MK-329 (BioDeep_00000008821)
Volatile Flavor Compounds
代谢物信息卡片
Rac-Devazepide
化学式: C25H20N4O2 (408.158618)
中文名称: 地伐西匹
谱图信息:
最多检出来源 Anoectochilus roxburghii(viridiplantae) 85.71%
分子结构信息
SMILES: CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21
InChI: InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
Same as: D02693
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1].
同义名列表
5 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:4460
- KEGG: C11710
- PubChem: 443375
- PubChem: 59751
- Metlin: METLIN69169
- ChEMBL: CHEMBL9506
- MeSH: Devazepide
- CAS: 103420-77-5
- PMhub: MS000022523
- PubChem: 13875
- PDB-CCD: 1OZ
- NIKKAJI: J273.248C
- medchemexpress: HY-106301
- KNApSAcK: 4460
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Helen H Wang, Piero Portincasa, David Q-H Wang. The cholecystokinin-1 receptor antagonist devazepide increases cholesterol cholelithogenesis in mice.
European journal of clinical investigation.
2016 Feb; 46(2):158-69. doi:
10.1111/eci.12580. [PMID: 26683129] - D Ripken, N van der Wielen, J van der Meulen, T Schuurman, R F Witkamp, H F J Hendriks, S J Koopmans. Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy.
Physiology & behavior.
2015 Feb; 139(?):167-76. doi:
10.1016/j.physbeh.2014.11.031. [PMID: 25449395] - Gail L Matters, Timothy K Cooper, Christopher O McGovern, Evan L Gilius, Jiangang Liao, Brian M Barth, Mark Kester, Jill P Smith. Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat.
Digestive diseases and sciences.
2014 Jun; 59(6):1180-91. doi:
10.1007/s10620-014-3201-8. [PMID: 24817409] - Frank A Duca, Li Zhong, Mihai Covasa. Reduced CCK signaling in obese-prone rats fed a high fat diet.
Hormones and behavior.
2013 Nov; 64(5):812-7. doi:
10.1016/j.yhbeh.2013.09.004. [PMID: 24100196] - Wenda Wu, Melissa A Bates, Steven J Bursian, Brenna Flannery, Hui-Ren Zhou, Jane E Link, Haibin Zhang, James J Pestka. Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).
Toxicological sciences : an official journal of the Society of Toxicology.
2013 May; 133(1):186-95. doi:
10.1093/toxsci/kft033. [PMID: 23457120] - Brenna M Flannery, Erica S Clark, James J Pestka. Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Dec; 130(2):289-97. doi:
10.1093/toxsci/kfs255. [PMID: 22903826] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Clémence Blouet, Gary J Schwartz. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
PloS one.
2012; 7(12):e51898. doi:
10.1371/journal.pone.0051898. [PMID: 23251649] - Wenya Chen, Tohru Hira, Shingo Nakajima, Hiroshi Tomozawa, Masahito Tsubata, Kazuya Yamaguchi, Hiroshi Hara. Suppressive effect on food intake of a potato extract (Potein®) involving cholecystokinin release in rats.
Bioscience, biotechnology, and biochemistry.
2012; 76(6):1104-9. doi:
10.1271/bbb.110936. [PMID: 22790930] - Alireza Jahan-Mihan, Chris E Smith, G Harvey Anderson. Effect of protein source in diets fed during gestation and lactation on food intake regulation in male offspring of Wistar rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 May; 300(5):R1175-84. doi:
10.1152/ajpregu.00744.2010. [PMID: 21325647] - Rodrigo Rorato, Wagner Luis Reis, José Antunes-Rodrigues, Lucila Leico Kagohara Elias. Cholecystokinin and hypothalamic corticotrophin-releasing factor participate in endotoxin-induced hypophagia.
Experimental physiology.
2011 Apr; 96(4):439-50. doi:
10.1113/expphysiol.2010.056465. [PMID: 21239462] - Tim Lubbers, Jacco-Juri De Haan, M'Hamed Hadfoune, Yiren Zhang, Misha D Luyer, David Grundy, Wim A Buurman, Jan Willem Greve. Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis.
Critical care medicine.
