AIDS-045571 (BioDeep_00000869578)
Main id: BioDeep_00000173053
PANOMIX_OTCML-2023
代谢物信息卡片
InChI=1\C3H5N3\c4-3-5-1-2-6-3\h1-2H,(H3,4,5,6
化学式: C3H5N3 (83.04834500000001)
中文名称: 2-氨基咪唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=C(N1)N
InChI: InChI=1S/C3H5N3/c4-3-5-1-2-6-3/h1-2H,(H3,4,5,6)
描述信息
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lene Jacobs, Jolien Meesters, Ilse Parijs, Geert Hooyberghs, Erik V Van der Eycken, Bram Lories, Hans P Steenackers. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms.
Biofouling.
2021 01; 37(1):61-77. doi:
10.1080/08927014.2021.1874366. [PMID: 33573402] - T Vu Nguyen, Bradley M Minrovic, Roberta J Melander, Christian Melander. Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold.
ChemMedChem.
2019 05; 14(9):927-937. doi:
10.1002/cmdc.201900033. [PMID: 30834698] - Albert Byungyun Jeon, David F Ackart, Wei Li, Mary Jackson, Roberta J Melander, Christian Melander, Robert B Abramovitch, Adam J Chicco, Randall J Basaraba, Andrés Obregón-Henao. 2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain.
Scientific reports.
2019 02; 9(1):1513. doi:
10.1038/s41598-018-38064-7. [PMID: 30728417] - Tran Thi Thu Trang, Lise Dieltjens, Geert Hooyberghs, Kai Waldrant, Denis S Ermolat'ev, Erik V Van der Eycken, Hans P L Steenackers. Enhancing the anti-biofilm activity of 5-aryl-2-aminoimidazoles through nature inspired dimerisation.
Bioorganic & medicinal chemistry.
2018 05; 26(8):1470-1480. doi:
10.1016/j.bmc.2018.01.005. [PMID: 29449125] - Rupinder Kaur Gill, Virender Kumar, Stijn C A Robijns, Hans P L Steenackers, Erik V Van der Eycken, Jitender Bariwal. Polysubstituted 2-aminoimidazoles as anti-biofilm and antiproliferative agents: Discovery of potent lead.
European journal of medicinal chemistry.
2017 Sep; 138(?):152-169. doi:
10.1016/j.ejmech.2017.06.043. [PMID: 28667872] - Francisco J Hidalgo, Esmeralda Alcón, Rosario Zamora. Reactive carbonyl-scavenging ability of 2-aminoimidazoles: 2-amino-1-methylbenzimidazole and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Journal of agricultural and food chemistry.
2014 Dec; 62(49):12045-51. doi:
10.1021/jf504320a. [PMID: 25418848] - Hans Steenackers, Akanksha Dubey, Stijn Robijns, Denis Ermolat'ev, Nicolas Delattin, Barbara Dovgan, Lenart Girandon, Mirjam Fröhlich, Katrijn De Brucker, Bruno P A Cammue, Karin Thevissen, Jan Balzarini, Erik V Van der Eycken, Jozef Vanderleyden. Evaluation of the toxicity of 5-aryl-2-aminoimidazole-based biofilm inhibitors against eukaryotic cell lines, bone cells and the nematode Caenorhabditis elegans.
Molecules (Basel, Switzerland).
2014 Oct; 19(10):16707-23. doi:
10.3390/molecules191016707. [PMID: 25325155] - Hans Steenackers, Denis Ermolat'ev, Tran Thi Thu Trang, Bharat Savalia, Upendra K Sharma, Ami De Weerdt, Anamik Shah, Jozef Vanderleyden, Erik V Van der Eycken. Microwave-assisted one-pot synthesis and anti-biofilm activity of 2-amino-1H-imidazole/triazole conjugates.
Organic & biomolecular chemistry.
2014 Jun; 12(22):3671-8. doi:
10.1039/c3ob42282h. [PMID: 24763714] - Charlotte Passemar, Mariette Saléry, Patrice Njomnang Soh, Marie-Denise Linas, Alain Ahond, Christiane Poupat, Françoise Benoit-Vical. Indole and aminoimidazole moieties appear as key structural units in antiplasmodial molecules.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Oct; 18(13):1118-25. doi:
10.1016/j.phymed.2011.03.010. [PMID: 21612900] - Barbara Leitenmaier, Annelie Witt, Annabell Witzke, Anastasia Stemke, Wolfram Meyer-Klaucke, Peter M H Kroneck, Hendrik Küpper. Biochemical and biophysical characterisation yields insights into the mechanism of a Cd/Zn transporting ATPase purified from the hyperaccumulator plant Thlaspi caerulescens.
Biochimica et biophysica acta.
