(2R,3S,4R)-4-[(2R,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2S,3R,5S)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoic acid (BioDeep_00000896776)
代谢物信息卡片
化学式: C36H62O11 (670.4292)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)O)OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C
InChI: InChI=1S/C36H62O11/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40)/t19-,20+,21+,22+,23+,24+,25-,26-,27+,28-,29-,30-,31-,33+,34-,35+,36-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Pedro H V Carvalho, Brooke C Latack, Marcos V C Ferraz, Lester J R P Nolasco, Willi R Meireles, Heitor O M Oliveira, Richard A Zinn. Influence of low-level tannin supplementation on comparative growth performance of Holstein and Angus × Holstein cross calf-fed concentrate-based finishing diets for 328 d.
Journal of animal science.
2024 Jan; 102(?):. doi:
10.1093/jas/skae087
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Journal of dairy science.
2023 Sep; ?(?):. doi:
10.3168/jds.2023-23669
. [PMID: 37730175] - Ahu Demirtas, Cátia Pacífico, Theresa Gruber, Remigius Chizzola, Qendrim Zebeli, Ratchaneewan Khiaosa-Ard. Sigla storax (Liquidambar orientalis) mitigates in vitro methane production without disturbances in rumen microbiota and nutrient fermentation in comparison to monensin.
Journal of applied microbiology.
2023 Aug; 134(8):. doi:
10.1093/jambio/lxad154
. [PMID: 37475660] - Liqiang Chen, Peihang Jiang, Xinran Shen, Jiayan Lyu, Chendong Liu, Lian Li, Yuan Huang. Cascade Delivery to Golgi Apparatus and On-Site Formation of Subcellular Drug Reservoir for Cancer Metastasis Suppression.
Small (Weinheim an der Bergstrasse, Germany).
2023 03; 19(11):e2204747. doi:
10.1002/smll.202204747
. [PMID: 36585358] - Chaoxia Zeng, Mingxia Long, Ying Lu. Monensin synergizes with chemotherapy in uveal melanoma through suppressing RhoA.
Immunopharmacology and immunotoxicology.
2023 Feb; 45(1):35-42. doi:
10.1080/08923973.2022.2112219
. [PMID: 36043455] - Wenlin Liao, Mads E Nielsen, Carsten Pedersen, Wenjun Xie, Hans Thordal-Christensen. Barley endosomal MONENSIN SENSITIVITY1 is a target of the powdery mildew effector CSEP0162 and plays a role in plant immunity.
Journal of experimental botany.
2023 01; 74(1):118-129. doi:
10.1093/jxb/erac403
. [PMID: 36227010] - Liangsheng Xu, Xiaolong Zhang, Dian Zheng, Yali Chang, Feiran Zhang, Yinghao Wang, Lili Huang. VmMon1-Ccz1 Complex Is Required for Conidiation, Autophagy, and Virulence in Valsa mali.
Molecular plant-microbe interactions : MPMI.
2022 Oct; 35(10):906-916. doi:
10.1094/mpmi-03-22-0071-r
. [PMID: 35793146] - Mariam G Ahmed, Adham A Al-Sagheer, Samir Z El-Zarkouny, Eman A Elwakeel. Potential of selected plant extracts to control severe subacute ruminal acidosis in vitro as compared with monensin.
BMC veterinary research.
2022 Sep; 18(1):356. doi:
10.1186/s12917-022-03457-4
. [PMID: 36151574] - Larisse Borges Sousa, Mara Lúcia Albuquerque Pereira, Herymá Giovane de Oliveira Silva, Leandro Borges Sousa, Leandro Santos E Silva, Fernanda Samarini Machado, Thierry Ribeiro Tomich, Daniela Batista Oss, Alexandre Lima Ferreira, Mariana Magalhães Campos, Isabela Carvalho Costa, Luiz Gustavo Ribeiro Pereira. Prosopis juliflora piperidine alkaloid extract levels in diet for sheep change energy and nitrogen metabolism and affect enteric methane yield.
Journal of the science of food and agriculture.
2022 Sep; 102(12):5132-5140. doi:
10.1002/jsfa.11864
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Tropical animal health and production.
2022 Apr; 54(3):167. doi:
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Journal of dairy science.
2021 Jan; 104(1):324-336. doi:
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Meat science.