2010 Oct; 38(10):1996-2002. doi:
10.1097/ccm.0b013e3181eb90d7. [PMID: 20639744] - Chiu-Lung Wu, Ming-Luen Doong, Paulus S Wang. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats.
European journal of pharmacology.
2008 Feb; 580(3):407-15. doi:
10.1016/j.ejphar.2007.11.024. [PMID: 18078924] - Lori Asarian, Nori Geary. Estradiol enhances cholecystokinin-dependent lipid-induced satiation and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats.
Endocrinology.
2007 Dec; 148(12):5656-66. doi:
10.1210/en.2007-0341. [PMID: 17823256] - Naohiko Ueno, Akihiro Asakawa, Yoshiko Satoh, Akio Inui. Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide.
Regulatory peptides.
2007 Jun; 141(1-3):8-11. doi:
10.1016/j.regpep.2006.12.019. [PMID: 17306894] - Mireia Lorenzo-Figueras, Alfred M Merritt. Role of cholecystokinin in the gastric motor response to a meal in horses.
American journal of veterinary research.
2006 Dec; 67(12):1998-2005. doi:
10.2460/ajvr.67.12.1998. [PMID: 17144800] - K L Whited, D Lu, P Tso, K C Kent Lloyd, H E Raybould. Apolipoprotein A-IV is involved in detection of lipid in the rat intestine.
The Journal of physiology.
2005 Dec; 569(Pt 3):949-58. doi:
10.1113/jphysiol.2005.097634. [PMID: 16239275] - Cristina González-Puga, Ana García-Navarro, Germaine Escames, Josefa León, Manuel López-Cantarero, Eduardo Ros, Darío Acuña-Castroviejo. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin.
Journal of pineal research.
2005 Oct; 39(3):243-50. doi:
10.1111/j.1600-079x.2005.00239.x. [PMID: 16150104] - Elodie Archer-Lahlou, Irina Tikhonova, Chantal Escrieut, Marlène Dufresne, Catherine Seva, Lucien Pradayrol, Luis Moroder, Bernard Maigret, Daniel Fourmy. Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor.
Journal of medicinal chemistry.
2005 Jan; 48(1):180-91. doi:
10.1021/jm049886y. [PMID: 15634012] - M Latorre, J M Bartolomé-Nebreda, M T García-López, R González-Muñiz, R Herranz, J Del Río, E Cenarruzabeitia. Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.
Pharmacology.
2004 Oct; 72(2):68-76. doi:
10.1159/000079134. [PMID: 15331911] - J Glatzle, N Darcel, A J Rechs, T J Kalogeris, P Tso, H E Raybould. Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK1 pathway.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Aug; 287(2):R354-9. doi:
10.1152/ajpregu.00705.2003. [PMID: 15117731] - Jolanta Jaworek, Katarzyna Nawrot, Stanisław J Konturek, Anna Leja-Szpak, Piotr Thor, Wiesław W Pawlik. Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro.
Journal of pineal research.
2004 Apr; 36(3):155-64. doi:
10.1046/j.1600-079x.2003.00110.x. [PMID: 15009505] - Ana Maria de la Mano, Sara Sevillano, Manuel Antonio Manso, Martin Pérez, Isabel de Dios. Cholecystokinin blockade alters the systemic immune response in rats with acute pancreatitis.
International journal of experimental pathology.
2004 Apr; 85(2):75-84. doi:
10.1111/j.0959-9673.2004.00372.x. [PMID: 15154913] - Ingo Damm, Ulrike Mikkat, Frank Kirchhoff, Sabine Böckmann, Ludwig Jonas. Inhibitory effect of the lectin wheat germ agglutinin on the binding of 125I-CCK-8s to the CCK-A and -B receptors of AR42J cells.
Pancreas.
2004 Jan; 28(1):31-7. doi:
10.1097/00006676-200401000-00005. [PMID: 14707727] - Ashok K Saluja, Lakshmi Bhagat. Pathophysiology of alcohol-induced pancreatic injury.
Pancreas.
2003 Nov; 27(4):327-31. doi:
10.1097/00006676-200311000-00010. [PMID: 14576496] - Aránzazu Uruñuela, Manuel A Manso, Ana M de la Mano, Isabel de Dios. Cholecystokinin blockade triggers earlier and enhanced intra-acinar oxygen free radical generation in acute pancreatitis induced by pancreatic duct obstruction in rats.
