3-(2-Ethylhexyl)phthalic acid (BioDeep_00000896406)
human metabolite blood metabolite
代谢物信息卡片
3-(2-ethylhexyl)benzene-1,2-dicarboxylic acid
化学式: C16H22O4 (278.1518012)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.06%
分子结构信息
SMILES: CCCCC(CC)CC1=C(C(=CC=C1)C(=O)O)C(=O)O
InChI: InChI=1S/C16H22O4/c1-3-5-7-11(4-2)10-12-8-6-9-13(15(17)18)14(12)16(19)20/h6,8-9,11H,3-5,7,10H2,1-2H3,(H,17,18)(H,19,20)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Núria Monfort, Rosa Ventura, Georgina Balcells, Jordi Segura. Determination of five di-(2-ethylhexyl)phthalate metabolites in urine by UPLC-MS/MS, markers of blood transfusion misuse in sports.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Nov; 908(?):113-21. doi:
10.1016/j.jchromb.2012.09.030. [PMID: 23040990] - Y Suzuki, J Yoshinaga, Y Mizumoto, S Serizawa, H Shiraishi. Foetal exposure to phthalate esters and anogenital distance in male newborns.
International journal of andrology.
2012 Jun; 35(3):236-44. doi:
10.1111/j.1365-2605.2011.01190.x. [PMID: 21696396] - Chiara Testa, Francesca Nuti, Joussef Hayek, Claudio De Felice, Mario Chelli, Paolo Rovero, Giuseppe Latini, Anna Maria Papini. Di-(2-ethylhexyl) phthalate and autism spectrum disorders.
ASN neuro.
2012 May; 4(4):223-9. doi:
10.1042/an20120015. [PMID: 22537663] - Kyoungju Choi, Hyun Joo, Jerry L Campbell, Rebecca A Clewell, Melvin E Andersen, Harvey J Clewell. In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.
Toxicology in vitro : an international journal published in association with BIBRA.
2012 Mar; 26(2):315-22. doi:
10.1016/j.tiv.2011.12.002. [PMID: 22186153] - Núria Monfort, Rosa Ventura, Petra Platen, Timo Hinrichs, Klara Brixius, Wilhelm Schänzer, Mario Thevis, Hans Geyer, Jordi Segura. Plasticizers excreted in urine: indication of autologous blood transfusion in sports.
Transfusion.
2012 Mar; 52(3):647-57. doi:
10.1111/j.1537-2995.2011.03331.x. [PMID: 21895677] - Satoshi Takatori, Kazuhiko Akutsu, Fumio Kondo, Rie Ishii, Hiroyuki Nakazawa, Tsunehisa Makino. Di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in media for in vitro fertilization.
Chemosphere.
2012 Feb; 86(5):454-9. doi:
10.1016/j.chemosphere.2011.09.043. [PMID: 22024100] - Yoshimasa Kurata, Nobuaki Shimamura, Masanobu Katoh. Metabolite profiling and identification in human urine after single oral administration of DEHP.
The Journal of toxicological sciences.
2012; 37(2):401-14. doi:
10.2131/jts.37.401. [PMID: 22467031] - Lesa L Aylward, Sean M Hays. Consideration of dosimetry in evaluation of ToxCast™ data.
Journal of applied toxicology : JAT.
2011 Nov; 31(8):741-51. doi:
10.1002/jat.1626. [PMID: 21381051] - Michelle Romero-Franco, Raúl U Hernández-Ramírez, Antonia M Calafat, Mariano E Cebrián, Larry L Needham, Susan Teitelbaum, Mary S Wolff, Lizbeth López-Carrillo. Personal care product use and urinary levels of phthalate metabolites in Mexican women.
Environment international.
2011 Jul; 37(5):867-71. doi:
10.1016/j.envint.2011.02.014. [PMID: 21429583] - R Gaudin, P Marsan, S Ndaw, A Robert, P Ducos. Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: a field study.
International archives of occupational and environmental health.
2011 Jun; 84(5):523-31. doi:
10.1007/s00420-010-0566-7. [PMID: 20803214] - Tian Chen, Wenjie Yang, Yuanyuan Li, Xi Chen, Shunqing Xu. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells.
Toxicology letters.
2011 Feb; 201(1):34-41. doi:
10.1016/j.toxlet.2010.12.002. [PMID: 21145954] - Sung Hoon Kim, Sail Chun, Jin Yeon Jang, Hee Dong Chae, Chung-Hoon Kim, Byung Moon Kang. Increased plasma levels of phthalate esters in women with advanced-stage endometriosis: a prospective case-control study.