2020 Oct; 168(?):108195. doi:
10.1016/j.meatsci.2020.108195
. [PMID: 32470759] - Michał Sulik, Ewa Maj, Joanna Wietrzyk, Adam Huczyński, Michał Antoszczak. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores.
Biomolecules.
2020 07; 10(7):. doi:
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Journal of microscopy.
2020 06; 278(3):154-163. doi:
10.1111/jmi.12881
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PloS one.
2020; 15(8):e0237118. doi:
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Poultry science.
2019 Nov; 98(11):5456-5464. doi:
10.3382/ps/pez345
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Environmental toxicology and chemistry.
2018 12; 37(12):3145-3153. doi:
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. [PMID: 30183095] - Gemini D Bhalsod, Ya-Hui Chuang, Sangho Jeon, Wenjun Gui, Hui Li, Elliot T Ryser, Andrey K Guber, Wei Zhang. Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce.
Journal of agricultural and food chemistry.
2018 Jan; 66(4):822-830. doi:
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. [PMID: 29293328] - Vinoth Rajendran, Hema Saranya Ilamathi, Suparna Dutt, T S Lakshminarayana, Prahlad C Ghosh. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent.
Current topics in medicinal chemistry.
2018; 18(22):1976-1986. doi:
10.2174/1568026619666181129141151
. [PMID: 30499391] - Luis Bosch, Alexa M Bersenas, Shane Bateman. Acute polyneuromyopathy with respiratory failure secondary to monensin intoxication in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2018 Jan; 28(1):62-68. doi:
10.1111/vec.12684
. [PMID: 29210488] - Janis Hausmann, Carolin Deiner, Amlan K Patra, Irmgard Immig, Alexander Starke, Jörg R Aschenbach. Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition, energy metabolism and milk performance in transition dairy cows.
PloS one.
2018; 13(3):e0193685. doi:
10.1371/journal.pone.0193685
. [PMID: 29584764] - N L Bell, R C Anderson, T R Callaway, M O Franco, J E Sawyer, T A Wickersham. Effect of monensin inclusion on intake, digestion, and ruminal fermentation parameters by Bos taurus indicus and Bos taurus taurus steers consuming bermudagrass hay.
Journal of animal science.
2017 Jun; 95(6):2736-2746. doi:
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. [PMID: 28727060] - N L Bell, T R Callaway, R C Anderson, M O Franco, J E Sawyer, T A Wickersham. Effect of monensin withdrawal on intake, digestion, and ruminal fermentation parameters by Bos taurus indicus and Bos taurus taurus steers consuming bermudagrass hay.
Journal of animal science.
2017 Jun; 95(6):2747-2757. doi:
10.2527/jas.2016.1013
. [PMID: 28727043] - Sarah A Doydora, Peizhe Sun, Miguel Cabrera, Nehru Mantripragada, John Rema, Spyros G Pavlostathis, Ching-Hua Huang, Aaron Thompson. Long-term broiler litter amendments can alter the soil's capacity to sorb monensin.
Environmental science and pollution research international.
2017 May; 24(15):13466-13473. doi:
10.1007/s11356-017-8727-9
. [PMID: 28386903] - Yi Wang, Sukhmani Billing, Zhixiang Wang. Activation of Endosome-Associated Inert EGF Receptor Following Internalization.
Methods in molecular biology (Clifton, N.J.).
2017; 1652(?):117-126. doi:
10.1007/978-1-4939-7219-7_8
. [PMID: 28791638] - Duyen Quach, Cecilia Vitali, Fiona M La, Angel X Xiao, John S Millar, Chongren Tang, Daniel J Rader, Michael C Phillips, Nicholas N Lyssenko. Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.
Biochimica et biophysica acta.
2016 12; 1861(12 Pt A):1968-1979. doi:
10.1016/j.bbalip.2016.09.017
. [PMID: 27671775] - M Bozkurt, G Ege, N Aysul, H Akşit, A E Tüzün, K Küçükyılmaz, A E Borum, M Uygun, D Akşit, S Aypak, E Şimşek, K Seyrek, B Koçer, E Bintaş, A Orojpour. Effect of anticoccidial monensin with oregano essential oil on broilers experimentally challenged with mixed Eimeria spp.
Poultry science.