Clinical science (London, England : 1979).
2003 Aug; 105(2):203-12. doi:
10.1042/cs20030072. [PMID: 12713440] - Takashi Nishi, Hiroshi Hara, Kozo Asano, Fusao Tomita. The soybean beta-conglycinin beta 51-63 fragment suppresses appetite by stimulating cholecystokinin release in rats.
The Journal of nutrition.
2003 Aug; 133(8):2537-42. doi:
10.1093/jn/133.8.2537. [PMID: 12888633] - Jörg Glatzle, Yuhua Wang, David W Adelson, Theodore J Kalogeris, Tilman T Zittel, Patrick Tso, Jen-Yu Wei, Helen E Raybould. Chylomicron components activate duodenal vagal afferents via a cholecystokinin A receptor-mediated pathway to inhibit gastric motor function in the rat.
The Journal of physiology.
2003 Jul; 550(Pt 2):657-64. doi:
10.1113/jphysiol.2003.041673. [PMID: 12766241] - Megumi Nishimukai, Hiroshi Hara, Yoritaka Aoyama. The addition of soybean phosphatidylcholine to triglyceride increases suppressive effects on food intake and gastric emptying in rats.
The Journal of nutrition.
2003 May; 133(5):1255-8. doi:
10.1093/jn/133.5.1255. [PMID: 12730406] - Chiu-Lung Wu, Chen-Road Hung, Full-Young Chang, K-Y Francis Pau, Paulus S Wang. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2003 Apr; 367(4):406-13. doi:
10.1007/s00210-003-0690-y. [PMID: 12690433] - Isabel de Dios, Aranzazu Urunuela, Manuel Manso. Effects of early decompression and cholecystokinin inhibition in rats with acute pancreatitis induced by bile-pancreatic-duct obstruction.
The Journal of laboratory and clinical medicine.
2003 Apr; 141(4):265-71. doi:
10.1067/mlc.2003.33. [PMID: 12677172] - Ana M de la Mano, Sara Sevillano, Manuel A Manso, Isabel de Dios. Effect of long-term CCK blockade on the pancreatic acinar cell renewal in rats with acute pancreatitis.
Peptides.
2003 Apr; 24(4):535-41. doi:
10.1016/s0196-9781(03)00112-8. [PMID: 12860197] - Virmeet V Singh, Phillip P Toskes. Medical therapy for chronic pancreatitis pain.
Current gastroenterology reports.
2003 Apr; 5(2):110-6. doi:
10.1007/s11894-003-0079-6. [PMID: 12631450] - Takashi Nishi, Hiroshi Hara, Fusao Tomita. Soybean beta-conglycinin peptone suppresses food intake and gastric emptying by increasing plasma cholecystokinin levels in rats.
The Journal of nutrition.
2003 Feb; 133(2):352-7. doi:
10.1093/jn/133.2.352. [PMID: 12566466] - Chiu-Lung Wu, Chen-Road Hung, Full-Young Chang, Lie-Chwen Lin, K-Y Francis Pau, Paulus S Wang. Effects of evodiamine on gastrointestinal motility in male rats.
European journal of pharmacology.
2002 Dec; 457(2-3):169-76. doi:
10.1016/s0014-2999(02)02687-0. [PMID: 12464363] - Chiu-Lung Wu, Chen-Road Hung, Full-Young Chang, K-Y Francis Pau, Jui-Ling Wang, Paulus S Wang. Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats.
Pflugers Archiv : European journal of physiology.
2002 Nov; 445(2):187-93. doi:
10.1007/s00424-002-0925-7. [PMID: 12457239] - Ana De La Mano, Sara Sevillano, Isabel De Dios, Secundino Vicente, Manuel Antonio Manso. Low enzyme content in the pancreas does not reduce the severity of acute pancreatitis induced by bile-pancreatic duct obstruction.
Molecular and cellular biochemistry.
2002 Nov; 240(1-2):75-81. doi:
10.1023/a:1020603724002. [PMID: 12487374] - C L Wu, C R Hung, F Y Chang, K Y F Pau, P S Wang. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats.
