16,16-Dimethylprostaglandin E2 (BioDeep_00000895366)
代谢物信息卡片
16,16-Dimethylprostaglandin E2
化学式: C22H36O5 (380.2563)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC(C)(C)C(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
InChI: InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
C78568 - Prostaglandin Analogue
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:141046
- PubChem: 5283066
- ChEMBL: CHEMBL1221529
- MeSH: 16,16-Dimethylprostaglandin E2
- CAS: 39746-25-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Akihito Okazaki, Johsuke Hara, Noriyuki Ohkura, Masaki Fujimura, Tamami Sakai, Miki Abo, Nobuyuki Katayama, Kazuo Kasahara, Shinji Nakao. Role of prostaglandin E2 in bronchoconstriction-triggered cough response in guinea pigs.
Pulmonary pharmacology & therapeutics.
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10.1016/j.pupt.2017.09.003. [PMID: 28951192] - Yuan Xue, Xiaoyang Xu, Xue-Qing Zhang, Omid C Farokhzad, Robert Langer. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America.
2016 May; 113(20):5552-7. doi:
10.1073/pnas.1603840113. [PMID: 27140638] - Agnes Rasmuson, Anna Kock, Ole Martin Fuskevåg, Björn Kruspig, Jaione Simón-Santamaría, Vladimir Gogvadze, John Inge Johnsen, Per Kogner, Baldur Sveinbjörnsson. Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
PloS one.
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Prostaglandins & other lipid mediators.
2006 Dec; 81(3-4):150-61. doi:
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World journal of gastroenterology.
2005 Nov; 11(41):6450-8. doi:
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Endocrinology.
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Chemical research in toxicology.
2003 Mar; 16(3):312-9. doi:
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Japanese journal of pharmacology.
1999 Dec; 81(4):397-400. doi:
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The American journal of physiology.
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Digestive diseases and sciences.
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The Journal of nutrition.
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British journal of cancer.
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Prostaglandins.
1995 Apr; 49(4):205-24. doi:
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Prostaglandins.
1995 Mar; 49(3):141-53. doi:
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Gastroenterology.
1994 Nov; 107(5):1382-9. doi:
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Gastroenterology.
1994 Sep; 107(3):720-7. doi:
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Anticancer research.
1994 Sep; 14(5A):1979-82. doi:
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Digestive diseases and sciences.
1994 May; 39(5):957-60. doi:
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Inflammation.
1993 Oct; 17(5):563-71. doi:
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Transplantation.
1993 Aug; 56(2):417-22. doi:
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Gastroenterology.
1993 Feb; 104(2):361-8. doi:
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Gastroenterology.
1993 Jan; 104(1):103-13. doi:
10.1016/0016-5085(93)90841-y. [PMID: 8419232] - N V Bergasa, J Vergalla, K E Cole, L M Wahl, E A Jones. 16,16-dimethyl prostaglandin E2 modulates aflatoxin B1-induced injury of rat hepatocytes in primary culture: possible role of cAMP.
Journal of gastroenterology and hepatology.
1992 Nov; 7(6):608-13. doi:
10.1111/j.1440-1746.1992.tb01494.x. [PMID: 1336677] - Z Jiang, D Y You, X C Chen, J Wu. Monitoring of serum markers for fibrosis during CCl4-induced liver damage. Effects of anti-fibrotic agents.
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1992 Nov; 16(3):282-9. doi:
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Liver.
1992 Aug; 12(4 Pt 1):168-74. doi:
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Journal of lipid research.
1992 Jul; 33(7):1017-27. doi:
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Digestive diseases and sciences.
1992 May; 37(5):645-9. doi:
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Gastroenterology.
1992 Feb; 102(2):572-6. doi:
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Experimental and molecular pathology.
1991 Oct; 55(2):135-42. doi:
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In vitro cellular & developmental biology : journal of the Tissue Culture Association.
1991 Jan; 27(1):39-46. doi:
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Digestion.
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Digestive diseases and sciences.
1990 Dec; 35(12):1518-27. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
1990 Oct; 37(1):35-40. doi:
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1990 Feb; 98(2):361-70. doi:
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Hepatology (Baltimore, Md.).
1989 Nov; 10(5):801-6. doi:
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The Journal of burn care & rehabilitation.
1989 Nov; 10(6):481-5. doi:
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Laboratory investigation; a journal of technical methods and pathology.
1989 May; 60(5):677-91. doi:
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The Journal of surgical research.
1989 May; 46(5):502-6. doi:
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Calcified tissue international.
1989 Mar; 44(3):209-13. doi:
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Gastroenterology.
1988 Sep; 95(3):636-41. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1988 Aug; 33(2):121-7. doi:
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Gastroenterology.
1988 Mar; 94(3):726-32. doi:
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Prostaglandins.
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British journal of experimental pathology.
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The Journal of clinical investigation.
1987 Sep; 80(3):881-9. doi:
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European journal of clinical investigation.
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Prostaglandins.
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General and comparative endocrinology.
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Prostaglandins, leukotrienes, and medicine.
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American journal of obstetrics and gynecology.
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Hepatology (Baltimore, Md.).
1984 Jul; 4(4):658-60. doi:
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Prostaglandins, leukotrienes, and medicine.
1984 May; 14(2):215-24. doi:
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Biochemical pharmacology.
1984 Jan; 33(1):89-96. doi:
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Surgical gastroenterology.
1984; 3(2):60-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1983 May; 11(3):255-65. doi:
NULL. [PMID: 6135585] - A Terano, K J Ivey, J Stachura, S Sekhon, H Hosojima, W N McKenzie, W J Krause, J H Wyche. Cell culture of rat gastric fundic mucosa.