2016 Aug; 95(8):1858-68. doi:
10.3382/ps/pew077
. [PMID: 26976910] - Khondoker Alam, Sonia Pahwa, Xueying Wang, Pengyue Zhang, Kai Ding, Alaa H Abuznait, Lang Li, Wei Yue. Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions.
Molecular pharmaceutics.
2016 Mar; 13(3):839-51. doi:
10.1021/acs.molpharmaceut.5b00763
. [PMID: 26750564] - Belinda B Guo, Shayne A Bellingham, Andrew F Hill. Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions.
The Journal of biological chemistry.
2016 Mar; 291(10):5128-37. doi:
10.1074/jbc.m115.684258
. [PMID: 26769968] - C Benchaar. Diet supplementation with cinnamon oil, cinnamaldehyde, or monensin does not reduce enteric methane production of dairy cows.
Animal : an international journal of animal bioscience.
2016 Mar; 10(3):418-25. doi:
10.1017/s175173111500230x
. [PMID: 26888487] - Vinoth Rajendran, Shilpa Rohra, Mohsin Raza, Gulam Mustafa Hasan, Suparna Dutt, Prahlad C Ghosh. Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria.
Antimicrobial agents and chemotherapy.
2015 Dec; 60(3):1304-18. doi:
10.1128/aac.01796-15
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Journal of animal science.
2015 Aug; 93(8):3941-9. doi:
10.2527/jas.2014-8772
. [PMID: 26440174] - S Mann, F A Leal Yepes, T R Overton, J J Wakshlag, A L Lock, C M Ryan, D V Nydam. Dry period plane of energy: Effects on feed intake, energy balance, milk production, and composition in transition dairy cows.
Journal of dairy science.
2015 May; 98(5):3366-82. doi:
10.3168/jds.2014-9024
. [PMID: 25771059] - Yuri N Antonenko, Tatyana I Rokitskaya, Adam Huczyński. Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester.
Biochimica et biophysica acta.
2015 Apr; 1848(4):995-1004. doi:
10.1016/j.bbamem.2015.01.005
. [PMID: 25600660] - D M Oliveira, A Chalfun-Junior, M L Chizzotti, H G Barreto, T C Coelho, L V Paiva, C P Coelho, P D Teixeira, J P Schoonmaker, M M Ladeira. Expression of genes involved in lipid metabolism in the muscle of beef cattle fed soybean or rumen-protected fat, with or without monensin supplementation.
Journal of animal science.
2014 Dec; 92(12):5426-36. doi:
10.2527/jas.2014-7855
. [PMID: 25403202] - Khalil Dayekh, Stephanie Johnson-Obaseki, Martin Corsten, Patrick J Villeneuve, Harmanjatinder S Sekhon, Johanne I Weberpals, Jim Dimitroulakos. Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors.
Molecular cancer therapeutics.
2014 Nov; 13(11):2559-71. doi:
10.1158/1535-7163.mct-13-1086
. [PMID: 25189541] - Cynthia L Winkworth, Gavin Lear. Antimicrobial potential of the ionophore monensin on freshwater biofilm bacteria.
Environmental science and pollution research international.
2014 Sep; 21(17):10139-50. doi:
10.1007/s11356-014-2911-y
. [PMID: 24809489] - Khodadad Pirali Kheirabadi, Jahangir Kaboutari Katadj, Shahab Bahadoran, Jaime A Teixeira da Silva, Amir Dehghani Samani, Mehdi Cheraghchi Bashi. Comparison of the anticoccidial effect of granulated extract of Artemisia sieberi with monensin in experimental coccidiosis in broiler chickens.
Experimental parasitology.
2014 Jun; 141(?):129-33. doi:
10.1016/j.exppara.2014.03.022
. [PMID: 24703975] - Bruno A Rocha, Marilda D Assis, Ana P F Peti, Luiz A B Moraes, Fernanda L Moreira, Norberto P Lopes, Stanislav Pospíšil, Paul J Gates, Anderson R M de Oliveira. In vitro metabolism of monensin A: microbial and human liver microsomes models.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Apr; 44(4):326-35. doi:
10.3109/00498254.2013.845707
. [PMID: 24134149] - M Kim, M L Eastridge, Z Yu. Investigation of ruminal bacterial diversity in dairy cattle fed supplementary monensin alone and in combination with fat, using pyrosequencing analysis.