Scandinavian journal of gastroenterology.
2002 Oct; 37(10):1133-9. doi:
10.1080/003655202760373326. [PMID: 12408516] - U Mikkat, I Damm, F Kirchhoff, E Albrecht, B Nebe, L Jonas. Effects of lectins on CCK-8-stimulated enzyme secretion and differentiation of the rat pancreatic cell line AR42J.
Pancreas.
2001 Nov; 23(4):368-74. doi:
10.1097/00006676-200111000-00006. [PMID: 11668205] - S Lal, A J Kirkup, A M Brunsden, D G Thompson, D Grundy. Vagal afferent responses to fatty acids of different chain length in the rat.
American journal of physiology. Gastrointestinal and liver physiology.
2001 Oct; 281(4):G907-15. doi:
10.1152/ajpgi.2001.281.4.g907. [PMID: 11557510] - K C Lloyd, J Wang, T E Solomon. Acid inhibition by intestinal nutrients mediated by CCK-A receptors but not plasma CCK.
American journal of physiology. Gastrointestinal and liver physiology.
2001 Oct; 281(4):G924-30. doi:
10.1152/ajpgi.2001.281.4.g924. [PMID: 11557512] - M Covasa, R C Ritter. Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors.
Peptides.
2001 Aug; 22(8):1339-48. doi:
10.1016/s0196-9781(01)00461-2. [PMID: 11457530] - A Weller, L Tsitolovskya, I H Gispan, S Rabinovitz. Examining the role of cholecystokinin in appetitive learning in the infant rat.
Peptides.
2001 Aug; 22(8):1317-23. doi:
10.1016/s0196-9781(01)00458-2. [PMID: 11457527] - H C Lin, W Y Chey, X Zhao. Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK.
Peptides.
2000 Oct; 21(10):1561-3. doi:
10.1016/s0196-9781(00)00312-0. [PMID: 11068105] - B R Choi, D L Palmquist, M S Allen. Cholecystokinin mediates depression of feed intake in dairy cattle fed high fat diets.
Domestic animal endocrinology.
2000 Oct; 19(3):159-75. doi:
10.1016/s0739-7240(00)00075-8. [PMID: 11064219] - B Ohlsson, K Borg, H Mulder, J F Rehfeld, J Axelson, F Sundler. Continuous infusion of cholecystokinin leads to down-regulation of the cholecystokinin-A receptor in the rat pancreas.
Scandinavian journal of gastroenterology.
2000 Jun; 35(6):612-8. doi:
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Scandinavian journal of gastroenterology.
1999 Dec; 34(12):1224-9. doi:
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Molecular and cellular biochemistry.
1999 Oct; 200(1-2):35-41. doi:
10.1023/a:1006920217206. [PMID: 10569181] - H E Day, H Akil. Evidence that cholecystokinin receptors are not involved in the hypothalamic-pituitary-adrenal response to intraperitoneal administration of interleukin-1beta.
Journal of neuroendocrinology.
1999 Jul; 11(7):561-8. doi:
10.1046/j.1365-2826.1999.00358.x. [PMID: 10444313] - A C García-Montero, M A Manso, A Orfao, S Vicente, I De Dios. Zymogen granule alterations in caerulein-induced pancreatitis developed during continuous hydrocortisone administration.
European journal of clinical investigation.
1999 Jun; 29(6):496-503. doi:
10.1046/j.1365-2362.1999.00466.x. [PMID: 10354211] - H E Raybould, Y Tabrizi, J H Meyer, J H Walsh. PYY immunoneutralization does not alter lipid-induced inhibition of gastric emptying in rats.
Regulatory peptides.
1999 Feb; 79(2-3):125-30. doi:
10.1016/s0167-0115(98)00157-8. [PMID: 10100925] - A J Smith, R M McKernan. Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin.
British journal of pharmacology.
1999 Jan; 126(1):79-86. doi:
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Digestion.
1999; 60 Suppl 1(?):69-74. doi:
10.1159/000051458. [PMID: 10026436] - B Ohlsson, J F Rehfeld, J Axelson. CCK stimulates growth of both the pancreas and the liver.
