6-[6-[5-Acetamido-6-[4-acetyloxy-6-[4-acetyloxy-6-[4-acetyloxy-5-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-3-[4-acetyloxy-5-[4-acetyloxy-3-hydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxyoxane-2-carboxylic acid (BioDeep_00000896155)

代谢物信息卡片

6-[6-[5-Acetamido-6-[4-acetyloxy-6-[4-acetyloxy-6-[4-acetyloxy-5-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-3-[4-acetyloxy-5-[4-acetyloxy-3-hydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxyoxane-2-carboxylic acid

化学式: C66H101NO49 (1691.5441936)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC1C(C(C(OC1OC2C(OC(C(C2OC(=O)C)O)OC3C(OC(C(C3OC(=O)C)O)OC4C(OC(C(C4OC(=O)C)O)OC)CO)CO)CO)CO)OC5C(C(C(C(O5)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)CO)OC)OC(=O)C)O)OC(=O)C)O)OC(=O)C)O)OC(=O)C)O)O
InChI: InChI=1S/C66H101NO49/c1-18(75)67-33-34(83)42(26(11-68)102-59(33)110-44-29(14-71)106-63(38(87)51(44)97-21(4)78)113-46-30(15-72)107-64(39(88)53(46)99-23(6)80)111-45-28(13-70)103-60(94-10)35(84)50(45)96-20(3)77)109-61-37(86)52(98-22(5)79)48(32(17-74)105-61)114-66-41(90)55(101-25(8)82)56(57(116-66)58(91)92)115-65-40(89)54(100-24(7)81)47(31(16-73)108-65)112-62-36(85)49(95-19(2)76)43(93-9)27(12-69)104-62/h26-57,59-66,68-74,83-90H,11-17H2,1-10H3,(H,67,75)(H,91,92)

描述信息

D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D005765 - Gastrointestinal Agents
D000970 - Antineoplastic Agents
D007155 - Immunologic Factors

