Thiole (BioDeep_00000865948)
代谢物信息卡片
5-17-01-00297 (Beilstein Handbook Reference)
化学式: C4H4S (84.0034)
中文名称: 噻吩, 聚(噻吩-2,5-二基)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CSC=C1
InChI: InChI=1S/C4H4S/c1-2-4-5-3-1/h1-4H
描述信息
同义名列表
45 个代谢物同义名
5-17-01-00297 (Beilstein Handbook Reference); POLY(THIOPHENE-2,5-DIYL), BR TERMINATED; Thiophene [UN2414] [Flammable liquid]; InChI=1\C4H4S\c1-2-4-5-3-1\h1-4; Thiophene, homopolymer; Thiacyclopentadiene; Divinylene sulfide; EINECS 203-729-4; NCGC00091806-01; Thiofen [Czech]; 442802_SUPELCO; T31801_ALDRICH; 516694_ALDRICH; Polythiophene; ZINC01597767; Thiofurfuran; USAF EK-1860; Furan, thio-; 06914_FLUKA; BRN 0103222; Thiotetrole; AIDS-018335; CHEBI:30856; CCRIS 2935; 25233-34-5; NSC 405073; AIDS018335; 8014-23-1; Huile HSO; NSC405073; Thiofuran; ST5214534; WLN: T5SJ; THIOPHENE; Thiofuram; AI3-15417; Thiaphene; Huile H50; HSDB 130; 110-02-1; Thiophen; Thiole; UN2414; CP 34; Thiophene
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:30856
- PubChem: 8030
- ChEMBL: CHEMBL278958
- MeSH: Thiophenes
- CAS: 107760-19-0
- CAS: 51325-05-4
- CAS: 25233-34-5
- CAS: 110-02-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 13443 - Coffea arabica: 10.1021/JF60160A010
- 13708 - Tagetes erecta:
- 169607 - Tagetes minuta: 10.1093/JXB/38.2.322
- 55843 - Tagetes patula:
- 33090 - 薤白: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jun Qian, Qian Li, Yangjie Song, Xuyan Gong, Kaili Hu, Guangbo Ge, Yao Sun. Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155587. doi:
10.1016/j.phymed.2024.155587. [PMID: 38608598] - Minju Park, Seo-Yeong Mun, Wenwen Zhuang, Junsu Jeong, Hye Ryung Kim, Hongzoo Park, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Hongliang Li, Won Sun Park. The antidiabetic drug ipragliflozin induces vasorelaxation of rabbit femoral artery by activating a Kv channel, the SERCA pump, and the PKA signaling pathway.
European journal of pharmacology.
2024 Jun; 972(?):176589. doi:
10.1016/j.ejphar.2024.176589. [PMID: 38631503] - Jun Sang, Chen-Kai Liu, Jue Liu, Guan-Cong Luo, Wei-Ji Zheng, Ya Bai, De-Yun Jiang, Jiang-Ni Pu, Su An, Tian-Rui Xu. Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells.
Biochemical pharmacology.
2024 May; 223(?):116194. doi:
10.1016/j.bcp.2024.116194. [PMID: 38583812] - Christine Bassila, George E G Kluck, Narmadaa Thyagarajan, Kevin M Chathely, Leticia Gonzalez, Bernardo L Trigatti. Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques.
Journal of lipid research.
2024 May; 65(5):100541. doi:
10.1016/j.jlr.2024.100541. [PMID: 38583587] - Furong Ma, Yulong Li, Maohua Cai, Wenyan Yang, Zumei Wu, Jinyun Dong, Jiang-Jiang Qin. ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation.
European journal of medicinal chemistry.
2024 Apr; 270(?):116387. doi:
10.1016/j.ejmech.2024.116387. [PMID: 38593589] - Agnieszka Tomczyk-Warunek, Karolina Turżańska, Agnieszka Posturzyńska, Filip Kowal, Tomasz Blicharski, Inés Torné Pano, Anna Winiarska-Mieczan, Anna Nikodem, Sławomir Dresler, Ireneusz Sowa, Magdalena Wójciak, Piotr Dobrowolski. Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis.
