Glypressin;Gly Gly Gly 8 Lys vasopressin (BioDeep_00000896330)
human metabolite blood metabolite
代谢物信息卡片
6-Amino-2-({[1-(19-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-13-benzyl-6,9,12,15,18-pentahydroxy-10-[2-(C-hydroxycarbonimidoyl)ethyl]-7-[(C-hydroxycarbonimidoyl)methyl]-16-[(4-hydroxyphenyl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carbonyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-N-[(C-hydroxycarbonimidoyl)methyl]hexanimidate
化学式: C52H74N16O15S2 (1226.4960734000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CCCCN)C(=O)NCC(=O)N
InChI: InChI=1S/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80)
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D014667 - Vasopressins
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
4 个代谢物同义名
6-Amino-2-({[1-(19-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-13-benzyl-6,9,12,15,18-pentahydroxy-10-[2-(C-hydroxycarbonimidoyl)ethyl]-7-[(C-hydroxycarbonimidoyl)methyl]-16-[(4-hydroxyphenyl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carbonyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-N-[(C-hydroxycarbonimidoyl)methyl]hexanimidate; 6-amino-2-{[1-(19-{2-[2-(2-aminoacetamido)acetamido]acetamido}-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidin-2-yl]formamido}-N-(carbamoylmethyl)hexanamide; Glypressin;Gly Gly Gly 8 Lys vasopressin; Glipressin
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Justin M Belcher, Xavier Vela Parada, Douglas A Simonetto, Luis A Juncos, Nithin Karakala, Hani M Wadei, Pratima Sharma, Kevin R Regner, Mitra K Nadim, Guadalupe Garcia-Tsao, Juan Carlos Q Velez, Samir M Parikh, Raymond T Chung, Andrew S Allegretti. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2022 05; 79(5):737-745. doi:
10.1053/j.ajkd.2021.08.016. [PMID: 34606933] - Sebastiano Buccheri, Ben L Da. Hepatorenal Syndrome: Definitions, Diagnosis, and Management.
Clinics in liver disease.
2022 05; 26(2):181-201. doi:
10.1016/j.cld.2022.01.002. [PMID: 35487604] - Luciana Marcondes Ferreira, Débora Raquel Terrabuio, Caroline Marcondes Ferreira, Daniel Ferraz de Campos Mazo, Luciana Bertocco de Paiva Haddad. COST EFFECTIVENESS OF USING TERLIPRESSIN TO TREAT HEPATORENAL SYNDROME.
Arquivos de gastroenterologia.
2022 Apr; 59(2):268-274. doi:
10.1590/s0004-2803.202202000-48. [PMID: 35830040] - Anand V Kulkarni, Sowmya Tirumalige Ravikumar, Harshvardhan Tevethia, Madhumita Premkumar, Karan Kumar, Mithun Sharma, Rajesh Gupta, Padaki Nagaraja Rao, Duvvuru Nageshwar Reddy. Safety and efficacy of terlipressin in acute-on-chronic liver failure with hepatorenal syndrome-acute kidney injury (HRS-AKI): a prospective cohort study.
Scientific reports.
2022 04; 12(1):5503. doi:
10.1038/s41598-022-09505-1. [PMID: 35365736] - Mladena Glavaš, Agata Gitlin-Domagalska, Dawid Dębowski, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka. Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23063068. [PMID: 35328489] - Juan Carlos Q Velez. Hepatorenal Syndrome Type 1: From Diagnosis Ascertainment to Goal-Oriented Pharmacologic Therapy.
Kidney360.
2022 02; 3(2):382-395. doi:
10.34067/kid.0006722021. [PMID: 35373127] - Paul J Gow, Marie Sinclair, Phoebe A Thwaites, Peter W Angus, Brooke Chapman, Ryma Terbah, Adam G Testro. Safety and efficacy of outpatient continuous terlipressin infusion for the treatment of portal hypertensive complications in cirrhosis.
European journal of gastroenterology & hepatology.
2022 02; 34(2):206-212. doi:
10.1097/meg.0000000000001950. [PMID: 32976193] - R Ismail, H Awad, R Allam, O Youssef, M Ibrahim, B Shehata. Methylene blue versus vasopressin analog for refractory septic shock in the preterm neonate: A randomized controlled trial.
Journal of neonatal-perinatal medicine.
2022; 15(2):265-273. doi:
10.3233/npm-210824. [PMID: 34719443] - Saro Khemichian, Claire Francoz, Mitra K Nadim. Advances in management of hepatorenal syndrome.
Current opinion in nephrology and hypertension.
2021 09; 30(5):501-506. doi:
10.1097/mnh.0000000000000730. [PMID: 34397647] - Steven L Flamm, Kimberly Brown, Hani M Wadei, Robert S Brown, Marcelo Kugelmas, Milagros Samaniego-Picota, Patrizia Burra, Fred Poordad, Sammy Saab. The Current Management of Hepatorenal Syndrome-Acute Kidney Injury in the United States and the Potential of Terlipressin.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2021 08; 27(8):1191-1202. doi:
10.1002/lt.26072. [PMID: 33848394] - Ezequiel Mauro, Lucrecia Garcia-Olveira, Adrián Gadano. End-stage liver disease: Management of hepatorenal syndrome.