International journal of surgical investigation.
1999; 1(1):47-54. doi:
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International journal of pancreatology : official journal of the International Association of Pancreatology.
1998 Dec; 24(3):211-8. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
1998 Sep; 358(3):287-92. doi:
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Endocrinology.
1998 Jan; 139(1):189-94. doi:
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European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
1998; 30(6):378-84. doi:
10.1159/000008602. [PMID: 9838229] - Y Zavros, A Shulkes. Cholecystokinin (CCK) regulates somatostatin secretion through both the CCK-A and CCK-B/gastrin receptors in sheep.
The Journal of physiology.
1997 Dec; 505 ( Pt 3)(?):811-21. doi:
10.1111/j.1469-7793.1997.811ba.x. [PMID: 9457654] - H Mönnikes, G Lauer, C Bauer, J Tebbe, T T Zittel, R Arnold. Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid.
The American journal of physiology.
1997 12; 273(6):R2059-71. doi:
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The American journal of physiology.
1997 10; 273(4):G891-8. doi:
10.1152/ajpgi.1997.273.4.g891. [PMID: 9357832] - Y Li, Y Hao, C Owyang. High-affinity CCK-A receptors on the vagus nerve mediate CCK-stimulated pancreatic secretion in rats.
The American journal of physiology.
1997 Sep; 273(3 Pt 1):G679-85. doi:
10.1152/ajpgi.1997.273.3.g679. [PMID: 9316472] - K H Herzig, S Bardocz, G Grant, R Nustede, U R Fölsch, A Pusztai. Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth.
Gut.
1997 Sep; 41(3):333-8. doi:
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The American journal of physiology.
1997 Jun; 272(6 Pt 1):G1550-9. doi:
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Scandinavian journal of gastroenterology.
1997 Apr; 32(4):380-6. doi:
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The Journal of clinical investigation.
1997 Feb; 99(3):506-12. doi:
10.1172/jci119186. [PMID: 9022085] - A Pusztai, G Grant, S Bardocz, K Baintner, E Gelencsér, S W Ewen. Both free and complexed trypsin inhibitors stimulate pancreatic secretion and change duodenal enzyme levels.
The American journal of physiology.
1997 Feb; 272(2 Pt 1):G340-50. doi:
10.1152/ajpgi.1997.272.2.g340. [PMID: 9124359] - C Miles, P Dickson, K Rana, C Lippert, D Fleisher. CCK antagonist pre-treatment inhibits meal-enhanced drug absorption in dogs.
Regulatory peptides.
1997 Jan; 68(1):9-14. doi:
10.1016/s0167-0115(96)00128-0. [PMID: 9094749] - M E Forgue-Lafitte, A M Coudray, J P Aubert, C Gespach, J Bara. Devazepide (L-364718) inhibits growth and increases expression of tumor markers in HT29-S-B6 cells.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.
1996 Dec; 319(12):1133-8. doi:
. [PMID: 9091185] - H Kim, K H Kim. Secretory response of cultured acinar cells of rat pancreas to cholecystokinin.
Yonsei medical journal.
1996 Dec; 37(6):405-11. doi:
10.3349/ymj.1996.37.6.405. [PMID: 9048493] - M O Urban, M C Jiang, G F Gebhart. Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil.
Brain research.
1996 Oct; 737(1-2):83-91. doi:
10.1016/0006-8993(96)00631-2. [PMID: 8930354] - J Axelson, B G Fan, B Ohlsson, J Rehfeld, M Ekelund, I Ihse. The changes in the rat parotid glands following total parenteral nutrition and pancreatico-biliary diversion are not mediated by cholecystokinin.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1996 Oct; 20(2):109-18. doi:
10.1007/bf02825509. [PMID: 8968866] - M E Presti, M L Niehoff, F R Burton, H Solomon, P J Garvin. Effect of L-364,718 on pancreatic endocrine function following partial pancreatectomy.
The Journal of surgical research.
1996 Aug; 64(2):170-5. doi:
10.1006/jsre.1996.0324. [PMID: 8812629] - E Niebergall-Roth, S Teyssen, D Wetzel, M Hartel, C Beglinger, R L Riepl, M V Singer. Comparison of the effects of two cholecystokinin-receptor antagonists, loxiglumide and L-364,718, on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Scandinavian journal of gastroenterology.