International journal of molecular sciences.
2024 Apr; 25(7):. doi:
10.3390/ijms25074075. [PMID: 38612883] - Yang Xu, Dejuan Sun, Liangliang Xiong, Zhiqi Zhang, Yuxia Li, Kexin Liu, Hua Li, Lixia Chen. Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Bioorganic chemistry.
2024 Apr; 145(?):107190. doi:
10.1016/j.bioorg.2024.107190. [PMID: 38377816] - Sana Parveen, Nasrin Akhtar, Teerasak E-Kobon, Richard Burchmore, Abdullah Ijaz Hussain, Kalsoom Akhtar. Biodesulfurization of organosulfur compounds by a trehalose biosurfactant producing Gordonia sp. isolated from crude oil contaminated soil.
World journal of microbiology & biotechnology.
2024 Feb; 40(3):103. doi:
10.1007/s11274-024-03899-y. [PMID: 38372854] - Mitzy F Porras, Juan Antonio Raygoza Garay, Malachi Brought, Tomas López-Londoño, Alexander Chautá, Makaylee Crone, Edwin G Rajotte, Ngoc Phan, Neelendra K Joshi, Kari Peter, David Biddinger. Fungicide ingestion reduces net energy gain and microbiome diversity of the solitary mason bee.
Scientific reports.
2024 02; 14(1):3229. doi:
10.1038/s41598-024-53935-y. [PMID: 38332135] - Zifeng Tang, Jie Li, Lijie Peng, Fang Xu, Yi Tan, Xiaoqiang He, Chengjun Zhu, Zhi-Min Zhang, Zhang Zhang, Pinghua Sun, Ke Ding, Zhengqiu Li. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy.
Journal of medicinal chemistry.
2024 Feb; 67(3):1872-1887. doi:
10.1021/acs.jmedchem.3c01608. [PMID: 38265413] - Mototsugu Nagao, Jun Sasaki, Kyoko Tanimura-Inagaki, Ichiro Sakuma, Hitoshi Sugihara, Shinichi Oikawa. Ipragliflozin and sitagliptin differentially affect lipid and apolipoprotein profiles in type 2 diabetes: the SUCRE study.
Cardiovascular diabetology.
2024 02; 23(1):56. doi:
10.1186/s12933-024-02149-7. [PMID: 38331780] - Linli Zhang, Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong, Xianwen Zhang. Effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on serum uric acid levels in patients with chronic kidney disease: a systematic review and network meta-analysis.
BMJ open diabetes research & care.
2024 Jan; 12(1):. doi:
10.1136/bmjdrc-2023-003836. [PMID: 38238025] - Qiaofeng Ai, Lirong Gao, Di Huang, Jing Yang, Qiang Fu, Xuan Zheng, Yang Liu, Lin Qiao, Jiyuan Weng, Minghui Zheng. Non-target and target analysis to identify and characterize thiophenes in soil from an abandoned coking plant.
Journal of hazardous materials.
2023 10; 460(?):132444. doi:
10.1016/j.jhazmat.2023.132444. [PMID: 37660621] - Yogesh Sutar, Sudhanshu Kumar Singh, Sagar Dhoble, Jaishree Mali, Joseph Adams, Tejabhiram Yadavalli, Abhijit A Date, Deepak Shukla. Oral Self-Nanoemulsifying System Containing Ionic Liquid of BX795 Is Effective against Genital HSV-2 Infection in Mice.
ACS infectious diseases.
2023 Oct; ?(?):. doi:
10.1021/acsinfecdis.3c00212. [PMID: 37807721] - Fan-Zhu Meng, Zuo-Qian Wang, Mei Luo, Wen-Kai Wei, Liang-Fen Yin, Wei-Xiao Yin, Guido Schnabel, Chao-Xi Luo. The velvet family proteins mediate low resistance to isoprothiolane in Magnaporthe oryzae.