Liver international : official journal of the International Association for the Study of the Liver.
2021 06; 41 Suppl 1(?):119-127. doi:
10.1111/liv.14866. [PMID: 34155791] - Salvatore Piano, Carmine Gambino, Elia Vettore, Valeria Calvino, Marta Tonon, Patrizia Boccagni, Enrico Gringeri, Giacomo Germani, Patrizia Burra, Umberto Cillo, Paolo Angeli. Response to Terlipressin and Albumin Is Associated With Improved Liver Transplant Outcomes in Patients With Hepatorenal Syndrome.
Hepatology (Baltimore, Md.).
2021 05; 73(5):1909-1919. doi:
10.1002/hep.31529. [PMID: 32870499] - Florence Wong, S Chris Pappas, Michael P Curry, K Rajender Reddy, Raymond A Rubin, Michael K Porayko, Stevan A Gonzalez, Khalid Mumtaz, Nicholas Lim, Douglas A Simonetto, Pratima Sharma, Arun J Sanyal, Marlyn J Mayo, R Todd Frederick, Shannon Escalante, Khurram Jamil. Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome.
The New England journal of medicine.
2021 03; 384(9):818-828. doi:
10.1056/nejmoa2008290. [PMID: 33657294] - Lukas Otero Sanchez, Claire Francoz. Global strategy for the diagnosis and management of acute kidney injury in patients with liver cirrhosis.
United European gastroenterology journal.
2021 03; 9(2):220-228. doi:
10.1177/2050640620980713. [PMID: 33337286] - Xiangbo Xu, Bang Liu, Su Lin, Bimin Li, Yunhai Wu, Yiling Li, Qiang Zhu, Yida Yang, Shanhong Tang, Fanping Meng, Yu Chen, Shanshan Yuan, Lichun Shao, Mauro Bernardi, Eric M Yoshida, Xingshun Qi. Terlipressin May Decrease In-Hospital Mortality of Cirrhotic Patients with Acute Gastrointestinal Bleeding and Renal Dysfunction: A Retrospective Multicenter Observational Study.
Advances in therapy.
2020 10; 37(10):4396-4413. doi:
10.1007/s12325-020-01466-z. [PMID: 32860184] - Rohit Mehtani, Arka De, Virendra Singh. Letter: HRS-AKI - a frequent misdiagnosis in the real-world setting?.
Alimentary pharmacology & therapeutics.
2020 09; 52(6):1090-1091. doi:
10.1111/apt.15964. [PMID: 33119170] - Kevin Moore, Khurram Jamil, Andrew S Allegretti. Letter: HRS-AKI-a frequent misdiagnosis in the real world setting? Authors' reply.
Alimentary pharmacology & therapeutics.
2020 09; 52(6):1092. doi:
10.1111/apt.16001. [PMID: 33119161] - Florence Wong, Thomas D Boyer, Arun J Sanyal, Stephen C Pappas, Shannon Escalante, Khurram Jamil. Reduction in acute kidney injury stage predicts survival in patients with type-1 hepatorenal syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 09; 35(9):1554-1561. doi:
10.1093/ndt/gfz048. [PMID: 30887050] - Romit Saxena, Aravind Anand, Akash Deep. Use of terlipressin in critically ill children with liver disease.
BMC nephrology.
2020 08; 21(1):360. doi:
10.1186/s12882-020-01914-6. [PMID: 32819297] - Rakhi Krishna, Jina Raj, Drishya Dev, Sruthy C Prasad, Remya Reghu, Sudheer O V. A study on clinical outcomes of combination of terlipressin and albumin in Hepatorenal Syndrome.
Scandinavian journal of gastroenterology.
2020 Jul; 55(7):860-864. doi:
10.1080/00365521.2020.1786851. [PMID: 32634332] - Kevin Moore, Khurram Jamil, Katharina Verleger, Linlin Luo, Nehemiah Kebede, Marieke Heisen, Shelby Corman, Roberta Leonardi, Rachel Bakker, Christine Maï, Nisreen Shamseddine, Xingyue Huang, Andrew S Allegretti. Real-world treatment patterns and outcomes using terlipressin in 203 patients with the hepatorenal syndrome.
Alimentary pharmacology & therapeutics.
2020 07; 52(2):351-358. doi:
10.1111/apt.15836. [PMID: 32495956] - Xiao-Long Li, Xiao-Dong Zhu, Nan Xiao, Xue-Feng Liu, Bin Xu, Guo-Ming Shi, Cheng Huang, Ying-Hao Shen, Jia-Bin Cai, Jian Zhou, Jia Fan, Hui-Chuan Sun. A prospective study of the effect of terlipressin on portal vein pressure and clinical outcomes after hepatectomy: A pilot study.
Surgery.
