Dehydrocholate (BioDeep_00000896811)
Bile acids
代谢物信息卡片
Dehydrocholate
化学式: C24H33O5- (401.23278680000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(bile_acids) 85.71%
分子结构信息
SMILES: CC(CCC(=O)[O-])C1CCC2C1(C(=O)CC3C2C(=O)CC4C3(CCC(=O)C4)C)C
InChI: InChI=1S/C24H34O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-14,16-18,22H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,16-,17+,18+,22+,23+,24-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoyu Zhang, Guang Xin, Shiyi Li, Zeliang Wei, Yue Ming, Jiyan Yuan, E Wen, Zhihua Xing, Kui Yu, Youping Li, Junhua Zhang, Boli Zhang, Hai Niu, Wen Huang. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice.
Biological & pharmaceutical bulletin.
2020; 43(6):985-993. doi:
10.1248/bpb.b20-00021. [PMID: 32475920] - Keita Hayashi, Kazutoshi Morimoto, Toshiyuki Kamei, Eiko Mieda, Sosaku Ichikawa, Takashi Kuroiwa, Sakiko Fujita, Hidemi Nakamura, Hiroshi Umakoshi. Effect of dehydrocholic acid conjugated with a hydrocarbon on a lipid bilayer composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine.
Colloids and surfaces. B, Biointerfaces.
2019 Sep; 181(?):58-65. doi:
10.1016/j.colsurfb.2019.05.009. [PMID: 31121382] - María Del Carmen Martinez, Silvina Fernanda Ruspini, Susana Graciela Afonso, Roberto Meiss, Ana Maria Buzaleh, Alcira Batlle. Experimental protoporphyria: effect of bile acids on liver damage induced by griseofulvin.
BioMed research international.
2015; 2015(?):436319. doi:
10.1155/2015/436319. [PMID: 25945334] - Satoshi Fukuoka, Walter Richter, Jörg Howe, Jörg Andrä, Manfred Rössle, Christian Alexander, Thomas Gutsmann, Klaus Brandenburg. Biophysical investigations into the interactions of endotoxins with bile acids.
Innate immunity.
2012 Apr; 18(2):307-17. doi:
10.1177/1753425911404093. [PMID: 21954318] - Ernst Seiffert, Jens P Dreier, Sebastian Ivens, Ingo Bechmann, Oren Tomkins, Uwe Heinemann, Alon Friedman. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Sep; 24(36):7829-36. doi:
10.1523/jneurosci.1751-04.2004. [PMID: 15356194] - W B Mors, M C Nascimento, B M Pereira, N A Pereira. Plant natural products active against snake bite--the molecular approach.
Phytochemistry.
2000 Nov; 55(6):627-42. doi:
10.1016/s0031-9422(00)00229-6. [PMID: 11130675] - K Ishizaki, S Kinbara, N Miyazawa, Y Takeuchi, N Hirabayashi, H Kasai, T Araki. Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats.
European journal of pharmacology.
1997 Aug; 333(2-3):207-13. doi:
10.1016/s0014-2999(97)01143-6. [PMID: 9314037] - J Ratan, S Rohatgi, D K Gupta, S Ratan. A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats.
The Tohoku journal of experimental medicine.
1997 Jan; 181(1):161-6. doi:
10.1620/tjem.181.161. [PMID: 9149351] - H Toure, G Balansard, A M Pauli, A M Scotto. Pharmacological investigation of alkaloids from leaves of Mitragyna inermis (Rubiaceae).
Journal of ethnopharmacology.
1996 Oct; 54(1):59-62. doi:
10.1016/0378-8741(96)01446-8. [PMID: 8941870] - M Fürll. [Effects of dehydrocholic acid (Biliton) on metabolism and liver function in cows].
DTW. Deutsche tierarztliche Wochenschrift.
1993 Sep; 100(9):375-8. doi:
. [PMID: 8223242] - I Portal, T Clerc, V Sbarra, H Portugal, A M Pauli, H Lafont, B Tuchweber, I Yousef, F Chanussot. Importance of high-density lipoprotein-phosphatidylcholine in secretion of phospholipid and cholesterol in bile.
The American journal of physiology.
1993 Jun; 264(6 Pt 1):G1052-6. doi:
10.1152/ajpgi.1993.264.6.g1052. [PMID: 8333532] - F Chanussot, N Domingo, B Tuchweber, H Lafont, I Yousef. Influence of dehydrocholic and cholic acids on the biliary secretion of anionic polypeptide fraction, the major apoprotein of the biliary lipoprotein complex.