PLoS pathogens.
2023 Jun; 19(6):e1011011. doi:
10.1371/journal.ppat.1011011. [PMID: 37276223] - Rokas Žvirblis, Karolina Maleckaitė, Jelena Dodonova-Vaitkūnienė, Džiugas Jurgutis, Rugilė Žilėnaitė, Vitalijus Karabanovas, Sigitas Tumkevičius, Aurimas Vyšniauskas. A red-emitting thiophene-modified BODIPY probe for fluorescence lifetime-based polarity imaging of lipid droplets in living cells.
Journal of materials chemistry. B.
2023 May; 11(17):3919-3928. doi:
10.1039/d3tb00305a. [PMID: 37060145] - Elek Ferencz, Gabriella Spengler, István Zupkó, Martin Vollár, Zoltán Péter Zomborszki, Norbert Kúsz, Judit Hohmann, Balázs Kovács, Dezső Csupor, Eszter Laczkó-Zöld, Boglárka Csupor-Löffler. Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2023 Apr; ?(?):. doi:
10.1515/znc-2022-0239. [PMID: 37029666] - Renle Xu, Shihao Gu, Kun Chen, Jinyu Chen, Yong Wang, Yanqing Gao, Shibin Shang, Zhanqian Song, Jie Song, Jian Li. Discovery of rosin-based acylhydrazone derivatives as potential antifungal agents against rice Rhizoctonia solani for sustainable crop protection.
Pest management science.
2023 Feb; 79(2):655-665. doi:
10.1002/ps.7232. [PMID: 36223125] - Romain Marteau, Séverine Ravez, Darius Mazhari Dorooee, Hind Bouchaoui, Karine Porte, Jean-Christophe Devedjian, Patricia Melnyk, David Devos, Raphaël Frédérick, Jamal El Bakali. Repositioning of FDA-Approved antifungal agents to interrogate Acyl-CoA synthetase long chain family member 4 (ACSL4) in ferroptosis.
Biochemical pharmacology.
2022 Oct; 204(?):115239. doi:
10.1016/j.bcp.2022.115239. [PMID: 36075462] - Weibo Sun, Qingyong Wang, Tiansong Yang, Chuwen Feng, Yuanyuan Qu, Yan Yang, Chaoran Li, Zhongren Sun, Tetsuya Asakawa. A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2022 Oct; 43(10):5821-5837. doi:
10.1007/s10072-022-06159-9. [PMID: 35691972] - Jing-Ru Wang, Yong-Mei Hu, Han Zhou, An-Ping Li, Shao-Yong Zhang, Xiong-Fei Luo, Bao-Qi Zhang, Jun-Xia An, Zhi-Jun Zhang, Ying-Qian Liu. Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents.
Journal of agricultural and food chemistry.
2022 Sep; 70(37):11782-11791. doi:
10.1021/acs.jafc.2c03765. [PMID: 36067412] - Yuxiang Hu, Jiaqi Bai, Yongqing Xia, Yan Lin, Li Ma, Xuemei Xu, Yanfeng Ding, Lin Chen. Increasing SnRK1 activity with the AMPK activator A-769662 accelerates seed germination in rice.
Plant physiology and biochemistry : PPB.
2022 Aug; 185(?):155-166. doi:
10.1016/j.plaphy.2022.06.005. [PMID: 35696890] - Rui Liu, Yue Deng, Meiling Zheng, Yuping Liu, Zikang Wang, Simin Yu, Yufan Nie, Wentao Zhu, Zhiqiang Zhou, Jinling Diao. Nano selenium repairs the fruit growth and flavor quality of tomato under the stress of penthiopyrad.
Plant physiology and biochemistry : PPB.
