N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (BioDeep_00000896761)
代谢物信息卡片
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
化学式: C20H20BrN3O2S (445.046)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br
InChI: InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Cell reports.
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Molecular pharmacology.
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Reproduction (Cambridge, England).
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American journal of physiology. Heart and circulatory physiology.
2006 Oct; 291(4):H1959-71. doi:
10.1152/ajpheart.00956.2005. [PMID: 16648185] - Anastasia Mashukova, Marc Spehr, Hanns Hatt, Eva M Neuhaus. Beta-arrestin2-mediated internalization of mammalian odorant receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Sep; 26(39):9902-12. doi:
10.1523/jneurosci.2897-06.2006. [PMID: 17005854] - Elizabeth A Potter, Gavin Stewart, Craig P Smith. Urea flux across MDCK-mUT-A2 monolayers is acutely sensitive to AVP, cAMP, and [Ca2+]i.
American journal of physiology. Renal physiology.
2006 Jul; 291(1):F122-8. doi:
10.1152/ajprenal.00423.2005. [PMID: 16449356] - Julie Baumber, Stuart A Meyers. Changes in membrane lipid order with capacitation in rhesus macaque (Macaca mulatta) spermatozoa.
Journal of andrology.
2006 Jul; 27(4):578-87. doi:
10.2164/jandrol.05135. [PMID: 16582419] - Brenda Gonzalez, Francisco Paz, Leonor Florán, Jorge Aceves, David Erlij, Benjamín Florán. Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat.
Neuropharmacology.
2006 Jul; 51(1):154-9. doi:
10.1016/j.neuropharm.2006.03.011. [PMID: 16730753] - Raogo Ouedraogo, Xiangdong Wu, Shi-Qiong Xu, Lauren Fuchsel, Hiroyuki Motoshima, Kalyankar Mahadev, Kelly Hough, Rosario Scalia, Barry J Goldstein. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway.
Diabetes.
2006 Jun; 55(6):1840-6. doi:
10.2337/db05-1174. [PMID: 16731851] - Akira Ikari, Satomi Matsumoto, Hitoshi Harada, Kuniaki Takagi, Hisayoshi Hayashi, Yuichi Suzuki, Masakuni Degawa, Masao Miwa. Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions.
Journal of cell science.
2006 May; 119(Pt 9):1781-9. doi:
10.1242/jcs.02901. [PMID: 16608877] - Julie Baumber, Stuart A Meyers. Hyperactivated motility in rhesus macaque (Macaca mulatta) spermatozoa.
Journal of andrology.
2006 May; 27(3):459-68. doi:
10.2164/jandrol.05107. [PMID: 16339455] - Tsong-Long Hwang, Shang-Hsin Yeh, Yann-Lii Leu, Ching-Yuh Chern, Hui-Chi Hsu. Inhibition of superoxide anion and elastase release in human neutrophils by 3'-isopropoxychalcone via a cAMP-dependent pathway.
British journal of pharmacology.
2006 May; 148(1):78-87. doi:
10.1038/sj.bjp.0706712. [PMID: 16501579] - Diane Gesty-Palmer, Minyong Chen, Eric Reiter, Seungkirl Ahn, Christopher D Nelson, Shuntai Wang, Allen E Eckhardt, Conrad L Cowan, Robert F Spurney, Louis M Luttrell, Robert J Lefkowitz. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
The Journal of biological chemistry.
2006 Apr; 281(16):10856-64. doi:
10.1074/jbc.m513380200. [PMID: 16492667] - Weili Yan, Hsin-Hsiung Tai. Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation, and cell morphology change following stimulation of thromboxane receptor alpha.
The Journal of pharmacology and experimental therapeutics.
2006 Apr; 317(1):267-74. doi:
10.1124/jpet.105.096826. [PMID: 16352701] - Ming-Qing Dong, Chu-Pak Lau, Zhan Gao, Gea-Ny Tseng, Gui-Rong Li. Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells.
The Journal of membrane biology.