Fertility and sterility.
2011 Jan; 95(1):357-9. doi:
10.1016/j.fertnstert.2010.07.1059. [PMID: 20797718] - Moon-seo Park, Yun-jung Yang, Yeon-pyo Hong, Sang-yon Kim, Yong-pil Lee. Assessment of di (2-ethylhexyl) phthalate exposure by urinary metabolites as a function of sampling time.
Journal of preventive medicine and public health = Yebang Uihakhoe chi.
2010 Jul; 43(4):301-8. doi:
10.3961/jpmph.2010.43.4.301. [PMID: 20689356] - Fumio Kondo, Yoshitomo Ikai, Rumiko Hayashi, Masanao Okumura, Satoshi Takatori, Hiroyuki Nakazawa, Shun-ichiro Izumi, Tsunehisa Makino. Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry.
Bulletin of environmental contamination and toxicology.
2010 Jul; 85(1):92-6. doi:
10.1007/s00128-010-0051-8. [PMID: 20574658] - S H Swan, F Liu, M Hines, R L Kruse, C Wang, J B Redmon, A Sparks, B Weiss. Prenatal phthalate exposure and reduced masculine play in boys.
International journal of andrology.
2010 Apr; 33(2):259-69. doi:
10.1111/j.1365-2605.2009.01019.x. [PMID: 19919614] - Rupesh K Gupta, Jeffery M Singh, Tracie C Leslie, Sharon Meachum, Jodi A Flaws, Humphrey H-C Yao. Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro.
Toxicology and applied pharmacology.
2010 Jan; 242(2):224-30. doi:
10.1016/j.taap.2009.10.011. [PMID: 19874833] - Núria Monfort, Rosa Ventura, Ana Latorre, Viviana Belalcazar, Mercè López, Jordi Segura. Urinary di-(2-ethylhexyl)phthalate metabolites in athletes as screening measure for illicit blood doping: a comparison study with patients receiving blood transfusion.
Transfusion.
2010 Jan; 50(1):145-9. doi:
10.1111/j.1537-2995.2009.02352.x. [PMID: 19694994] - Erdem Durmaz, Elif N Ozmert, Pinar Erkekoglu, Belma Giray, Orhan Derman, Filiz Hincal, Kadriye Yurdakök. Plasma phthalate levels in pubertal gynecomastia.
Pediatrics.
2010 Jan; 125(1):e122-9. doi:
10.1542/peds.2009-0724. [PMID: 20008419] - Bung-Nyun Kim, Soo-Churl Cho, Yeni Kim, Min-Sup Shin, Hee-Jeong Yoo, Jae-Won Kim, Young Hee Yang, Hyo-Won Kim, Soo-Young Bhang, Yun-Chul Hong. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children.
Biological psychiatry.
2009 Nov; 66(10):958-63. doi:
10.1016/j.biopsych.2009.07.034. [PMID: 19748073] - Caroline Herr, Anja zur Nieden, Holger M Koch, Hans-Christian Schuppe, Christian Fieber, Jürgen Angerer, Thomas Eikmann, Nikolaos I Stilianakis. Urinary di(2-ethylhexyl)phthalate (DEHP)--metabolites and male human markers of reproductive function.
International journal of hygiene and environmental health.
2009 Nov; 212(6):648-53. doi:
10.1016/j.ijheh.2009.08.001. [PMID: 19733116] - John D Meeker, Antonia M Calafat, Russ Hauser. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men.
Journal of andrology.
2009 May; 30(3):287-97. doi:
10.2164/jandrol.108.006403. [PMID: 19059903] - Rena Kusu, Ami Oishi, Kimi Kakizawa, Tomomi Kimura, Chitose Toda, Kiyomatsu Hashizume, Koji Ueda, Nakao Kojima. Effects of phthalate ester derivatives including oxidized metabolites on coactivator recruiting by PPARalpha and PPARgamma.
Toxicology in vitro : an international journal published in association with BIBRA.
2008 Sep; 22(6):1534-8. doi:
10.1016/j.tiv.2008.05.010. [PMID: 18602795] - Debajit Sircar, Sargon J Albazi, Yousef Atallah, William Pizzi. Validation and application of an HPLC method for determination of di (2-ethylhexyl) phthalate and mono (2-ethylhexyl) phthalate in liver samples.
Journal of chromatographic science.