2022 Aug; 184(?):126-136. doi:
10.1016/j.plaphy.2022.05.026. [PMID: 35640519] - S Khalid, S Calderon-Larranaga, A Sami, S Hawley, A Judge, N Arden, T P Van Staa, C Cooper, B Abrahamsen, M Kassim Javaid, D Prieto-Alhambra. Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Jul; 33(7):1579-1589. doi:
10.1007/s00198-021-06262-1. [PMID: 35138412] - Zenghao Wang, Haotian Bai, Wen Yu, Zhiqiang Gao, Weijian Chen, Zhiwen Yang, Chuanwei Zhu, Yiming Huang, Fengting Lv, Shu Wang. Flexible bioelectronic device fabricated by conductive polymer-based living material.
Science advances.
2022 06; 8(25):eabo1458. doi:
10.1126/sciadv.abo1458. [PMID: 35731871] - Kouji Fukuyama, Eishi Motomura, Motohiro Okada. Brexpiprazole Reduces 5-HT7 Receptor Function on Astroglial Transmission Systems.
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126571. [PMID: 35743014] - Shihan Cao, Bochui Zhao, Yize Zou, Zhonghua Sun, Hongtao Zhang, Shiwei Wei, Mingshan Ji. P450s mediated enhanced herbicide metabolism involved in the thifensulfuron-methyl resistance in Ipomoea purpurea L.
Pesticide biochemistry and physiology.
2022 Jun; 184(?):105111. doi:
10.1016/j.pestbp.2022.105111. [PMID: 35715050] - B Haridevamuthu, Tamilvelan Manjunathan, Ajay Guru, Rajendran Saravana Kumar, Rajakrishnan Rajagopal, Palaniselvam Kuppusamy, Annie Juliet, Pushparathinam Gopinath, Jesu Arockiaraj. Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle.
Life sciences.
2022 Jun; 298(?):120507. doi:
10.1016/j.lfs.2022.120507. [PMID: 35358593] - Min-Chun Liao, Kana N Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R Ingelfinger, John S D Chan, Shao-Ling Zhang. Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice.
Clinical science (London, England : 1979).
2022 05; 136(10):715-731. doi:
10.1042/cs20220188. [PMID: 35502764] - Zhi-Chao Lei, Na Li, Nai-Rong Yu, Wei Ju, Xiao-Na Sun, Xue-Ling Zhang, Hai-Juan Dong, Jian-Bo Sun, Li Chen. Design and Synthesis of Novel Celastrol Derivatives as Potential Anticancer Agents against Gastric Cancer Cells.
Journal of natural products.
2022 05; 85(5):1282-1293. doi:
10.1021/acs.jnatprod.1c01236. [PMID: 35536757] - Chen Chen, Xing-Xing Yang, Zhi Zhao, Bo Han, Wei Du, Ying-Chun Chen. Asymmetric inverse-electron-demand 1,3-dipolar cycloadditions of cyclopentadienones and thiophene-1,1-dioxide with C,N-cyclic azomethine imines.
Chemical communications (Cambridge, England).
2022 May; 58(36):5502-5505. doi:
10.1039/d2cc01103d. [PMID: 35416818] - Heying Liu, Xin Xiong, Jie Wang, Kun Pei, Zhenhua Zhong, Zhiqiang Zhou, Qizhen Cheng. Determination, Isolation, and Identification of Related Impurities in Erdosteine Bulk Drug.
Journal of AOAC International.
2022 Apr; 105(3):696-702. doi:
10.1093/jaoacint/qsab131. [PMID: 34677591] - Hiroshi Akasaka, Ken Sugimoto, Ayumi Shintani, Satsuki Taniuchi, Koichi Yamamoto, Katsuomi Iwakura, Atsunori Okamura, Shin Takiuchi, Masahiro Fukuda, Kei Kamide, Yasushi Fujio, Satoshi Nakatani, Toshio Ogihara, Hiromi Rakugi. Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study.
Geriatrics & gerontology international.
