(+)-Hydrastine (BioDeep_00000896837)

 

Secondary id: BioDeep_00000016676

natural product


代谢物信息卡片


(+)-beta-Hydrastine

化学式: C21H21NO6 (383.13688060000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC3=C(C=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OCO3
InChI: InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m0/s1

描述信息

同义名列表

2 个代谢物同义名

(+)-beta-Hydrastine; (+)-Hydrastine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Manead Khin, Nadja B Cech, Joshua J Kellogg, Lindsay K Caesar. Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches. The Yale journal of biology and medicine. 2020 06; 93(2):265-275. doi: . [PMID: 32607087]
  • Phuong Mai Le, Clément Milande, Estelle Martineau, Patrick Giraudeau, Jonathan Farjon. Quantification of natural products in herbal supplements: A combined NMR approach applied on goldenseal. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 165(?):155-161. doi: 10.1016/j.jpba.2018.11.062. [PMID: 30544050]
  • Bingyu Guo, Xiaodong Li, Shuai Song, Meng Chen, Maosheng Cheng, Dongmei Zhao, Feng Li. (-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity. Oncology reports. 2016 Apr; 35(4):2246-56. doi: 10.3892/or.2016.4594. [PMID: 26821251]
  • Xinwen Wang, Hao-Jie Zhu, Juliana Munoz, Bill J Gurley, John S Markowitz. An ex vivo approach to botanical-drug interactions: a proof of concept study. Journal of ethnopharmacology. 2015 Apr; 163(?):149-56. doi: 10.1016/j.jep.2015.01.021. [PMID: 25623616]
  • Michelle L Dawes, Thomas Brettell. Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 880(1):114-8. doi: 10.1016/j.jchromb.2011.11.026. [PMID: 22177787]
  • Keivan A Ettefagh, Johnna T Burns, Hiyas A Junio, Glenn W Kaatz, Nadja B Cech. Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition. Planta medica. 2011 May; 77(8):835-40. doi: 10.1055/s-0030-1250606. [PMID: 21157683]
  • James A Douglas, John M Follett, Graeme A Parmenter, Catherine E Sansom, Nigel B Perry, Ray A Littler. Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis. Fitoterapia. 2010 Oct; 81(7):925-8. doi: 10.1016/j.fitote.2010.06.006. [PMID: 20550958]
  • Paula N Brown, Mark C Roman. Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study. Journal of AOAC International. 2008 Jul; 91(4):694-701. doi: . [PMID: 18727526]
  • Matthias Unger, Stefanie Laug, Ulrike Holzgrabe. Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts. Electrophoresis. 2005 Jun; 26(12):2430-6. doi: 10.1002/elps.200410322. [PMID: 15912542]
  • Catherine E McNamara, Nigel B Perry, John M Follett, Graeme A Parmenter, James A Douglas. A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis. Journal of natural products. 2004 Nov; 67(11):1818-22. doi: 10.1021/np049868j. [PMID: 15568768]
  • Holly A Weber, Maureen Joseph. [Extraction and HPLC analysis of alkaloids in goldenseal]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2004 Mar; 20(2):306-8. doi: . [PMID: 15969129]
  • W H M W Herath, D Ferreira, I A Khan. Microbial transformation of the phthalideisoquinoline alkaloid, (-)-beta-hydrastine. Natural product research. 2003 Aug; 17(4):269-74. doi: 10.1080/1057563021000060158. [PMID: 12822906]
  • David J Edwards, Emily J Draper. Variations in alkaloid content of herbal products containing goldenseal. Journal of the American Pharmacists Association : JAPhA. 2003 May; 43(3):419-23. doi: 10.1331/154434503321831148. [PMID: 12836794]
  • M Goel, U P Singh, R N Jha, V B Pandey, M B Pandey. Individual and combined effect of (+/-)-alpha-hydrastine and (+/-)-beta-hydrastine on spore germination of some fungi. Folia microbiologica. 2003; 48(3):363-8. doi: 10.1007/bf02931368. [PMID: 12879748]
  • Wenkui Li, John F Fitzloff. A validated high performance liquid chromatographic method for the analysis of Goldenseal. The Journal of pharmacy and pharmacology. 2002 Mar; 54(3):435-9. doi: 10.1211/0022357021778510. [PMID: 11902811]
  • S H Kim, J S Shin, J J Lee, S Y Yin, M Kai, M K Lee. Effects of hydrastine derivatives on dopamine biosynthesis in PC12 cells. Planta medica. 2001 Oct; 67(7):609-13. doi: 10.1055/s-2001-17356. [PMID: 11582536]
  • H Abdel-Haq, M F Cometa, M Palmery, M G Leone, B Silvestrini, L Saso. Relaxant effects of Hydrastis canadensis L. and its major alkaloids on guinea pig isolated trachea. Pharmacology & toxicology. 2000 Nov; 87(5):218-22. doi: 10.1034/j.1600-0773.2000.d01-77.x. [PMID: 11129501]
  • E J Gentry, H B Jampani, A Keshavarz-Shokri, M D Morton, D V Velde, H Telikepalli, L A Mitscher, R Shawar, D Humble, W Baker. Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. Journal of natural products. 1998 Oct; 61(10):1187-93. doi: 10.1021/np9701889. [PMID: 9784149]
  • N I Chernevskaja, O A Krishtal, A Y Valeyev. Inhibitions of the GABA-induced currents of rat neurons by the alkaloid isocoryne from the plant Corydalis pseudoadunca. Toxicon : official journal of the International Society on Toxinology. 1990; 28(6):727-30. doi: 10.1016/0041-0101(90)90263-7. [PMID: 2169659]