1996 Jul; 31(7):723-32. doi:
10.3109/00365529609009157. [PMID: 8819225] - F Hernando, J A Fuentes, M Ruiz-Gayo. Impairment of stress adaptive behaviours in rats by the CCKA receptor antagonist, devazepide.
British journal of pharmacology.
1996 May; 118(2):400-6. doi:
10.1111/j.1476-5381.1996.tb15416.x. [PMID: 8735644] - A W Spannagel, G M Green, D Guan, R A Liddle, K Faull, J R Reeve. Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion.
Proceedings of the National Academy of Sciences of the United States of America.
1996 Apr; 93(9):4415-20. doi:
10.1073/pnas.93.9.4415. [PMID: 8633081] - P J Garvin, M L Niehoff, F R Burton, F A Dysarz, R Meadow, H Solomon. Exocrine effects of the CCK antagonist L-364,718 in canine pancreatic autografts.
The Journal of surgical research.
1996 Feb; 61(1):256-9. doi:
10.1006/jsre.1996.0113. [PMID: 8769975] - C D Liu, O J Hines, T R Newton, T E Adrian, M J Zinner, S W Ashley, D W McFadden. Cholecystokinin mediation of colonic absorption via peptide YY: foregut-hindgut axis.
World journal of surgery.
1996 Feb; 20(2):221-7. doi:
10.1007/s002689900034. [PMID: 8661821] - B Ahrén, R L Gingerich, P J Havel. Effects of cholecystokinin and glucagon-like peptide 1 on the secretion of pancreatic polypeptide in mice.
Regulatory peptides.
1995 Nov; 59(3):297-302. doi:
10.1016/0167-0115(95)00081-l. [PMID: 8577934] - S C Huang, V D Talkad, K P Fortune, S Jonnalagadda, C Severi, G Delle Fave, J D Gardner. Modulation of cholecystokinin activity by albumin.
Proceedings of the National Academy of Sciences of the United States of America.
1995 Oct; 92(22):10312-6. doi:
10.1073/pnas.92.22.10312. [PMID: 7479774] - M A Manso, A I Rodriguez, A C Garcia-Montero, I De Dios. Effects of the cholecystokinin receptor antagonist L-364,718 on pancreatitis induced by a deficient in choline and supplemented with ethionine (CDE) diet in the rat.
Archives of physiology and biochemistry.
1995 Aug; 103(4):410-5. doi:
10.3109/13813459509047130. [PMID: 8548474] - A Borgström, J Axelson, I Ihse, J F Rehfeld. The ratio between anionic and cationic trypsin in rat pancreas varies with CCK stimulation.
Pancreas.
1995 Aug; 11(2):179-84. doi:
10.1097/00006676-199508000-00011. [PMID: 7479676] - J G Pauletzki, Q W Xu, E A Shaffer. Inhibition of gallbladder emptying decreases cholesterol saturation in bile in the Richardson ground squirrel.
Hepatology (Baltimore, Md.).
1995 Jul; 22(1):325-31. doi:
. [PMID: 7601426] - Y Li, Y Hao, C Owyang. Evidence for autoregulation of cholecystokinin secretion during diversion of bile pancreatic juice in rats.
Gastroenterology.
1995 Jul; 109(1):231-8. doi:
10.1016/0016-5085(95)90289-9. [PMID: 7797020] - E F Lhoste, A M Gueugneau, A Garofano, C Philippe, F Levenez, T Corring. Role of CCK in the regulation of secretion and adaptation in the pig pancreas.
Pancreas.
1995 Jul; 11(1):86-94. doi:
10.1097/00006676-199507000-00009. [PMID: 7667247] - M A Manso, A Rebollo, R Pescador, I de Dios. Action of CCK on CDE diet-induced acute pancreatitis in rats treated with hydrocortisone.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1995 Jun; 111(2):257-63. doi:
10.1016/0742-8413(95)00045-p. [PMID: 8521247] - T K Pradhan, J M Qian, V E Sutliff, S A Mantey, R T Jensen. Identification of CCK-A receptors on chief cells with use of a novel, highly selective ligand.