2022 Apr; 22(4):298-304. doi:
10.1111/ggi.14363. [PMID: 35212104] - Eleonora Amante, Andrea Cerrato, Eugenio Alladio, Anna Laura Capriotti, Chiara Cavaliere, Federico Marini, Carmela Maria Montone, Susy Piovesana, Aldo Laganà, Marco Vincenti. Comprehensive biomarker profiles and chemometric filtering of urinary metabolomics for effective discrimination of prostate carcinoma from benign hyperplasia.
Scientific reports.
2022 03; 12(1):4361. doi:
10.1038/s41598-022-08435-2. [PMID: 35288652] - Nuria Saiz, Lisbeth Herrera-Castillo, Esther Isorna, María Jesús Delgado, Marta Conde-Sieira, José Luis Soengas, Nuria de Pedro. REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23062921. [PMID: 35328345] - Yavuz Osman Birdane, Gulcan Avci, Fatih Mehmet Birdane, Ruhi Turkmen, Orkun Atik, Hulya Atik. The protective effects of erdosteine on subacute diazinon-induced oxidative stress and inflammation in rats.
Environmental science and pollution research international.
2022 Mar; 29(15):21537-21546. doi:
10.1007/s11356-021-17398-2. [PMID: 34766221] - Camila A Ortega Ramírez, Travers Ching, Brandon Yoza, Qing X Li. Glycerol-assisted degradation of dibenzothiophene by Paraburkholderia sp. C3 is associated with polyhydroxyalkanoate granulation.
Chemosphere.
2022 Mar; 291(Pt 3):133054. doi:
10.1016/j.chemosphere.2021.133054. [PMID: 34838841] - Helen K Boffey, Timothy P C Rooney, Henriette M G Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E Scott, David Winpenny, James Duce, John Skidmore, Jonathan H Clarke, Stephen P Andrews. Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Journal of medicinal chemistry.
2022 02; 65(4):3359-3370. doi:
10.1021/acs.jmedchem.1c01819. [PMID: 35148092] - Shuxuan Wang, Yao Chen, Houshun Fang, Yan Xu, Ming Ding, Chunshuang Ma, Yanyan Lin, Zhiyan Cui, Huiying Sun, Qun Niu, Shuzhang Sun, Bin-Bing S Zhou, Ning Xiao, Hui Li. A γ-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells.
FEBS letters.
2022 02; 596(4):437-448. doi:
10.1002/1873-3468.14285. [PMID: 35040120] - Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg. Colorimetric and Fluorometric Profiling of Advanced Glycation End Products.
ACS applied materials & interfaces.
2022 Jan; 14(1):94-103. doi:
10.1021/acsami.1c16261. [PMID: 34964349] - Peter Manu. Repurposing Drugs for Post-COVID-19 Fatigue Syndrome: Methylphenidate, Duloxetine, and Brexpiprazole.
American journal of therapeutics.
2022 01; 29(2):e229-e230. doi:
10.1097/mjt.0000000000001471. [PMID: 35389574] - Asahiro Morishita, Tomoko Tadokoro, Shintaro Fujihara, Hisakazu Iwama, Kyoko Oura, Koji Fujita, Joji Tani, Kei Takuma, Mai Nakahara, Tingting Shi, Reiji Haba, Keiichi Okano, Akira Nishiyama, Masafumi Ono, Takashi Himoto, Tsutomu Masaki. Ipragliflozin attenuates non-alcoholic steatohepatitis development in an animal model.
PloS one.
2022; 17(2):e0261310. doi:
10.1371/journal.pone.0261310. [PMID: 35192632] - Abolfazl Akbari, Mahdi Rafiee, Thozhukat Sathyapalan, Amirhossein Sahebkar. Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis.
Journal of diabetes research.
2022; 2022(?):7520632. doi:
10.1155/2022/7520632. [PMID: 35224108] - Tingting Zhao, Yu Liu, Hongwu Liang, Li Li, Kaiwei Shi, Jia Wang, Yuke Zhu, Cheng Ma. Simultaneous determination of penthiopyrad enantiomers and its metabolite in vegetables, fruits, and cereals using ultra-high performance liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2022 Jan; 45(2):441-455. doi:
10.1002/jssc.202100446. [PMID: 34713971] - David Pearson, Yi Jin, Andrea Romeo, Bertrand-Luc Birlinger, Hilmar Schiller, Yan Ji, Mithat Gunduz, Daniela Baldoni, Markus Walles. Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation.
