6,11-Dihydro[1]benzothiopyrano[4,3-b]indole (BioDeep_00000895175)
代谢物信息卡片
6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
化学式: C15H11NS (237.0612)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
InChI: InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Hao Guo, Iris C Verhoek, Gerian G H Prins, Ramon van der Vlag, Petra E van der Wouden, Ronald van Merkerk, Wim J Quax, Peter Olinga, Anna K H Hirsch, Frank J Dekker. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity.
Journal of medicinal chemistry.
2019 05; 62(9):4624-4637. doi:
10.1021/acs.jmedchem.9b00212. [PMID: 30964295] - Bing Yan, Yang Wang, Ying Li, Chengshuo Wang, Luo Zhang. Inhibition of arachidonate 15-lipoxygenase reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps.
International forum of allergy & rhinology.
2019 03; 9(3):270-280. doi:
10.1002/alr.22243. [PMID: 30452122] - Jessica L H Walters, Geoffry N De Iuliis, Matthew D Dun, Robert John Aitken, Eileen A McLaughlin, Brett Nixon, Elizabeth G Bromfield. Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.
Biology of reproduction.
2018 06; 98(6):784-794. doi:
10.1093/biolre/ioy058. [PMID: 29546268] - Michelle M Armstrong, Cody J Freedman, Joo Eun Jung, Yi Zheng, Chakrapani Kalyanaraman, Matthew P Jacobson, Anton Simeonov, David J Maloney, Klaus van Leyen, Ajit Jadhav, Theodore R Holman. A potent and selective inhibitor targeting human and murine 12/15-LOX.
Bioorganic & medicinal chemistry.
2016 Mar; 24(6):1183-90. doi:
10.1016/j.bmc.2016.01.042. [PMID: 26899595] - Arunabh Bhattacharya, Ryan Hamilton, Amanda Jernigan, Yiqiang Zhang, Marian Sabia, Md M Rahman, Yan Li, Rochelle Wei, Asish Chaudhuri, Holly Van Remmen. Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.
Free radical biology & medicine.
2014 Feb; 67(?):30-40. doi:
10.1016/j.freeradbiomed.2013.10.002. [PMID: 24121057] - Dileep G Nair, Colin D Funk. A cell-based assay for screening lipoxygenase inhibitors.
Prostaglandins & other lipid mediators.
2009 Dec; 90(3-4):98-104. doi:
10.1016/j.prostaglandins.2009.09.006. [PMID: 19804839] - Alexander Seiler, Manuela Schneider, Heidi Förster, Stephan Roth, Eva K Wirth, Carsten Culmsee, Nikolaus Plesnila, Elisabeth Kremmer, Olof Rådmark, Wolfgang Wurst, Georg W Bornkamm, Ulrich Schweizer, Marcus Conrad. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Cell metabolism.
2008 Sep; 8(3):237-48. doi:
10.1016/j.cmet.2008.07.005. [PMID: 18762024] - Lorraine M Sordillo, Katie L Streicher, Isis K Mullarky, Jeffery C Gandy, Wendy Trigona, Chris M Corl. Selenium inhibits 15-hydroperoxyoctadecadienoic acid-induced intracellular adhesion molecule expression in aortic endothelial cells.
Free radical biology & medicine.
2008 Jan; 44(1):34-43. doi:
10.1016/j.freeradbiomed.2007.09.002. [PMID: 18045545] - Martin J Mangino, Lionel Brounts, Bruce Harms, Charles Heise. Lipoxin biosynthesis in inflammatory bowel disease.
Prostaglandins & other lipid mediators.
2006 Mar; 79(1-2):84-92. doi:
10.1016/j.prostaglandins.2005.10.004. [PMID: 16516812] - Robert F Klein, John Allard, Zafrira Avnur, Tania Nikolcheva, David Rotstein, Amy S Carlos, Marie Shea, Ruth V Waters, John K Belknap, Gary Peltz, Eric S Orwoll. Regulation of bone mass in mice by the lipoxygenase gene Alox15.
Science (New York, N.Y.).
2004 Jan; 303(5655):229-32. doi:
10.1126/science.1090985. [PMID: 14716014] - T M Bocan, W S Rosebury, S B Mueller, S Kuchera, K Welch, A Daugherty, J A Cornicelli. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.
Atherosclerosis.
1998 Feb; 136(2):203-16. doi:
10.1016/s0021-9150(97)00204-9. [PMID: 9543090] - S M Sendobry, J A Cornicelli, K Welch, T Bocan, B Tait, B K Trivedi, N Colbry, R D Dyer, S J Feinmark, A Daugherty. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.
British journal of pharmacology.
1997 Apr; 120(7):1199-206. doi:
10.1038/sj.bjp.0701007. [PMID: 9105693]