Scandinavian journal of gastroenterology.
1992; 27(3):238-42. doi:
10.3109/00365529208999956. [PMID: 1502488] - A Magnaghi, S D Giannini, I L Sinhorini, J L Merusse. [Behavior of the arterial wall of non-selected rats, old and young, subjected to potentially atherogenic dietary factors].
Arquivos brasileiros de cardiologia.
1991 May; 56(5):385-8. doi:
NULL. [PMID: 1823737] - R Bobowiec, T Studziński, M Sikorska. Effects of sodium taurocholate and sodium dehydrocholate on bile flow, lipid and bilirubin secretion in sheep.
Acta physiologica Polonica.
1990 Nov; 41(7):146-54. doi:
". [PMID: 2136309] - F Chanussot, H Lafont, J Hauton, B Tuchweber, I Yousef. Studies on the origin of biliary phospholipid. Effect of dehydrocholic acid and cholic acid infusions on hepatic and biliary phospholipids.
The Biochemical journal.
1990 Sep; 270(3):691-5. doi:
10.1042/bj2700691. [PMID: 2241901] - I M Yousef, D Mignault, A M Weber, B Tuchweber. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats.
Digestion.
1990; 45(1):40-51. doi:
10.1159/000200223. [PMID: 2340963] - M Yoneda, I Makino, N Tamasawa, K Takebe, K Sakuraba, J Goto, T Nambara. The biotransformed metabolite profiles in blood after intravenous administration of dehydrocholic acid.
The American journal of gastroenterology.
1989 Mar; 84(3):290-5. doi:
NULL. [PMID: 2919585] - M Yoneda, N Tamasawa, I Makino, K Takebe. [Development of enzymatic determination of 3-keto bile acids in serum].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1988 Apr; 85(4):904-9. doi:
NULL. [PMID: 3404755] - V I Zapadniuk, T N Panteleĭmonova. [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis].
Biulleten' eksperimental'noi biologii i meditsiny.
1987 Jul; 104(7):30-2. doi:
NULL. [PMID: 3620644] - N Tamasawa. [Detection of the reduced dehydrocholic acid in serum following administration of dehydrocholic acid and its metabolism in normal subjects].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1987 Apr; 84(4):948. doi:
NULL. [PMID: 3613238] - N Tamasawa. [Development of enzymatic determination of dehydrocholic acid in serum and its application].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1987 Feb; 84(2):309. doi:
NULL. [PMID: 3586381] - Kh Kh Mansurov, Z M Orziev. [Gas chromatographic determination of serum bile acid levels in chronic cholecystitis patients].
Terapevticheskii arkhiv.
1986; 58(2):96-100. doi:
NULL. [PMID: 3704950] - A E Stillman, D L Earnest, J M Woolfenden. Hepatobiliary scintigraphy for cholestasis in congenital hepatic fibrosis. Diagnosis and treatment.
American journal of diseases of children (1960).
1985 Jan; 139(1):41-5. doi:
10.1001/archpedi.1985.02140030043025. [PMID: 3969982] - L Manara, P Coccia, T Croci. Prevention of TCDD toxicity in laboratory rodents by addition of charcoal or cholic acids to chow.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1984 Oct; 22(10):815-8. doi:
10.1016/0278-6915(84)90120-0. [PMID: 6541620] - T Wakushima, Y Kishimoto, C Hirayama. Intravenous dehydrocholate tolerance test in patients with liver disease.
Hepato-gastroenterology.
1983 Aug; 30(4):137-9. doi:
. [PMID: 6629304] - K Uchida, Y Nomura, M Kadowaki, K Arisue, N Takeuchi, Y Ishikawa. Effects of sodium ursodeoxycholate, hyodeoxycholate and dehydrocholate on cholesterol and bile acid metabolism in rats.
Journal of pharmacobio-dynamics.
1983 May; 6(5):346-57. doi:
10.1248/bpb1978.6.346. [PMID: 6620121] - G J Becker, R W Holden. Sodium dehydrocholate circulation times in digital subtraction angiography.
AJR. American journal of roentgenology.
1983 Apr; 140(4):817-8. doi:
10.2214/ajr.140.4.817. [PMID: 6601397] - S Bar-Meir, R Levy, Z Halperin, C Levy-Gigi, T Gilat. Impairment of bromosulfophthalein clearance by bile salt administration in normal volunteers and patients with Dubin-Johnson syndrome.