Xenobiotica; the fate of foreign compounds in biological systems.
2022 Jan; 52(1):26-37. doi:
10.1080/00498254.2022.2037027. [PMID: 35098863] - Prawej Ansari, Peter R Flatt, Patrick Harriott, Yasser H A Abdel-Wahab. Insulin secretory and antidiabetic actions of Heritiera fomes bark together with isolation of active phytomolecules.
PloS one.
2022; 17(3):e0264632. doi:
10.1371/journal.pone.0264632. [PMID: 35239729] - Charlotte Cutler, Daniel Leigh White, Marjaana Viljanto. In vitro metabolism of the REV-ERB agonist SR-9009 and subsequent detection of metabolites in associated routine equine plasma and urine doping control samples.
Drug testing and analysis.
2022 Jan; 14(1):169-174. doi:
10.1002/dta.3124. [PMID: 34224639] - Manuel A Patarroyo, Manuel E Patarroyo, Laura Pabón, Martha P Alba, Adriana Bermudez, María Teresa Rugeles, Diana Díaz-Arevalo, Wildeman Zapata-Builes, María Isabel Zapata, César Reyes, Carlos F Suarez, William Agudelo, Carolina López, Jorge Aza-Conde, Miguel Melo, Luis Escamilla, Jairo Oviedo, Fanny Guzmán, Yolanda Silva, Martha Forero, Lizdany Flórez-Álvarez, Wbeimar Aguilar-Jimenez, Armando Moreno-Vranich, Jason Garry, Catalina Avendaño. SM-COLSARSPROT: Highly Immunogenic Supramutational Synthetic Peptides Covering the World's Population.
Frontiers in immunology.
2022; 13(?):859905. doi:
10.3389/fimmu.2022.859905. [PMID: 35693819] - Christopher D Bruno, Ahmed Elmokadem, Conrad Housand, Eric Burroughs Jordie, Christina R Chow, Thomas P Laughren, David J Greenblatt. Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment.
Journal of clinical pharmacology.
2022 01; 62(1):55-65. doi:
10.1002/jcph.1947. [PMID: 34339048] - Ahmed Elmokadem, Christopher D Bruno, Conrad Housand, Eric Burroughs Jordie, Christina R Chow, Lawrence J Lesko, David J Greenblatt. Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations.
Journal of clinical pharmacology.
2022 01; 62(1):66-75. doi:
10.1002/jcph.1946. [PMID: 34328221] - Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A Boisvert, Thomas Unger, María S Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega. AT2R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet.
Clinical science (London, England : 1979).
2021 12; 135(24):2763-2780. doi:
10.1042/cs20210971. [PMID: 34854902] - E H El-Mossalamy, Mervette E L Batouti, H A Fetouh. The role of natural biological macromolecules: Deoxyribonucleic and ribonucleic acids in the formulation of new stable charge transfer complexes of thiophene Schiff bases for various life applications.
International journal of biological macromolecules.
2021 Dec; 193(Pt B):1572-1586. doi:
10.1016/j.ijbiomac.2021.10.220. [PMID: 34743030] - Lei Cao, Fen Ping, Fengrui Zhang, Haixiang Gao, Ping Li, Xiaohui Ning, Guohuan Cui, Zheng Ma, Xin Jiang, Suyan Li, Shuzhi Han. Tissue-Protective Effect of Erdosteine on Multiple-Organ Injuries Induced by Fine Particulate Matter.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Dec; 27(?):e930909. doi:
10.12659/msm.930909. [PMID: 34873140] - Zhi Jian Zhong, Xiao Tong Hu, Li Ping Cheng, Xing Yong Zhang, Qiang Zhang, Ju Zhang. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors.
