4-((6-Methoxyquinolin-8-yl)amino)pentanoic acid (BioDeep_00000893916)
代谢物信息卡片
4-((6-Methoxyquinolin-8-yl)amino)pentanoic acid
化学式: C15H18N2O3 (274.1317358)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC(=O)O)NC1=C2C(=CC(=C1)OC)C=CC=N2
InChI: InChI=1S/C15H18N2O3/c1-10(5-6-14(18)19)17-13-9-12(20-2)8-11-4-3-7-16-15(11)13/h3-4,7-10,17H,5-6H2,1-2H3,(H,18,19)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Warunee Hanpithakpong, Nicholas P J Day, Nicholas J White, Joel Tarning. Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.
Malaria journal.
2022 Jun; 21(1):169. doi:
10.1186/s12936-022-04191-w. [PMID: 35659684] - Cindy S Chu, James A Watson, Aung Pyae Phyo, Htun Htun Win, Widi Yotyingaphiram, Suradet Thinraow, Nay Lin Soe, Aye Aye Aung, Pornpimon Wilaisrisak, Kanokpich Kraft, Mallika Imwong, Warunee Hanpithakpong, Daniel Blessborn, Joel Tarning, Stéphane Proux, Clare Ling, François H Nosten, Nicholas J White. Determinants of Primaquine and Carboxyprimaquine Exposures in Children and Adults with Plasmodium vivax Malaria.
Antimicrobial agents and chemotherapy.
2021 10; 65(11):e0130221. doi:
10.1128/aac.01302-21. [PMID: 34398667] - Washim Khan, Yan-Hong Wang, N P Dhammika Nanayakkara, H M T Bandara Herath, Zachara Catchings, Shabana Khan, Pius S Fasinu, Mahmoud A ElSohly, James D McChesney, Ikhlas A Khan, Narayan D Chaurasiya, Babu L Tekwani, Larry A Walker. Quantitative determination of primaquine-5,6-ortho-quinone and carboxyprimaquine-5,6-ortho-quinone in human erythrocytes by UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jan; 1163(?):122510. doi:
10.1016/j.jchromb.2020.122510. [PMID: 33387859] - Mary Ellen Gilder, Warunee Hanpithakphong, Richard M Hoglund, Joel Tarning, Htun Htun Win, Naw Hilda, Cindy S Chu, Germana Bancone, Verena I Carrara, Pratap Singhasivanon, Nicholas J White, François Nosten, Rose McGready. Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2018 09; 67(7):1000-1007. doi:
10.1093/cid/ciy235. [PMID: 29590311] - Bronner P Gonçalves, Helmi Pett, Alfred B Tiono, Daryl Murry, Sodiomon B Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob Ter Heine. Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02590-16. [PMID: 28289025] - Babu L Tekwani, Bharathi Avula, Rajnish Sahu, Narayan D Chaurasiya, Shabana I Khan, Surendra Jain, Pius S Fasinu, H M T Bandara Herath, Donald Stanford, N P Dhammika Nanayakkara, James D McChesney, Travis W Yates, Mahmoud A ElSohly, Ikhlas A Khan, Larry A Walker. Enantioselective pharmacokinetics of primaquine in healthy human volunteers.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Apr; 43(4):571-7. doi:
10.1124/dmd.114.061127. [PMID: 25637634] - Podjanee Jittamala, Sasithon Pukrittayakamee, Elizabeth A Ashley, François Nosten, Borimas Hanboonkunupakarn, Sue J Lee, Praiya Thana, Kalayanee Chairat, Daniel Blessborn, Salwaluk Panapipat, Nicholas J White, Nicholas P J Day, Joel Tarning. Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects.
Antimicrobial agents and chemotherapy.
2015 Jan; 59(1):505-13. doi:
10.1128/aac.03829-14. [PMID: 25385096] - Sasithon Pukrittayakamee, Joel Tarning, Podjanee Jittamala, Prakaykaew Charunwatthana, Saranath Lawpoolsri, Sue J Lee, Warunee Hanpithakpong, Borimas Hanboonkunupakarn, Nicholas P J Day, Elizabeth A Ashley, Nicholas J White. Pharmacokinetic interactions between primaquine and chloroquine.