2008 Aug; 46(7):627-31. doi:
10.1093/chromsci/46.7.627. [PMID: 18718139] - R Gaudin, P Marsan, A Robert, P Ducos, A Pruvost, M Lévi, P Bouscaillou. Biological monitoring of occupational exposure to di(2-ethylhexyl) phthalate: survey of workers exposed to plastisols.
International archives of occupational and environmental health.
2008 Aug; 81(8):959-66. doi:
10.1007/s00420-007-0289-6. [PMID: 18097680] - Estela Sasso-Cerri, Paulo S Cerri. Morphological evidences indicate that the interference of cimetidine on the peritubular components is responsible for detachment and apoptosis of Sertoli cells.
Reproductive biology and endocrinology : RB&E.
2008 May; 6(?):18. doi:
10.1186/1477-7827-6-18. [PMID: 18471284] - Johan Högberg, Annika Hanberg, Marika Berglund, Staffan Skerfving, Mikael Remberger, Antonia M Calafat, Agneta Falk Filipsson, Bo Jansson, Niklas Johansson, Malin Appelgren, Helen Håkansson. Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations.
Environmental health perspectives.
2008 Mar; 116(3):334-9. doi:
10.1289/ehp.10788. [PMID: 18335100] - Pietro Mazzeo, Dorina Di Pasquale, Fabrizio Ruggieri, Maria Fanelli, Angelo Antonio D'Archivio, Giuseppe Carlucci. HPLC with diode-array detection for the simultaneous determination of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in seminal plasma.
Biomedical chromatography : BMC.
2007 Nov; 21(11):1166-71. doi:
10.1002/bmc.870. [PMID: 17583543] - Po-Chin Huang, Pao-Lin Kuo, Yue-Liang Guo, Pao-Chi Liao, Ching-Chang Lee. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women.
Human reproduction (Oxford, England).
2007 Oct; 22(10):2715-22. doi:
10.1093/humrep/dem205. [PMID: 17704099] - Shigeru Suna, Fuminori Yamaguchi, Shoji Kimura, Masaaki Tokuda, Fumihiko Jitsunari. Preventive effect of D-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury in rat.
Toxicology letters.
2007 Sep; 173(2):107-17. doi:
10.1016/j.toxlet.2007.06.015. [PMID: 17698303] - John D Meeker, Antonia M Calafat, Russ Hauser. Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men.
Environmental health perspectives.
2007 Jul; 115(7):1029-34. doi:
10.1289/ehp.9852. [PMID: 17637918] - Tina Mose, Lisbeth E Knudsen, Morten Hedegaard, Gerda K Mortensen. Transplacental transfer of monomethyl phthalate and mono(2-ethylhexyl) phthalate in a human placenta perfusion system.
International journal of toxicology.
2007 May; 26(3):221-9. doi:
10.1080/10915810701352721. [PMID: 17564903] - Jitka Stilund Hansen, Søren Thor Larsen, Lars K Poulsen, Gunnar Damgård Nielsen. Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice.
Toxicology.
2007 Mar; 232(1-2):79-88. doi:
10.1016/j.tox.2006.12.011. [PMID: 17241728] - Yumi Miura, Munekazu Naito, Maira Ablake, Hayato Terayama, Shuang-Qin Yi, Ning Qu, Lin-Xian Cheng, Shigeru Suna, Fumihiko Jitsunari, Masahiro Itoh. Short-term effects of di-(2-ethylhexyl) phthalate on testes, liver, kidneys and pancreas in mice.
Asian journal of andrology.
2007 Mar; 9(2):199-205. doi:
10.1111/j.1745-7262.2007.00220.x. [PMID: 16855774] - Hyun Jung Koo, Byung Mu Lee. Toxicokinetic relationship between di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in rats.
Journal of toxicology and environmental health. Part A.
2007 Mar; 70(5):383-7. doi:
10.1080/15287390600882150. [PMID: 17454563] - Yuji Kamijo, Kazuhiko Hora, Tamie Nakajima, Keiichi Kono, Kyoko Takahashi, Yuki Ito, Makoto Higuchi, Kendo Kiyosawa, Hidekazu Shigematsu, Frank J Gonzalez, Toshifumi Aoyama. Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate.
Journal of the American Society of Nephrology : JASN.
2007 Jan; 18(1):176-88. doi:
10.1681/asn.2006060597. [PMID: 17135395] - Matthias Wittassek, Wolfgang Heger, Holger M Koch, Kerstin Becker, Jürgen Angerer, Marike Kolossa-Gehring. Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children -- A comparison of two estimation models based on urinary DEHP metabolite levels.
International journal of hygiene and environmental health.