European journal of medicinal chemistry.
2021 Dec; 225(?):113762. doi:
10.1016/j.ejmech.2021.113762. [PMID: 34411893] - Yuanyuan Zhang, Bingke Ma, Shuangshuang Hao, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Chenxi Shi, Liang Yuan, Rui Li, Changwen Li, Fangping Liu. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.
Journal of applied toxicology : JAT.
2021 12; 41(12):2011-2020. doi:
10.1002/jat.4181. [PMID: 33959992] - Alexander Burashnikov, Hector Barajas-Martinez, Robert Cox, Mark A Demitrack, Michael J Fossler, Michael Kramer, Robert B Kleiman, Peter Kowey, Charles Antzelevitch. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk.
Heart rhythm.
2021 12; 18(12):2177-2186. doi:
10.1016/j.hrthm.2021.08.028. [PMID: 34481984] - Byeong Woo Kim, Hye Jung Kim, Sun-Hee Kim, Hyung Joo Baik, Mi Seon Kang, Dong-Hyun Kim, Sanford D Markowitz, Sun Woo Kang, Ki Beom Bae. 15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury.
Renal failure.
2021 Dec; 43(1):168-179. doi:
10.1080/0886022x.2020.1870139. [PMID: 33459127] - Mio Iijima, Shota Takemi, Sayaka Aizawa, Takafumi Sakai, Ichiro Sakata. The suppressive effect of REVERBs on ghrelin and GOAT transcription in gastric ghrelin-producing cells.
Neuropeptides.
2021 Dec; 90(?):102187. doi:
10.1016/j.npep.2021.102187. [PMID: 34450431] - María Fernanda Fussi, Florencia Hidalgo, Gabriel Marcelo Buono, Susana Beatriz Marquez, Alejandro Pedro Pariani, Jorge Luis Molinas, María Cecilia Larocca, Liliana Alicia Monasterolo, Sara María Molinas. Angiotensin II type 2 receptor agonist, compound 21, prevents tubular epithelial cell damage caused by renal ischemia.
Biochemical pharmacology.
2021 12; 194(?):114804. doi:
10.1016/j.bcp.2021.114804. [PMID: 34678223] - Constantin Yanicostas, Nadia Soussi-Yanicostas. SDHI Fungicide Toxicity and Associated Adverse Outcome Pathways: What Can Zebrafish Tell Us?.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212362. [PMID: 34830252] - Toru Kuramoto, Denan Jin, Koji Komeda, Kohei Taniguchi, Fumitoshi Hirokawa, Shinji Takai, Kazuhisa Uchiyama. Chymase as a Novel Therapeutic Target in Acute Pancreatitis.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212313. [PMID: 34830195] - Atsuo Tahara. SGLT2 inhibitor ipragliflozin exerts antihyperglycemic effects via the blood glucose-dependent increase in urinary glucose excretion in type 2 diabetic mice.
European journal of pharmacology.
2021 Nov; 910(?):174486. doi:
10.1016/j.ejphar.2021.174486. [PMID: 34487707] - Yi Wang, Zhigang Wang, Zhengping Wu, Menglin Chen, Dong Dong, Pei Yu, Danyi Lu, Baojian Wu. Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury.
Biochemical pharmacology.
2021 11; 193(?):114807. doi:
10.1016/j.bcp.2021.114807. [PMID: 34673015] - Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang, Li-Yu He. IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy.
Molecular medicine (Cambridge, Mass.).
2021 10; 27(1):137. doi:
10.1186/s10020-021-00398-w. [PMID: 34711178] - Masao Koike, Hitoki Saito, Genta Kohno, Masahiro Takubo, Kentaro Watanabe, Hisamitsu Ishihara. Effects of GLP-1RA and SGLT2i, Alone or in Combination, on Mouse Models of Type 2 Diabetes Representing Different Disease Stages.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111463. [PMID: 34768897] - Kaibo Guo, Peipei Wang, Leyin Zhang, Yiwen Zhou, Xinyang Dai, Yici Yan, Yuxuan Chen, Harpreet S Wasan, Jieru Yu, Shanming Ruan, Leitao Sun. Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog-mediated epithelial-mesenchymal transition.