Israel journal of medical sciences.
1982 Feb; 18(2):211-4. doi:
NULL. [PMID: 7068349] - S Takeda, T Endo, M Aburada. Pharmacological studies on iridoid compounds. III. The choleretic mechanism of iridoid compounds.
Journal of pharmacobio-dynamics.
1981 Aug; 4(8):612-23. doi:
10.1248/bpb1978.4.612. [PMID: 7299624] - R J Vonk, P Westra, M C Houwertjes, S Agoston. Prolongation by bile salts of the duration of action of a steroidal neuromuscular blocking agent.
British journal of anaesthesia.
1979 Aug; 51(8):719-23. doi:
10.1093/bja/51.8.719. [PMID: 497068] - Y I Ivanov. The evidence of production or activation of a natriuretic factor in the liver.
Endocrinologia experimentalis.
1979; 13(4):195-200. doi:
. [PMID: 316383] - H Biffl, R Goebel, G Leb. [The clinical significance of radioimmunologically determined serum bile acids as a new liver function test and the development of a new intravenous sulfolithoglycocholic acid (SLGC) stimulation test].
Acta medica Austriaca.
1979; 6(4):113-20. doi:
NULL. [PMID: 552771] - V E Iakovlev. [Effect of cholagogic agents on volumetric natriuresis in rats with experimental dystrophy of the liver].
Farmakologiia i toksikologiia.
1978 Jan; 41(1):73-6. doi:
. [PMID: 624393] - M S Anwer, R Kroker, D Hegner, A Petter. Cholic acid binding to isolated rat liver plasma membranes.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
1977 May; 358(5):543-53. doi:
10.1515/bchm2.1977.358.1.543. [PMID: 881162] - B A Nemchausky, T J Layden, J L Boyer. Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study.
Laboratory investigation; a journal of technical methods and pathology.
1977 Mar; 36(3):259-67. doi:
. [PMID: 138767] - V E Iakovlev. [Volumetric regulation under the influence of dehydrocholic acid].
Fiziolohichnyi zhurnal.
1977 Jan; 23(1):78-82. doi:
NULL. [PMID: 863001] - D K Meijer, R J Vonk, E J Scholtens, W G Levine. The influence of dehydrocholate on hepatic uptake and biliary excretion of 3H-taurocholate and 3H-ouabain.
Drug metabolism and disposition: the biological fate of chemicals.
1976 Jan; 4(1):1-7. doi:
. [PMID: 3395] - Y Delage, S Erlinger, M Duval, J P Bpenhamou. Influence of dehydrocholate and taurocholate on bromsulphthalein uptake, storage, and excretion in the dog.
Gut.
1975 Feb; 16(2):105-8. doi:
10.1136/gut.16.2.105. [PMID: 1126660] - J L Boyer, J R Bloomer. Canalicular bile secretion in man. Studies utilizing the biliary clearance of (14C)mannitol.
The Journal of clinical investigation.
1974 Oct; 54(4):773-81. doi:
10.1172/jci107817. [PMID: 4610005] - P Guzelian, J L Boyer. Glucose reabsorption from bile. Evidence for a biliohepatic circulation.
The Journal of clinical investigation.
1974 Feb; 53(2):526-35. doi:
10.1172/jci107586. [PMID: 11344566] - R J Vonk, Veen H vd, G Prop, D K Meijer. The influence of taurocholate and dehydrocholate choleresis on plasma disappearance and biliary excretion of indocyanine green in the rat.
Naunyn-Schmiedeberg's archives of pharmacology.
1974; 282(4):401-10. doi:
10.1007/bf00500988. [PMID: 4277030] - N W DiTullio, E J Stack. Alterations in biliary lipids of mice during dehydrocholic acid feeding.
Journal of lipid research.
1973 Sep; 14(5):552-6. doi:
. [PMID: 4729971] - J D Conklin, R J Sobers, D L Wagner. Further studies on nitrofurantoin excretion in dog hepatic bile.
British journal of pharmacology.
1973 Jun; 48(2):273-7. doi:
10.1111/j.1476-5381.1973.tb06913.x. [PMID: 4733729] - E Lagrange, M Aurousseau. [Effect of nebulized Fumaria officinalis on experimental gallbladder calculi in mice].
Annales pharmaceutiques francaises.