2020 06; 167(6):926-932. doi:
10.1016/j.surg.2020.01.013. [PMID: 32113581] - Andreas Kohler, Stéphanie Perrodin, Andrea De Gottardi, Daniel Candinas, Guido Beldi. Effectiveness of terlipressin for prevention of complications after major liver resection - A randomized placebo-controlled trial.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
2020 06; 22(6):884-891. doi:
10.1016/j.hpb.2019.10.011. [PMID: 31680011] - Mary J Thomson, Arthur Taylor, Pratima Sharma, Anna S Lok, Elliot B Tapper. Limited Progress in Hepatorenal Syndrome (HRS) Reversal and Survival 2002-2018: A Systematic Review and Meta-Analysis.
Digestive diseases and sciences.
2020 05; 65(5):1539-1548. doi:
10.1007/s10620-019-05858-2. [PMID: 31571102] - Xiangbo Xu, Su Lin, Yida Yang, Yu Chen, Bang Liu, Bimin Li, Yunhai Wu, Fanping Meng, Qiang Zhu, Yiling Li, Shanhong Tang, Shanshan Yuan, Lichun Shao, Xingshun Qi. Development of hyponatremia after terlipressin in cirrhotic patients with acute gastrointestinal bleeding: a retrospective multicenter observational study.
Expert opinion on drug safety.
2020 May; 19(5):641-647. doi:
10.1080/14740338.2020.1734558. [PMID: 32101054] - Mads Israelsen, Emilie Kristine Dahl, Bjørn Stæhr Madsen, Signe Wiese, Flemming Bendtsen, Søren Møller, Annette Dam Fialla, Boye L Jensen, Aleksander Krag. Dobutamine reverses the cardio-suppressive effects of terlipressin without improving renal function in cirrhosis and ascites: a randomized controlled trial.
American journal of physiology. Gastrointestinal and liver physiology.
2020 02; 318(2):G313-G321. doi:
10.1152/ajpgi.00328.2019. [PMID: 31841026] - Xiaofeng Pan, Ziye Zhou, Xiangxiang Jin, Dawei Shi. Clinical characteristics and risk factors of severe hyponatremia in cirrhotic patients treated with terlipressin.
Journal of clinical pharmacy and therapeutics.
2020 Feb; 45(1):191-198. doi:
10.1111/jcpt.13057. [PMID: 31557362] - Wenzhe Li, Pengfei Pan, Yi Wang, Xinxin Du, Xiangyou Yu. [Effect of terlipressin on prognosis of adult septic shock patients: a Meta-analysis].
Zhonghua wei zhong bing ji jiu yi xue.
2020 Feb; 32(2):134-139. doi:
10.3760/cma.j.cn121430-20200210-00025. [PMID: 32274994] - Vinod Arora, Rakhi Maiwall, Vijayaraghavan Rajan, Ankur Jindal, Saggere Muralikrishna Shasthry, Guresh Kumar, Priyanka Jain, Shiv Kumar Sarin. Terlipressin Is Superior to Noradrenaline in the Management of Acute Kidney Injury in Acute on Chronic Liver Failure.
Hepatology (Baltimore, Md.).
2020 02; 71(2):600-610. doi:
10.1002/hep.30208. [PMID: 30076614] - Anand V Kulkarni, Pramod Kumar, Nagaraj P Rao, Nageshwar Reddy. Terlipressin-induced ischaemic skin necrosis.
BMJ case reports.
2020 Jan; 13(1):. doi:
10.1136/bcr-2019-233089. [PMID: 31948983] - Zhaohui Bai, Yang An, Xiaozhong Guo, Rolf Teschke, Nahum Méndez-Sánchez, Hongyu Li, Xingshun Qi. Role of Terlipressin in Cirrhotic Patients with Ascites and without Hepatorenal Syndrome: A Systematic Review of Current Evidence.
Canadian journal of gastroenterology & hepatology.
2020; 2020(?):5106958. doi:
10.1155/2020/5106958. [PMID: 32676484] - Margarita Rey R, Andrés F Delgado, Alejandra De Zubiria, Renzo Pinto, José A De la Hoz-Valle, Erika D Pérez-Riveros, Gerardo Ardila, Fernando Sierra-Arango. Prevalence and short-term outcome of hepatorenal syndrome: A 9-year experience in a high-complexity hospital in Colombia.
PloS one.
2020; 15(10):e0239834. doi:
10.1371/journal.pone.0239834. [PMID: 33079947] - Zi-Meng Liu, Han-Jin Lai, Xiang-Dong Guan, Shi-Hong Wen, Jian-Tong Shen, Yao Nie, Ning Liu, Xu-Yu Zhang. Terlipressin relieves intestinal and renal injuries induced by acute mesenteric ischemia via PI3K/Akt pathway.
International journal of medical sciences.
2020; 17(17):2751-2762. doi:
10.7150/ijms.46302. [PMID: 33162803] - F Xing, S Li, J J Zhang, C Y Sun, J R Huang, Z L Gao, T T Zhu, Q Zhao, H Zhang, C H Liu. [Observation of the therapeutic and characteristic effects of terlipressin on refractory cirrhotic ascites].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Dec; 27(12):982-988. doi:
10.3760/cma.j.issn.1007-3418.2019.12.010. [PMID: 31941260] - C H Liu, F Xing, J Wang. [Research progress of terlipressin in the treatment of cirrhotic ascites-related complications].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Dec; 27(12):929-932. doi:
10.3760/cma.j.issn.1007-3418.2019.12.005. [PMID: 31941255] - Qingbo Meng, Xiaowei Dang, Luhao Li, Zhaochen Liu, Lin Li, Haohao Wang. Severe hyponatraemia with neurological manifestations in patients treated with terlipressin: Two case reports.