Canadian journal of microbiology.
2014 Feb; 60(2):65-71. doi:
10.1139/cjm-2013-0746
. [PMID: 24498983] - Bruno Alves Rocha, Anderson Rodrigo Moraes de Oliveira, Murilo Pazin, Daniel Junqueira Dorta, Andresa Piacezzi Nascimento Rodrigues, Andresa Aparecida Berretta, Ana Paula Ferranti Peti, Luiz Alberto Beraldo de Moraes, Norberto Peporine Lopes, Stanislav Pospíšil, Paul Jonathan Gates, Marilda das Dores Assis. Jacobsen catalyst as a cytochrome P450 biomimetic model for the metabolism of monensin A.
BioMed research international.
2014; 2014(?):152102. doi:
10.1155/2014/152102
. [PMID: 24987668] - M M Ladeira, L C Santarosa, M L Chizzotti, E M Ramos, O R Machado Neto, D M Oliveira, J R R Carvalho, L S Lopes, J S Ribeiro. Fatty acid profile, color and lipid oxidation of meat from young bulls fed ground soybean or rumen protected fat with or without monensin.
Meat science.
2014 Jan; 96(1):597-605. doi:
10.1016/j.meatsci.2013.04.062
. [PMID: 24018278] - Pierre Bonnafous, Marie-Claire Nicolaï, Jean-Christophe Taveau, Michel Chevalier, Fabienne Barrière, Julie Medina, Olivier Le Bihan, Olivier Adam, Frédéric Ronzon, Olivier Lambert. Treatment of influenza virus with beta-propiolactone alters viral membrane fusion.
Biochimica et biophysica acta.
2014 Jan; 1838(1 Pt B):355-63. doi:
10.1016/j.bbamem.2013.09.021
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Journal of the science of food and agriculture.
2013 Aug; 93(10):2517-22. doi:
10.1002/jsfa.6068
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Journal of animal physiology and animal nutrition.
2013 Aug; 97(4):666-74. doi:
10.1111/j.1439-0396.2012.01307.x
. [PMID: 22533457] - Yan Yan Yeap, Natalie L Trevaskis, Tim Quach, Patrick Tso, William N Charman, Christopher J H Porter. Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.
Molecular pharmaceutics.
2013 May; 10(5):1874-89. doi:
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PloS one.
2013; 8(7):e70283. doi:
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BioMed research international.
2013; 2013(?):742149. doi:
10.1155/2013/742149
. [PMID: 23509771] - Pinky Sharma, Shailender Singh Kanwar, S N Sanyal. Effect of cationic ionophore monensin on the lipid composition and fluidity of rat epididymal spermatozoal membrane.
Drug and chemical toxicology.
2013 Jan; 36(1):79-87. doi:
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. [PMID: 22320440] - Yulia Evdokimovskaya, Yuri Skarga, Veronika Vrublevskaya, Oleg Morenkov. Release of the glucose-regulated protein 94 by baby hamster kidney cells.
Cell biochemistry and function.
2012 Oct; 30(7):558-62. doi:
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Parasitology research.
2012 Jul; 111(1):231-40. doi:
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Biochimica et biophysica acta.
2012 Jun; 1821(6):934-42. doi:
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Journal of dairy science.
2012 Apr; 95(4):2061-9. doi:
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Journal of dairy science.
2012 Apr; 95(4):2046-60. doi:
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British poultry science.
2012; 53(3):325-32. doi:
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Cellular signalling.
2011 Nov; 23(11):1777-84. doi:
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The Journal of urology.
2011 Oct; 186(4):1481-8. doi:
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Journal of psychiatric research.
2011 Sep; 45(9):1170-7. doi:
10.1016/j.jpsychires.2011.03.007
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Journal of dairy science.
2010 Aug; 93(8):3755-63. doi:
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. [PMID: 20655445] - Jeffery A McGarvey, Scott W Hamilton, Edward J DePeters, Frank M Mitloehner. Effect of dietary monensin on the bacterial population structure of dairy cattle colonic contents.
Applied microbiology and biotechnology.
2010 Feb; 85(6):1947-52. doi:
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Investigative ophthalmology & visual science.
2009 Dec; 50(12):5805-10. doi:
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The Journal of dairy research.
2009 Nov; 76(4):475-82. doi:
10.1017/s0022029909990215
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