4,6-Diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-c-methyl-3-(methylamino)pentopyranoside (BioDeep_00000893854)
代谢物信息卡片
4,6-Diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-c-methyl-3-(methylamino)pentopyranoside
化学式: C19H37N5O7 (447.2692852)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CN)N)N)N)O
InChI: InChI=1S/C19H37N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27H,4-7,20-23H2,1-2H3
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
同义名列表
相关代谢途径
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代谢反应
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文献列表
- William Earle, Ramón G B Bonegio, Donald B Smith, Westyn Branch-Elliman. Plazomicin for the treatment of multidrug-resistant Klebsiella bacteraemia in a patient with underlying chronic kidney disease and acute renal failure requiring renal replacement therapy.
BMJ case reports.
2021 Aug; 14(8):. doi:
10.1136/bcr-2021-243609. [PMID: 34413038] - Xiaotang Chen, Hui Zhang, Shaotong Zhou, Mingjun Bi, Shizhou Qi, Huiyuan Gao, Xianpu Ni, Huanzhang Xia. The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3',4'-di-deoxygenation via reduction and transamination activities.
Microbial cell factories.
2020 Mar; 19(1):62. doi:
10.1186/s12934-020-01317-0. [PMID: 32156271] - Louis D Saravolatz, Gary E Stein. Plazomicin: A New Aminoglycoside.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 02; 70(4):704-709. doi:
10.1093/cid/ciz640. [PMID: 31328228] - Jonathan Gall, Taylor Choi, Valerie Riddle, Scott Van Wart, Jacqueline A Gibbons, Julie Seroogy. A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics.
Clinical pharmacology in drug development.
2019 11; 8(8):1032-1041. doi:
10.1002/cpdd.653. [PMID: 30650259] - Tomefa E Asempa, Joseph L Kuti, Julie D Seroogy, Allison S Komirenko, David P Nicolau. Application of the Hartford Hospital Nomogram for Plazomicin Dosing Interval Selection in Patients with Complicated Urinary Tract Infection.
Antimicrobial agents and chemotherapy.
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10.1128/aac.00148-19. [PMID: 31358580] - Taylor Choi, Allison S Komirenko, Valerie Riddle, Aryun Kim, Shyeilla V Dhuria. No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects.
Clinical pharmacology in drug development.
2019 08; 8(6):818-826. doi:
10.1002/cpdd.648. [PMID: 30605260] - Michael Trang, Julie D Seroogy, Scott A Van Wart, Sujata M Bhavnani, Aryun Kim, Jacqueline A Gibbons, Paul G Ambrose, Christopher M Rubino. Population Pharmacokinetic Analyses for Plazomicin Using Pooled Data from Phase 1, 2, and 3 Clinical Studies.
Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02329-18. [PMID: 30670433] - Allison S Komirenko, Valerie Riddle, Jacqueline A Gibbons, Scott Van Wart, Julie D Seroogy. A Phase 1 Study To Assess the Pharmacokinetics of Intravenous Plazomicin in Adult Subjects with Varying Degrees of Renal Function.
Antimicrobial agents and chemotherapy.
2018 12; 62(12):. doi:
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2009 Dec; 877(31):4022-6. doi:
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1989 Sep; 34(9):687-91. doi:
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1989 Aug; 34(8):596-601. doi:
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Drugs under experimental and clinical research.
1989; 15(3):137-40. doi:
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Chemical & pharmaceutical bulletin.
1989 Jan; 37(1):174-6. doi:
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Nephrologie.
1989; 10(1):27-31. doi:
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Journal of chromatography.
1988 Mar; 425(1):143-52. doi:
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1987 Feb; 19(2):233-8. doi:
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1986 Oct; 31(10):785-90. doi:
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The American journal of medicine.
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The American journal of medicine.
1986 Jun; 80(6B):39-43. doi:
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British journal of pharmacology.
1985 Dec; 86(4):799-803. doi:
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The Japanese journal of antibiotics.
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Clinical chemistry.
1985 Nov; 31(11):1921-2. doi:
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1985 Oct; 30(10):765-70. doi:
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The Japanese journal of antibiotics.
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1985 Jun; 30(6):456-9. doi:
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1985 May; 30(5):369-75. doi:
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1985 May; 30(5):352-5. doi:
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The Journal of antimicrobial chemotherapy.
1985 May; 15(5):607-11. doi:
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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology.
