Continentalic acid (BioDeep_00000893883)
Main id: BioDeep_00000396839
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C20H30O2 (302.224568)
中文名称: 长白楤木酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(CCC2C(=C1)CCC3C2(CCCC3(C)C(=O)O)C)C=C
InChI: InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)
描述信息
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 μg/mL against S. aureus, including the Methicillin (HY-121544) susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA) standard strains[1].
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
12 个相关的物种来源信息
- 103964 - Austrocedrus chilensis: 10.3390/MOLECULES19056489
- 99808 - Chamaecyparis pisifera: 10.1248/CPB.49.1479
- 318982 - Commiphora myrrha: 10.1016/J.JEP.2010.12.003
- 46385 - Eleutherococcus trifoliatus: 10.1055/S-2004-818926
- 50182 - Juniperus chinensis:
- 244307 - Juniperus communis var. communis: 10.1016/S0031-9422(00)98270-0
- 13102 - Juniperus rigida var. conferta: 10.1248/YAKUSHI1947.72.10_1324
- 71649 - Pinus pumila:
- 33090 - Plants: -
- 13637 - Platycladus: 10.1016/J.PHYTOCHEM.2007.07.023
- 28982 - Taxodium distichum: 10.1007/S10886-009-9646-0
- 56998 - Wollemia nobilis: 10.1002/CBDV.201600332
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Byeol-Eun Jeon, Chan-Seong Kwon, Ji-Eun Lee, Keumok Moon, Jaeho Cha, Inmyoung Park, Sara Koh, Myunghee Yoon, Sang-Woo Kim, Jeong Nam Kim. Anticancer Activity of Continentalic Acid in B-Cell Lymphoma.
Molecules (Basel, Switzerland).
2021 Nov; 26(22):. doi:
10.3390/molecules26226845. [PMID: 34833935] - Iqra Liaquat, Arif-Ullah Khan, Salman Khan. Pharmacological evaluation of continentalic acid for antidiabetic potential.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111411. doi:
10.1016/j.biopha.2021.111411. [PMID: 33711550] - Ju Sung Lee, Norman G Quilantang, Dae-Hyun Hahm, Ki Sung Kang, Sonia D Jacinto, Yu-Jin Choi, Sang Cheon Lee, Sanghyun Lee. Optimization of Extraction Conditions of Continentalic and Kaurenoic Acids from Aralia continentalis by HPLC/UV and Their Validation.
Journal of chromatographic science.
2020 Jul; 58(7):672-677. doi:
10.1093/chromsci/bmaa019. [PMID: 32448886] - Riwon Hong, Kyoung Soo Kim, Gwang Muk Choi, Mijung Yeom, Bombi Lee, Sanghyun Lee, Ki Sung Kang, Hyang Sook Lee, Hi-Joon Park, Dae-Hyun Hahm. Continentalic Acid Rather Than Kaurenoic Acid Is Responsible for the Anti-Arthritic Activity of Manchurian Spikenard In Vitro and In Vivo.
International journal of molecular sciences.
2019 Nov; 20(21):. doi:
10.3390/ijms20215488. [PMID: 31690022] - Kyoung Jin Lee, Kwang Ho Song, Wonmin Choi, Yeong Shik Kim. A strategy for the separation of diterpenoid isomers from the root of Aralia continentalis by countercurrent chromatography: The distribution ratio as a substitute for the partition coefficient and a three-phase solvent system.
Journal of chromatography. A.
2015 Aug; 1406(?):224-30. doi:
10.1016/j.chroma.2015.06.038. [PMID: 26138601] - Hyo Seon Kim, A Yeong Lee, Ji Eun Jo, Byeong Cheol Moon, Yunui Ji, Ho Kyoung Kim. Optimization of ultrasonic-assisted extraction of continentalic acid from the root of Aralia continentalis by using the response surface methodology.
Archives of pharmacal research.
2014 Nov; 37(11):1437-44. doi:
10.1007/s12272-013-0291-3. [PMID: 24293061] - Seung-Il Jeong, Wan-Soo Han, Yeon-Hee Yun, Kang-Ju Kim. Continentalic acid from Aralia continentalis shows activity against methicillin-resistant Staphylococcus aureus.
Phytotherapy research : PTR.
2006 Jun; 20(6):511-4. doi:
10.1002/ptr.1894. [PMID: 16619343] - Nguyen Thi Phuong, Kyung Ah Lee, Su Jin Jeong, Cai Xing Fu, Jung Kap Choi, Young Ho Kim, Jong Seong Kang. Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species.
Journal of pharmaceutical and biomedical analysis.
2006 Jan; 40(1):56-61. doi:
10.1016/j.jpba.2005.05.023. [PMID: 15990266] - J J Cohen, N E Madias, C J Wolf, W B Schwartz. Regulation of acid-base equilibrium in chronic hypocapnia. Evidence that the response of the kidney is not geared to the defense of extracellular (H+).
The Journal of clinical investigation.
1976 Jun; 57(6):1483-9. doi:
10.1172/jci108418. [PMID: 6488]