3-Hydroxymorphinan (BioDeep_00000896375)

   

human metabolite blood metabolite


代谢物信息卡片


17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-trien-4-ol

化学式: C16H21NO (243.1623)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC23CCNC(C2C1)CC4=C3C=C(C=C4)O
InChI: InChI=1S/C16H21NO/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12/h4-5,10,13,15,17-18H,1-3,6-9H2

描述信息

D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids

同义名列表

5 个代谢物同义名

17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-trien-4-ol; Norlevorphanol, 9alpha,13alpha,14alpha-isomer; Norlevorphanol hydrobromide; 3-Hydroxymorphinan; norlevorphanol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tae Woo Jung, Eui Jin Hwang, Do Hyeon Pyun, Tae Jin Kim, Hyun Jung Lee, A M Abd El-Aty, Joon Seok Bang, Hyoung-Chun Kim, Ji Hoon Jeong. 3-hydroxymorphinan enhances mitochondrial biogenesis and adipocyte browning through AMPK-dependent pathway. Biochemical and biophysical research communications. 2021 11; 577(?):17-23. doi: 10.1016/j.bbrc.2021.08.083. [PMID: 34487960]
  • Walter J Loos, Anne-Joy M de Graan, Peter de Bruijn, Ron H N van Schaik, Marianne A C van Fessem, Mei-Ho Lam, Ron H J Mathijssen, Erik A C Wiemer. Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Jan; 54(2):387-94. doi: 10.1016/j.jpba.2010.08.033. [PMID: 20926215]
  • Marios Spanakis, Ioannis S Vizirianakis, Maria Mironidou-Tzouveleki, Ioannis Niopas. A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. Biomedical chromatography : BMC. 2009 Nov; 23(11):1131-7. doi: 10.1002/bmc.1234. [PMID: 19444798]
  • Shyr-Yi Lin, Chien-Ho Chen, Hsiu-O Ho, Hsueh-Hui Chen, Ming-Thau Sheu. Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Nov; 859(1):141-6. doi: 10.1016/j.jchromb.2007.09.017. [PMID: 17919999]
  • K C Carlsson, N O Hoem, E R Moberg, L C Mathisen. Analgesic effect of dextromethorphan in neuropathic pain. Acta anaesthesiologica Scandinavica. 2004 Mar; 48(3):328-36. doi: 10.1111/j.0001-5172.2004.0325.x. [PMID: 14982566]
  • Shailesh S Vengurlekar, Jennifer Heitkamp, Fred McCush, Poonam R Velagaleti, Jerry H Brisson, Steven L Bramer. A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. Journal of pharmaceutical and biomedical analysis. 2002 Aug; 30(1):113-24. doi: 10.1016/s0731-7085(02)00134-6. [PMID: 12151071]
  • A Yu, R L Haining. Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?. Drug metabolism and disposition: the biological fate of chemicals. 2001 Nov; 29(11):1514-20. doi: . [PMID: 11602530]
  • E K Bendriss, N Markoglou, I W Wainer. High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 754(1):209-15. doi: 10.1016/s0378-4347(00)00609-5. [PMID: 11318417]
  • H T Kristensen. Simultaneous determination of dextromethorphan and its metabolites in human plasma by capillary electrophoresis. Journal of pharmaceutical and biomedical analysis. 1998 Dec; 18(4-5):827-38. doi: 10.1016/s0731-7085(98)00273-8. [PMID: 9919985]
  • N Nagai, T Kawakubo, F Kaneko, M Ishii, R Shinohara, Y Saito, H Shimamura, A Ohnishi, H Ogata. Pharmacokinetics and polymorphic oxidation of dextromethorphan in a Japanese population. Biopharmaceutics & drug disposition. 1996 Jul; 17(5):421-33. doi: 10.1002/(sici)1099-081x(199607)17:5<421::aid-bdd421>3.0.co;2-9. [PMID: 8830977]
  • N L Kerry, A A Somogyi, F Bochner, G Mikus. The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes. British journal of clinical pharmacology. 1994 Sep; 38(3):243-8. doi: 10.1111/j.1365-2125.1994.tb04348.x. [PMID: 7826826]
  • Z R Chen, A A Somogyi, F Bochner. Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man. Therapeutic drug monitoring. 1990 Jan; 12(1):97-104. doi: 10.1097/00007691-199001000-00018. [PMID: 2305428]
  • O Mortimer, B Lindström, H Laurell, U Bergman, A Rane. Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolites in man. British journal of clinical pharmacology. 1989 Feb; 27(2):223-7. doi: 10.1111/j.1365-2125.1989.tb05354.x. [PMID: 2713216]
  • S J Vetticaden, B E Cabana, V K Prasad, E D Purich, J H Jonkman, R de Zeeuw, L Ball, L J Leeson, R L Braun. Phenotypic differences in dextromethorphan metabolism. Pharmaceutical research. 1989 Jan; 6(1):13-9. doi: 10.1023/a:1015835215945. [PMID: 2717511]
  • H Mascher. High-performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up. Journal of chromatography. 1987 Sep; 420(1):217-22. doi: 10.1016/0378-4347(87)80177-9. [PMID: 3667825]