1973 May; 31(5):357-62. doi:
". [PMID: 4794071] - R D Soloway, A F Hofmann, P J Thomas, L J Schoenfield, P D Klein. Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man.
The Journal of clinical investigation.
1973 Mar; 52(3):715-24. doi:
10.1172/jci107233. [PMID: 4685091] - H O Wheeler, K K King. Biliary excretion of lecithin and cholesterol in the dog.
The Journal of clinical investigation.
1972 Jun; 51(6):1337-50. doi:
10.1172/jci106930. [PMID: 5024035] - O A Levander. Metabolic interrelationships and adaptations in selenium toxicity.
Annals of the New York Academy of Sciences.
1972 Apr; 192(?):181-92. doi:
10.1111/j.1749-6632.1972.tb52589.x. [PMID: 4503561] - S K Hong, Y S Park. Transport of bromcresol green in the rabbit kidney slice.
The American journal of physiology.
1971 Dec; 221(6):1779-84. doi:
10.1152/ajplegacy.1971.221.6.1779. [PMID: 5124323] - Y S Park, H S Yoo, S K Hong. Kinetic studies on transport of organic acids in rabbit kidney slices.
The American journal of physiology.
1971 Jan; 220(1):95-9. doi:
10.1152/ajplegacy.1971.220.1.95. [PMID: 5538677] - M Frimmer, G Weil. [Effect of choleretics on the potassium loss of isolated perfused rat liver poisoned with phalloidin].
Klinische Wochenschrift.
1969 Oct; 47(20):1116-7. doi:
10.1007/bf01496650. [PMID: 5381997] - O Nieschulz, P Schmersahl. [On choleretic agents from Artemisia abrotanum L].
Arzneimittel-Forschung.
1968 Oct; 18(10):1330-6. doi:
NULL. [PMID: 5755714] - E B Berkhin. [Effect of dehydrocholic acid on diuresis].
Biulleten' eksperimental'noi biologii i meditsiny.
1968 Oct; 66(10):60-2. doi:
NULL. [PMID: 5748081] - M P Skakun. [Choleretics of synthetic and plant origin].
Farmatsevtychnyi zhurnal.
1968; 23(3):18-23. doi:
". [PMID: 4236350] - D L Fletcher, D C Harwood-Nash, E L Lansdown. Nephrotomography in various renal disorders.
Journal of the Canadian Association of Radiologists.
1967 Dec; 18(4):427-33. doi:
NULL. [PMID: 6080021] - T N Calvey. The transport of 14C-neostigmine from plasma to bile.
Biochemical pharmacology.
1967 Oct; 16(10):1989-95. doi:
10.1016/0006-2952(67)90310-3. [PMID: 4965192] - V Hoenig, J Hoenigova. [Study of the mechanism of diuresis induced by synthetic bile salts].
Revue internationale d'hepatologie.
1967 May; 17(6):511-8. doi:
NULL. [PMID: 5585946] - L U Mailloux, C D Swartz, G Onesti, C Heider, O Ramirez, A N Brest. Peritoneal dialysis for refractory congestive heart failure.
JAMA.
1967 Mar; 199(12):873-8. doi:
NULL. [PMID: 6071553] - V Hoenig, J Hoenigová. Plasma and urinary bilirubin after administration of sodium dehydrocholate to jaundiced patients.
Gastroenterologia.
1967; 108(4):226-31. doi:
10.1159/000201618. [PMID: 6077155] - E L Forker, C A Hogben. Diodrast transit time in guinea pig biliary tree.
The American journal of physiology.
1967 Jan; 212(1):104-12. doi:
10.1152/ajplegacy.1967.212.1.104. [PMID: 6015990] - E R O'Máille, T G Richards, A H Short. Factors determining the maximal rate of organic anion secretion by the liver and further evidence on the hepatic site of action of the hormone secretin.
The Journal of physiology.
1966 Oct; 186(2):424-38. doi:
10.1113/jphysiol.1966.sp008044. [PMID: 5972117] - G G Mitchell, H B Torrance. The effects of a bile-salt sodium dehydrocholate upon liver blood-flow in man.
The British journal of surgery.
1966 Sep; 53(9):807-8. doi:
10.1002/bjs.1800530919. [PMID: 5911770] - D Lüders. [Effect of x-irradiation and sodium dehydrocholate on the blood-brain barrier: results of animal experiments with gamma-encephalography].
Arzneimittel-Forschung.