Journal of clinical pharmacy and therapeutics.
2019 Dec; 44(6):981-984. doi:
10.1111/jcpt.13031. [PMID: 31421059] - George N Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Haralampos J Milionis. Efficacy of treatment with terlipressin plus albumin in hepatorenal syndrome diagnosed with the new acute kidney injury versus the conventional criteria.
European journal of gastroenterology & hepatology.
2019 Oct; 31(10):1292-1294. doi:
10.1097/meg.0000000000001460. [PMID: 31498285] - D Y Cheng, G Wan, W N Ou, H C Xing. [Clinical curative effect observation of therapy of terlipressin combined with albumin in acute kidney injury with liver cirrhosis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 09; 27(9):704-707. doi:
10.3760/cma.j.issn.1007-3418.2019.09.009. [PMID: 31594096] - Cristina Solé, Elsa Solà, Patricia Huelin, Marta Carol, Rebeca Moreira, Unai Cereijo, José-Manuel Mas, Isabel Graupera, Elisa Pose, Laura Napoleone, Gloria dePrada, Adrià Juanola, Núria Fabrellas, Ferran Torres, Manuel Morales-Ruiz, Judith Farrés, Wladimiro Jiménez, Pere Ginès. Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival.
Liver international : official journal of the International Association for the Study of the Liver.
2019 07; 39(7):1246-1255. doi:
10.1111/liv.14037. [PMID: 30597709] - Magdy Mohammed Mahdy, Mostafa Samy Abbas, Emad Zarief Kamel, Mohamed Fathy Mostafa, Ragaa Herdan, Shimaa Abbas Hassan, Ramy Hassan, Ahmed M Taha, Tameem M Ibraheem, Bashir A Fadel, Mohammed Geddawy, Jehan Ahmed Sayed, Osama Ali Ibraheim. Effects of terlipressin infusion during hepatobiliary surgery on systemic and splanchnic haemodynamics, renal function and blood loss: a double-blind, randomized clinical trial.
BMC anesthesiology.
2019 06; 19(1):106. doi:
10.1186/s12871-019-0779-6. [PMID: 31200638] - Raheel Ahmed, Abdul Haseeb. Ischemic Skin Necrosis in Hepatorenal Syndrome Patient Secondary to Terlipressin.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jun; 29(6):S26-S28. doi:
10.29271/jcpsp.2019.06.s26. [PMID: 31142412] - Jingqiao Zhang, Martin Rössle, Xinmiao Zhou, Jiao Deng, Lu Liu, Xingshun Qi. Terlipressin for the treatment of hepatorenal syndrome: an overview of current evidence.
Current medical research and opinion.
2019 05; 35(5):859-868. doi:
10.1080/03007995.2018.1552575. [PMID: 30474439] - Vinod Arora, Rakhi Maiwall, Vijayaraghavan Rajan, Ankur Jindal, Saggere Muralikrishna Shasthry, Guresh Kumar, Priyanka Jain, Shiv Kumar Sarin. Reply.
Hepatology (Baltimore, Md.).
2019 04; 69(4):1846. doi:
10.1002/hep.30536. [PMID: 30702757] - Shengtao Lin, Da Dorothy Zhang, Yuan Gao, Yueke Zhu, Bing Hou. Letter to Editor: The Synergistic Effect of Albumin on Terlipressin in Acute-on-Chronic Liver Failure With Acute Kidney Injury.
Hepatology (Baltimore, Md.).
2019 04; 69(4):1845. doi:
10.1002/hep.30539. [PMID: 30706495] - P Karaaslan, S Sevmis. Effect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital.
Nigerian journal of clinical practice.
2019 Feb; 22(2):265-269. doi:
10.4103/njcp.njcp_268_17. [PMID: 30729953] - Abhinav Anand, Shalimar. Is Terlipressin Superior to Noradrenaline in the Treatment of Acute Kidney Injury in Acute-on-Chronic Liver Failure?.
Hepatology (Baltimore, Md.).
2019 01; 69(1):463-464. doi:
10.1002/hep.30299. [PMID: 30281816] - Wagner L Nedel, Tatiana H Rech, Rodrigo A Ribeiro, José Augusto S Pellegrini, Rafael B Moraes. Renal Outcomes of Vasopressin and Its Analogs in Distributive Shock: A Systematic Review and Meta-Analysis of Randomized Trials.
Critical care medicine.
2019 01; 47(1):e44-e51. doi:
10.1097/ccm.0000000000003471. [PMID: 30303842] - Sandeep Satsangi. Noradrenaline for Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure: Hope Remains!.
Hepatology (Baltimore, Md.).
