3-(4-Chlorophenyl)-N-((4-chlorophenyl)sulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide (BioDeep_00000895149)
代谢物信息卡片
化学式: C23H20Cl2N4O2S (486.068396)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN=C(NS(=O)(=O)C1=CC=C(C=C1)Cl)N2CC(C(=N2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4
InChI: InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Shiran Udi, Liad Hinden, Majdoleen Ahmad, Adi Drori, Malliga R Iyer, Resat Cinar, Michal Herman-Edelstein, Joseph Tam. Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease.
British journal of pharmacology.
2020 01; 177(1):110-127. doi:
10.1111/bph.14849. [PMID: 31454063] - Liad Hinden, Shiran Udi, Adi Drori, Asaad Gammal, Alina Nemirovski, Rivka Hadar, Saja Baraghithy, Anna Permyakova, Matan Geron, Merav Cohen, Sabina Tsytkin-Kirschenzweig, Yael Riahi, Gil Leibowitz, Yaakov Nahmias, Avi Priel, Joseph Tam. Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy.
Journal of the American Society of Nephrology : JASN.
2018 02; 29(2):434-448. doi:
10.1681/asn.2017040371. [PMID: 29030466] - Robert J Chorvat, Jennifer Berbaum, Kristine Seriacki, John F McElroy. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.
Bioorganic & medicinal chemistry letters.
2012 Oct; 22(19):6173-80. doi:
10.1016/j.bmcl.2012.08.004. [PMID: 22959249] - Haiying Zhang, Laura Patrone, John Kozlosky, Lindsay Tomlinson, Greg Cosma, Joseph Horvath. Pooled sample strategy in conjunction with high-resolution liquid chromatography-mass spectrometry-based background subtraction to identify toxicological markers in dogs treated with ibipinabant.
Analytical chemistry.
2010 May; 82(9):3834-9. doi:
10.1021/ac100287a. [PMID: 20387806] - Jos H M Lange, Hein K A C Coolen, Martina A W van der Neut, Alice J M Borst, Bob Stork, Peter C Verveer, Chris G Kruse. Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism.
Journal of medicinal chemistry.
2010 Feb; 53(3):1338-46. doi:
10.1021/jm901614b. [PMID: 20047331] - Jos H M Lange, Hein K A C Coolen, Herman H van Stuivenberg, Jessica A R Dijksman, Arnoud H J Herremans, Eric Ronken, Hiskias G Keizer, Koos Tipker, Andrew C McCreary, Willem Veerman, Henri C Wals, Bob Stork, Peter C Verveer, Arnold P den Hartog, Natasja M J de Jong, Tiny J P Adolfs, Jan Hoogendoorn, Chris G Kruse. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.
Journal of medicinal chemistry.
2004 Jan; 47(3):627-43. doi:
10.1021/jm031019q. [PMID: 14736243]