2006 Apr; 210(3):183-92. doi:
10.1007/s00232-006-0006-5. [PMID: 16909339] - Emilia Zmuda-Trzebiatowska, Alina Oknianska, Vincent Manganiello, Eva Degerman. Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
Cellular signalling.
2006 Mar; 18(3):382-90. doi:
10.1016/j.cellsig.2005.05.007. [PMID: 15961276] - Anna S Hui, Amy L Bauer, Justin B Striet, Phillip O Schnell, Maria F Czyzyk-Krzeska. Calcium signaling stimulates translation of HIF-alpha during hypoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006 Mar; 20(3):466-75. doi:
10.1096/fj.05-5086com. [PMID: 16507764] - Takahiro Tsujita. Basal lipolysis in epididymal fat cells from streptozotocin-induced diabetic rats.
Journal of nutritional science and vitaminology.
2006 Feb; 52(1):47-53. doi:
10.3177/jnsv.52.47. [PMID: 16637229] - Petar N Grozdanov, Petko M Petkov, L K Karagyozov, Mariana D Dabeva. Expression and localization of PCSK9 in rat hepatic cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2006 Feb; 84(1):80-92. doi:
10.1139/o05-155. [PMID: 16462892] - Sudha K Shenoy, Matthew T Drake, Christopher D Nelson, Daniel A Houtz, Kunhong Xiao, Srinivasan Madabushi, Eric Reiter, Richard T Premont, Olivier Lichtarge, Robert J Lefkowitz. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
The Journal of biological chemistry.
2006 Jan; 281(2):1261-73. doi:
10.1074/jbc.m506576200. [PMID: 16280323] - Andrew C Skinn, Wallace K MacNaughton. Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Oct; 289(4):G739-44. doi:
10.1152/ajpgi.00425.2004. [PMID: 15994425] - Jean-Marie Mouillon, Bengt L Persson. Inhibition of the protein kinase A alters the degradation of the high-affinity phosphate transporter Pho84 in Saccharomyces cerevisiae.
Current genetics.
2005 Oct; 48(4):226-34. doi:
10.1007/s00294-005-0019-0. [PMID: 16160831] - Anne E Carlson, Timothy A Quill, Ruth E Westenbroek, Sonya M Schuh, Bertil Hille, Donner F Babcock. Identical phenotypes of CatSper1 and CatSper2 null sperm.
The Journal of biological chemistry.
2005 Sep; 280(37):32238-44. doi:
10.1074/jbc.m501430200. [PMID: 16036917] - Nadia Mehebik, Anne-Marie Jaubert, Dominique Sabourault, Yves Giudicelli, Catherine Ribière. Leptin-induced nitric oxide production in white adipocytes is mediated through PKA and MAP kinase activation.
American journal of physiology. Cell physiology.
2005 Aug; 289(2):C379-87. doi:
10.1152/ajpcell.00320.2004. [PMID: 15772123] - Most Nahid Parvin, Shingo Kurabuchi, Kwartarini Murdiastuti, Chenjuan Yao, Chisato Kosugi-Tanaka, Tetsuya Akamatsu, Norio Kanamori, Kazuo Hosoi. Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner's gland of the rat duodenum.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Jun; 288(6):G1283-91. doi:
10.1152/ajpgi.00030.2004. [PMID: 15650134] - Akira Ikari, Hitoshi Harada, Kuniaki Takagi. Role of actin in the cAMP-dependent activation of sodium/glucose cotransporter in renal epithelial cells.
Biochimica et biophysica acta.
2005 Jun; 1711(1):20-4. doi:
10.1016/j.bbamem.2005.02.008. [PMID: 15904659] - Lene N Nejsum, Marina Zelenina, Anita Aperia, Jørgen Frøkiaer, Søren Nielsen. Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation.
American journal of physiology. Renal physiology.
