4-Hydroxy-5-[[4-[[(2R)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]methoxy]phenyl]methyl]-3H-1,3-thiazol-2-one (BioDeep_00000896448)
human metabolite blood metabolite
代谢物信息卡片
4-hydroxy-5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-2,3-dihydro-1,3-thiazol-2-one
化学式: C24H27NO5S (441.1609852000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90%
分子结构信息
SMILES: CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4=C(NC(=O)S4)O)C(=C1O)C)C
InChI: InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,26-27H,9-12H2,1-4H3,(H,25,28)
描述信息
同义名列表
4 个代谢物同义名
4-hydroxy-5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-2,3-dihydro-1,3-thiazol-2-one; 4-hydroxy-5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-1-benzopyran-2-yl)methoxy]phenyl}methyl)-3H-1,3-thiazol-2-one; 4-Hydroxy-5-[[4-[[(2R)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]methoxy]phenyl]methyl]-3H-1,3-thiazol-2-one; 5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Dermato-endocrinology.
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Prostaglandins & other lipid mediators.
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Chinese medicine.
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Physiological genomics.
2011 Feb; 43(3):110-20. doi:
10.1152/physiolgenomics.00115.2010. [PMID: 21081660] - Felipe Cabezas, Jonathan Lagos, Carlos Céspedes, Carlos P Vio, Miguel Bronfman, María-Paz Marzolo. Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function.
PloS one.
2011 Feb; 6(2):e16794. doi:
10.1371/journal.pone.0016794. [PMID: 21311715] - Sunhyo Jeong, Michung Yoon. 17β-Estradiol inhibition of PPARγ-induced adipogenesis and adipocyte-specific gene expression.
Acta pharmacologica Sinica.
2011 Feb; 32(2):230-8. doi:
10.1038/aps.2010.198. [PMID: 21293475] - Pierre-Henri Villard, Fabrice Barlesi, Martine Armand, Thi-Mai-Anh Dao, Jean-Marc Pascussi, Francis Fouchier, Serge Champion, Claire Dufour, Christian Giniès, Ayman Khalil, Marie-Josephe Amiot, Yves Barra, Eric Seree. CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site.
PloS one.
2011 Jan; 6(1):e14629. doi:
10.1371/journal.pone.0014629. [PMID: 21304969] - Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata, Izumi Matsuo, Heike Keilhack, Fawaz G Haj. Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B.
PloS one.
2011 Jan; 6(1):e16446. doi:
10.1371/journal.pone.0016446. [PMID: 21305007] - Fu-Tian Tang, Yuan Cao, Tie-Qiao Wang, Li-Jing Wang, Jiao Guo, Xiao-Shi Zhou, Suo-Wen Xu, Wei-Hua Liu, Pei-Qing Liu, He-Qing Huang. Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression.
European journal of pharmacology.
2011 Jan; 650(1):275-84. doi:
10.1016/j.ejphar.2010.07.038. [PMID: 20854809] - Atsushi Momose, Mariko Fujita, Takayuki Ohtomo, Natsumi Umemoto, Kouichi Tanonaka, Hiroo Toyoda, Masako Morikawa, Junji Yamada. Regulated expression of acyl-CoA thioesterases in the differentiation of cultured rat brown adipocytes.
Biochemical and biophysical research communications.
2011 Jan; 404(1):74-8. doi:
10.1016/j.bbrc.2010.11.066. [PMID: 21094633] - Chutwadee Krisanapun, Seong-Ho Lee, Penchom Peungvicha, Rungravi Temsiririrkkul, Seung Joon Baek. Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):167684. doi:
10.1093/ecam/neq004. [PMID: 21603234] - Andreas Pfützner, Alexander Weise, Elisabeth Pfützner-Riehn, Georg Lübben, Michael Morcos, Efstrathios Karagiannis, Matthias Weber, Thomas Forst. Downregulation of the proinflammatory state of circulating mononuclear cells by short-term treatment with pioglitazone in patients with type 2 diabetes mellitus and coronary artery disease.
PPAR research.