同义名列表

1 个代谢物同义名

数据库引用编号

1 个数据库交叉引用编号

PubChem: 21883405

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Francesca Comas-Serra, José Luis Miró, Mónica M Umaña, Rafael Minjares-Fuentes, Antoni Femenia, María Mota-Ituarte, Aurelio Pedroza-Sandoval. Role of acemannan and pectic polysaccharides in saline-water stress tolerance of Aloe vera (Aloe barbadensis Miller) plant. International journal of biological macromolecules. 2024 May; 268(Pt 1):131601. doi: 10.1016/j.ijbiomac.2024.131601. [PMID: 38626833]
Asma B Omer, Hisham N Altayb, Fahad A Al-Abbasi, Gaurav Gupta, Mohammed Muqtader Ahmed, Amira M Alghamdi, Sami I Alzarea, Nadeem Sayyed, Muhammad Shahid Nadeem, Imran Kazmi. Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway. International journal of biological macromolecules. 2023 Sep; 253(Pt 5):127127. doi: 10.1016/j.ijbiomac.2023.127127. [PMID: 37776926]
Lu Li, Weijie Xu, Yinzhu Luo, Chunqin Lao, Xueli Tong, Junxi Du, Bihong Huang, Di Li, Jingmian Chen, Huiling Ye, Feng Cong, Xiaofeng Guo, Jiejing Li. Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism. Carbohydrate polymers. 2022 Dec; 297(?):120032. doi: 10.1016/j.carbpol.2022.120032. [PMID: 36184177]
Anu Sharma, Parul Mittal, Anita Yadav, Anil K Mishra, Puja Panwar Hazari, Rakesh Kumar Sharma. Sustained Activity of Stimuli-Responsive Curcumin and Acemannan Based Hydrogel Patches in Wound Healing. ACS applied bio materials. 2022 02; 5(2):598-609. doi: 10.1021/acsabm.1c01078. [PMID: 35089010]
Luísa C Rodrigues, Emanuel M Fernandes, Ana R Ribeiro, Adriana P Ribeiro, Simone S Silva, Rui L Reis. Physicochemical features assessment of acemannan-based ternary blended films for biomedical purposes. Carbohydrate polymers. 2021 Apr; 257(?):117601. doi: 10.1016/j.carbpol.2020.117601. [PMID: 33541636]
Maylem Z Rodríguez-Rodríguez, Carmen O Meléndez-Pizarro, José C Espinoza-Hicks, Armando Quintero-Ramos, Miguel Á Sánchez-Madrigal, Jorge A Meza-Velázquez, Jorge A Jiménez-Castro. Effects of UV-C irradiation and traditional thermal processing on acemannan contained in Aloe vera gel blends. Carbohydrate polymers. 2019 Oct; 222(?):114998. doi: 10.1016/j.carbpol.2019.114998. [PMID: 31320065]
Chang Liu, Yan Cui, Fuwei Pi, Yuliang Cheng, Yahui Guo, He Qian. Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081554. [PMID: 31010204]
Sumit Kumar, Raj Kumar. Role of acemannan O-acetyl group in murine radioprotection. Carbohydrate polymers. 2019 Mar; 207(?):460-470. doi: 10.1016/j.carbpol.2018.12.003. [PMID: 30600029]
Rafael Minjares-Fuentes, Antoni Femenia, Francesca Comas-Serra, Victor Manuel Rodríguez-González. Compositional and Structural Features of the Main Bioactive Polysaccharides Present in the Aloe vera Plant. Journal of AOAC International. 2018 Nov; 101(6):1711-1719. doi: 10.5740/jaoacint.18-0119. [PMID: 29895349]
Maria Paz Quezada, Carlos Salinas, Martin Gotteland, Liliana Cardemil. Acemannan and Fructans from Aloe vera (Aloe barbadensis Miller) Plants as Novel Prebiotics. Journal of agricultural and food chemistry. 2017 Nov; 65(46):10029-10039. doi: 10.1021/acs.jafc.7b04100. [PMID: 29072072]
Siriporn Songsiripradubboon, Wijit Banlunara, Polkit Sangvanich, Chutima Trairatvorakul, Pasutha Thunyakitpisal. Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes. Odontology. 2016 Sep; 104(3):329-37. doi: 10.1007/s10266-015-0215-4. [PMID: 26264630]
Cláudio Rodrigues Rezende Costa, Bruna Rabelo Amorim, Pérola de Magalhães, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra. Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review. Phytotherapy research : PTR. 2016 Apr; 30(4):519-31. doi: 10.1002/ptr.5568. [PMID: 26822584]
Beatriz Gullón, Patricia Gullón, Freni Tavaria, José Luis Alonso, Manuela Pintado. In vitro assessment of the prebiotic potential of Aloe vera mucilage and its impact on the human microbiota. Food & function. 2015 Feb; 6(2):525-31. doi: 10.1039/c4fo00857j. [PMID: 25504136]
Talitha Best, Peter Howe, Janet Bryan, Jonathan Buckley, Andrew Scholey. Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults. Nutritional neuroscience. 2015 Feb; 18(2):76-86. doi: 10.1179/1476830513y.0000000101. [PMID: 24621069]
Gerardo Daniel Sierra-García, Rocío Castro-Ríos, Azucena González-Horta, Jorge Lara-Arias, Abelardo Chávez-Montes. Acemannan, an extracted polysaccharide from Aloe vera: A literature review. Natural product communications. 2014 Aug; 9(8):1217-21. doi: ". [PMID: 25233608]
P Chantarawaratit, P Sangvanich, W Banlunara, K Soontornvipart, P Thunyakitpisal. Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. Journal of periodontal research. 2014 Apr; 49(2):164-78. doi: 10.1111/jre.12090. [PMID: 23710575]
Kanokporn Bhalang, Pasutha Thunyakitpisal, Nuttanit Rungsirisatean. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. Journal of alternative and complementary medicine (New York, N.Y.). 2013 May; 19(5):429-34. doi: 10.1089/acm.2012.0164. [PMID: 23240939]
