lancemaside A (BioDeep_00000894790)
代谢物信息卡片
化学式: C57H90O26 (1190.572)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OC2C(C(COC2OC(=O)C34CCC(CC3C5=CCC6C7(CCC(C(C7CCC6(C5(CC4O)C)C)(C)C)OC8C(C(C(C(O8)C(=O)O)O)O)O)C)(C)C)O)O)O)O)OC9C(C(C(CO9)O)OC1C(C(C(CO1)O)O)O)O
InChI: InChI=1S/C57H90O26/c1-22-41(79-47-40(70)42(27(60)21-75-47)80-46-37(67)32(62)25(58)19-74-46)36(66)39(69)48(77-22)82-44-33(63)26(59)20-76-50(44)83-51(73)57-16-15-52(2,3)17-24(57)23-9-10-29-54(6)13-12-31(78-49-38(68)34(64)35(65)43(81-49)45(71)72)53(4,5)28(54)11-14-55(29,7)56(23,8)18-30(57)61/h9,22,24-44,46-50,58-70H,10-21H2,1-8H3,(H,71,72)
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Tai Young Kim, Sangeun Jeon, Meehyun Ko, Young Eun Du, So-Ri Son, Dae Sik Jang, Seungtaek Kim, C Justin Lee. Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern.
Antimicrobial agents and chemotherapy.
2022 12; 66(12):e0120122. doi:
10.1128/aac.01201-22. [PMID: 36374087] - Ji-Hye Ahn, Dae Sik Jang, Jung-Hye Choi. Lancemaside A Isolated from the Root of Codonopsis lanceolata Inhibits Ovarian Cancer Cell Invasion via the Reactive Oxygen Species (ROS)-Mediated p38 Pathway.
The American journal of Chinese medicine.
2020; 48(4):1021-1034. doi:
10.1142/s0192415x20500494. [PMID: 32471314] - You Kyoung Shin, A Young Han, Yu Shan Hsieh, Soonho Kwon, Jinhye Kim, Kwang-Won Lee, Geun Hee Seol. Lancemaside A from Codonopsis lanceolata prevents hypertension by inhibiting NADPH oxidase 2-mediated MAPK signalling and improving NO bioavailability in rats.
The Journal of pharmacy and pharmacology.
2019 Sep; 71(9):1458-1468. doi:
10.1111/jphp.13140. [PMID: 31350796] - Young Seok Lee, HeeEun Kim, Jinhye Kim, Geun Hee Seol, Kwang-Won Lee. Lancemaside A, a major triterpene saponin of Codonopsis lanceolata enhances regulation of nitric oxide synthesis via eNOS activation.
BMC complementary and alternative medicine.
2019 May; 19(1):110. doi:
10.1186/s12906-019-2516-6. [PMID: 31126276] - Young Eun Du, Jin Su Lee, Hye Mi Kim, Ji-Hye Ahn, In Ho Jung, Jong Hoon Ryu, Jung-Hye Choi, Dae Sik Jang. Chemical constituents of the roots of Codonopsis lanceolata.
Archives of pharmacal research.
2018 Nov; 41(11):1082-1091. doi:
10.1007/s12272-018-1080-9. [PMID: 30264325] - Eun-Ha Joh, Jin-Ju Jeong, Dong-Hyun Kim. Inhibitory effect of echinocystic acid on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice.
Archives of pharmacal research.
2014 Feb; 37(2):225-31. doi:
10.1007/s12272-013-0092-8. [PMID: 23515933] - Supriya R Hyam, Se-Eun Jang, Jin-Ju Jeong, Eun-Ha Joh, Myung Joo Han, Dong-Hyun Kim. Echinocystic acid, a metabolite of lancemaside A, inhibits TNBS-induced colitis in mice.
International immunopharmacology.
2013 Feb; 15(2):433-41. doi:
10.1016/j.intimp.2012.12.017. [PMID: 23352442] - Noriko Komoto, Makoto Ichikawa, Sanae Ohta, Daisuke Nakano, Takeshi Nishihama, Mitsuyasu Ushijima, Yukihiro Kodera, Minoru Hayama, Osamu Shirota, Setsuko Sekita, Masanori Kuroyanagi. Murine metabolism and absorption of lancemaside A, an active compound in the roots of Codonopsis lanceolata.
Journal of natural medicines.
2010 Jul; 64(3):321-9. doi:
10.1007/s11418-010-0415-8. [PMID: 20383596] - Eun-Ha Joh, Dong-Hyun Kim. A sensitive liquid chromatography-electrospray tandem mass spectrometric method for lancemaside A and its metabolites in plasma and a pharmacokinetic study in mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jul; 878(21):1875-80. doi:
10.1016/j.jchromb.2010.05.003. [PMID: 20570220] - Eun-Ha Joh, In-Ah Lee, Sang-Jun Han, Sunju Chae, Dong-Hyun Kim. Lancemaside A ameliorates colitis by inhibiting NF-kappaB activation in TNBS-induced colitis mice.
International journal of colorectal disease.
2010 May; 25(5):545-51. doi:
10.1007/s00384-009-0858-0. [PMID: 19956958] - Makoto Ichikawa, Sanae Ohta, Noriko Komoto, Mitsuyasu Ushijima, Yukihiro Kodera, Minoru Hayama, Osamu Shirota, Setsuko Sekita, Masanori Kuroyanagi. Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry.
Journal of natural medicines.
2009 Jan; 63(1):52-7. doi:
10.1007/s11418-008-0294-4. [PMID: 18841442] - Osamu Shirota, Kumi Nagamatsu, Setsuko Sekita, Noriko Komoto, Masanori Kuroyanagi, Makoto Ichikawa, Sanae Ohta, Mitsuyasu Ushijima. Preparative separation of the saponin lancemaside a from Codonopsis lanceolata by centrifugal partition chromatography.
Phytochemical analysis : PCA.
2008 Sep; 19(5):403-10. doi:
10.1002/pca.1065. [PMID: 18438758]
