n-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide (BioDeep_00000895141)
代谢物信息卡片
n-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide
化学式: C18H13ClF6N2O3 (454.0518850000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)NC1=CC=C(C=C1)Cl)ONC(=O)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
InChI: InChI=1S/C18H13ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9H,1H3,(H,26,28)(H,27,29)
描述信息
CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes[1][2][3].
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
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文献列表
- Ivana Barravecchia, Sara Mariotti, Angela Pucci, Francesca Scebba, Chiara De Cesari, Silvio Bicciato, Enrico Tagliafico, Elena Tenedini, Carla Vindigni, Marco Cecchini, Gabriele Berti, Marianna Vitiello, Laura Poliseno, Chiara Maria Mazzanti, Debora Angeloni. MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
Biochimica et biophysica acta. Molecular basis of disease.
2019 09; 1865(9):2111-2124. doi:
10.1016/j.bbadis.2019.04.008. [PMID: 31004710] - Yao Xiong, Kenneth Bedi, Simon Berritt, Bennette K Attipoe, Thomas G Brooks, Kevin Wang, Kenneth B Margulies, Jeffrey Field. Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset.
JCI insight.
2019 03; 4(6):. doi:
10.1172/jci.insight.124629. [PMID: 30762586] - Li Liu, Xiaoyan Wu, Huihui Xu, Liming Yu, Xinjian Zhang, Luyang Li, Jianliang Jin, Tao Zhang, Yong Xu. Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.
Biochimica et biophysica acta. Molecular basis of disease.
2018 10; 1864(10):3109-3121. doi:
10.1016/j.bbadis.2018.05.026. [PMID: 29908908] - Md Zahirul Kabir, Hamidah Ghani, Saharuddin B Mohamad, Zazali Alias, Saad Tayyab. Interactive association between RhoA transcriptional signaling inhibitor, CCG1423 and human serum albumin: Biophysical and in silico studies.
Journal of biomolecular structure & dynamics.
2018 Aug; 36(10):2495-2507. doi:
10.1080/07391102.2017.1360207. [PMID: 28749242] - David Gau, William Veon, Teresa L Capasso, Ralph Bottcher, Sanjeev Shroff, Beth L Roman, Partha Roy. Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis.
Angiogenesis.
2017 Nov; 20(4):663-672. doi:
10.1007/s10456-017-9560-y. [PMID: 28638990] - Long Zhao, Xueling Wang, Lina Sun, Huibin Nie, Xiangchun Liu, Zhixin Chen, Guangju Guan. Critical role of serum response factor in podocyte epithelial-mesenchymal transition of diabetic nephropathy.
Diabetes & vascular disease research.
2016 Jan; 13(1):81-92. doi:
10.1177/1479164115588545. [PMID: 26408645] - Bunta Watanabe, Saki Minami, Hideaki Ishida, Ryuzo Yoshioka, Yoshiaki Nakagawa, Tsuyoshi Morita, Ken'ichiro Hayashi. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A.
PloS one.
2015; 10(8):e0136242. doi:
10.1371/journal.pone.0136242. [PMID: 26295164] - Andrew J Haak, Pei-Suen Tsou, Mohammad A Amin, Jeffrey H Ruth, Phillip Campbell, David A Fox, Dinesh Khanna, Scott D Larsen, Richard R Neubig. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.
The Journal of pharmacology and experimental therapeutics.
2014 Jun; 349(3):480-6. doi:
10.1124/jpet.114.213520. [PMID: 24706986] - Tara M Nordgren, Todd A Wyatt, Jenea Sweeter, Kristina L Bailey, Jill A Poole, Art J Heires, Joseph H Sisson, Debra J Romberger. Motile cilia harbor serum response factor as a mechanism of environment sensing and injury response in the airway.
American journal of physiology. Lung cellular and molecular physiology.
2014 May; 306(9):L829-39. doi:
10.1152/ajplung.00364.2013. [PMID: 24610937] - Mark R Lundquist, Andrew J Storaska, Ting-Chun Liu, Scott D Larsen, Todd Evans, Richard R Neubig, Samie R Jaffrey. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.
Cell.
2014 Jan; 156(3):563-76. doi:
10.1016/j.cell.2013.12.035. [PMID: 24440334] - Laura A Johnson, Eva S Rodansky, Andrew J Haak, Scott D Larsen, Richard R Neubig, Peter D R Higgins. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.
Inflammatory bowel diseases.
2014 Jan; 20(1):154-65. doi:
10.1097/01.mib.0000437615.98881.31. [PMID: 24280883] - Jessica L Bell, Andrew J Haak, Susan M Wade, Paul D Kirchhoff, Richard R Neubig, Scott D Larsen. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.
Bioorganic & medicinal chemistry letters.
2013 Jul; 23(13):3826-32. doi:
10.1016/j.bmcl.2013.04.080. [PMID: 23707258] - Nathan Sandbo, Caitlyn Ngam, Elizabeth Torr, Steve Kregel, Jacob Kach, Nickolai Dulin. Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2.
The Journal of biological chemistry.
2013 May; 288(22):15466-73. doi:
10.1074/jbc.m113.464461. [PMID: 23580645] - Wanzhu Jin, Allison B Goldfine, Tanner Boes, Robert R Henry, Theodore P Ciaraldi, Eun-Young Kim, Merve Emecan, Connor Fitzpatrick, Anish Sen, Ankit Shah, Edward Mun, Vokes Vokes, Joshua Schroeder, Elizabeth Tatro, Jose Jimenez-Chillaron, Mary-Elizabeth Patti. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance.
The Journal of clinical investigation.
2011 Mar; 121(3):918-29. doi:
10.1172/jci41940. [PMID: 21393865] - Shin-Ichi Mae, Sakiko Shirasawa, Susumu Yoshie, Fumi Sato, Yoshiya Kanoh, Hinako Ichikawa, Tadayuki Yokoyama, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki. Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.
Biochemical and biophysical research communications.
2010 Mar; 393(4):877-82. doi:
10.1016/j.bbrc.2010.02.111. [PMID: 20171952] - Chris R Evelyn, Susan M Wade, Qin Wang, Mei Wu, Jorge A Iñiguez-Lluhí, Sofia D Merajver, Richard R Neubig. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.
Molecular cancer therapeutics.
2007 Aug; 6(8):2249-60. doi:
10.1158/1535-7163.mct-06-0782. [PMID: 17699722]