2018 12; 68(6):2443-2444. doi:
10.1002/hep.30283. [PMID: 30229972] - Sapana Verma, Shaleen Agarwal, Shweta Singh, Nivedita Pandey, Subhash Gupta. Letter To Editor: Terlipressin is Superior to Noradrenaline in the Management of Acute Kidney Injury in Acute On Chronic Liver Failure.
Hepatology (Baltimore, Md.).
2018 12; 68(6):2442-2443. doi:
10.1002/hep.30269. [PMID: 30216483] - Salvatore Piano, Hartmut H Schmidt, Xavier Ariza, Alex Amoros, Antonietta Romano, Anna Hüsing-Kabar, Elsa Solà, Alexander Gerbes, Mauro Bernardi, Carlo Alessandria, Bernhard Scheiner, Marta Tonon, Miriam Maschmeier, Cristina Solè, Jonel Trebicka, Thierry Gustot, Frederik Nevens, Vicente Arroyo, Pere Gines, Paolo Angeli. Association Between Grade of Acute on Chronic Liver Failure and Response to Terlipressin and Albumin in Patients With Hepatorenal Syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2018 11; 16(11):1792-1800.e3. doi:
10.1016/j.cgh.2018.01.035. [PMID: 29391267] - Lotte Borg Lange, Kristine Borg. [Severe reversible penile ischaemia after terlipressin treatment of hepatorenal syndrome].
Ugeskrift for laeger.
2018 Oct; 180(43):. doi:
NULL. [PMID: 30375954] - Pere Ginès, Elsa Solà, Paolo Angeli, Florence Wong, Mitra K Nadim, Patrick S Kamath. Hepatorenal syndrome.
Nature reviews. Disease primers.
2018 09; 4(1):23. doi:
10.1038/s41572-018-0022-7. [PMID: 30213943] - Riyaz U Saif, Hilal Ahmad Dar, Sozia Mohammad Sofi, Mushtaq Saif Andrabi, Gul Javid, Showkat Ali Zargar. Noradrenaline versus terlipressin in the management of type 1 hepatorenal syndrome: A randomized controlled study.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
2018 Sep; 37(5):424-429. doi:
10.1007/s12664-018-0876-3. [PMID: 30178092] - Wanqi Tang, Xiaoyuan Ma, Wei Ma, Xue Yang, Yuhao Yi, Li Luo, Jun Yan, Huaping Liang. [Effects of terlipressin on blood pressure and survival in septic mice following trauma and its mechanism].
Zhonghua wei zhong bing ji jiu yi xue.
2018 Jul; 30(7):619-624. doi:
10.3760/cma.j.issn.2095-4352.2018.07.001. [PMID: 30045786] - Qun-Qun Jiang, Mei-Fang Han, Ke Ma, Guang Chen, Xiao-Yang Wan, Semvua Bukheti Kilonzo, Wen-Yu Wu, Yong-Li Wang, Jie You, Qin Ning. Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis.
World journal of gastroenterology.
2018 Jun; 24(21):2300-2310. doi:
10.3748/wjg.v24.i21.2300. [PMID: 29881239] - Georgios N Kalambokis, Ilias Tsiakas, Maria Christaki, Christina Koustousi, Leonidas Christou, Gerasimos Baltayiannis, Dimitrios Christodoulou. Systemic hemodynamic response to terlipressin predicts development of hepatorenal syndrome and survival in advanced cirrhosis.
European journal of gastroenterology & hepatology.
2018 06; 30(6):659-667. doi:
10.1097/meg.0000000000001088. [PMID: 29432366] - Tim G Kampmeier, Philip H Arnemann, Michael Hessler, Laura M Seidel, Karsten Becker, Andrea Morelli, Sebastian W Rehberg, Christian Ertmer. Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock.
Scientific reports.
2018 05; 8(1):7105. doi:
10.1038/s41598-018-25570-x. [PMID: 29740065] - Haiqing Wang, Aixiang Liu, Wentao Bo, Xielin Feng, Yong Hu. Terlipressin in the treatment of hepatorenal syndrome: A systematic review and meta-analysis.
Medicine.
2018 Apr; 97(16):e0431. doi:
10.1097/md.0000000000010431. [PMID: 29668606] - Isabelle Colle, Pierre-François Laterre. Hepatorenal syndrome: the clinical impact of vasoactive therapy.
Expert review of gastroenterology & hepatology.
2018 Feb; 12(2):173-188. doi:
10.1080/17474124.2018.1417034. [PMID: 29258378] - Salvatore Piano, Marta Tonon, Paolo Angeli. Management of ascites and hepatorenal syndrome.
Hepatology international.
2018 Feb; 12(Suppl 1):122-134. doi:
10.1007/s12072-017-9815-0. [PMID: 28836115] - François Durand, Jody C Olson, Mitra K Nadim. Renal dysfunction and cirrhosis.
Current opinion in critical care.
2017 Dec; 23(6):457-462. doi:
10.1097/mcc.0000000000000457. [PMID: 29023314] - Ji-Na Zheng, Yi-Jing Han, Tian-Tian Zou, Yu-Jie Zhou, Dan-Qin Sun, Jian-Hong Zhong, Martin Braddock, Ming-Hua Zheng. Comparative efficacy of vasoconstrictor therapies for type 1 hepatorenal syndrome: a network meta-analysis.