Eli Harlev, Eviatar Nevo, Ephraim P Lansky, Rivka Ofir, Anupam Bishayee. Anticancer potential of aloes: antioxidant, antiproliferative, and immunostimulatory attributes. Planta medica. 2012 Jun; 78(9):843-52. doi: 10.1055/s-0031-1298453. [PMID: 22516934]
Göksel Şimşek Kaya, Günay Yapici, Zeynep Savaş, Metin Güngörmüş. Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2011 Jun; 69(6):1571-7. doi: 10.1016/j.joms.2010.11.005. [PMID: 21398006]
Avinash S Bidra, Jeffery J Tarrand, Dianna B Roberts, Kenneth V Rolston, Mark S Chambers. Antimicrobial efficacy of oral topical agents on microorganisms associated with radiated head and neck cancer patients: an in vitro study. Quintessence international (Berlin, Germany : 1985). 2011 Apr; 42(4):307-15. doi: ". [PMID: 21516276]
Elena Rodríguez Rodríguez, Jacinto Darias Martín, Carlos Díaz Romero. Aloe vera as a functional ingredient in foods. Critical reviews in food science and nutrition. 2010 Apr; 50(4):305-26. doi: 10.1080/10408390802544454. [PMID: 20301017]
Bryce Davis, Warren J Goux. Single-laboratory validation of an NMR method for the determination of aloe vera polysaccharide in pharmaceutical formulations. Journal of AOAC International. 2009 Nov; 92(6):1607-16. doi: 10.1093/jaoac/92.6.1607. [PMID: 20166576]
James Talmadge, Jennifer Chavez, Lori Jacobs, Corey Munger, Tony Chinnah, Jimmy T Chow, David Williamson, Kenneth Yates. Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity. International immunopharmacology. 2004 Dec; 4(14):1757-73. doi: 10.1016/j.intimp.2004.07.013. [PMID: 15531292]
Miles R Poor, John E Hall, Anne S Poor. Reduction in the incidence of alveolar osteitis in patients treated with the SaliCept patch, containing Acemannan hydrogel. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2002 Apr; 60(4):374-9; discussion 379. doi: 10.1053/joms.2002.31222. [PMID: 11928091]
A Djeraba, P Quere. In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera. International journal of immunopharmacology. 2000 May; 22(5):365-72. doi: 10.1016/s0192-0561(99)00091-0. [PMID: 10708884]
D R Thomas, P S Goode, K LaMaster, T Tennyson. Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial. Advances in wound care : the journal for prevention and healing. 1998 Oct; 11(6):273-6. doi: ". [PMID: 10326343]
C G Tello, P Ford, A M Iacopino. In vitro evaluation of complex carbohydrate denture adhesive formulations. Quintessence international (Berlin, Germany : 1985). 1998 Sep; 29(9):585-93. doi: ". [PMID: 9807143]
R W Stuart, D L Lefkowitz, J A Lincoln, K Howard, M P Gelderman, S S Lefkowitz. Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan. International journal of immunopharmacology. 1997 Feb; 19(2):75-82. doi: 10.1016/s0192-0561(97)00010-6. [PMID: 9278177]
J DeVengencie, M C Ng, P Ford, A M Iacopino. In vitro evaluation of denture adhesives: possible efficacy of complex carbohydrates. The International journal of prosthodontics. 1997 Jan; 10(1):61-72. doi: ". [PMID: 9484072]
S F Egger, G S Brown, L S Kelsey, K M Yates, L J Rosenberg, J E Talmadge. Hematopoietic augmentation by a beta-(1,4)-linked mannan. Cancer immunology, immunotherapy : CII. 1996 Dec; 43(4):195-205. doi: 10.1007/s002620050322. [PMID: 9003464]
L Zhang, I R Tizard. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 1996 Nov; 35(2):119-28. doi: 10.1016/s0162-3109(96)00135-x. [PMID: 8956975]
K Karaca, J M Sharma, R Nordgren. Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera. International journal of immunopharmacology. 1995 Mar; 17(3):183-8. doi: 10.1016/0192-0561(94)00102-t. [PMID: 7558512]
". Oral ulcers remedy gets FDA clearance. Journal of the American Dental Association (1939). 1994 Oct; 125(10):1308, 1310. doi: ". [PMID: 7844295]
K M Yates, L J Rosenberg, C K Harris, D C Bronstad, G K King, G A Biehle, B Walker, C R Ford, J E Hall, I R Tizard. Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus. Veterinary immunology and immunopathology. 1992 Dec; 35(1-2):177-89. doi: 10.1016/0165-2427(92)90130-i. [PMID: 1337396]
R W Fogleman, J M Chapdelaine, R H Carpenter, B H McAnalley. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. Veterinary and human toxicology. 1992 Jun; 34(3):201-5. doi: ". [PMID: 1609484]
J B Kahlon, M C Kemp, N Yawei, R H Carpenter, W M Shannon, B H McAnalley. In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir. Molecular biotherapy. 1991 Dec; 3(4):214-23. doi: ". [PMID: 1662957]
C Harris, K Pierce, G King, K M Yates, J Hall, I Tizard. Efficacy of acemannan in treatment of canine and feline spontaneous neoplasms. Molecular biotherapy. 1991 Dec; 3(4):207-13. doi: ". [PMID: 1768373]
S Y Peng, J Norman, G Curtin, D Corrier, H R McDaniel, D Busbee. Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan. Molecular biotherapy. 1991 Jun; 3(2):79-87. doi: ". [PMID: 1910624]
D Womble, J H Helderman. Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn). International journal of immunopharmacology. 1988; 10(8):967-74. doi: 10.1016/0192-0561(88)90043-4. [PMID: 2975271]