Cyclo(D-trp-D-asp-pro-D-val-leu) (BioDeep_00000894478)
human metabolite blood metabolite
代谢物信息卡片
化学式: C31H42N6O7 (610.3114822)
中文名称:
谱图信息:
最多检出来源 Danio rerio(blood) 94.74%
分子结构信息
SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
InChI: InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)
描述信息
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D065128 - Endothelin Receptor Antagonists
同义名列表
5 个代谢物同义名
2-{1,4,7,10-tetrahydroxy-9-[(1H-indol-3-yl)methyl]-6-(2-methylpropyl)-13-oxo-3-(propan-2-yl)-3H,6H,9H,12H,13H,15H,16H,17H,17ah-pyrrolo[1,2-a]1,4,7,10,13-pentaazacyclopentadecan-12-yl}acetate; 2-{9-[(1H-indol-3-yl)methyl]-6-(2-methylpropyl)-1,4,7,10,13-pentaoxo-3-(propan-2-yl)-hexadecahydro-1H-pyrrolo[1,2-a]1,4,7,10,13-pentaazacyclopentadecan-12-yl}acetic acid; [9-(1H-indol-3-ylmethyl)-3-isopropyl-6-(2-methylpropyl)-1,4,7,10,13-pentaoxo-dodecahydropyrrolo[1,2-a]1,4,7,10,13-pentaazacyclopentadecan-12-yl]acetic acid; Cyclo(D-trp-D-asp-pro-D-val-leu); BQ-123 sodium salt
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xia Sun, Shuping Zhang, Haitao Song. Quercetin attenuates reduced uterine perfusion pressure -induced hypertension in pregnant rats through regulation of endothelin-1 and endothelin-1 type A receptor.
Lipids in health and disease.
2020 Aug; 19(1):180. doi:
10.1186/s12944-020-01357-w. [PMID: 32758232] - Natalie K Jones, Kevin Stewart, Alicja Czopek, Robert I Menzies, Adrian Thomson, Carmel M Moran, Carolynn Cairns, Bryan R Conway, Laura Denby, Dawn E W Livingstone, John Wiseman, Patrick W Hadoke, David J Webb, Neeraj Dhaun, James W Dear, John J Mullins, Matthew A Bailey. Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation.
Hypertension (Dallas, Tex. : 1979).
2020 05; 75(5):1213-1222. doi:
10.1161/hypertensionaha.119.14308. [PMID: 32200679] - Francesca Schinzari, Augusto Veneziani, Nadia Mores, Angela Barini, Nicola Di Daniele, Carmine Cardillo, Manfredi Tesauro. Vascular Effects of Obestatin in Lean and Obese Subjects.
Diabetes.
2017 05; 66(5):1214-1221. doi:
10.2337/db16-1067. [PMID: 28174289] - P Kleniewska, A Gorąca. Influence of endothelin 1 receptor blockers and a nitric oxide synthase inhibitor on reactive oxygen species formation in rat lungs.
Physiological research.
2016 11; 65(5):789-798. doi:
10.33549/physiolres.933263. [PMID: 27429120] - Umberto Campia, Linda A Matuskey, Manfredi Tesauro, Carmine Cardillo, Julio A Panza. PPARγ activation does not affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia.
Atherosclerosis.
2014 Jun; 234(2):436-40. doi:
10.1016/j.atherosclerosis.2014.03.035. [PMID: 24769306] - Aleksandra Piechota-Polańczyk, Anna Gorąca. Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia.
Pharmacological reports : PR.
2012; 64(6):1434-41. doi:
10.1016/s1734-1140(12)70941-6. [PMID: 23406754] - Aleksandra Piechota, Andrzej Polańczyk, Anna Goraca. Protective effects of endothelin-A receptor antagonist BQ123 against LPS-induced oxidative stress in lungs.
Pharmacological reports : PR.
2011; 63(2):494-500. doi:
10.1016/s1734-1140(11)70516-3. [PMID: 21602605] - Yang Zhou, Jie Gu, Lie-ming Xu. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2007 Jan; 5(1):61-4. doi:
10.3736/jcim20070112. [PMID: 17214938] - Hasan Erdogan, Ersin Fadillioglu, Memet Hanifi Emre. Protection from renal ischemia reperfusion injury by an endothelin-A receptor antagonist BQ-123 in relation to nitric oxide production.