Expert review of gastroenterology & hepatology.
2017 Nov; 11(11):1009-1018. doi:
10.1080/17474124.2017.1356223. [PMID: 28708431] - Tom Florian Ulmer, Anne Weiland, Georg Lurje, Christian Klink, Anne Andert, Hamid Alizai, Christoph Heidenhain, Ulf Neumann. Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2017 Oct; 16(5):506-511. doi:
10.1016/s1499-3872(17)60036-5. [PMID: 28992883] - Mettu Srinivas Reddy, Ilankumaran Kaliamoorthy, Akila Rajakumar, Selvakumar Malleeshwaran, Ellango Appuswamy, Sukanya Lakshmi, Joy Varghese, Mohamed Rela. Double-blind randomized controlled trial of the routine perioperative use of terlipressin in adult living donor liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2017 08; 23(8):1007-1014. doi:
10.1002/lt.24759. [PMID: 28294557] - Mohamed A Kandil, Khalid M Abouelenain, Ayman Alsebaey, Hanaa S Rashed, Mohamed H Afifi, Mohamed A Mahmoud, Khaled A Yassen. Impact of terlipressin infusion during and after live donor liver transplantation on incidence of acute kidney injury and neutrophil gelatinase-associated lipocalin serum levels: A randomized controlled trial.
Clinical transplantation.
2017 08; 31(8):. doi:
10.1111/ctr.13019. [PMID: 28564127] - Ladan Golestaneh, Joel Neugarten. Dual Organ Duel: The Hepatorenal Axis.
Advances in chronic kidney disease.
2017 07; 24(4):253-260. doi:
10.1053/j.ackd.2017.05.009. [PMID: 28778366] - F J Gifford, J R Morling, J A Fallowfield. Systematic review with meta-analysis: vasoactive drugs for the treatment of hepatorenal syndrome type 1.
Alimentary pharmacology & therapeutics.
2017 03; 45(5):593-603. doi:
10.1111/apt.13912. [PMID: 28052382] - Florence Wong, Stephen Chris Pappas, Thomas D Boyer, Arun J Sanyal, Jasmohan S Bajaj, Shannon Escalante, Khurram Jamil. Terlipressin Improves Renal Function and Reverses Hepatorenal Syndrome in Patients With Systemic Inflammatory Response Syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2017 02; 15(2):266-272.e1. doi:
10.1016/j.cgh.2016.07.016. [PMID: 27464593] - Zhi Chen, Ping Zhou, Yuanhua Lu, Chunli Yang. [Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial].
Zhonghua wei zhong bing ji jiu yi xue.
2017 Feb; 29(2):111-116. doi:
10.3760/cma.j.issn.2095-4352.2017.02.004. [PMID: 28625256] - Kei Taniguchi, Yoshifuru Tamura, Takanori Kumagai, Shigeru Shibata, Shunya Uchida. Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: insight into pathogenesis of hypouricemia in SIADH.
Clinical and experimental nephrology.
2016 Dec; 20(6):845-852. doi:
10.1007/s10157-016-1248-x. [PMID: 26935049] - So Mi Kim, Il Han Song. [Acute Kidney Injury in Cirrhotic Patients with Portal Hypertension].
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi.
2016 Nov; 68(5):237-244. doi:
10.4166/kjg.2016.68.5.237. [PMID: 27871159] - Tsung-Hsing Hung, Chen-Chi Tsai, Chih-Wei Tseng, Kuo-Chih Tseng, Yu-Hsi Hsieh, Chih-Chun Tsai. No difference in mortality between terlipressin and somatostatin treatments in cirrhotic patients with esophageal variceal bleeding and renal functional impairment.
European journal of gastroenterology & hepatology.
2016 Nov; 28(11):1275-9. doi:
10.1097/meg.0000000000000703. [PMID: 27455080] - Gaetano Bertino, Graziella Privitera, Francesco Purrello, Shirin Demma, Emanuele Crisafulli, Luisa Spadaro, Nikolaos Koukias, Emmanuel A Tsochatzis. Emerging hepatic syndromes: pathophysiology, diagnosis and treatment.
Internal and emergency medicine.
2016 Oct; 11(7):905-16. doi:
10.1007/s11739-016-1478-7. [PMID: 27273018] - Florence Wong. Diagnosing and treating renal disease in cirrhotic patients.
Minerva gastroenterologica e dietologica.
2016 Sep; 62(3):253-66. doi:
. [PMID: 27096702] - Tary A Salman, Ahmed M Edrees, Hala H El-Said, Osama L El-Abd, Gasser I El-Azab. Effect of different therapeutic modalities on systemic, renal, and hepatic hemodynamics and short-term outcomes in cirrhotic patients with spontaneous bacterial peritonitis.
European journal of gastroenterology & hepatology.