The American journal of physiology.
1995 Apr; 268(4 Pt 1):G605-12. doi:
10.1152/ajpgi.1995.268.4.g605. [PMID: 7733286] - M A McMillen, A Ferrara, T E Adrian, D S Margolis, H C Schaefer, K A Zucker. Cholecystokinin effect on human lymphocyte ionized calcium and mitogenesis.
The Journal of surgical research.
1995 Feb; 58(2):149-58. doi:
10.1006/jsre.1995.1024. [PMID: 7861766] - J P Smith, A P Fantaskey, G Liu, I S Zagon. Identification of gastrin as a growth peptide in human pancreatic cancer.
The American journal of physiology.
1995 Jan; 268(1 Pt 2):R135-41. doi:
10.1152/ajpregu.1995.268.1.r135. [PMID: 7840313] - J Fioramonti, M J Fargeas, V Bertrand, L Pradayrol, L Buéno. Induction of postprandial intestinal motility and release of cholecystokinin by polyamines in rats.
The American journal of physiology.
1994 Dec; 267(6 Pt 1):G960-5. doi:
10.1152/ajpgi.1994.267.6.g960. [PMID: 7810663] - R Jamshidipour, E B Pinho, S B Howell. In vivo modulation of cisplatin cytotoxicity by the cholecystokinin antagonist MK-329 in human pancreatic cancer xenografts.
Anticancer research.
1994 Nov; 14(6B):2611-6. doi:
. [PMID: 7872689] - R F Parrott, M L Forsling. The CCKA receptor antagonist devazepide inhibits the effect of apomorphine on vasopressin release in pigs.
General pharmacology.
1994 Nov; 25(7):1337-40. doi:
10.1016/0306-3623(94)90156-2. [PMID: 7896043] - D A Pollo, J J Baldassare, T Honda, P A Henderson, V D Talkad, J D Gardner. Effects of cholecystokinin (CCK) and other secretagogues on isoforms of protein kinase C (PKC) in pancreatic acini.
Biochimica et biophysica acta.
1994 Oct; 1224(1):127-38. doi:
10.1016/0167-4889(94)90120-1. [PMID: 7524684] - J S Tokarski, A J Hopfinger. Three-dimensional molecular shape analysis-quantitative structure-activity relationship of a series of cholecystokinin-A receptor antagonists.
Journal of medicinal chemistry.
1994 Oct; 37(21):3639-54. doi:
10.1021/jm00047a021. [PMID: 7932591] - H H Hölzer, C M Turkelson, T E Solomon, H E Raybould. Intestinal lipid inhibits gastric emptying via CCK and a vagal capsaicin-sensitive afferent pathway in rats.
The American journal of physiology.
1994 Oct; 267(4 Pt 1):G625-9. doi:
10.1152/ajpgi.1994.267.4.g625. [PMID: 7943327] - Y Li, C Owyang. Endogenous cholecystokinin stimulates pancreatic enzyme secretion via vagal afferent pathway in rats.
Gastroenterology.
1994 Aug; 107(2):525-31. doi:
10.1016/0016-5085(94)90180-5. [PMID: 8039628] - R Hosotani, R Doi, Y Gu, M Wada, K Inoue, N Fujii, P L Rayford, M Imamura. Metabolism of cholecystokinin-33 in vivo: effect of L-364,718, a CCK receptor antagonist.
Annals of clinical and laboratory science.
1994 Jul; 24(4):346-54. doi:
NULL. [PMID: 7944271] - I Koop, R Eissele, S Richter, H Patberg, F Meyer, J Mössner, R Arnold, H Koop. A new CCK-B/gastrin receptor antagonist acts as an agonist on the rat pancreas.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1994 Jun; 15(3):215-22. doi:
10.1007/bf02924197. [PMID: 7523549] - A C Garcia-Montero, M A Manso, A I Rodriguez, I De Dios. Therapeutic and protective effect of subcutaneous injections of L-364,718 on caerulein-induced acute pancreatitis.
Pancreas.
1994 May; 9(3):309-15. doi:
10.1097/00006676-199405000-00005. [PMID: 7517544]