2007 Jan; 210(1):35-42. doi:
10.1016/j.ijheh.2006.11.009. [PMID: 17185035] - Mary S Wolff, Susan L Teitelbaum, Gayle Windham, Susan M Pinney, Julie A Britton, Carol Chelimo, James Godbold, Frank Biro, Lawrence H Kushi, Christine M Pfeiffer, Antonia M Calafat. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.
Environmental health perspectives.
2007 Jan; 115(1):116-21. doi:
10.1289/ehp.9488. [PMID: 17366830] - Thomas Stroheker, Jean-François Regnier, Julie Lassurguere, Marie-Christine Chagnon. Effect of in utero exposure to di-(2-ethylhexyl)phthalate: distribution in the rat fetus and testosterone production by rat fetal testis in culture.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2006 Dec; 44(12):2064-9. doi:
10.1016/j.fct.2006.07.007. [PMID: 16979278] - Chad M McKee, Yang Ye, John H Richburg. Testicular germ cell sensitivity to TRAIL-induced apoptosis is dependent upon p53 expression and is synergistically enhanced by DR5 agonistic antibody treatment.
Apoptosis : an international journal on programmed cell death.
2006 Dec; 11(12):2237-50. doi:
10.1007/s10495-006-0288-1. [PMID: 17051329] - Guowei Pan, Tomoyuki Hanaoka, Mariko Yoshimura, Shujuan Zhang, Ping Wang, Hiromasa Tsukino, Koichi Inoue, Hiroyuki Nakazawa, Shoichiro Tsugane, Ken Takahashi. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China.
Environmental health perspectives.
2006 Nov; 114(11):1643-8. doi:
10.1289/ehp.9016. [PMID: 17107847] - Antonia M Calafat, Richard H McKee. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study.
Environmental health perspectives.
2006 Nov; 114(11):1783-9. doi:
10.1289/ehp.9059. [PMID: 17107868] - Kyoko Nabae, Yuko Doi, Satoru Takahashi, Toshio Ichihara, Chitose Toda, Koji Ueda, Yoshinori Okamoto, Nakao Kojima, Seiko Tamano, Tomoyuki Shirai. Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative.
Reproductive toxicology (Elmsford, N.Y.).
2006 Oct; 22(3):411-7. doi:
10.1016/j.reprotox.2006.07.003. [PMID: 16952438] - Jennifer Weuve, Brisa N Sánchez, Antonia M Calafat, Ted Schettler, Ronald A Green, Howard Hu, Russ Hauser. Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites.
Environmental health perspectives.
2006 Sep; 114(9):1424-31. doi:
10.1289/ehp.8926. [PMID: 16966100] - Jun-Ping Lu, Li-Xing Zheng, De-Pei Cai. [Determination of four kinds of environmental endocrine disruptors in blood serum of precocious puberty patients by high performance liquid chromatography].
Wei sheng yan jiu = Journal of hygiene research.
2006 May; 35(3):288-90. doi:
. [PMID: 16921750] - Kayumi Fujimaki, Jun Yoshinaga, Chiho Watanabe, Shigeko Serizawa, Hiroaki Shiraishi, Yoshifumi Mizumoto. [Estimation of intake level of di (2-ethyhexyl) phthalate (DEHP) in Japanese pregnant women based on measurement of concentrations of three urinary metabolites].
Nihon eiseigaku zasshi. Japanese journal of hygiene.
2006 May; 61(3):340-7. doi:
10.1265/jjh.61.340. [PMID: 16768165] - Yan Xu, Gregory T Knipp, Thomas J Cook. Effects of di-(2-ethylhexyl)-phthalate and its metabolites on the lipid profiling in rat HRP-1 trophoblast cells.
Archives of toxicology.
2006 May; 80(5):293-8. doi:
10.1007/s00204-005-0047-z. [PMID: 16328440] - Stefano Luisi, Giuseppe Latini, Claudio de Felice, Francesca Sanseverino, Dorina di Pasquale, Pietro Mazzeo, Felice Petraglia. Low serum concentrations of di-(2-ethylhexyl)phthalate in women with uterine fibromatosis.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2006 Feb; 22(2):92-5. doi:
10.1080/09513590600551312. [PMID: 16603434] - Antonia M Calafat, John W Brock, Manori J Silva, L Earl Gray, John A Reidy, Dana B Barr, Larry L Needham. Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate.
Toxicology.
2006 Jan; 217(1):22-30. doi:
10.1016/j.tox.2005.08.013. [PMID: 16171919] - Ronald Green, Russ Hauser, Antonia M Calafat, Jennifer Weuve, Ted Schettler, Steven Ringer, Kenneth Huttner, Howard Hu. Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants.
