7-[2-(3-Hydroxyoctyl)-5-oxopyrrolidin-1-YL]heptanoic acid (BioDeep_00000895177)
代谢物信息卡片
化学式: C19H35NO4 (341.25659500000006)
中文名称: 1-吡咯烷庚酸，2-（3-羟基辛基）-5-氧代
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(CCC1CCC(=O)N1CCCCCCC(=O)O)O
InChI: InChI=1S/C19H35NO4/c1-2-3-6-9-17(21)13-11-16-12-14-18(22)20(16)15-8-5-4-7-10-19(23)24/h16-17,21H,2-15H2,1H3,(H,23,24)
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相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fan Ying, Yin Cai, Hoi Kin Wong, Xin Yi Chen, Ianto Bosheng Huang, Paul M Vanhoutte, Zhengyuan Xia, Aimin Xu, Eva Hoi Ching Tang. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2018 09; 1863(9):1029-1040. doi:
10.1016/j.bbalip.2018.06.003. [PMID: 29890224] - Emma T B Olesen, Hanne B Moeller, Mette Assentoft, Nanna MacAulay, Robert A Fenton. The vasopressin type 2 receptor and prostaglandin receptors EP2 and EP4 can increase aquaporin-2 plasma membrane targeting through a cAMP-independent pathway.
American journal of physiology. Renal physiology.
2016 11; 311(5):F935-F944. doi:
10.1152/ajprenal.00559.2015. [PMID: 27558562] - Min Gao, Rong Cao, Shengnan Du, Xiao Jia, Senfeng Zheng, Shizheng Huang, Qifei Han, Jia Liu, Xiaoyan Zhang, Yifei Miao, Jihong Kang, Jan-Åke Gustafsson, Youfei Guan. Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Jul; 112(27):8397-402. doi:
10.1073/pnas.1509565112. [PMID: 26100911] - Eva H C Tang, Yin Cai, Chi Kin Wong, Viviane Z Rocha, Galina K Sukhova, Koichi Shimizu, Ge Xuan, Paul M Vanhoutte, Peter Libby, Aimin Xu. Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue.
Journal of lipid research.
2015 Feb; 56(2):358-68. doi:
10.1194/jlr.m054817. [PMID: 25510249] - Hao Zheng, Ying Li, Yuzhong Wang, Haixia Zhao, Jing Zhang, Hongyan Chai, Tian Tang, Jiang Yue, Austin M Guo, Jing Yang. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.
Toxicology and applied pharmacology.
2014 Oct; 280(1):10-20. doi:
10.1016/j.taap.2014.07.018. [PMID: 25094029] - Emma T B Olesen, Michael R Rützler, Hanne B Moeller, Helle A Praetorius, Robert A Fenton. Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Aug; 108(31):12949-54. doi:
10.1073/pnas.1104691108. [PMID: 21768374] - R L Smith, T Lee, N P Gould, E J Cragoe. Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
Journal of medicinal chemistry.
1977 Oct; 20(10):1292-9. doi:
10.1021/jm00220a013. [PMID: 198545]