Antimicrobial agents and chemotherapy.
2014 Jun; 58(6):3354-9. doi:
10.1128/aac.02794-13. [PMID: 24687509] - Madhu Page-Sharp, Kenneth F Ilett, Inoni Betuela, Timothy M E Davis, Kevin T Batty. Simultaneous determination of primaquine and carboxyprimaquine in plasma using solid phase extraction and LC-MS assay.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Aug; 902(?):142-6. doi:
10.1016/j.jchromb.2012.06.019. [PMID: 22771236] - Bharathi Avula, Shabana I Khan, Babu L Tekwani, N P Dhammika Nanayakkara, James D McChesney, Larry A Walker, Ikhlas A Khan. Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification.
Biomedical chromatography : BMC.
2011 Sep; 25(9):1010-7. doi:
10.1002/bmc.1557. [PMID: 21058417] - Yang-Ree Kim, Hyo-Jeong Kuh, Mi-Young Kim, Yo-Sook Kim, Woo-Chul Chung, Sang-Il Kim, Moon-Won Kang. Pharmacokinetics of primaquine and carboxyprimaquine in Korean patients with vivax malaria.
Archives of pharmacal research.
2004 May; 27(5):576-80. doi:
10.1007/bf02980134. [PMID: 15202566] - V K Dua, P K Kar, R Sarin, V P Sharma. High-performance liquid chromatographic determination of primaquine and carboxyprimaquine concentrations in plasma and blood cells in Plasmodium vivax malaria cases following chronic dosage with primaquine.
Journal of chromatography. B, Biomedical applications.
1996 Jan; 675(1):93-8. doi:
10.1016/0378-4347(95)00357-6. [PMID: 8634775] - R A Dean, W Ochieng, J Black, S F Queener, M S Bartlett, N G Dumaual. Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical applications.
1994 Apr; 655(1):89-96. doi:
10.1016/0378-4347(94)00087-5. [PMID: 8061837] - G Edwards, C S McGrath, S A Ward, W Supanaranond, S Pukrittayakamee, T M Davis, N J White. Interactions among primaquine, malaria infection and other antimalarials in Thai subjects.
British journal of clinical pharmacology.
1993 Feb; 35(2):193-8. doi:
10.1111/j.1365-2125.1993.tb05685.x. [PMID: 8443039] - Y S Endoh, H Yoshimura, N Sasaki, Y Ishihara, H Sasaki, S Nakamura, Y Inoue, M Nishikawa. High-performance liquid chromatographic determination of pamaquine, primaquine and carboxy primaquine in calf plasma using electrochemical detection.
Journal of chromatography.
1992 Aug; 579(1):123-9. doi:
10.1016/0378-4347(92)80370-6. [PMID: 1447338] - H Frischer, R L Mellovitz, T Ahmad, M V Nora. The conversion of primaquine into primaquine-aldehyde, primaquine-alcohol, and carboxyprimaquine, a major plasma metabolite.
The Journal of laboratory and clinical medicine.
1991 Jun; 117(6):468-76. doi:
NULL. [PMID: 2045714] - H Frischer, T Ahmad, M V Nora, P E Carson, M Sivarajan, R Mellovitz, L Ptak, G W Parkhurst, H S Chow, H Kaizer. Biotransformation of primaquine in vitro with human K562 and bone marrow cells.
The Journal of laboratory and clinical medicine.
1987 Apr; 109(4):414-21. doi:
NULL. [PMID: 3819579] - G W Mihaly, S A Ward, G Edwards, M L Orme, A M Breckenridge. Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite.
British journal of clinical pharmacology.
1984 Apr; 17(4):441-6. doi:
10.1111/j.1365-2125.1984.tb02369.x. [PMID: 6721990] - J K Baker, J D McChesney, C D Hufford, A M Clark. High-performance liquid chromatographic analysis of the metabolism of primaquine and the identification of a new mammalian metabolite.
Journal of chromatography.
1982 Jun; 230(1):69-77. doi:
10.1016/s0378-4347(00)81431-0. [PMID: 7107769]