1966 Feb; 16(2):206-9. doi:
NULL. [PMID: 6014015] - D G Friend. Effect of oral enzyme therapy on roughage content of stools.
The Journal of new drugs.
1965 Jul; 5(4):236-9. doi:
10.1002/j.1552-4604.1965.tb00369.x. [PMID: 5325541] - D LUEDERS. [EXPERIMENTAL STUDIES ON BILIRUBIN SOLUBILITY. V. EXPERIMENTAL ANIMAL STUDIES ON THE EFFECT OF DECHOLIN ON RENAL BILIRUBIN EXCRETION].
Zeitschrift fur Kinderheilkunde.
1965 Jan; 92(?):27-41. doi:
NULL. [PMID: 14305244] - D LUEDERS. [EXPERIMENTAL STUDIES ON BILIRUBIN SOLUBILITY. IV. EXPERIMENTAL ANIMAL STUDIES ON THE EFFECT OF DECHOLIN ON THE SERUM BILIRUBIN LEVEL].
Zeitschrift fur Kinderheilkunde.
1965 Jan; 92(?):15-26. doi:
NULL. [PMID: 14305242] - D LUEDERS. [EXPERIMENTAL STUDIES ON THE SOLUBILITY OF BILIRUBIN. I. ACCELETATION OF THE DIAZO-REACTION OF INDIRECT SERUM BILIRUBIN BY DECHOLIN AND OTHER SUBSTANCES].
Zeitschrift fur Kinderheilkunde.
1964 Nov; 91(?):254-64. doi:
NULL. [PMID: 14333489] - C COSTA. [RESEARCH ON THE DIURETIC ACTIVITY OF SODIUM DEHYDROCHOLATE].
La Clinica terapeutica.
1963 Dec; 27(?):641-60. doi:
NULL. [PMID: 14117068] - G COLALONGO, M GRECO, G MURARI, G DEDOLA, W RABITTI. [ACTION OF PHARMACOLOGICALLY INDUCED HYPERCHOLERESIS ON INTESTINAL ABSORPTION STUDIED WITH THE WARTER AND METAIS TEST].
Archivio italiano delle malattie dell'apparato digerente.
1963 Sep; 30(?):417-21. doi:
". [PMID: 14108446] - R I ELLIN, A I MENDELOFF, D A TURNER. Quantitative determination of 3,7,12-triketocholanic acid in biological fluids by gas-liquid chromatography.
Analytical biochemistry.
1962 Sep; 4(?):198-203. doi:
10.1016/0003-2697(62)90002-7. [PMID: 13889914] - C DEBRAY, J P HARDOUIN, J FABLET. [Protective effect of Tilia silvestris alburnum on the painful manifestations induced in biliary patients by the combined action of sodium dehydrocholate and morphine].
Therapie.
1960; 15(?):1040-1. doi:
". [PMID: 13721035] - F COCUZZA, G COLOMBRITA. [The effect of sodium dehydrocholate after intravenous administration on the serum lipid and lipoproteins picture in normal and arteriosclerotic subjects].
La Riforma medica.
1958 Aug; 72(32):889-92. doi:
NULL. [PMID: 13579966] - H WAREMBOURG, G NIQUET, J LEKIEFFRE. [Bile salts and therapy of vascular diseases; effects of sodium dehydrocholate on lipidprotein balance of plasma].
La Presse medicale.
1956 May; 64(35):829-30. doi:
NULL. [PMID: 13335906] - L PELNER, S WALDMAN. Serum-sickness type of penicillin reactions treated with sodium dehydrocholate.
Postgraduate medicine.
1952 Jan; 11(1):49-55. doi:
10.1080/00325481.1952.11694185. [PMID: 14900082] - U BAZZI, G NICOLOSI. [Modifications induced by the administration of massive doses of substances with sterolic nucleus on the elimination of hormone steroids of human urine (11-oxycorticosteroids, 17-ketosteroids). III. Action of dehydrocholic acid. General conclusions].
Bollettino della Societa italiana di biologia sperimentale.
1951 Jul; 27(7-8):1309-11. doi:
NULL. [PMID: 14904682] - U BAZZI. [Activity of substances with sterolic nucleus on carbohydrate metabolism. IV. Effects of administration of dehydrocholic acid. Conclusive considerations on the relations between steroid substances and glucide metabolism].
Bollettino della Societa italiana di biologia sperimentale.
1951 Jul; 27(7-8):1303-5. doi:
NULL. [PMID: 14904679]