2005 May; 288(5):F930-8. doi:
10.1152/ajprenal.00291.2004. [PMID: 15625084] - Katrin Fricke, Axel Schulz, Harald John, Wolf-Georg Forssmann, Erik Maronde. Isolation and characterization of a novel proopiomelanocortin-derived peptide from hemofiltrate of chronic renal failure patients.
Endocrinology.
2005 Apr; 146(4):2060-8. doi:
10.1210/en.2004-1097. [PMID: 15650078] - Grewo Lim, Shuxing Wang, Jianren Mao. cAMP and protein kinase A contribute to the downregulation of spinal glutamate transporters after chronic morphine.
Neuroscience letters.
2005 Mar; 376(1):9-13. doi:
10.1016/j.neulet.2004.11.016. [PMID: 15694265] - Jian-Zhong Han, Wen Lin, Yi-Zhang Chen. Inhibition of ATP-induced calcium influx in HT4 cells by glucocorticoids: involvement of protein kinase A.
Acta pharmacologica Sinica.
2005 Feb; 26(2):199-204. doi:
10.1111/j.1745-7254.2005.00539.x. [PMID: 15663899] - Milan Rusnak, Harold Gainer. Differential effects of forskolin on tyrosine hydroxylase gene transcription in identified brainstem catecholaminergic neuronal subtypes in organotypic culture.
The European journal of neuroscience.
2005 Feb; 21(4):889-98. doi:
10.1111/j.1460-9568.2005.03913.x. [PMID: 15787695] - Kerstin Rabausch, Ellen Bretschneider, Mario Sarbia, Jutta Meyer-Kirchrath, Petra Censarek, Robert Pape, Jens W Fischer, Karsten Schrör, Artur-Aron Weber. Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins.
Circulation research.
2005 Jan; 96(1):e1-6. doi:
10.1161/01.res.0000153150.27690.f2. [PMID: 15591227] - Dimin Li, Yuan Wei, Wen-Hui Wang. Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb.
American journal of physiology. Renal physiology.
2004 Nov; 287(5):F954-9. doi:
10.1152/ajprenal.00183.2004. [PMID: 15265768] - L Guerra, M Favia, T Fanelli, G Calamita, M Svetlo, A Bagorda, K A Jacobson, S J Reshkin, V Casavola. Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.
Pflugers Archiv : European journal of physiology.
2004 Oct; 449(1):66-75. doi:
10.1007/s00424-004-1293-2. [PMID: 15235914] - Kouichi Tamura, Yuqing E Chen, Yutaka Tanaka, Masashi Sakai, Yuko Tsurumi, Yuichi Koide, Minoru Kihara, Richard E Pratt, Masatsugu Horiuchi, Satoshi Umemura, Victor J Dzau. Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression.
Molecular and cellular endocrinology.
2004 Sep; 224(1-2):11-20. doi:
10.1016/j.mce.2004.07.005. [PMID: 15353176] - Stuart J Mundell, Giordano Pula, Julia C A More, David E Jane, Peter J Roberts, Eamonn Kelly. Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b.
Molecular pharmacology.
2004 Jun; 65(6):1507-16. doi:
10.1124/mol.65.6.1507. [PMID: 15155843] - Tomas Kasparovsky, Jean-Pierre Blein, Vladimir Mikes. Ergosterol elicits oxidative burst in tobacco cells via phospholipase A2 and protein kinase C signal pathway.
Plant physiology and biochemistry : PPB.
2004 May; 42(5):429-35. doi:
10.1016/j.plaphy.2004.04.003. [PMID: 15191747] - Vigdis Sørensen, Andreas Brech, Denis Khnykin, Elona Kolpakova, Lucia Citores, Sjur Olsnes. Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus.
Journal of cell science.
2004 Apr; 117(Pt 9):1807-19. doi:
10.1242/jcs.01047. [PMID: 15075241] - C Sauvant, D Hesse, H Holzinger, K K Evans, W H Dantzler, M Gekle. Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells.
American journal of physiology. Renal physiology.
2004 Apr; 286(4):F774-83. doi:
10.1152/ajprenal.00326.2003. [PMID: 14644751]