2016 Jul; 28(7):777-85. doi:
10.1097/meg.0000000000000635. [PMID: 27097354] - Ángelo Zambam de Mattos, Angelo Alves de Mattos, Nahum Méndez-Sánchez. Hepatorenal syndrome: Current concepts related to diagnosis and management.
Annals of hepatology.
2016 Jul; 15(4):474-81. doi:
NULL. [PMID: 27236146] - Thomas D Boyer, Arun J Sanyal, Florence Wong, R Todd Frederick, John R Lake, Jacqueline G O'Leary, Daniel Ganger, Khurram Jamil, Stephen Chris Pappas. Terlipressin Plus Albumin Is More Effective Than Albumin Alone in Improving Renal Function in Patients With Cirrhosis and Hepatorenal Syndrome Type 1.
Gastroenterology.
2016 Jun; 150(7):1579-1589.e2. doi:
10.1053/j.gastro.2016.02.026. [PMID: 26896734] - K Lenz, R Buder, G Lohr, P Piringer, M Voglmayr. [Hepatorenal syndrome in decompensated cirrhosis : A special form of acute renal failure].
Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2016 Jun; 111(5):440-6. doi:
10.1007/s00063-016-0177-5. [PMID: 27241778] - Marta Cavallin, Salvatore Piano, Antonietta Romano, Silvano Fasolato, Anna Chiara Frigo, Gianpiero Benetti, Elisabetta Gola, Filippo Morando, Marialuisa Stanco, Silvia Rosi, Antonietta Sticca, Umberto Cillo, Paolo Angeli. Terlipressin given by continuous intravenous infusion versus intravenous boluses in the treatment of hepatorenal syndrome: A randomized controlled study.
Hepatology (Baltimore, Md.).
2016 Mar; 63(3):983-92. doi:
10.1002/hep.28396. [PMID: 26659927] - Ankur Jindal, Ajeet S Bhadoria, Rakhi Maiwall, Shiv K Sarin. Evaluation of acute kidney injury and its response to terlipressin in patients with acute-on-chronic liver failure.
Liver international : official journal of the International Association for the Study of the Liver.
2016 Jan; 36(1):59-67. doi:
10.1111/liv.12895. [PMID: 26081914] - Xudong Xiao, Jie Zhang, Yaoli Wang, Jian Zhou, Yu Zhu, Dongpo Jiang, Liangming Liu, Tao Li. Effects of terlipressin on patients with sepsis via improving tissue blood flow.
The Journal of surgical research.
2016 Jan; 200(1):274-82. doi:
10.1016/j.jss.2015.07.016. [PMID: 26253455] - Martin Janicko, Eduard Veseliny, Gabriela Senajova, Peter Jarcuska. Predictors of hepatorenal syndrome in alcoholic liver cirrhosis.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2015 Dec; 159(4):661-5. doi:
10.5507/bp.2015.010. [PMID: 25820623] - Ezequiel Rodriguez, Gustavo Henrique Pereira, Elsa Solà, Chiara Elia, Rogelio Barreto, Elisa Pose, Jordi Colmenero, Javier Fernandez, Miquel Navasa, Vicente Arroyo, Pere Ginès. Treatment of type 2 hepatorenal syndrome in patients awaiting transplantation: Effects on kidney function and transplantation outcomes.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2015 Nov; 21(11):1347-54. doi:
10.1002/lt.24210. [PMID: 26178066] - Marta Cavallin, Patrick S Kamath, Manuela Merli, Silvano Fasolato, Pierluigi Toniutto, Francesco Salerno, Mauro Bernardi, Roberto Giulio Romanelli, Cosimo Colletta, Freddy Salinas, Antonio Di Giacomo, Lorenzo Ridola, Ezio Fornasiere, Paolo Caraceni, Filippo Morando, Salvatore Piano, Angelo Gatta, Paolo Angeli. Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial.
Hepatology (Baltimore, Md.).
2015 Aug; 62(2):567-74. doi:
10.1002/hep.27709. [PMID: 25644760] - Sun Young Yim, Yeon Seok Seo, Chang Ho Jung, Tae Hyung Kim, Eun Sun Kim, Bora Keum, Ji Hoon Kim, Hyonggin An, Hyung Joon Yim, Jong Eun Yeon, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Kwan Soo Byun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu. Risk Factors for Developing Hyponatremia During Terlipressin Treatment: A Retrospective Analyses in Variceal Bleeding.
Journal of clinical gastroenterology.
2015 Aug; 49(7):607-12. doi:
10.1097/mcg.0000000000000217. [PMID: 25216384] - Y J Won, H J Kim, B G Lim, H S Ahn, M H Hwang, I O Lee. Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation: A Meta-Analysis of Randomized Controlled Trials.
Transplantation proceedings.
2015 Jul; 47(6):1917-25. doi:
10.1016/j.transproceed.2015.06.023. [PMID: 26293074] - Vladimír Hrabovský, Alice Mendlová, Terezie Vavříčková. [Hepatorenal syndrome - pathophysiology, diagnosis and treatment].
Vnitrni lekarstvi.