1985 Mar; 30(3):190-6. doi:
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International journal of clinical pharmacology research.
1985; 5(5):351-5. doi:
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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology.
1985 Jan; 30(1):50-4. doi:
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1985; 43(4):341-5. doi:
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Drugs under experimental and clinical research.
1985; 11(5):343-50. doi:
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1984 Oct; 3(5):271-7. doi:
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1984 Jun; 27(6):548-78. doi:
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1984 Jun; 3(3):159-62. doi:
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The Japanese journal of antibiotics.
1984 May; 37(5):835-46. doi:
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Journal of chromatography.
1984 Feb; 305(2):373-9. doi:
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Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
1984 Feb; 75(2):181-96. doi:
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Annales de biologie clinique.
1984; 42(1):15-9. doi:
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The Japanese journal of antibiotics.
1983 Dec; 36(12):3405-11. doi:
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Antibiotiki.
1983 Dec; 28(12):904-8. doi:
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Antibiotiki.
1983 Nov; 28(11):826-34. doi:
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Antibiotiki.
1983 Oct; 28(10):772-8. doi:
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1983 Sep; 28(9):678-82. doi:
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Antibiotiki.
1983 Jul; 28(7):539-45. doi:
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Clinical nephrology.
1983 Jan; 19(1):37-44. doi:
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1983; 11 Suppl 2(?):S81-2. doi:
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1982 Nov; 27(11):830-5. doi:
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The Japanese journal of antibiotics.
1982 Jun; 35(6):1411-26. doi:
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The Japanese journal of antibiotics.
1982 Jun; 35(6):1427-36. doi:
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Antibiotiki.
1982 Apr; 27(4):287-92. doi:
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European journal of clinical pharmacology.
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1982; 3(2):114-8. doi:
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Infection.
1982; 10 Suppl 3(?):S229-33. doi:
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Journal of pharmacokinetics and biopharmaceutics.
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Antibiotiki.
1981 Aug; 26(8):612-7. doi:
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Antibiotiki.
1981 May; 26(5):367-70. doi:
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Journal of chromatography.
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Arzneimittel-Forschung.
1981; 31(3):473-7. doi:
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Chemotherapy.
1981; 27(5):297-302. doi:
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Antibiotiki.
1981 Jan; 26(1):50-5. doi:
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The Journal of antibiotics.
1981 Jan; 34(1):103-13. doi:
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Therapie.
1980 Jul; 35(4):556-8. doi:
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Antibiotiki.
1980 Apr; 25(4):275-80. doi:
NULL. [PMID: 7369731] - T P Svinogeeva, E K Berezina. [Comparative study of sisomicin and gentamycin action on the cells in a tissue culture].
Antibiotiki.
1980 Apr; 25(4):271-4. doi:
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International journal of clinical pharmacology, therapy, and toxicology.
1980 Mar; 18(3):128-32. doi:
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The Japanese journal of antibiotics.
1980 Mar; 33(3):333-51. doi:
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Antibiotiki.
1980 Mar; 25(3):201-6. doi:
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Infection.
1980; 8(3):107-14. doi:
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The Journal of infectious diseases.
1980 Jan; 141(1):71-5. doi:
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Zentralblatt fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie.
1980; 247(2):241-7. doi:
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Wiadomosci lekarskie (Warsaw, Poland : 1960).
1979 Nov; 32(22):1585-9. doi:
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The Medical journal of Australia.
1979 Oct; 2(7):375-6. doi:
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Therapie der Gegenwart.
1979 Aug; 118(8):1217-23. doi:
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Nihon Seikeigeka Gakkai zasshi.
1979 Jul; 53(7):777-92. doi:
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Archivos espanoles de urologia.
1979 Jul; 32(4):387-96. doi:
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The Japanese journal of antibiotics.
1979 Mar; 32(3):312-24. doi:
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Arzneimittel-Forschung.
1979; 29(1):134-7. doi:
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Infection.
1979; 7(3):119-27. doi:
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Infection.
1979; 7(3):102-8. doi:
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1979; 25(2):96-105. doi:
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Chemotherapy.
1979; 25(4):204-13. doi:
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Minerva medica.
1978 Dec; 69(61):4215-25. doi:
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Lymphology.
1978 Dec; 11(4):186-92. doi:
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Recenti progressi in medicina.
1978 Dec; 65(6):524-50. doi:
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La Nouvelle presse medicale.
1978 Nov; 7(42):3849-53. doi:
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