2011; 2011(?):647017. doi:
10.1155/2011/647017. [PMID: 21808640] - Juan Peng, Jian-Ping Yuan, Chou-Fei Wu, Jiang-Hai Wang. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health.
Marine drugs.
2011; 9(10):1806-1828. doi:
10.3390/md9101806. [PMID: 22072997] - Ho Sun Jung, Yun Hee Kim, Jin Woo Lee. Duration and magnitude of extracellular signal-regulated protein kinase phosphorylation determine adipogenesis or osteogenesis in human bone marrow-derived stem cells.
Yonsei medical journal.
2011 Jan; 52(1):165-72. doi:
10.3349/ymj.2011.52.1.165. [PMID: 21155050] - Yawei Liu, Bing Dai, Chenggang Xu, Lili Fu, Zhenhao Hua, Changlin Mei. Rosiglitazone inhibits transforming growth factor-β1 mediated fibrogenesis in ADPKD cyst-lining epithelial cells.
PloS one.
2011; 6(12):e28915. doi:
10.1371/journal.pone.0028915. [PMID: 22174924] - Saket M Ghaisas. Effect of insulin plant leaves on dexamethasone-induced hyperglycemia.
International journal of Ayurveda research.
2011 Jan; 2(1):60. doi:
10.4103/0974-7788.83174. [PMID: 21897647] - Yuebin Ge, Yan Zhang, Rui Li, Wei Chen, Yang Li, Guoxun Chen. Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes.
International journal of biological sciences.
2011; 7(5):673-84. doi:
10.7150/ijbs.7.673. [PMID: 21647250] - Pamela Maher, Richard Dargusch, Jennifer L Ehren, Shinichi Okada, Kumar Sharma, David Schubert. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes.
PloS one.
2011; 6(6):e21226. doi:
10.1371/journal.pone.0021226. [PMID: 21738623] - Dianne Deplewski, Kenan Qin, Nancy Ciletti, Robert L Rosenfield. Unique mode of lipogenic activation in rat preputial sebocytes.
Journal of nutrition and metabolism.
2011; 2011(?):163631. doi:
10.1155/2011/163631. [PMID: 21808727] - Salvatore Salomone. Pleiotropic effects of glitazones: a double edge sword?.
Frontiers in pharmacology.
2011; 2(?):14. doi:
10.3389/fphar.2011.00014. [PMID: 21687509] - Takuji Tanaka, Masashi Hosokawa, Yumiko Yasui, Rikako Ishigamori, Kazuo Miyashita. Cancer chemopreventive ability of conjugated linolenic acids.
International journal of molecular sciences.
2011; 12(11):7495-509. doi:
10.3390/ijms12117495. [PMID: 22174613] - Ahmad Slim, Laudino Castillo-Rojas, Eddie Hulten, Jennifer N Slim, Dorette Pearce Moore, Todd C Villines. Rosiglitazone and fenofibrate additive effects on lipids.
Cholesterol.
2011; 2011(?):286875. doi:
10.1155/2011/286875. [PMID: 22162805] - Katsuhiko Takayanagi. Prevention of Adiposity by the Oral Administration of β-Cryptoxanthin.
Frontiers in neurology.
2011; 2(?):67. doi:
10.3389/fneur.2011.00067. [PMID: 22131983] - José María Moreno-Navarrete, Francisco J Ortega, José-Ignacio Rodríguez-Hermosa, Mònica Sabater, Gerard Pardo, Wifredo Ricart, José Manuel Fernández-Real. OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.
Diabetes.
2011 Jan; 60(1):168-76. doi:
10.2337/db10-0805. [PMID: 20956498] - Yan Zhang, Wei Chen, Rui Li, Yang Li, Yuebin Ge, Guoxun Chen. Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions.
PloS one.
2011; 6(6):e21342. doi:
10.1371/journal.pone.0021342. [PMID: 21731709] - Prajna Mishra, Suresh K Paramasivam, Ramesh P Thylur, Ajay Rana, Basabi Rana. Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt.
Journal of molecular signaling.