Environmental health perspectives.
2005 Sep; 113(9):1222-5. doi:
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Journal of toxicology and environmental health. Part A.
2005 Aug; 68(16):1379-92. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2005 Aug; 358(1-2):159-66. doi:
10.1016/j.cccn.2005.02.019. [PMID: 15893743] - Holger M Koch, Hermann M Bolt, Ralf Preuss, Jürgen Angerer. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP.
Archives of toxicology.
2005 Jul; 79(7):367-76. doi:
10.1007/s00204-004-0642-4. [PMID: 15700144] - NULL. [Material monograph on di(2-ethylhexyl)phthalat (DEHP)--reference values for 5oxo-MEHP und 5OH-MEHP in urine].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.
2005 Jun; 48(6):706-22. doi:
10.1007/s00103-005-1086-6. [PMID: 15983852] - Yan Xu, Thomas J Cook, Gregory T Knipp. Effects of di-(2-ethylhexyl)-phthalate (DEHP) and its metabolites on fatty acid homeostasis regulating proteins in rat placental HRP-1 trophoblast cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Apr; 84(2):287-300. doi:
10.1093/toxsci/kfi083. [PMID: 15647598] - Russ Hauser, Paige Williams, Larisa Altshul, Antonia M Calafat. Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility.
Environmental health perspectives.
2005 Apr; 113(4):425-30. doi:
10.1289/ehp.7305. [PMID: 15811833] - Ralf Preuss, Holger M Koch, Jürgen Angerer. Biological monitoring of the five major metabolites of di-(2-ethylhexyl)phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):269-80. doi:
10.1016/j.jchromb.2004.11.048. [PMID: 15664359] - Yamini Chandrasekaran, John H Richburg. The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP.
Biology of reproduction.
2005 Jan; 72(1):206-13. doi:
10.1095/biolreprod.104.030858. [PMID: 15371270] - Hiroaki Itoh, Kikuo Yoshida, Shigeki Masunaga. Evaluation of the effect of governmental control of human exposure to two phthalates in Japan using a urinary biomarker approach.
International journal of hygiene and environmental health.
2005; 208(4):237-45. doi:
10.1016/j.ijheh.2005.02.004. [PMID: 16078637] - Tsutomu Fukuwatari, Seiko Ohsaki, Shin-ichi Fukuoka, Ryuzo Sasaki, Katsumi Shibata. Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway.
Toxicological sciences : an official journal of the Society of Toxicology.
2004 Oct; 81(2):302-8. doi:
10.1093/toxsci/kfh204. [PMID: 15229365] - Bibin Bintang Andriana, Tat Wei Tay, Ishii Maki, Mohammad Abdul Awal, Yoshiakira Kanai, Masamichi Kurohmaru, Yoshihiro Hayashi. An ultrastructural study on cytotoxic effects of mono(2-ethylhexyl) phthalate (MEHP) on testes in Shiba goat in vitro.
Journal of veterinary science.
2004 Sep; 5(3):235-40. doi:
10.4142/jvs.2004.5.3.235. [PMID: 15365238] - Karl Ljungvall, Bart Tienpont, Frank David, Ulf Magnusson, Karolina Törneke. Kinetics of orally administered di(2-ethylhexyl) phthalate and its metabolite, mono(2-ethylhexyl) phthalate, in male pigs.
Archives of toxicology.
2004 Jul; 78(7):384-9. doi:
10.1007/s00204-004-0558-z. [PMID: 15022035] - S Takatori, Y Kitagawa, M Kitagawa, H Nakazawa, S Hori. Determination of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in human serum using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 May; 804(2):397-401. doi:
10.1016/j.jchromb.2004.01.056. [PMID: 15081935] - Antonia M Calafat, Larry L Needham, Manori J Silva, George Lambert. Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit.
Pediatrics.
2004 May; 113(5):e429-34. doi:
10.1542/peds.113.5.e429. [PMID: 15121985] - Bibin Bintang Andriana, Tat Wei Tay, Tsuyoshi Tachiwana, Takeshi Sato, Maki Ishii, Mohammad Abdul Awal, Yoshiakira Kanai, Masamichi Kurohmaru, Yoshihiro Hayashi. Effects of mono(2-ethylhexyl) phthalate (MEHP) on testes in rats in vitro.
Okajimas folia anatomica Japonica.
2004 Mar; 80(5-6):127-36. doi:
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