Gastroenterology.
1982 Dec; 83(6):1280-91. doi:
. [PMID: 6290309] - K Bremme, P Eneroth, M Bygdeman. Maternal serum hormone changes during abortion induced with 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2.
Journal of endocrinological investigation.
1982 Nov; 5(6):387-91. doi:
10.1007/bf03350538. [PMID: 7169514] - K Gréen, O Vesterqvist, M Bygdeman, N J Christenssen, S Bergström. Plasma levels of 9-deoxo-16,16-dimethyl-9-methylene-PGE2 in connection with its development as an abortifacient.
Prostaglandins.
1982 Oct; 24(4):451-66. doi:
10.1016/0090-6980(82)90003-x. [PMID: 7178484] - C Favalli, P Leport, B M Jaffe, M G Santoro, T Simmet, V Del Gobbo, E Garaci. The differential effects of PGE on the immune response in normal and immunosuppressed mice.
Cellular immunology.
1982 Sep; 72(2):351-9. doi:
10.1016/0008-8749(82)90483-x. [PMID: 6983915] - C Rinaldi-Garaci, V Del Gobbo, C Favalli, E Garaci, F Bistoni, B M Jaffe. Induction of serum thymic-like activity in adult thymectomized mice by a synthetic analog of PGE2.
Cellular immunology.
1982 Sep; 72(1):97-101. doi:
10.1016/0008-8749(82)90286-6. [PMID: 6983392] - A G Shapiro, K Lasseter, A Cobiella, M Domenzain. Intravaginal administration of 9-deoxo-9-methylene-16,16-dimethyl PGE2 for cervical dilation prior to suction curettage.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
1982 Apr; 20(2):137-40. doi:
10.1016/0020-7292(82)90026-1. [PMID: 6125434] - J Stachura, A Tarnawski, K J Ivey, T Mach, J Bogdal, J Szczudrawa, B klimczyk. Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat.
Gastroenterology.
1981 Aug; 81(2):211-7. doi:
10.1016/s0016-5085(81)80049-2. [PMID: 7239130] - C Favalli, C Rinaldi, M G Premrov, F Mastroviti, A Mastino. [Restoration of the humoral immune response in mice immunosuppressed by treatment with di-M-PGE2].
Bollettino della Societa italiana di biologia sperimentale.
1981 Jul; 57(14):1524-7. doi:
NULL. [PMID: 6975108] - J M Arce, B A Naughton, G A Kolks, P Liu, A S Gordon, S J Piliero. The effect of prostaglandins A2,E1,E2,15 methyl E2, 16, 16 dimethyl E2 and F2 alpha on erythropoiesis.
Prostaglandins.
1981 Mar; 21(3):367-77. doi:
10.1016/0090-6980(81)90082-4. [PMID: 7232763] - A F Ippoliti, J I Isenberg, L Hagie. Effect of oral and intravenous 16,16-dimethyl prostaglandin E2 in duodenal ulcer and Zollinger-Ellison syndrome patients.
Gastroenterology.
1981 Jan; 80(1):55-9. doi:
10.1016/0016-5085(81)90190-6. [PMID: 7450412] - A Materia, I M Modlin, D Albert, A Sank, R F Crochelt, B M Jaffe. The effect of somatostatin and 16,16-dimethyl-prostaglandin E2 on bombesin-stimulated canine gastric acid, plasma gastrin and pancreatic polypeptide secretion.
Regulatory peptides.
1981 Jan; 1(4):297-305. doi:
10.1016/0167-0115(81)90053-7. [PMID: 6114518] - K Gréen, F A Kimball, B A Thornburgh, A J WickremaSinha. Quantitative determination of 9-deoxo-16, 16-dimethyl-9-methylene-PGE2 in human plasma by GC-MS, RIA and HPLC.
Prostaglandins.
1980 Oct; 20(4):767-80. doi:
10.1016/0090-6980(80)90115-x. [PMID: 7465866] - J A Balint, E C Kyriakides, D A Beeler. Fatty acid desaturation in lung: inhibition by unsaturated fatty acids.
Journal of lipid research.
1980 Sep; 21(7):868-73. doi:
10.1016/s0022-2275(20)34783-0. [PMID: 7441058] - F A Kimball, J C Cornette, G L Bundy, K T Kirton. Plasma concentrations of 9-deoxo-16-dimethyl-9-methylene-PGE2 in rhesus monkeys after administration by various routes.
Prostaglandins.
1980 Sep; 20(3):559-69. doi:
10.1016/0090-6980(80)90043-x. [PMID: 7422900] - G Beck, W Bartmann, U Lerch, H Teufel, B Schölkens. Antihypertensive activity of 16, 16-dimethyl-oxa-alkyl-prostaglandins of the PGA2, PGE2 and trans-delta 2-11-deoxy-PGE1 series: structure-activity relationships.
Prostaglandins.
1980 Jul; 20(1):153-69. doi:
10.1016/0090-6980(80)90015-5. [PMID: 7403571] - S Steffenrud, F H Lincoln. Method for quantitative analysis of 16, 16-dimethyl-prostaglandin E2 from plasma using deuterated carrier and gas chromatography-mass spectrometry.
Analytical biochemistry.
1979 Nov; 100(1):109-17. doi:
10.1016/0003-2697(79)90118-0. [PMID: 396812] - L Axelrod, S D Slowman, P Lloyd-Jones, D B Martin. Persistence of ketosis despite suppression of lipolysis by 16,16-dimethylprostaglandin E2 in experimental diabetic ketoacidosis in rats.
Diabetes.
1979 Oct; 28(10):905-13. doi:
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