2010 Dec; 5(?):20. doi:
10.1186/1750-2187-5-20. [PMID: 21144036] - Bambang Ardianto, Takeshi Sugimoto, Seiji Kawano, Shimpei Kasagi, Siti N A Jauharoh, Chiyo Kurimoto, Eiji Tatsumi, Keiko Morikawa, Shunichi Kumagai, Yoshitake Hayashi. The HPB-AML-I cell line possesses the properties of mesenchymal stem cells.
Journal of experimental & clinical cancer research : CR.
2010 Dec; 29(?):163. doi:
10.1186/1756-9966-29-163. [PMID: 21144016] - Bee K Tan, Raghu Adya, Syed Farhatullah, Jing Chen, Hendrik Lehnert, Harpal S Randeva. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome.
Diabetes.
2010 Dec; 59(12):3023-31. doi:
10.2337/db10-0124. [PMID: 20852028] - M Membrez, C J Chou, F Raymond, R Mansourian, M Moser, I Monnard, C Ammon-Zufferey, K Mace, G Mingrone, C Binnert. Six weeks' sebacic acid supplementation improves fasting plasma glucose, HbA1c and glucose tolerance in db/db mice.
Diabetes, obesity & metabolism.
2010 Dec; 12(12):1120-6. doi:
10.1111/j.1463-1326.2010.01308.x. [PMID: 20977585] - Chong-Zhi Yang, Hui-Tang Zhang, Gong-Sheng Wang, Hai-Quan Zhou, Chi Ma, Da-Hai Hu. [Mechanism underlying the inhibitory effects of peroxisome proliferator-activated receptor γ agonists on transforming growth factor β1 in adult skin fibroblasts].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2010 Dec; 26(6):448-51. doi:
. [PMID: 21223655] - Cimen Karasu. Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.
The open cardiovascular medicine journal.
2010 Nov; 4(?):240-56. doi:
10.2174/1874192401004010240. [PMID: 21270942] - Caio Sm Motoyama, Mônica Js Pinto, Fabio S Lira, Eliane B Ribeiro, Claudia Mo do Nascimento, Lila M Oyama. Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats.
Diabetology & metabolic syndrome.
2010 Oct; 2(?):61. doi:
10.1186/1758-5996-2-61. [PMID: 20979642] - Asja Wagener, Helge F Goessling, Armin O Schmitt, Susanne Mauel, Achim D Gruber, Richard Reinhardt, Gudrun A Brockmann. Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity.
Lipids in health and disease.
2010 Sep; 9(?):99. doi:
10.1186/1476-511x-9-99. [PMID: 20831792] - Curtis Triplitt, Eugenio Cersosimo, Ralph A DeFronzo. Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.
Vascular health and risk management.
2010 Sep; 6(?):671-90. doi:
10.2147/vhrm.s4852. [PMID: 20859539] - Kye Won Park, Hironori Waki, Sung-Pil Choi, Ki-Moon Park, Peter Tontonoz. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.
Journal of lipid research.
2010 Sep; 51(9):2775-84. doi:
10.1194/jlr.m008490. [PMID: 20519739] - Giulio G Muccioli, Damien Naslain, Fredrik Bäckhed, Christopher S Reigstad, Didier M Lambert, Nathalie M Delzenne, Patrice D Cani. The endocannabinoid system links gut microbiota to adipogenesis.
Molecular systems biology.
2010 Jul; 6(?):392. doi:
10.1038/msb.2010.46. [PMID: 20664638] - Sapna N Shetty, Sushma Mengi, Rama Vaidya, Ashok D B Vaidya. A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease.
Journal of Ayurveda and integrative medicine.
2010 Jul; 1(3):203-10. doi:
10.4103/0975-9476.72622. [PMID: 21547049] - R A DeFronzo. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.
Diabetologia.
2010 Jul; 53(7):1270-87. doi:
10.1007/s00125-010-1684-1. [PMID: 20361178] - Siddharth H Sheth, Robin J Larson. The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: a meta-analysis of randomized trials.
BMC infectious diseases.
2010 Jun; 10(?):183. doi:
10.1186/1471-2334-10-183. [PMID: 20573187] - David G Popovich, Lu Li, Wei Zhang. Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Jun; 48(6):1619-26. doi:
10.1016/j.fct.2010.03.035. [PMID: 20347917]