2015 Jul; 61(7-8):649-54. doi:
NULL. [PMID: 26375691] - Chiara Elia, Elsa Solà Vergés, Ezequiel Rodríguez, Pere Ginès. Transient increase in urine protein excretion during treatment with terlipressin and albumin for type-1 hepatorenal syndrome.
Journal of hepatology.
2015 Feb; 62(2):493-5. doi:
10.1016/j.jhep.2014.09.030. [PMID: 25283143] - Antoine G Schneider, Anthony Schelleman, Mark D Goodwin, Michael Bailey, Glenn M Eastwood, Rinaldo Bellomo. Contrast-enhanced ultrasound evaluation of the renal microcirculation response to terlipressin in hepato-renal syndrome: a preliminary report.
Renal failure.
2015 Feb; 37(1):175-9. doi:
10.3109/0886022x.2014.977140. [PMID: 25365636] - Mads Egerod Israelsen, Lise Lotte Gluud, Aleksander Krag. Acute kidney injury and hepatorenal syndrome in cirrhosis.
Journal of gastroenterology and hepatology.
2015 Feb; 30(2):236-43. doi:
10.1111/jgh.12709. [PMID: 25160511] - Marc Nguyen-Tat, Esther Götz, Peter Scholz-Kreisel, Juliane Ahrens, Visvakanth Sivanathan, Jörn Schattenberg, Johannes W Rey, Marcus-Alexander Wörns, Peter R Galle, Jens U Marquardt. [Response to Terlipressin and albumin is associated with improved outcome in patients with cirrhosis and hepatorenal syndrome].
Deutsche medizinische Wochenschrift (1946).
2015 Jan; 140(2):e21-6. doi:
10.1055/s-0040-100444. [PMID: 25612289] - Ahmed Mukhtar, Ihab Mahmoud, Gihan Obayah, Ahmed Hasanin, Fawzia Aboul-Fetouh, Hany Dabous, Mohamed Bahaa, Amr Abdelaal, Mohamed Fathy, Mahmoud El Meteini. Intraoperative terlipressin therapy reduces the incidence of postoperative acute kidney injury after living donor liver transplantation.
Journal of cardiothoracic and vascular anesthesia.
2015; 29(3):678-83. doi:
10.1053/j.jvca.2014.10.008. [PMID: 25620766] - Ezequiel Rodríguez, Chiara Elia, Elsa Solà, Rogelio Barreto, Isabel Graupera, Alida Andrealli, Gustavo Pereira, Maria Poca, Jordi Sánchez, Mónica Guevara, Germán Soriano, Carlo Alessandria, Javier Fernández, Vicente Arroyo, Pere Ginès. Terlipressin and albumin for type-1 hepatorenal syndrome associated with sepsis.
Journal of hepatology.
2014 May; 60(5):955-61. doi:
10.1016/j.jhep.2013.12.032. [PMID: 24447876] - Shiqian Wan, Xuefa Wan, Qingjing Zhu, Jianxin Peng. [A comparative study of high-or low-dose terlipressin therapy in patients with cirrhosis and type 1 hepatorenal syndrome].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2014 May; 22(5):349-53. doi:
10.3760/cma.j.issn.1007-3418.2014.05.006. [PMID: 25180869] - Claire Francoz, François Durand. Type-1 hepatorenal syndrome in patients with cirrhosis and infection vs. sepsis-induced acute kidney injury: what matters?.
Journal of hepatology.
2014 May; 60(5):907-9. doi:
10.1016/j.jhep.2014.02.001. [PMID: 24508549] - Fa-Yauh Lee, Sun-Sang Wang, Ming-Hung Tsai, Hui-Chun Huang, Han-Chieh Lin, Shou-Dong Lee. Adrenal dysfunction in portal hypertensive rats with acute hemorrhage.
PloS one.
2014; 9(3):e92093. doi:
10.1371/journal.pone.0092093. [PMID: 24633079] - Chien-Chang Lee, Meng-Tse Gabriel Lee, Shy-Shin Chang, Si-Huei Lee, Yu-Chi Huang, Chia-Hung Yo, Shih-Hao Lee, Shyr-Chyr Chen. A comparison of vasopressin, terlipressin, and lactated ringers for resuscitation of uncontrolled hemorrhagic shock in an animal model.
PloS one.
2014; 9(4):e95821. doi:
10.1371/journal.pone.0095821. [PMID: 24759799] - Yao-Kuang Wang, Daw-Yang Hwang, Sophie S W Wang, Shang-Jyh Hwang, Li-Tzong Chen, Mei-Chuan Kuo. Terlipressin-induced hyponatremic encephalopathy in a noncirrhotic patient.
The Kaohsiung journal of medical sciences.
2013 Dec; 29(12):691-4. doi:
10.1016/j.kjms.2013.08.003. [PMID: 24296059] - Saubhik Ghosh, Narendra S Choudhary, Arun K Sharma, Baljinder Singh, Pradeep Kumar, Ritesh Agarwal, Navneet Sharma, Ashish Bhalla, Yogesh K Chawla, Virendra Singh. Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study.
Liver international : official journal of the International Association for the Study of the Liver.
2013 Sep; 33(8):1187-93. doi:
10.1111/liv.12179. [PMID: 23601499]