Toxicology.
2006 Dec; 228(2-3):219-28. doi:
10.1016/j.tox.2006.08.039. [PMID: 17046139] - Michael Peled, Aviv Shaish, Liron Frishman, Hofit Cohen, Reshef Tal, Dror Harats. Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo.
Journal of cardiovascular pharmacology.
2006 May; 47(5):668-72. doi:
10.1097/01.fjc.0000211755.54691.ba. [PMID: 16775506] - Ramazan Ozdemir, Hakan Parlakpinar, Alaadin Polat, Cemil Colak, Necip Ermis, Ahmet Acet. Selective endothelin a (ETA) receptor antagonist (BQ-123) reduces both myocardial infarct size and oxidant injury.
Toxicology.
2006 Feb; 219(1-3):142-9. doi:
10.1016/j.tox.2005.11.022. [PMID: 16406210] - Catherina Caballero-George, Patrick M L Vanderheyden, Sandra Apers, Hilde Van den Heuvel, Pablo N Solis, Mahabir P Gupta, Magda Claeys, Luc Pieters, Georges Vauquelin, Arnold J Vlietinck. Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.
Planta medica.
2002 Sep; 68(9):770-5. doi:
10.1055/s-2002-34406. [PMID: 12357384] - C Caballero-George, P M Vanderheyden, P N Solis, L Pieters, A A Shahat, M P Gupta, G Vauquelin, A J Vlietinck. Biological screening of selected medicinal Panamanian plants by radioligand-binding techniques.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2001 Jan; 8(1):59-70. doi:
10.1078/0944-7113-00011. [PMID: 11292241] - H Xie, J A Bevan. Oxidized low-density lipoprotein enhances myogenic tone in the rabbit posterior cerebral artery through the release of endothelin-1.
Stroke.
1999 Nov; 30(11):2423-29; discussion 2429. doi:
10.1161/01.str.30.11.2423. [PMID: 10548680] - G K Oriji, H R Keiser. Role of nitric oxide in cyclosporine A-induced hypertension.
Hypertension (Dallas, Tex. : 1979).
1998 Nov; 32(5):849-55. doi:
10.1161/01.hyp.32.5.849. [PMID: 9822443] - N Bhowmick, P Narayan, D Puett. The endothelin subtype A receptor undergoes agonist- and antagonist-mediated internalization in the absence of signaling.
Endocrinology.
1998 Jul; 139(7):3185-92. doi:
10.1210/endo.139.7.6105. [PMID: 9645692] - Q Tian, D Zhao, J Zhang, L Gao, S Liu, J Yang, J Su, Z Zhang, J Tang, C Tang. Investigation on inhibition of biological effects of endothelin.
Science in China. Series C, Life sciences.
1996 Apr; 39(2):207-16. doi:
". [PMID: 8760467] - O Büyükgebiz, A O Aktan, G Haklar, A S Yalçin, C Yeğen, R Yalin, Z S Ercan. BQ-123, a specific endothelin (ETA) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation.
Transplant international : official journal of the European Society for Organ Transplantation.
1996; 9(3):201-7. doi:
10.1007/bf00335386. [PMID: 8723187] - V Sowemimo, D Scanlon, P Jones, D J Craik. Synthesis of cyclic penta- and hexapeptides: a general synthetic strategy on DAS resin.
Journal of protein chemistry.
1994 Apr; 13(3):339-46. doi:
10.1007/bf01901567. [PMID: 7945797] - F Ishida, K Saeki, T Saeki, K Ishikawa, M Ihara, T Kamei, M Yano. Suppressive effects of the endothelin receptor (ETA) antagonist BQ-123 on ET-1-induced reduction of lipoprotein lipase activity in 3T3-L1 adipocytes.
Biochemical pharmacology.
1992 Oct; 44(7):1431-6. doi:
10.1016/0006-2952(92)90545-t. [PMID: 1417963]