradation I (reductive):
5,6-dihydrouracil + H2O ⟶ 3-ureidopropanoate + H+ - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - superpathway of pyrimidine ribonucleosides degradation:
H2O + cytidine ⟶ ammonia + uridine - uracil degradation I (reductive):
3-ureidopropionate + H2O + H+ ⟶ β-alanine + CO2 + ammonia - superpathway of pyrimidine ribonucleosides degradation:
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - superpathway of pyrimidine ribonucleosides degradation:
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + NADP+ ⟶ H+ + NADPH + uracil - uracil degradation I (reductive):
5,6-dihydrouracil + H2O ⟶ 3-ureidopropanoate + H+ - tetracycline resistance:
11a-hydroxytetracycline ⟶ 11a-hydroxytetracycline-6,12-hemiketal - nitrate reduction V (assimilatory):
H2O + NADP+ + nitrite ⟶ H+ + NADPH + nitrate - nitrate reduction V (assimilatory):
ATP + ammonia + glt ⟶ ADP + H+ + gln + phosphate - nitrate reduction V (assimilatory):
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - tetracenomycin C biosynthesis:
H+ + NADPH + O2 + tetracenomycin A2 ⟶ H2O + NADP+ + tetracenomycin C - plumbagin biosynthesis:
1,8-dihydroxy-3-methylnaphthalene ⟶ plumbagin - raspberry ketone biosynthesis:
4-hydroxyphenylbutan-2-one + NADP+ ⟶ 4-hydroxybenzalacetone + H+ + NADPH - superpathway of diterpene resin acids biosynthesis:
(+)-copalyl diphosphate ⟶ abieta-7,13-diene + diphosphate - dehydroabietic acid biosynthesis:
(+)-copalyl diphosphate ⟶ abieta-7,13-diene + diphosphate - homofuraneol biosynthesis:
NADP+ + homofuraneol ⟶ (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + H+ + NADPH - homofuraneol biosynthesis:
NADP+ + homofuraneol ⟶ (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + H+ + NADPH - hydrogen oxidation III (anaerobic, NADP):
H2 + NADP+ ⟶ H+ + NADPH - hydrogen production IV:
H2 + NADP+ ⟶ H+ + NADPH - hydrogen oxidation III (anaerobic, NADP):
H2 + NADP+ ⟶ H+ + NADPH - hydrogen oxidation III (anaerobic, NADP):
H2 + NADP+ ⟶ H+ + NADPH - hydrogen oxidation III (anaerobic, NADP):
H2 + NADP+ ⟶ H+ + NADPH - secologanin and strictosidine biosynthesis:
(6E)-8-oxogeranial + H+ + NAD(P)H ⟶ (+)-cis,trans-nepetalactol + NAD(P)+ - limonene degradation II (L-limonene):
(1R,2R,4S)-limonene-1,2-diol + oxidized DCPIP ⟶ (1R,4S)-1-hydroxymenth-8-en-2-one + H+ + reduced DCPIP - curcumin degradation:
H+ + NADPH + dihydrocurcumin ⟶ NADP+ + tetrahydrocurcumin - curcumin degradation:
H+ + NADPH + curcumin ⟶ NADP+ + dihydrocurcumin - curcumin degradation:
H+ + NADPH + curcumin ⟶ NADP+ + dihydrocurcumin - curcumin degradation:
H+ + NADPH + dihydrocurcumin ⟶ NADP+ + tetrahydrocurcumin - pentose phosphate pathway (oxidative branch):
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - NAD/NADP-NADH/NADPH cytosolic interconversion (yeast):
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway NAD/NADP - NADH/NADPH interconversion (yeast):
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - formaldehyde oxidation I:
hexulose 6-phosphate ⟶ D-ribulose 5-phosphate + formaldehyde - superpathway of glycolysis and the Entner-Doudoroff pathway:
ATP + pyruvate ⟶ ADP + H+ + phosphoenolpyruvate - D-sorbitol biosynthesis I:
D-sorbitol 6-phosphate + NADP+ ⟶ D-glucopyranose 6-phosphate + H+ + NADPH - Entner-Doudoroff pathway I:
ATP + pyruvate ⟶ ADP + H+ + phosphoenolpyruvate - heterolactic fermentation:
ATP + D-glucopyranose ⟶ ADP + D-glucopyranose 6-phosphate + H+ - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch) I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glucose and xylose degradation:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch) I:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway of glycolysis and the Entner-Doudoroff pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway NAD/NADP - NADH/NADPH interconversion:
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - NAD/NADP-NADH/NADPH cytosolic interconversion:
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - pentose phosphate pathway (oxidative branch):
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway (oxidative branch) I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glycolysis and the Entner-Doudoroff pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch) I:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway (oxidative branch) I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch):
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glycolysis and the Entner-Doudoroff pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch):
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch) I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glucose and xylose degradation:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glycolysis and the Entner-Doudoroff pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - Entner-Doudoroff pathway I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch) I:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway of glucose and xylose degradation:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway of glycolysis and the Entner-Doudoroff pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - formaldehyde oxidation I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - heterolactic fermentation:
ATP + D-glucopyranose ⟶ ADP + D-glucopyranose 6-phosphate + H+ - superpathway of glycolysis and Entner-Doudoroff:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway (oxidative branch):
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway (oxidative branch) I:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway of glycolysis and the Entner-Doudoroff pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch):
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glycolysis and Entner-Doudoroff:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - superpathway of glycolysis and Entner-Doudoroff:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch):
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch):
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - heterolactic fermentation:
ATP + D-glucopyranose ⟶ ADP + D-glucopyranose 6-phosphate + H+ - heterolactic fermentation:
ATP + D-glucopyranose ⟶ ADP + D-glucopyranose 6-phosphate + H+ - pentose phosphate pathway:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - pentose phosphate pathway (oxidative branch) I:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway of glucose and xylose degradation:
D-gluconate 6-phosphate + NADP+ ⟶ CO2 + D-ribulose 5-phosphate + NADPH - superpathway of glycolysis and Entner-Doudoroff:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - formaldehyde oxidation I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway (oxidative branch) I:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - pentose phosphate pathway:
D-glucopyranose 6-phosphate + NADP+ ⟶ 6-phospho D-glucono-1,5-lactone + H+ + NADPH - heterolactic fermentation:
ATP + D-glucopyranose ⟶ ADP + D-glucopyranose 6-phosphate + H+ - allopregnanolone biosynthesis:
5-α-pregnane-3,20-dione + NADP+ ⟶ H+ + NADPH + progesterone - allopregnanolone biosynthesis:
NAD(P)+ + allopregnanolone ⟶ 5-α-pregnane-3,20-dione + H+ + NAD(P)H - (R)-canadine biosynthesis:
7,8-dihydroberberine + H+ + NADPH ⟶ (R)-canadine + NADP+ - chlorinated phenols degradation:
3-chlorophenol + H+ + NADPH + O2 ⟶ 3-chlorocatechol + H2O + NADP+ - plant sterol biosynthesis II:
4α-methyl-zymosterol ⟶ 4α-methyl-5α-cholesta-7,24-dien-3β-ol - superpathway of microbial D-galacturonate and D-glucuronate degradation:
aldehydo-D-glucuronate ⟶ D-fructuronate - D-galacturonate degradation III:
NADP+ + glycerol ⟶ H+ + L-glyceraldehyde + NADPH - ubiquinol-8 biosynthesis (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H+ ⟶ 2-methoxy-6-(all-trans-octaprenyl)phenol + CO2 - ubiquinol-8 biosynthesis (eukaryotic):
2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 ⟶ 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol + H2O + NADP+ - ubiquinol-8 biosynthesis (eukaryotic):
3-octaprenyl-4-hydroxybenzoate + H+ + NADPH + O2 ⟶ 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + H2O + NADP+ - pyruvate fermentation to acetate VIII:
H2O + NADP+ + acetaldehyde ⟶ H+ + NADPH + acetate - triethylamine degradation:
H+ + diethylamine N-oxide ⟶ acetaldehyde + ethylamine - pyruvate fermentation to acetate VIII:
H+ + pyruvate ⟶ CO2 + acetaldehyde - oxidative ethanol degradation III (microsomal):
H+ + NADPH + O2 + ethanol ⟶ H2O + NADP+ + acetaldehyde - oxidative ethanol degradation III (microsomal):
H+ + NADPH + O2 + ethanol ⟶ H2O + NADP+ + acetaldehyde - ethylene glycol biosynthesis (engineered):
H+ + NADPH + glycolaldehyde ⟶ NADP+ + ethylene glycol - autoinducer CAI-1 biosynthesis:
SAM + decanoyl-CoA ⟶ 3-aminotridec-2-en-4-one + S-methyl-5'-thioadenosine + CO2 + coenzyme A - superpathway of hyoscyamine and scopolamine biosynthesis:
(S)-atropinium + 2-oxoglutarate + O2 ⟶ (6S)-hydroxyhyoscyamine + CO2 + succinate - calystegine biosynthesis:
pseudotropine ⟶ an unknown compound - hyoscyamine and scopolamine biosynthesis:
(S)-atropinium + 2-oxoglutarate + O2 ⟶ (6S)-hydroxyhyoscyamine + CO2 + succinate - dihydroconiferyl alcohol biosynthesis:
H+ + NADPH + coniferaldehyde ⟶ NADP+ + dihydroconiferyl aldehyde - D-galactose degradation IV:
H+ + L-xylo-3-hexulose + NADPH ⟶ D-sorbitol + NADP+ - phenolphthiocerol biosynthesis:
19-(4-hydroxyphenyl)nonadecanoyl adenylate + holo-(phenol)carboxyphthiodiolenone synthase ⟶ AMP + H+ + a 19-(4-hydroxyphenyl)-nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] - phenolphthiocerol biosynthesis:
19-(4-hydroxyphenyl)nonadecanoyl adenylate + holo-(phenol)carboxyphthiodiolenone synthase ⟶ AMP + H+ + a 19-(4-hydroxyphenyl)-nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] - 4-hydroxymandelate degradation:
2-(4-hydroxyphenyl)-2-oxoacetate + H+ ⟶ 4-hydroxybenzaldehyde + CO2 - superpathway of aromatic compound degradation via 2-hydroxypentadienoate:
O2 + catechol ⟶ H+ + HMS - superpathway of aromatic compound degradation via 3-oxoadipate:
O2 + catechol ⟶ H+ + HMS - toluene degradation III (aerobic) (via p-cresol):
4-methylphenol + H2O + an oxidized azurin ⟶ 4-hydroxybenzyl alcohol + H+ + a reduced azurin - 4-methylphenol degradation to protocatechuate:
4-methylphenol + H2O + an oxidized azurin ⟶ 4-hydroxybenzyl alcohol + H+ + a reduced azurin - superpathway of aerobic toluene degradation:
4-methylphenol + H2O + an oxidized azurin ⟶ 4-hydroxybenzyl alcohol + H+ + a reduced azurin - 4-hydroxymandelate degradation:
4-hydroxybenzoate + H+ + NADPH + O2 ⟶ H2O + NADP+ + protocatechuate - 4-hydroxymandelate degradation:
4-hydroxybenzoate + H+ + NADPH + O2 ⟶ H2O + NADP+ + protocatechuate - superpathway of aromatic compound degradation via 3-oxoadipate:
O2 + trp ⟶ N-formylkynurenine - 4-hydroxymandelate degradation:
4-hydroxybenzoate + H+ + NADPH + O2 ⟶ H2O + NADP+ + protocatechuate - 4-hydroxymandelate degradation:
4-hydroxybenzoate + H+ + NADPH + O2 ⟶ H2O + NADP+ + protocatechuate - superpathway of ergotamine biosynthesis:
chanoclavine-I aldehyde ⟶ 6,8-dimethyl-6,7,8,9-tetradehydroergoline + H2O - ergotamine biosynthesis:
chanoclavine-I aldehyde ⟶ 6,8-dimethyl-6,7,8,9-tetradehydroergoline + H2O - 2,4-dichlorophenoxyacetate degradation:
2,4-dichlorophenoxyacetate + 2-oxoglutarate + O2 ⟶ 2,4-dichlorophenol + CO2 + glyoxylate + succinate - patulin biosynthesis:
NADP+ + ascladiol ⟶ H+ + NADPH + patulin - carnosate bioynthesis:
11-hydroxyferruginol + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + carnosate - 2,3-cis-flavanols biosynthesis:
(-)-epicatechin + NADP+ ⟶ H+ + NADPH + cyanidin - 2,3-cis-flavanols biosynthesis:
(-)-epicatechin + NADP+ ⟶ H+ + NADPH + cyanidin - isopimaric acid biosynthesis:
(+)-isopimara-7,15-diene + H+ + NADPH + O2 ⟶ H2O + NADP+ + isopimara-7,15-dienol - stipitatate biosynthesis:
H2O + stipitatonate ⟶ CO2 + H+ + stipitatate - chlorophyll cycle:
H+ + chlorophyllide a + phytyl diphosphate ⟶ chlorophyll a + diphosphate - resorcinol degradation:
O2 + hydroxyquinol ⟶ 2-maleylacetate + H+ - resorcinol degradation:
H+ + NADPH + O2 + resorcinol ⟶ H2O + NADP+ + hydroxyquinol - rosamicin biosynthesis:
(2S)-ethylmalonyl-CoA + (S)-methylmalonyl-CoA + H+ + NADPH + malonyl-CoA ⟶ CO2 + H2O + NADP+ + coenzyme A + tylactone - tylosin biosynthesis:
(2S)-ethylmalonyl-CoA + (S)-methylmalonyl-CoA + H+ + NADPH + malonyl-CoA ⟶ CO2 + H2O + NADP+ + coenzyme A + tylactone - vestitol and sativan biosynthesis:
(-)-medicarpin + H+ + NADPH ⟶ (-)-vestitol + NADP+ - baicalein metabolism:
UDP-α-D-glucose + baicalein ⟶ H+ + UDP + baicalein 7-O-β-D-glucoside - assimilatory sulfate reduction I:
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - assimilatory sulfate reduction III:
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - superpathway of sulfate assimilation and cysteine biosynthesis:
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - superpathway of L-methionine biosynthesis (by sulfhydrylation):
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae):
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - assimilatory sulfate reduction I:
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phosphooxypyruvate + glu - superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae):
ATP + H+ + sulfate ⟶ APS + diphosphate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phosphooxypyruvate + Glu - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - superpathway of L-methionine biosynthesis (by sulfhydrylation):
3',5'-ADP + H+ + an oxidized thioredoxin + sulfite ⟶ PAPS + a reduced thioredoxin - assimilatory sulfate reduction I:
3',5'-ADP + H+ + an oxidized thioredoxin + sulfite ⟶ PAPS + a reduced thioredoxin - superpathway of sulfate assimilation and cysteine biosynthesis:
3',5'-ADP + H+ + an oxidized thioredoxin + sulfite ⟶ PAPS + a reduced thioredoxin - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of methionine biosynthesis (by sulfhydrylation):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ adenosine 5'-phosphosulfate + diphosphate - sulfate reduction III (assimilatory):
ATP + H+ + sulfate ⟶ adenosine 5'-phosphosulfate + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - superpathway of L-methionine biosynthesis (by sulfhydrylation):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of L-methionine biosynthesis (by sulfhydrylation):
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - assimilatory sulfate reduction I:
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - superpathway of sulfate assimilation and cysteine biosynthesis:
H2O + NADP+ + hydrogen sulfide ⟶ H+ + NADPH + sulfite - superpathway of L-methionine biosynthesis (by sulfhydrylation):
2-oxoglutarate + asp ⟶ glu + oxaloacetate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phosphooxypyruvate + glu - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - assimilatory sulfate reduction I:
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phosphooxypyruvate + glu - superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae):
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - sulfate reduction I (assimilatory):
ATP + adenosine 5'-phosphosulfate ⟶ ADP + H+ + phosphoadenosine-5'-phosphosulfate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + adenosine 5'-phosphosulfate ⟶ ADP + H+ + phosphoadenosine-5'-phosphosulfate - sulfate reduction III (assimilatory):
ATP + H+ + sulfate ⟶ adenosine 5'-phosphosulfate + diphosphate - sulfate reduction I (assimilatory):
ATP + adenosine 5'-phosphosulfate ⟶ ADP + H+ + phosphoadenosine-5'-phosphosulfate - superpathway of sulfate assimilation and cysteine biosynthesis:
2-oxoglutarate + 3-phospho-L-serine ⟶ 3-phospho-hydroxypyruvate + glt - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - superpathway of L-methionine biosynthesis (by sulfhydrylation):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - sulfate reduction I (assimilatory):
ATP + H+ + sulfate ⟶ APS + diphosphate - nicotine degradation III:
H2O + O2 + nicotine-Δ1'5'-iminium ion ⟶ H+ + cotinine + hydrogen peroxide - phenylethanol biosynthesis:
2-phenylethylamine + H2O + O2 ⟶ ammonium + hydrogen peroxide + phenylacetaldehyde - phenylethanol biosynthesis:
2-phenylethylamine + H2O + O2 ⟶ ammonium + hydrogen peroxide + phenylacetaldehyde - phenylethanol biosynthesis:
H2O + O2 + phe ⟶ CO2 + ammonia + hydrogen peroxide + phenylacetaldehyde - superpathway of citrulline metabolism:
ATP + CO2 + H2O + ammonia ⟶ ADP + H+ + carbamoyl-phosphate + phosphate - citrulline-nitric oxide cycle:
L-arginino-succinate ⟶ arg + fumarate - citrulline-nitric oxide cycle:
L-arginino-succinate ⟶ arg + fumarate - superpathway of citrulline metabolism:
H2O + gln ⟶ H+ + ammonia + glt - citrulline-nitric oxide cycle:
L-arginino-succinate ⟶ arg + fumarate - citrulline-nitric oxide cycle:
L-arginino-succinate ⟶ arg + fumarate - superpathway of erythromycin biosynthesis:
dTDP-β-L-mycarose + erythronolide B ⟶ 3-α-mycarosylerythronolide B + H+ + dTDP - superpathway of megalomicin A biosynthesis:
dTDP-β-L-mycarose + erythronolide B ⟶ 3-α-mycarosylerythronolide B + H+ + dTDP - erythromycin D biosynthesis:
dTDP-β-L-mycarose + erythronolide B ⟶ 3-α-mycarosylerythronolide B + H+ + dTDP - superpathway of erythromycin biosynthesis (without sugar biosynthesis):
dTDP-β-L-mycarose + erythronolide B ⟶ 3-α-mycarosylerythronolide B + H+ + dTDP - phaseollin biosynthesis:
(-)-phaseollidin + H+ + NADPH + O2 ⟶ (-)-phaseollin + H2O + NADP+ - superpathway of pterocarpan biosynthesis (via daidzein):
(-)-glycinol + DMAPP ⟶ (6αS,11αS)-2-dimethylallyl-3,6α,9-trihydroxypterocarpan + diphosphate - artemisinin biosynthesis:
(+)-amorpha-4,11-diene + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + artemisinic alcohol - superpathway of lipoxygenase:
(3Z)-hex-3-en-1-ol + NAD+ ⟶ (Z)-3-hexanal + H+ + NADH - traumatin and (Z)-3-hexen-1-yl acetate biosynthesis:
(3Z)-hex-3-en-1-ol + NAD+ ⟶ (Z)-3-hexanal + H+ + NADH - traumatin and (Z)-3-hexen-1-yl acetate biosynthesis:
(Z)-hex-3-en-ol + NAD+ ⟶ (Z)-3-hexanal + H+ + NADH - trichloroethene degradation:
O2 + trichloroethanol ⟶ 2,2,2-trichloroacetate + H+ + H2O - nitrobenzene degradation I:
hydroxyaminobenzene ⟶ 2-aminophenol - ceramide de novo biosynthesis:
H+ + palmitoyl-CoA + ser ⟶ 3-dehydrosphinganine + CO2 + coenzyme A - sphingolipid biosynthesis (mammals):
D-erythro-sphinganine + an acyl-CoA ⟶ H+ + a dihydroceramide + coenzyme A - ceramide de novo biosynthesis:
D-erythro-sphinganine + an acyl-CoA ⟶ H+ + a dihydroceramide + coenzyme A - sphingolipid biosynthesis (plants):
H+ + O2 + a dihydroceramide + a ferrocytochrome b5 ⟶ H2O + a ferricytochrome b5 + a phytoceramide - sphingolipid biosynthesis (yeast):
D-erythro-sphinganine + NADP+ ⟶ 3-dehydrosphinganine + H+ + NADPH - sphingolipid biosynthesis:
H+ + palmitoyl-CoA + ser ⟶ 3-dehydrosphinganine + CO2 + coenzyme A - ceramide de novo biosynthesis:
D-erythro-sphinganine + NADP+ ⟶ 3-dehydrosphinganine + H+ + NADPH - hinokinin biosynthesis:
(-)-matairesinol + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ (-)-pluviatolide + H2O + an oxidized [NADPH-hemoprotein reductase] - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - superpathway of methylglyoxal degradation:
(S)-propane-1,2-diol + NAD+ ⟶ H+ + NADH + acetol - propane degradation II:
NAD+ + propan-2-ol ⟶ H+ + NADH + acetone - methylglyoxal degradation III:
(S)-propane-1,2-diol + NAD+ ⟶ H+ + NADH + acetol - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - superpathway of methylglyoxal degradation:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
(S)-propane-1,2-diol + NAD+ ⟶ H+ + NADH + acetol - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - superpathway of methylglyoxal degradation:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - superpathway of methylglyoxal degradation:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - superpathway of methylglyoxal degradation:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation III:
NADP+ + acetol ⟶ H+ + NADPH + methylglyoxal - lactose degradation II:
3'-ketolactose + H2O ⟶ β-D-glucose + 3-keto-β-D-galactose - lactose degradation II:
3'-ketolactose + H2O ⟶ β-D-glucose + 3-keto-β-D-galactose - coumarin metabolism (to melilotic acid):
H2O + dihydrocoumarin ⟶ H+ + melilotate - phenylmercury acetate degradation:
H+ + mercuriphenyl acetate ⟶ Hg2+ + acetate + benzene - phenylmercury acetate degradation:
H+ + mercuriphenyl acetate ⟶ Hg2+ + acetate + benzene - phenylmercury acetate degradation:
H+ + mercuriphenyl acetate ⟶ Hg2+ + acetate + benzene - phenylmercury acetate degradation:
H+ + mercuriphenyl acetate ⟶ Hg2+ + acetate + benzene - phenylmercury acetate degradation:
H+ + mercuriphenyl acetate ⟶ Hg2+ + acetate + benzene - phenylmercury acetate degradation:
H+ + mercuriphenyl acetate ⟶ Hg2+ + acetate + benzene - sphingosine and sphingosine-1-phosphate metabolism:
NADP+ + palmitaldehyde ⟶ (2E)-hexadecenal + H+ + NADPH - sphingosine and sphingosine-1-phosphate metabolism:
sphingosine 1-phosphate ⟶ (2E)-hexadecenal + O-phosphoethanolamine - sphingosine and sphingosine-1-phosphate metabolism:
ATP + sphingosine ⟶ ADP + H+ + sphingosine-1-phosphate - sphingosine and sphingosine-1-phosphate metabolism:
NADP+ + palmitaldehyde ⟶ (2E)-hexadecenal + H+ + NADPH - sphingosine and sphingosine-1-phosphate metabolism:
ATP + sphingosine ⟶ ADP + H+ + sphingosine-1-phosphate - sphingosine and sphingosine-1-phosphate metabolism:
ATP + sphingosine ⟶ ADP + H+ + sphingosine-1-phosphate - polybrominated dihydroxylated diphenyl ethers biosynthesis:
3,5-dibromocatechol + H+ + O2 + a reduced ferredoxin [iron-sulfur] cluster ⟶ 3-bromo-5-(3,5-dibromo-2-hydroxyphenoxy)benzene-1,2-diol + H2O + an oxidized ferredoxin [iron-sulfur] cluster + bromide - spongiadioxin C biosynthesis:
2,4-dibromophenol + 3,5-dibromocatechol + H+ + O2 + a reduced ferredoxin [iron-sulfur] cluster ⟶ 6,6'-oxybis(2,4-dibromophenol) + H2O + an oxidized ferredoxin [iron-sulfur] cluster - bacteriochlorophyll b biosynthesis:
ADP + an oxidized ferredoxin [iron-sulfur] cluster + bacteriochlorophyllide g + phosphate ⟶ 3,8-divinyl chlorophyllide a + ATP + H+ + H2O + a reduced ferredoxin [iron-sulfur] cluster - superpathway of seleno-compound metabolism:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - selenate reduction:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - selenate reduction:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - selenate reduction:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - selenate reduction:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - selenate reduction:
H+ + NADPH + selenodiglutathione ⟶ NADP+ + glutathione + glutathioselenol - selenate reduction:
H+ + NADPH + selenodiglutathione ⟶ NADP+ + glutathione + glutathioselenol - selenate reduction:
NADP+ + glutathione + hydrogen selenide ⟶ H+ + NADPH + glutathioselenol - mannitol biosynthesis:
D-mannitol 1-phosphate + H2O ⟶ D-mannitol + phosphate - mannitol biosynthesis:
D-mannitol 1-phosphate + H2O ⟶ D-mannitol + phosphate - tetrahydroxyxanthone biosynthesis (from benzoate):
2,3',4,6-tetrahydroxybenzophenone + NADPH + O2 ⟶ 1,3,7-trihydroxyxanthone + H2O + NADP+ - tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate):
2,3',4,6-tetrahydroxybenzophenone + NADPH + O2 ⟶ 1,3,5-trihydroxyxanthone + H2O + NADP+ - superpathway of tetrahydroxyxanthone biosynthesis:
2,3',4,6-tetrahydroxybenzophenone + NADPH + O2 ⟶ 1,3,5-trihydroxyxanthone + H2O + NADP+ - methylglyoxal degradation V:
(S)-lactaldehyde + H2O + NAD+ ⟶ (S)-lactate + H+ + NADH - methylglyoxal degradation IV:
(S)-lactaldehyde + H2O + NAD+ ⟶ (S)-lactate + H+ + NADH - L-rhamnose degradation II:
2-dehydro-3-deoxy-L-rhamnonate ⟶ (S)-lactaldehyde + pyruvate - methylglyoxal degradation IV:
(S)-lactaldehyde + NADP+ ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation V:
(S)-lactaldehyde + NADP+ ⟶ H+ + NADPH + methylglyoxal - methylglyoxal degradation V:
L-lactaldehyde + NADP+ ⟶ H+ + NADPH + methylglyoxal - L-rhamnose degradation II:
H2O + L-lactaldehyde + NADP+ ⟶ (S)-lactate + H+ + NADPH - methylglyoxal degradation V:
L-lactaldehyde + NADP+ ⟶ H+ + NADPH + methylglyoxal - plant sterol biosynthesis:
24-epi-campesterol + NADP+ ⟶ H+ + NADPH + brassicasterol - L-rhamnose degradation III:
L-rhamnofuranose + NADP+ ⟶ H+ + L-rhamnono-1,4-lactone + NADPH - narbomycin, pikromycin and novapikromycin biosynthesis:
(S)-methylmalonyl-CoA + H+ + NADPH + malonyl-CoA ⟶ CO2 + H2O + NADP+ + coenzyme A + narbonolide - L-arabinose degradation II:
D-xylitol + NADP+ ⟶ H+ + L-xylulose + NADPH - L-arabinose degradation II:
L-arabitol + NADP+ ⟶ H+ + L-arabinose + NADPH - (-)-maackiain biosynthesis:
(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol ⟶ (-)-maackiain + H2O - 4-nitrophenol degradation I:
4-nitrophenol + H+ + NAD(P)H + O2 ⟶ 1,4-benzoquinone + H2O + NAD(P)+ + nitrite - ursodeoxycholate biosynthesis (bacteria):
NADP+ + ursodeoxycholate ⟶ 7-oxolithocholate + H+ + NADPH - Entner-Doudoroff pathway II (non-phosphorylative):
D-glucopyranose + NADP+ ⟶ D-glucono-1,5-lactone + H+ + NADPH - sucrose degradation VII (sucrose 3-dehydrogenase):
A + sucrose ⟶ 3'-ketosucrose + A(H2) - Entner-Doudoroff pathway III (semi-phosphorylative):
D-glucopyranose + NADP+ ⟶ D-glucono-1,5-lactone + H+ + NADPH - brassinosteroid biosynthesis I:
6-deoxotyphasterol + A ⟶ 3-dehydro-6-deoxoteasterone + A(H2) - brassinosteroid biosynthesis III:
NAD+ + campesterol ⟶ NADH + campest-5-en-3-one - botryococcenes and methylated squalene biosynthesis:
SAM + showacene ⟶ 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H+ + SAH - D-xylose degradation III:
D-xylopyranose + NADP+ ⟶ D-xylono-1,5-lactone + H+ + NADPH - cinchona alkaloids biosynthesis:
corynantheal ⟶ quinidinone - aclacinomycin biosynthesis:
aklavinone + dTDP-β-L-rhodosamine ⟶ H+ + aclacinomycin T + dTDP - oryzalide A biosynthesis:
(-)-ent-copalyl diphosphate ⟶ ent-isokaurene + diphosphate - leucopelargonidin and leucocyanidin biosynthesis:
(2R,3S,4S)-leucopelargonidin + NADP+ ⟶ (+)-dihydrokaempferol + H+ + NADPH - leucopelargonidin and leucocyanidin biosynthesis:
(+)-dihydrokaempferol + NADPH + O2 ⟶ (+)-taxifolin + H2O + NADP+ - leucodelphinidin biosynthesis:
(+)-dihydrokaempferol + NADPH + O2 ⟶ (+)-taxifolin + H2O + NADP+ - flavonol biosynthesis:
(+)-dihydrokaempferol + NADPH + O2 ⟶ (+)-taxifolin + H2O + NADP+ - syringetin biosynthesis:
(+)-dihydrokaempferol + NADPH + O2 ⟶ (+)-taxifolin + H2O + NADP+ - flavonoid biosynthesis:
(2S)-naringenin + 2-oxoglutarate + O2 ⟶ (+)-dihydrokaempferol + CO2 + succinate - flavonoid biosynthesis:
(2S)-naringenin + 2-oxoglutarate + O2 ⟶ (+)-dihydrokaempferol + CO2 + succinate - methylglyoxal degradation II:
H2O + NADP+ + methylglyoxal ⟶ H+ + NADPH + pyruvate - shikonin biosynthesis:
A + H2O + deoxyshikonin ⟶ A(H2) + shikonin - diphenyl ethers degradation:
O2 + diphenyl ether 2,3-diol ⟶ (2Z,4E)-2-hydroxy-6-oxo-6-phenoxyhexa-2,4-dienoate + H+ - 2,5-xylenol and 3,5-xylenol degradation:
(2E)-3-methyl-4,6-dioxohept-2-enedioate + H2O ⟶ H+ + citraconate + pyruvate - pinitol biosynthesis II:
myo-inositol + SAM ⟶ H+ + SAH + sequoyitol - (4R)-carveol and (4R)-dihydrocarveol degradation:
(-)-cis-carveol + oxidized DCPIP ⟶ (-)-carvone + H+ + reduced DCPIP - geraniol and geranial biosynthesis:
NADP+ + geraniol ⟶ H+ + NADPH + geranial - phthiocerol biosynthesis:
(behenoyl)adenylate + holo-(phenol)carboxyphthiodiolenone synthase ⟶ AMP + H+ + a behenoyl-[(phenol)carboxyphthiodiolenone synthase] - phthiocerol biosynthesis:
(behenoyl)adenylate + holo-(phenol)carboxyphthiodiolenone synthase ⟶ AMP + H+ + a behenoyl-[(phenol)carboxyphthiodiolenone synthase] - polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium):
3,6,7-trimethylquercetagetin + SAM ⟶ 3,6,7,4'-tetramethylquercetagetin + H+ + SAH - superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium):
3,6,7-trimethylquercetagetin + SAM ⟶ 3,6,7,4'-tetramethylquercetagetin + H+ + SAH - 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis (yeast):
2'-hydroxypyridoxol + A(H2) ⟶ A + H2O + pyridoxine - pyridoxal 5'-phosphate salvage II (plants):
H2O + pyridoxine 5'-phosphate ⟶ phosphate + pyridoxine - superpathway of thiamin diphosphate biosynthesis III (eukaryotes):
O2 + pyridoxine 5'-phosphate ⟶ PLP + hydrogen peroxide - 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis:
O2 + pyridoxine 5'-phosphate ⟶ PLP + hydrogen peroxide - pyridoxal 5'-phosphate salvage II (plants):
ATP + pyridoxal ⟶ ADP + H+ + PLP - polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium):
2-oxoglutarate + 3,7,4'-trimethylquercetin + O2 ⟶ 3,7,4'-trimethylquercetagetin + CO2 + succinate - (-)-glycinol biosynthesis:
(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ (-)-glycinol + H2O + an oxidized [NADPH-hemoprotein reductase] - apigeninidin 5-O-glucoside biosynthesis:
NADP+ + apiforol ⟶ (2S)-naringenin + H+ + NADPH - cholesterol biosynthesis III (via desmosterol):
4,4-dimethyl-14α-formyl-5α-cholesta-8,24-dien-3β-ol + NADPH + O2 ⟶ 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + H2O + NADP+ + formate - superpathway of cholesterol biosynthesis:
ATP + mevalonate-diphosphate ⟶ ADP + CO2 + H+ + isopentenyl diphosphate + phosphate - cholesterol biosynthesis III (via desmosterol):
4,4-dimethyl-14α-formyl-5α-cholesta-8,24-dien-3β-ol + NADPH + O2 ⟶ 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + H2O + NADP+ + formate - cholesterol biosynthesis III (via desmosterol):
4,4-dimethyl-14α-formyl-5α-cholesta-8,24-dien-3β-ol + NADPH + O2 ⟶ 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + H2O + NADP+ + formate - superpathway of cholesterol biosynthesis:
H+ + NADPH + desmosterol ⟶ NADP+ + cholesterol - cholesterol biosynthesis III (via desmosterol):
H+ + NADPH + desmosterol ⟶ NADP+ + cholesterol - methymycin, neomethymycin and novamethymycin biosynthesis:
(S)-methylmalonyl-CoA + H+ + NADPH + malonyl-CoA ⟶ 10-deoxymethynolide + CO2 + H2O + NADP+ + coenzyme A - 1,8-cineole degradation:
1,6,6-trimethyl-2,7-dioxobicyclo-(3,2,2)nonan-3-one ⟶ 4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one - UDP-sugars interconversion:
NADP+ + UDP-β-L-rhamnose ⟶ H+ + NADPH + UDP-4-dehydro-β-L-rhamnose - UDP-β-L-rhamnose biosynthesis:
NADP+ + UDP-β-L-rhamnose ⟶ H+ + NADPH + UDP-4-dehydro-β-L-rhamnose - 6-methoxymellein biosynthesis:
6-hydroxymellein + SAM ⟶ 6-methoxymellein + H+ + SAH - coelimycin P1 biosynthesis:
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate ⟶ (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + ala - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis VI:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis II:
L-2-acetamido-6-oxoheptanedioate + glu ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - L-lysine biosynthesis III:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis I:
N-succinyl-L,L-2,6-diaminopimelate + H2O ⟶ L,L-diaminopimelate + succinate - spermidine biosynthesis II:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - grixazone biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - norspermidine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of polyamine biosynthesis III:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - ectoine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-methionine biosynthesis (transsulfuration):
L-homocysteine + a 5-methyltetrahydrofolate ⟶ a tetrahydrofolate + met - superpathway of L-homoserine and L-methionine biosynthesis:
L-homocysteine + a 5-methyltetrahydrofolate ⟶ a tetrahydrofolate + met - L-methionine biosynthesis IV (archaea):
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-lysine, L-threonine and L-methionine biosynthesis I:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - superpathway of L-lysine, L-threonine and L-methionine biosynthesis II:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - superpathway of L-threonine biosynthesis:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - aspartate superpathway:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - superpathway of S-adenosyl-L-methionine biosynthesis:
ATP + H2O + met ⟶ SAM + diphosphate + phosphate - 3-dehydroquinate biosynthesis II (archaea):
enolaldehyde ⟶ methylglyoxal - superpathway of L-isoleucine biosynthesis I:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - superpathway of S-adenosyl-L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-lysine, L-threonine and L-methionine biosynthesis I:
2-oxoglutarate + asp ⟶ glu + oxaloacetate - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glu + oxaloacetate - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glu - aspartate superpathway:
O2 + asp ⟶ 2-iminosuccinate + H+ + hydrogen peroxide - superpathway of L-homoserine and L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis VI:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-isoleucine biosynthesis I:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-lysine, L-threonine and L-methionine biosynthesis II:
N5-methyl--tetrahydropteroyl tri-L-glutamate + L-homocysteine ⟶ met + tetrahydropteroyl tri-L-glutamate - superpathway of L-threonine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - L-homoserine and L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-lysine, L-threonine and L-methionine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + Glu - ectoine biosynthesis:
2-oxoglutarate + L-2,4-diaminobutanoate ⟶ Glu + L-aspartate-semialdehyde - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + Glu - aspartate superpathway:
O2 + asp ⟶ 2-iminosuccinate + H+ + hydrogen peroxide - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + Glu - superpathway of lysine, threonine and methionine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + glt - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of S-adenosyl-L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - aspartate superpathway:
O2 + asp ⟶ α-iminosuccinate + H+ + hydrogen peroxide - homoserine and methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - aspartate superpathway:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - superpathway of lysine, threonine and methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-threonine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis I:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of L-isoleucine biosynthesis I:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-homoserine and L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of S-adenosyl-L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glu - isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + glt - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - homoserine and methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of lysine, threonine and methionine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - aspartate superpathway:
O2 + asp ⟶ α-iminosuccinate + H+ + hydrogen peroxide - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of S-adenosyl-L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of S-adenosyl-L-methionine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - aspartate superpathway:
O2 + asp ⟶ α-iminosuccinate + H+ + hydrogen peroxide - isoleucine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - superpathway of lysine, threonine and methionine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine and methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine and methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - isoleucine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of L-lysine, L-threonine and L-methionine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - superpathway of L-methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-homoserine and L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - aspartate superpathway:
O2 + asp ⟶ 2-iminosuccinate + H+ + hydrogen peroxide - L-lysine biosynthesis I:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-homoserine biosynthesis:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-threonine biosynthesis:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-isoleucine biosynthesis I:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + glu - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glu + oxaloacetate - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glu - L-homoserine biosynthesis:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - ectoine biosynthesis:
2-oxoglutarate + L-2,4-diaminobutanoate ⟶ L-aspartate 4-semialdehyde + glu - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - aspartate superpathway:
O2 + asp ⟶ 2-iminosuccinate + H+ + hydrogen peroxide - superpathway of L-lysine, L-threonine and L-methionine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - ectoine biosynthesis:
2-oxoglutarate + L-2,4-diaminobutanoate ⟶ L-aspartate-semialdehyde + glt - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - aspartate threonine lysine biosynthesis superpathway:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine and methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + glt - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-homoserine and L-methionine biosynthesis:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-homoserine biosynthesis:
L-aspartate 4-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis II:
L-2-acetamido-6-oxoheptanedioate + glu ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + glt - L-lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O + glt - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - superpathway of lysine, threonine and methionine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine and methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - aspartate superpathway:
O2 + asp ⟶ α-iminosuccinate + H+ + hydrogen peroxide - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - aspartate superpathway:
O2 + asp ⟶ α-iminosuccinate + H+ + hydrogen peroxide - superpathway of lysine, threonine and methionine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - homoserine and methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - homoserine and methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - superpathway of S-adenosyl-L-methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - lysine biosynthesis II:
L-2-acetamido-6-oxoheptanedioate + glt ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - isoleucine biosynthesis I:
thr ⟶ 2-oxobutanoate + H+ + ammonia - superpathway of S-adenosyl-L-methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of methionine biosynthesis (transsulfuration):
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - homoserine and methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - superpathway of S-adenosyl-L-methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - homoserine and methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - superpathway of methionine biosynthesis (transsulfuration):
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + H2O + H+ + glt - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - isoleucine biosynthesis I:
thr ⟶ 2-oxobutanoate + H+ + ammonia - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of methionine biosynthesis (by sulfhydrylation):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - homoserine and methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - isoleucine biosynthesis I:
thr ⟶ 2-oxobutanoate + H+ + ammonia - superpathway of methionine biosynthesis (transsulfuration):
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - lysine biosynthesis II:
L-2-acetamido-6-oxoheptanedioate + glt ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - spermidine biosynthesis II:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - L-lysine biosynthesis II:
Glu + L-2-acetamido-6-oxoheptanedioate ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-homoserine and L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - homoserine and methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - lysine biosynthesis III:
meso-diaminopimelate + H2O + NADP+ ⟶ H+ + L-α-amino-ε-keto-pimelate + NADPH + ammonium - superpathway of methionine biosynthesis (by sulfhydrylation):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - isoleucine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + glt - L-homoserine and L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-lysine, L-threonine and L-methionine biosynthesis I:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - superpathway of L-methionine biosynthesis (transsulfuration):
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - aspartate superpathway:
O2 + asp ⟶ 2-iminosuccinate + H+ + hydrogen peroxide - superpathway of S-adenosyl-L-methionine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis III:
meso-diaminopimelate + H2O + NADP+ ⟶ H+ + L-α-amino-ε-keto-pimelate + NADPH + ammonium - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + glt - L-lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O + glt - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-lysine biosynthesis II:
L-2-acetamido-6-oxoheptanedioate + glt ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + Glu - L-lysine biosynthesis III:
meso-diaminopimelate + H2O + NADP+ ⟶ H+ + L-α-amino-ε-keto-pimelate + NADPH + ammonium - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + Glu - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis III:
meso-diaminopimelate + H2O + NADP+ ⟶ H+ + L-α-amino-ε-keto-pimelate + NADPH + ammonium - L-lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + Glu + H+ + H2O - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + Glu + H+ + H2O - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + Glu - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis III:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + Glu + H+ + H2O - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - L-lysine biosynthesis VI:
2-oxoglutarate + L,L-diaminopimelate ⟶ (S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O + glt - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-lysine biosynthesis II:
Glu + L-2-acetamido-6-oxoheptanedioate ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - L-homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - superpathway of L-threonine biosynthesis:
2-oxoglutarate + asp ⟶ Glu + oxaloacetate - L-lysine biosynthesis I:
2-oxoglutarate + N-succinyl-L,L-2,6-diaminopimelate ⟶ N-succinyl-2-amino-6-ketopimelate + Glu - superpathway of L-isoleucine biosynthesis I:
2-oxoglutarate + ile ⟶ (S)-3-methyl-2-oxopentanoate + Glu - L-lysine biosynthesis II:
Glu + L-2-acetamido-6-oxoheptanedioate ⟶ 2-oxoglutarate + N-acetyl-L,L-2,6-diaminopimelate - cholesterol biosynthesis I:
NADP+ + cholesterol ⟶ 7-dehydro-cholesterol + H+ + NADPH - cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
NADP+ + cholesterol ⟶ 7-dehydro-cholesterol + H+ + NADPH - ascorbate recycling (cytosolic):
H+ + NADPH + monodehydroascorbate radical ⟶ H+ + L-ascorbate + NADP+ - ascorbate glutathione cycle:
monodehydroascorbate radical ⟶ H+ + L-ascorbate + L-dehydro-ascorbate - ascorbate recycling (cytosolic):
monodehydroascorbate radical ⟶ H+ + L-ascorbate + L-dehydro-ascorbate - 4-nitrotoluene degradation II:
(S)-4-hydroxy-2-oxohexanoate + A ⟶ (3Z)-4-hydroxy-2-oxohexenoate + A(H2) - dechlorogriseofulvin biosynthesis:
H+ + NADPH + O2 + griseophenone C ⟶ H2O + NADP+ + desmethyl-dehydro-dechlorogriseofulvin - polybrominated phenols biosynthesis:
2,4-dibromophenol + H+ + NADPH + O2 + bromide ⟶ 2,4,6-tribromophenol + H2O + NADP+ - superpathway of polybrominated aromatic compound biosynthesis:
2,4-dibromophenol + H+ + O2 + a reduced ferredoxin [iron-sulfur] cluster ⟶ 2-bromo-4-(2,4-dibromophenoxy)phenol + H2O + an oxidized ferredoxin [iron-sulfur] cluster + bromide - ergosterol biosynthesis:
5,7,24(28)-ergostatrienol + H+ + NADPH + O2 ⟶ 5,7,22,24(28)-ergostatetraenol + H2O + NADP+ - superpathway of ergosterol biosynthesis:
ATP + mevalonate-5-phosphate ⟶ ADP + H+ + mevalonate-diphosphate - superpathway of ergosterol biosynthesis:
(R)-mevalonate + ATP ⟶ ADP + H+ + mevalonate-5-phosphate - ergosterol biosynthesis:
NADP+ + ergosterol ⟶ 5,7,22,24(28)-ergostatetraenol + H+ + NADPH - superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass:
ATP + pyruvate ⟶ ADP + H+ + phosphoenolpyruvate - TCA cycle I (prokaryotic):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - mixed acid fermentation:
ATP + pyruvate ⟶ ADP + H+ + phosphoenolpyruvate - superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP):
IPP ⟶ DMAPP - taxadiene biosynthesis (engineered):
IPP ⟶ DMAPP - gluconeogenesis I:
β-D-fructose 1,6-bisphosphate ⟶ D-glyceraldehyde 3-phosphate + DHAP - methylerythritol phosphate pathway I:
IPP ⟶ DMAPP - methylerythritol phosphate pathway II:
MEP + NADP+ ⟶ 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH - superpathway of glyoxylate bypass and TCA:
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - TCA cycle I (prokaryotic):
2-oxoglutarate + NAD+ + coenzyme A ⟶ CO2 + NADH + succinyl-CoA - mixed acid fermentation:
NAD+ + ethanol ⟶ H+ + NADH + acetaldehyde - superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass:
2-oxoglutarate + NAD+ + coenzyme A ⟶ CO2 + NADH + succinyl-CoA - superpathway of glyoxylate bypass and TCA:
2-oxoglutarate + NAD+ + coenzyme A ⟶ CO2 + NADH + succinyl-CoA - gluconeogenesis I:
(S)-malate + NADP+ ⟶ CO2 + NADPH + pyruvate - methylerythritol phosphate pathway I:
D-glyceraldehyde 3-phosphate + H+ + pyruvate ⟶ 1-deoxy-D-xylulose 5-phosphate + CO2 - nicotine degradation II (pyrrolidine pathway):
6-hydroxy-3-succinoyl-pyridine + H+ + NADH + O2 ⟶ 2,5-dihydroxypyridine + H2O + NAD+ + succinate semialdehyde - nicotine degradation IV:
(S)-nicotine + A + H2O ⟶ A(H2) + formaldehyde + nornicotine - bisphenol A degradation:
NAD+ + S-1-(4-hydroxyphenyl)-ethanol ⟶ 4-hydroxyacetophenone + H+ + NADH - citrulline-nitric oxide cycle:
ATP + L-citrulline + asp ⟶ AMP + H+ + L-arginino-succinate + diphosphate - nitric oxide biosynthesis II (mammals):
H+ + NADPH + O2 + arg ⟶ H2O + L-citrulline + NADP+ + nitric oxide - superpathway of L-citrulline metabolism:
ATP + ammonium + hydrogencarbonate ⟶ ADP + H+ + carbamoyl phosphate + phosphate - nitric oxide biosynthesis I (plants):
Nω-hydroxy-L-arginine + NADPH + O2 ⟶ H+ + H2O + L-citrulline + NADP+ + nitric oxide - L-citrulline-nitric oxide cycle:
H+ + NADPH + O2 + arg ⟶ H2O + L-citrulline + NADP+ + nitric oxide - nitric oxide biosynthesis (plants):
H+ + NADPH + O2 + arg ⟶ H2O + L-citrulline + NADP+ + nitric oxide - L-citrulline-nitric oxide cycle:
L-arginino-succinate ⟶ arg + fumarate - gallate degradation III (anaerobic):
acetate + butanoyl-CoA ⟶ acetyl-CoA + butanoate - gallate degradation III (anaerobic):
3-hydroxy-5-oxohexanoate + acetyl-CoA ⟶ 3-hydroxy-5- oxohexanoyl-CoA + acetate - gallate degradation III (anaerobic):
acetate + butanoyl-CoA ⟶ acetyl-CoA + butanoate - gallate degradation III (anaerobic):
3-hydroxy-5-oxohexanoate + acetyl-CoA ⟶ 3-hydroxy-5- oxohexanoyl-CoA + acetate - gallate degradation III (anaerobic):
3-hydroxy-5- oxohexanoyl-CoA + acetate ⟶ 3-hydroxy-5-oxohexanoate + acetyl-CoA - selenate reduction:
H+ + NADPH + glutathioselenol ⟶ NADP+ + glutathione + hydrogen selenide - lysine biosynthesis IV:
2-oxoglutarate + H2O + acetyl-CoA ⟶ (R)-homocitrate + H+ + coenzyme A - salicortin biosynthesis:
benzylbenzoate ⟶ benzyl-6-hydroxy-2-cyclohexene-on-oyl - mandelate degradation I:
H+ + phenylglyoxylate ⟶ CO2 + benzaldehyde - mandelate degradation to acetyl-CoA:
O2 + catechol ⟶ H+ + HMS - mandelate degradation I:
H2O + NADP+ + benzaldehyde ⟶ H+ + NADPH + benzoate - linear furanocoumarin biosynthesis:
(+)-marmesin + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + acetone + an oxidized [NADPH-hemoprotein reductase] + psoralen - formylTHF biosynthesis I:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia - formylTHF biosynthesis II:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia - tetrahydrofolate biosynthesis:
7,8-dihydropteroate + ATP + glt ⟶ 7,8-dihydrofolate + ADP + H+ + phosphate - formylTHF biosynthesis I:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia - tetrahydrofolate biosynthesis II:
ATP + glt + tetrahydrofolate ⟶ ADP + H+ + phosphate + tetrahydrofolate-L-glutamate - lutein biosynthesis:
α-carotene + H+ + NADPH + O2 ⟶ H2O + NADP+ + zeinoxanthin - superpathway of carotenoid biosynthesis:
all-trans-β-carotene + H+ + NADH + O2 ⟶ β-cryptoxanthin + H2O + NAD+ - lutein biosynthesis:
α-carotene + H+ + NADPH + O2 ⟶ H2O + NADP+ + zeinoxanthin - levopimaric acid biosynthesis:
H+ + NADPH + O2 + levopimaradiene ⟶ H2O + NADP+ + levopimaradienol - m-cresol degradation:
3-hydroxybenzyl alcohol + NAD+ ⟶ 3-hydroxybenzaldehyde + H+ + NADH - 4-hydroxyacetophenone degradation:
(4-hydroxyphenyl)acetate + H2O ⟶ acetate + hydroquinone - lactose degradation II:
α-lactose + A ⟶ 3'-ketolactose + A(H2) - lactose degradation II:
3'-ketolactose + H2O ⟶ 3-keto-β-D-galactose + D-glucopyranose - luteolinidin 5-O-glucoside biosynthesis:
UDP-α-D-glucose + luteolinidin ⟶ H+ + UDP + luteolinidin 5-O-glucoside - cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
4,4-dimethyl-14α-formyl-5α-cholesta-8-en-3β-ol + NADPH + O2 ⟶ 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + H2O + NADP+ + formate - cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
4,4-dimethyl-14α-formyl-5α-cholesta-8-en-3β-ol + NADPH + O2 ⟶ 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + H2O + NADP+ + formate - cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
4,4-dimethyl-14α-formyl-5α-cholesta-8-en-3β-ol + NADPH + O2 ⟶ 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + H2O + NADP+ + formate - succinate fermentation to butanoate:
acetate + butanoyl-CoA ⟶ acetyl-CoA + butanoate - crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered):
4-hydroxybutanoate + ATP + coenzyme A ⟶ 4-hydroxybutanoyl-CoA + ADP + phosphate - TCA cycle IV (2-oxoglutarate decarboxylase):
2-oxoglutarate + H+ ⟶ CO2 + succinate semialdehyde - 4-hydroxyphenylacetate degradation:
(4Z)-2-oxohept-4-enedioate + H2O ⟶ (4S)-4-hydroxy-2-oxoheptanedioate - nicotine degradation I (pyridine pathway):
2,6-dihydroxypyridine + H+ + NADH + O2 ⟶ 2,3,6-trihydroxypyridine + H2O + NAD+ - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glu + succinate semialdehyde - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glu + succinate semialdehyde - superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation:
H2O + agmatine ⟶ putrescine + urea - superpathway of L-arginine and L-ornithine degradation:
4-aminobutanal ⟶ 1-pyrroline + H2O - L-glutamate degradation IV:
2-oxoglutarate + 4-aminobutanoate ⟶ glu + succinate semialdehyde - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glu + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glu + succinate semialdehyde - superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ 4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide - superpathway of L-arginine and L-ornithine degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ 4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - superpathway of 4-aminobutyrate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - glutamate degradation IX (via 4-aminobutyrate):
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glu + succinate semialdehyde - TCA cycle IV (2-oxoglutarate decarboxylase):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - glutamate degradation IX (via 4-aminobutyrate):
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-hydroxyphenylacetate degradation:
4-hydroxyphenylacetate + FADH2 + O2 ⟶ 3,4-dihydroxyphenylacetate + FAD + H+ + H2O - superpathway of 4-aminobutyrate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - glutamate degradation IX (via 4-aminobutyrate):
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - TCA cycle IV (2-oxoglutarate decarboxylase):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - superpathway of glycolysis and TCA variant VIII:
2-oxoglutarate + H+ ⟶ CO2 + succinate semialdehyde - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - TCA cycle IV (2-oxoglutarate decarboxylase):
2-oxoglutarate + H+ ⟶ CO2 + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - TCA cycle IV (2-oxoglutarate decarboxylase):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - superpathway of arginine, putrescine, and 4-aminobutyrate degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ 4-(γ-glutamylamino)butanal + ammonium + hydrogen peroxide - superpathway of arginine and ornithine degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ 4-(γ-glutamylamino)butanal + ammonium + hydrogen peroxide - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - superpathway of 4-aminobutyrate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-hydroxyphenylacetate degradation:
4-hydroxyphenylacetate + FADH2 + O2 ⟶ 3,4-dihydroxyphenylacetate + FAD + H+ + H2O - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - superpathway of 4-aminobutyrate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - superpathway of arginine, putrescine, and 4-aminobutyrate degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ 4-(γ-glutamylamino)butanal + ammonium + hydrogen peroxide - superpathway of arginine and ornithine degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ 4-(γ-glutamylamino)butanal + ammonium + hydrogen peroxide - 4-hydroxyphenylacetate degradation:
4-hydroxyphenylacetate + FADH2 + O2 ⟶ 3,4-dihydroxyphenylacetate + FAD + H+ + H2O - TCA cycle variation I:
2-oxoglutarate + H+ ⟶ CO2 + succinate semialdehyde - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutyrate ⟶ glt + succinate semialdehyde - 4-hydroxyphenylacetate degradation:
4-hydroxyphenylacetate + FADH2 + O2 ⟶ 3,4-dihydroxyphenylacetate + FAD + H2O - glutamate degradation IX (via 4-aminobutyrate):
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 3-hydroxypropionate/4-hydroxybutyrate cycle:
ATP + bicarbonate + propanoyl-CoA ⟶ (S)-methylmalonyl-CoA + ADP + H+ + phosphate - superpathway of 4-aminobutyrate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - 4-aminobutyrate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - succinate fermentation to butanoate:
acetate + butanoyl-CoA ⟶ acetyl-CoA + butanoate - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ Glu + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ Glu + succinate semialdehyde - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ glt + succinate semialdehyde - succinate fermentation to butanoate:
acetate + succinyl-CoA ⟶ acetyl-CoA + succinate - 4-aminobutanoate degradation II:
2-oxoglutarate + 4-aminobutanoate ⟶ Glu + succinate semialdehyde - superpathway of 4-aminobutanoate degradation:
2-oxoglutarate + 4-aminobutanoate ⟶ Glu + succinate semialdehyde - heme degradation V:
δ-anaerubin + NADP+ ⟶ H+ + NADPH + anaerobilin - hentriaconta-3,6,9,12,15,19,22,25,28-nonaene biosynthesis:
(6Z,9Z,12Z,15Z)-3-hydroxy-2-[(2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl]octadeca-6,9,12,15-tetraenoate + ATP ⟶ 3-[(3Z,6Z,9Z,12Z)-pentadeca-3,6,9,12-tetraen-1-yl]-4-[(2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl]oxetan-2-one + AMP + diphosphate - soybean saponin I biosynthesis:
β-amyrin + H+ + NADPH + O2 ⟶ H2O + NADP+ + sophoradiol - jasmonic acid biosynthesis:
3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxyoctanoyl)-CoA + NAD+ ⟶ 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3-oxooctanoyl)-CoA + H+ + NADH - (+)-pisatin biosynthesis:
(-)-maackiain ⟶ (+)-maackiain - nitrate reduction VI (assimilatory):
H2O + an oxidized ferredoxin [iron-sulfur] cluster + nitrite ⟶ H+ + a reduced ferredoxin [iron-sulfur] cluster + nitrate - canavanine degradation:
H2O + L-canavanine ⟶ H+ + L-canaline + urea - partial TCA cycle (obligate autotrophs):
oxaloacetate + phosphate ⟶ hydrogencarbonate + phosphoenolpyruvate - L-glutamate and L-glutamine biosynthesis:
ATP + ammonium + glu ⟶ ADP + H+ + gln + phosphate - toyocamycin biosynthesis:
NADP+ + [(1R,2R,3S,4S)-4-{5-cyano-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,3-dihydroxycyclopentyl]methyl phosphate + ammonium ⟶ 5-phospho-α-D-ribose-1-preQ0 + H+ + NADPH - L-glutamate biosynthesis III:
H2O + NADP+ + glu ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - linuron degradation:
3,4-dichloroaniline + H+ + NADPH + O2 ⟶ 4,5-dichlorobenzene-1,2-diol + NADP+ + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glu ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis from ammonia:
H2O + NADP+ + glu ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glu ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate and L-glutamine biosynthesis:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glu ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glu ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - valine degradation III:
H2O + NAD+ + coenzyme A + methylmalonate semialdehyde ⟶ H+ + NADH + hydrogen carbonate + propanoyl-CoA - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate and L-glutamine biosynthesis:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - nitrate reduction VI (assimilatory):
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
H2O + NADP+ + glt ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - L-glutamate biosynthesis III:
Glu + H2O + NADP+ ⟶ 2-oxoglutarate + H+ + NADPH + ammonium - NAD/NADH phosphorylation and dephosphorylation:
ATP + NAD+ ⟶ ADP + H+ + NADP+ - arginine biosynthesis IV:
H2O + NAD(P)+ + glt ⟶ 2-oxoglutarate + NAD(P)H + ammonia - proline biosynthesis III:
2-oxoglutarate + L-ornithine ⟶ L-glutamate γ-semialdehyde + glt - arginine biosynthesis IV:
H2O + NAD(P)+ + glt ⟶ 2-oxoglutarate + NAD(P)H + ammonia - NAD/NADH phosphorylation and dephosphorylation:
ATP + NADH ⟶ ADP + H+ + NADPH - Spodoptera littoralis pheromone biosynthesis:
acetyl-CoA + tetradecan-1-ol ⟶ coenzyme A + tetradecan-1-yl acetate - thymine degradation:
3-(carbamoylamino)-2-methylpropanoate + H+ + H2O ⟶ (R)-3-amino-2-methylpropanoate + CO2 + ammonium - thymine degradation:
5,6-dihydrothymine + H2O ⟶ 3-(carbamoylamino)-2-methylpropanoate + H+ - thymine degradation:
(R)-3-ureido-isobutanoate + H+ + H2O ⟶ (R)-3-amino-2-methylpropanoate + CO2 + ammonium - thymine degradation:
3-(carbamoylamino)-2-methylpropanoate + H+ + H2O ⟶ (R)-3-amino-2-methylpropanoate + CO2 + ammonium - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - thymine degradation:
3-ureido-isobutyrate + H2O + H+ ⟶ (R)-3-amino-2-methylpropanoate + CO2 + ammonia - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - thymine degradation:
5,6-dihydrothymine + NADP+ ⟶ H+ + NADPH + thymine - indole-3-acetate biosynthesis II:
(indole-3-yl)acetonitrile + H2O ⟶ (indol-3-yl)acetate + ammonium - indole-3-acetate biosynthesis II:
(E)-indol-3-ylacetaldoxime ⟶ H2O + indole-3-acetonitrile - IAA biosynthesis I:
H2O + indole-3-acetamide ⟶ H+ + ammonia + indole-3-acetate - tetrahydrobiopterin de novo biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP+ ⟶ (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + NADPH - erythro-tetrahydrobiopterin biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP+ ⟶ (6R)-6-lactoyl-5,6,7,8-tetrahydropterin + H+ + NADPH - erythro-tetrahydrobiopterin biosynthesis I:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP+ ⟶ (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + NADPH - tetrahydrobiopterin biosynthesis II:
GTP + H2O ⟶ 7,8-dihydroneopterin 3'-triphosphate + H+ + formate - tetrahydrobiopterin biosynthesis I:
GTP + H2O ⟶ 7,8-dihydroneopterin 3'-triphosphate + H+ + formate - tetrahydrobiopterin biosynthesis I:
GTP + H2O ⟶ 7,8-dihydroneopterin 3'-triphosphate + H+ + formate - camptothecin biosynthesis:
H+ + NADPH + O2 + loganin ⟶ H2O + NADP+ + secologanin - 4-chloro-2-methylphenoxyacetate degradation:
2-methyl-4-chlorophenol + H+ + NADPH + O2 ⟶ 5-chloro-3-methylcatechol + H2O + NADP+ - chrysophanol biosynthesis:
H+ + NADPH + emodin ⟶ H2O + NADP+ + chrysophanol - mycinamicin biosynthesis:
(S)-methylmalonyl-CoA + H+ + NADPH + malonyl-CoA ⟶ CO2 + H2O + NADP+ + coenzyme A + protomycinolide IV - hydroxyjasmonate sulfate biosynthesis:
PAPS + tuberonic acid ⟶ 3',5'-ADP + H+ + a 12-hydroxyjasmonate sulfate - bombykol biosynthesis:
(10E,12Z)-10,12-hexadecadienoate + H+ + NADPH ⟶ H2O + NADP+ + bombykol - phylloquinol biosynthesis:
SAM + demethylphylloquinol ⟶ H+ + SAH + phylloquinol - superpathway of phylloquinol biosynthesis:
SAM + demethylphylloquinol ⟶ H+ + SAH + phylloquinol - phylloquinol biosynthesis:
H+ + NADPH + demethylphylloquinone ⟶ NADP+ + demethylphylloquinol - plant sterol biosynthesis:
H+ + NADPH + O2 + sitosterol ⟶ H2O + NADP+ + stigmasterol - 4-coumarate degradation (aerobic):
4-hydroxybenzaldehyde + H2O + NAD(P)+ ⟶ 4-hydroxybenzoate + H+ + NAD(P)H - 4-chlorobenzoate degradation:
4-chlorobenzoyl-coA + H2O ⟶ 4-hydroxybenzoyl-CoA + H+ + chloride
WikiPathways(0)
Plant Reactome(62)
- Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Secondary metabolism:
GPP + H2O ⟶ PPi + geraniol - Linear furanocoumarin biosynthesis:
H+ + H2O + TPNH + psoralen ⟶ TPN + bergaptol - Medicarpin biosynthesis:
H+ + Oxygen + TPNH + formononetin ⟶ 2-hydroxyformononetin + H2O + TPN - Phenylpropanoid biosynthesis, initial reactions:
L-Phe ⟶ ammonia + trans-cinnamate - Suberin biosynthesis:
ATP + CoA-SH + ferulate ⟶ AMP + PPi + feruloyl-CoA - Coumarin biosynthesis (via 2-coumarate):
H2O + coumarinic acid-beta-D-glucoside ⟶ beta-D-glucose + coumarinate - Lignin biosynthesis:
4-coumarate + ATP + CoA-SH ⟶ 4-coumaroyl-CoA + AMP + PPi - Fatty acid and lipid metabolism:
NAD(P)H + Oxygen + lathosterol ⟶ H2O + NAD(P)+ + Provitamin D3 - Cholesterol biosynthesis II (via 24,25-dihydrolanosterol):
NAD(P)H + Oxygen + lathosterol ⟶ H2O + NAD(P)+ + Provitamin D3 - Leucodelphinidin biosynthesis:
2OG + Oxygen + eriodictyol ⟶ (+)-taxifolin + SUCCA + carbon dioxide - Hormone signaling, transport, and metabolism:
3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-octanoate + Oxygen ⟶ CH3COO- + jasmonic acid - GA12 biosynthesis:
H+ + Oxygen + TPNH + ent-kaurene ⟶ H2O + TPN + ent-kaur-16-en-19-ol - Cholesterol biosynthesis I:
NAD(P)H + Oxygen + lathosterol ⟶ H2O + NAD(P)+ + Provitamin D3 - Cholesterol biosynthesis III (via desmosterol):
DESMO + TPNH ⟶ CHOL + TPN - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Pantothenate biosynthesis I:
2OG + L-Val ⟶ KIV + L-Glu - Pantothenate biosynthesis II:
2OG + L-Val ⟶ KIV + L-Glu - Brassinosteroid biosynthesis II:
H+ + Oxygen + TPNH + campesterol ⟶ (22S)-22-hydroxycampesterol + H2O + TPN - Trans-zeatin biosynthesis:
AMP + DMAPP ⟶ PPi + isopentenyladenosine-5'-monophosphate - Growth and developmental processes:
AMP + DMAPP ⟶ PPi + isopentenyladenosine-5'-monophosphate - Vegetative structure development:
AMP + DMAPP ⟶ PPi + isopentenyladenosine-5'-monophosphate - Regulation of leaf development:
AMP + DMAPP ⟶ PPi + isopentenyladenosine-5'-monophosphate - Sterol biosynthesis:
delta24-25-sitosterol ⟶ sitosterol - Capsidiol biosynthesis:
5-epi-aristolochene + H+ + Oxygen + TPNH ⟶ 3-deoxy-capsidiol + H2O + TPN - Pantothenate and coenzyme A biosynthesis III:
b-Ala + pantoyl lactone ⟶ PanK - Pantothenate biosynthesis III:
b-Ala + pantoyl lactone ⟶ PanK - Amino acid metabolism:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid biosynthesis:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Valine biosynthesis:
2,3-dihydroxy-isovalerate ⟶ H2O + KIV - IAA biosynthesis I:
CH3COO- + indole ⟶ IAA - Secologanin and strictosidine biosynthesis:
GPP + H2O ⟶ PPi + geraniol - Flavin biosynthesis:
2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + H2O ⟶ 5-amino-6-(5'-phosphoribosylamino)uracil + ammonia - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Lysine biosynthesis I:
L-Glu + N-succinyl-2-amino-6-ketopimelate ⟶ 2OG + N-succinyl-L,L-2,6-diaminopimelate - Lysine biosynthesis II:
H2O + N-acetyl-L,L-2,6-diaminopimelate ⟶ CH3COO- + L,L-diaminopimelate - Maackiain biosynthesis:
Oxygen + TPNH + formononetin ⟶ H2O + TPN + calycosin - Kievitone biosynthesis:
2'-hydroxygenistein + H+ + TPNH ⟶ TPN + dalbergioidin - Tricin biosynthesis:
Oxygen + TPNH + apigenin ⟶ H2O + TPN + luteolin - Wighteone and luteone biosynthesis:
DMAPP + genistein ⟶ PPi + lupiwighteone - Proanthocyanidin biosynthesis from flavanols:
H+ + TPNH + leucopelargonidin ⟶ H2O + TPN + afzelechin - Sphingolipid metabolism:
PALM-CoA + Ser ⟶ 3-ketosphinganine + CoA-SH + carbon dioxide - Leucopelargonidin and leucocyanidin biosynthesis:
2OG + Oxygen + eriodictyol ⟶ (+)-taxifolin + SUCCA + carbon dioxide - Flavonoid biosynthesis:
4-coumarate + ATP + CoA-SH ⟶ 4-coumaroyl-CoA + AMP + PPi - Salicylate biosynthesis:
L-Phe ⟶ ammonia + trans-cinnamate - 6,7,4'-Trihydroxyisoflavone biosynthesis:
H+ + Oxygen + TPNH + liquiritigenin ⟶ 6,7,4'-trihydroxyflavanone + H2O + TPN - Isoleucine biosynthesis from threonine:
L-Thr ⟶ 2OBUTA + ammonia - Carbohydrate metabolism:
Suc ⟶ 1-kestose + beta-D-glucose - GDP-L-fucose biosynthesis I (from GDP-D-mannose):
GDP-4-dehydro-6-deoxy-D-mannose + TPNH ⟶ GDP-Fuc + TPN - MVA pathway:
HMG-CoA + TPNH ⟶ (R)-mevalonate + CoA-SH + TPN - Jasmonate biosynthesis:
3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-octanoate + Oxygen ⟶ CH3COO- + jasmonic acid - Peptidoglycan biosynthesis I:
ATP + L-Ala + UDP-N-acetylmuramate ⟶ ADP + Pi + UDP-N-acetylmuramoyl-L-alanine - Citrulline biosynthesis:
H2O + L-Gln ⟶ L-Glu + ammonia - Proline biosynthesis I:
2OG + H+ + TPNH + ammonia ⟶ H2O + L-Glu + TPN - Detoxification:
H+ + O2.- ⟶ H2O2 + Oxygen - Reactive oxygen species (ROS) homeostasis:
H+ + O2.- ⟶ H2O2 + Oxygen - Generation of superoxide radicals:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - Responses to stimuli: biotic stimuli and stresses:
H+ + O2.- ⟶ H2O2 + Oxygen - Cell Death and immunity:
H+ + O2.- ⟶ H2O2 + Oxygen - Inorganic nutrients metabolism:
Nitrite ⟶ H2O + ammonia - Response to iron deficiency:
2OG + nicotianamine ⟶ 3''-deamino-3''-oxonicotianamine + L-Glu - Mugineic acid biosynthesis:
2OG + nicotianamine ⟶ 3''-deamino-3''-oxonicotianamine + L-Glu
INOH(0)
PlantCyc(6875)
- linear furanocoumarin biosynthesis:
(+)-marmesin + H+ + NADPH + O2 ⟶ H2O + NADP+ + acetone + psoralen - linear furanocoumarin biosynthesis:
(+)-marmesin + H+ + NADPH + O2 ⟶ H2O + NADP+ + acetone + psoralen - linear furanocoumarin biosynthesis:
(+)-marmesin + H+ + NADPH + O2 ⟶ H2O + NADP+ + acetone + psoralen - sanguinarine and macarpine biosynthesis:
(S)-reticuline + O2 ⟶ (S)-scoulerine + H+ + hydrogen peroxide - sanguinarine and macarpine biosynthesis:
H+ + O2 + dihydrosanguinarine ⟶ hydrogen peroxide + sanguinarine - sanguinarine and macarpine biosynthesis:
(S)-reticuline + O2 ⟶ (S)-scoulerine + H+ + hydrogen peroxide - sanguinarine and macarpine biosynthesis:
(S)-reticuline + O2 ⟶ (S)-scoulerine + H+ + hydrogen peroxide - sanguinarine and macarpine biosynthesis:
(S)-reticuline + O2 ⟶ (S)-scoulerine + H+ + hydrogen peroxide - L-proline biosynthesis IV:
NAD(P)+ + pro ⟶ 1-pyrroline-2-carboxylate + H+ + NAD(P)H - L-proline biosynthesis IV:
NAD(P)+ + pro ⟶ 1-pyrroline-2-carboxylate + H+ + NAD(P)H - superpathway of pterocarpan biosynthesis (via formononetin):
H+ + NADPH + O2 + calycosin ⟶ H2O + NADP+ + pseudobaptigenin - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + calycosin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + pseudobaptigenin - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + calycosin - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + calycosin - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of formononetin derivative biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + calycosin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + pseudobaptigenin - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of formononetin derivative biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + calycosin - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + calycosin - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - (-)-medicarpin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase] - superpathway of pterocarpan biosynthesis (via formononetin):
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + calycosin - superpathway of formononetin derivative biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + calycosin - (-)-medicarpin biosynthesis:
(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP+ ⟶ (3R)-vestitone + H+ + NADPH - superpathway of formononetin derivative biosynthesis:
(3R)-sophorol + NADP+ ⟶ 2'-hydroxypseudobaptigenin + H+ + NADPH - soybean saponin I biosynthesis:
24-hydroxy-β-amyrin + H+ + NADPH + O2 ⟶ H2O + NADP+ + soyasapogenol B - soybean saponin I biosynthesis:
24-hydroxy-β-amyrin + H+ + NADPH + O2 ⟶ H2O + NADP+ + soyasapogenol B - ginsenosides biosynthesis:
H+ + NADPH + O2 + dammarenediol II ⟶ H2O + NADP+ + protopanaxadiol - soybean saponin I biosynthesis:
24-hydroxy-β-amyrin + H+ + NADPH + O2 ⟶ H2O + NADP+ + soyasapogenol B - soybean saponin I biosynthesis:
24-hydroxy-β-amyrin + H+ + NADPH + O2 ⟶ H2O + NADP+ + soyasapogenol B - soybean saponin I biosynthesis:
UDP-α-D-glucuronate + soyasapogenol B ⟶ H+ + UDP + soyasapogenol B-3-O-β-glucuronide - momilactone A biosynthesis:
3β-hydroxy-9β-pimara-7,15-diene-19,6β-olide + NAD(P)+ ⟶ H+ + NAD(P)H + momilactone A - momilactone A biosynthesis:
3β-hydroxy-9β-pimara-7,15-diene-19,6β-olide + NAD(P)+ ⟶ H+ + NAD(P)H + momilactone A - momilactone A biosynthesis:
3β-hydroxy-9β-pimara-7,15-diene-19,6β-olide + NAD(P)+ ⟶ H+ + NAD(P)H + momilactone A - phenylpropanoid biosynthesis:
4-coumaryl alcohol + NADP+ ⟶ 4-coumaraldehyde + H+ + NADPH - phenylpropanoid biosynthesis:
(E)-4-coumaroyl-CoA + H+ + NADPH ⟶ 4-coumaraldehyde + NADP+ + coenzyme A - ferulate and sinapate biosynthesis:
H+ + NADPH + O2 + coniferaldehyde ⟶ 5-hydroxy-coniferaldehyde + H2O + NADP+ - phenylpropanoid biosynthesis:
trans-feruloyl-CoA + H+ + NADPH ⟶ NADP+ + coenzyme A + coniferaldehyde - ferulate and sinapate biosynthesis:
H2O + NADP+ + sinapaldehyde ⟶ H+ + NADPH + sinapate - phenylpropanoid biosynthesis:
NADP+ + sinapyl alcohol ⟶ H+ + NADPH + sinapaldehyde - phenylpropanoid biosynthesis:
4-coumaryl alcohol + NADP+ ⟶ 4-coumaraldehyde + H+ + NADPH - ferulate and sinapate biosynthesis:
H2O + NADP+ + sinapaldehyde ⟶ H+ + NADPH + sinapate - phenylpropanoid biosynthesis:
5-hydroxy-coniferaldehyde + SAM ⟶ H+ + SAH + sinapaldehyde - phenylpropanoid biosynthesis:
trans-feruloyl-CoA + H+ + NADPH ⟶ NADP+ + coenzyme A + coniferaldehyde - phenylpropanoid biosynthesis:
trans-feruloyl-CoA + H+ + NADPH ⟶ NADP+ + coenzyme A + coniferaldehyde - phenylpropanoid biosynthesis:
H+ + NADPH + feruloyl-CoA ⟶ NADP+ + coenzyme A + coniferaldehyde - ferulate and sinapate biosynthesis:
H+ + NADPH + O2 + coniferaldehyde ⟶ 5-hydroxy-coniferaldehyde + H2O + NADP+ - phenylpropanoid biosynthesis:
NADP+ + coniferyl alcohol ⟶ H+ + NADPH + coniferaldehyde - phenylpropanoid biosynthesis:
4-coumaryl alcohol + NADP+ ⟶ 4-coumaraldehyde + H+ + NADPH - ferulate and sinapate biosynthesis:
H2O + NADP+ + sinapaldehyde ⟶ H+ + NADPH + sinapate - phenylpropanoid biosynthesis:
(E)-4-coumaroyl-CoA + H+ + NADPH ⟶ 4-coumaraldehyde + NADP+ + coenzyme A - ferulate and sinapate biosynthesis:
H+ + NADPH + O2 + coniferaldehyde ⟶ 5-hydroxy-coniferaldehyde + H2O + NADP+ - phenylpropanoid biosynthesis:
NADP+ + sinapyl alcohol ⟶ H+ + NADPH + sinapaldehyde - phenylpropanoid biosynthesis:
NADP+ + coniferyl alcohol ⟶ H+ + NADPH + coniferaldehyde - ferulate and sinapate biosynthesis:
H2O + NADP+ + sinapaldehyde ⟶ H+ + NADPH + sinapate - phenylpropanoid biosynthesis:
NADP+ + sinapyl alcohol ⟶ H+ + NADPH + sinapaldehyde - ferulate and sinapa