2011 Oct; 1808(10):2591-9. doi:
10.1016/j.bbamem.2011.05.010. [PMID: 21621506] - Anthony G Borel, Timothy M Jones, Robert J Barbuch, David A Jackson, Palaniappan Kulanthaivel, Edward Mattiuz, Valentine J Klimkowski, William J Wheeler, Gregory A Rener. Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite.
Drug metabolism and disposition: the biological fate of chemicals.
2011 May; 39(5):740-9. doi:
10.1124/dmd.110.037598. [PMID: 21346003] - K V Lobanov, L Errais Lopes, N V Korol'kova, B V Tyaglov, A V Glazunov, R S Shakulov, A S Mironov. Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer of AICAR: A New Drug with a Wide Range of Therapeutic Applications.
Acta naturae.
2011 Apr; 3(2):79-89. doi:
. [PMID: 22649686] - Kutti R Vinothkumar. Structure of rhomboid protease in a lipid environment.
Journal of molecular biology.
2011 Mar; 407(2):232-47. doi:
10.1016/j.jmb.2011.01.029. [PMID: 21256137] - Frank Morgner, Stefan Stufler, Daniel Geissler, Igor L Medintz, W Russ Algar, Kimihiro Susumu, Michael H Stewart, Juan B Blanco-Canosa, Philip E Dawson, Niko Hildebrandt. Terbium to quantum dot FRET bioconjugates for clinical diagnostics: influence of human plasma on optical and assembly properties.
Sensors (Basel, Switzerland).
2011; 11(10):9667-84. doi:
10.3390/s111009667. [PMID: 22163719] - S Samuel Yang, Oswaldo Valdés-López, Wayne W Xu, Bruna Bucciarelli, John W Gronwald, Georgina Hernández, Carroll P Vance. Transcript profiling of common bean (Phaseolus vulgaris L.) using the GeneChip Soybean Genome Array: optimizing analysis by masking biased probes.
BMC plant biology.
2010 May; 10(?):85. doi:
10.1186/1471-2229-10-85. [PMID: 20459672] - Daniele Sanna, Giovanni Micera, Eugenio Garribba. New developments in the comprehension of the biotransformation and transport of insulin-enhancing vanadium compounds in the blood serum.
Inorganic chemistry.
2010 Jan; 49(1):174-87. doi:
10.1021/ic9017213. [PMID: 19947643] - Shalaka Samant, Hyunwoo Lee, Mahmood Ghassemi, Juan Chen, James L Cook, Alexander S Mankin, Alexander A Neyfakh. Nucleotide biosynthesis is critical for growth of bacteria in human blood.
PLoS pathogens.
2008 Feb; 4(2):e37. doi:
10.1371/journal.ppat.0040037. [PMID: 18282099] - Petr Hornik, Petra Vyskocilová, David Friedecký, Anna Janostáková, Katerina Adamová, Tomás Adam. Analysis of aminoimidazole ribosides by capillary electrophoresis--diagnosing defects in second part of purine biosynthetic pathway.
Clinica chimica acta; international journal of clinical chemistry.
2007 Feb; 376(1-2):184-9. doi:
10.1016/j.cca.2006.08.020. [PMID: 17010959] - P Gizzi, B Henry, P Rubini, S Giroux, E Wenger. A multi-approach study of the interaction of the Cu(II) and Ni(II) ions with alanylglycylhistamine, a mimicking pseudopeptide of the serum albumine N-terminal residue.
Journal of inorganic biochemistry.
2005 May; 99(5):1182-92. doi:
10.1016/j.jinorgbio.2005.02.018. [PMID: 15833342] - Danica Erin Goggin, Richard Lipscombe, Elena Fedorova, A Harvey Millar, Anthea Mann, Craig Anthony Atkins, Penelope Mary Collina Smith. Dual intracellular localization and targeting of aminoimidazole ribonucleotide synthetase in cowpea.
Plant physiology.
2003 Mar; 131(3):1033-41. doi:
10.1104/pp.102.015081. [PMID: 12644656] - Penelope M C Smith, Heike Winter, Paul J Storer, John D Bussell, Kathryn A Schuller, Craig A Atkins. Effect of short-term N(2) deficiency on expression of the ureide pathway in cowpea root nodules.
Plant physiology.
2002 Jul; 129(3):1216-21. doi:
10.1104/pp.010714. [PMID: 12114575] - Bohumil Dolensky, Kenneth L Kirk. New building blocks for fluorinated bioimidazole derivatives II: preparation of beta-fluorourocanic acids.
The Journal of organic chemistry.
2002 May; 67(10):3468-73. doi:
10.1021/jo0200419. [PMID: 12003561] - N R Wurtz, J M Turner, E E Baird, P B Dervan. Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids.
Organic letters.
2001 Apr; 3(8):1201-3. doi:
10.1021/ol0156796. [PMID: 11348194]