Reduced ketanserin (BioDeep_00000896386)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H24FN3O3 (397.1801606)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCC1C(C2=CC=C(C=C2)F)O)CCN3C(=O)C4=CC=CC=C4NC3=O
InChI: InChI=1S/C22H24FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16,20,27H,9-14H2,(H,24,29)
描述信息
同义名列表
5 个代谢物同义名
3-(2-{4-[(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}ethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione; 3-(2-(4-((4-Fluorophenyl)hydroxymethyl)-1-piperidinyl)ethyl)-2,4-(1H,3H)quinazolinedione; 3-(2-{4-[(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}ethyl)-1H-quinazoline-2,4-dione; Reduced ketanserin; Ketanserinol
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Yassen, L M Hanff, A G Vulto. Simultaneous quantitative analysis of ketanserin and ketanserinol in plasma by RP-HPLC with fluorescence detection.
Biomedical chromatography : BMC.
2003 Dec; 17(8):517-21. doi:
10.1002/bmc.265. [PMID: 14648608] - D Lebrec, A Hadengue, C Gaudin, J C Levron, B Fraitag, P Berthelot, J P Benhamou. Pharmacokinetics of ketanserin in patients with cirrhosis.
Clinical pharmacokinetics.
1990 Aug; 19(2):160-6. doi:
10.2165/00003088-199019020-00005. [PMID: 2379381] - J N Barendregt, A Van Peer, J G Van Der Hoeven, J C Van Oene, Y I Tjandra. Ketanserin pharmacokinetics in patients with renal failure.
British journal of clinical pharmacology.
1990 Jun; 29(6):715-23. doi:
10.1111/j.1365-2125.1990.tb03693.x. [PMID: 2378791] - W Meuldermans, J Van Houdt, E Mostmans, F Knaeps, W Verluyten, J Heykants. Plasma protein binding of ketanserin and its distribution in blood.
Arzneimittel-Forschung.
1988 Jun; 38(6):794-800. doi:
. [PMID: 3178920] - J Heykants, M Michiels, R Woestenborghs, F Awouters, J E Leysen, J Schuurkes, J M Van Nueten. Pharmacokinetic evaluation of the in vitro and in vivo pharmacological profile of the major metabolites of ketanserin in the rat.
Arzneimittel-Forschung.
1988 Jun; 38(6):785-8. doi:
NULL. [PMID: 3178918] - W Meuldermans, J Hendrickx, R Woestenborghs, A Van Peer, W Lauwers, J De Cree, J Heykants. Absorption, metabolism and excretion of ketanserin in man after oral administration.
Arzneimittel-Forschung.
1988 Jun; 38(6):789-94. doi:
NULL. [PMID: 3178919] - B Persson, A Pettersson, T Hedner. Pharmacokinetics of ketanserin in patients with essential hypertension.
European journal of clinical pharmacology.
1987; 32(3):259-65. doi:
10.1007/bf00607573. [PMID: 3595699] - J Heykants, A Van Peer, R Woestenborghs, S Gould, J Mills. Pharmacokinetics of ketanserin and its metabolite ketanserin-ol in man after intravenous, intramuscular and oral administration.
European journal of clinical pharmacology.
1986; 31(3):343-50. doi:
10.1007/bf00981135. [PMID: 3792432] - A Van Peer, R Woestenborghs, L Embrechts, J Heykants. Pharmacokinetic approach to equilibrium between ketanserin and ketanserin-ol.
European journal of clinical pharmacology.
1986; 31(3):339-42. doi:
10.1007/bf00981134. [PMID: 3792431] - M Frenken, A J Kaumann. Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf.
Naunyn-Schmiedeberg's archives of pharmacology.
1984 Jul; 326(4):334-9. doi:
10.1007/bf00501438. [PMID: 6482982] - F Lindelauf. Determination of ketanserin and its major metabolite (reduced ketanserin) in human plasma by high-performance liquid chromatography.
Journal of chromatography.
1983 Oct; 277(?):396-400. doi:
10.1016/s0378-4347(00)84865-3. [PMID: 6643628]