Cancer science.
2021 Oct; 112(10):4176-4186. doi:
10.1111/cas.15089. [PMID: 34327778] - Santino Caserta, Anna Maria Zaccuri, Vanessa Innao, Caterina Musolino, Alessandro Allegra. Immune thrombocytopenia: options and new perspectives.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2021 Oct; 32(7):427-433. doi:
10.1097/mbc.0000000000001058. [PMID: 34224465] - Hong-Xu Xie, Juan Zhang, Yue Li, Jin-He Zhang, Shan-Kui Liu, Jie Zhang, Hua Zheng, Gui-Zhou Hao, Kong-Kai Zhu, Cheng-Shi Jiang. Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation.
Bioorganic chemistry.
2021 10; 115(?):105236. doi:
10.1016/j.bioorg.2021.105236. [PMID: 34411978] - Daniel A Hussar. New Drugs 2021, Part 2.
Nursing.
2021 Oct; 51(10):18-29. doi:
10.1097/01.nurse.0000791756.56705.dd. [PMID: 34580258] - Andrzej Pokrywka, Monika Skrzypiec-Spring, Jarosław Krzywański, Michał Rynkowski, Martial Saugy, Raphael Faiss. Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control.
Drug testing and analysis.
2021 Oct; 13(10):1803-1806. doi:
10.1002/dta.3156. [PMID: 34463045] - Yuri Saeki, Megumi Kayanuma, Aki Nitta, Yasuteru Shigeta, Izuru Kawamura, Tetsuya Nakagawa, Takashi Ubukata, Yasushi Yokoyama. On-Demand Chirality Transfer of Human Serum Albumin to Bis(thiophen-2-yl)hexafluorocyclopentenes through Their Photochromic Ring Closure.
The Journal of organic chemistry.
2021 09; 86(18):12549-12558. doi:
10.1021/acs.joc.1c00849. [PMID: 34324316] - Fangjun Yu, Zhigang Wang, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu, Baojian Wu. Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Nature communications.
2021 09; 12(1):5323. doi:
10.1038/s41467-021-25674-5. [PMID: 34493722] - Yumi Harada, Hitomi Sekine, Kunitsugu Kubota, Daichi Sadatomi, Seiichi Iizuka, Naoki Fujitsuka. Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111860. doi:
10.1016/j.biopha.2021.111860. [PMID: 34246954] - Yuan-Dong Zheng, Hua Zhang, Yan Zhan, Yi-Cong Bian, Sheng Ma, Hai-Xian Gan, Xiao-Juan Lai, Yong-Qiang Liu, Yan-Chun Gong, Xue-Fang Liu, Hong-Bin Sun, Yong-Guo Li, Da-Fang Zhong, Li-Yan Miao, Xing-Xing Diao. Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta pharmacologica Sinica.
2021 Sep; 42(9):1535-1546. doi:
10.1038/s41401-020-00547-7. [PMID: 33244163] - Zhihong Yang, Rana V Smalling, Yi Huang, Yanchao Jiang, Praveen Kusumanchi, Will Bogaert, Li Wang, Don A Delker, Nicholas J Skill, Sen Han, Ting Zhang, Jing Ma, Nazmul Huda, Suthat Liangpunsakul. The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease.
JCI insight.
2021 08; 6(16):. doi:
10.1172/jci.insight.140687. [PMID: 34423788] - Christopher Päslack, Chandan K Das, Jürgen Schlitter, Lars V Schäfer. Spectrally Resolved Estimation of Water Entropy in the Active Site of Human Carbonic Anhydrase II.
Journal of chemical theory and computation.
2021 Aug; 17(8):5409-5418. doi:
10.1021/acs.jctc.1c00554. [PMID: 34259506] - Paulina Cieślik, Adrianna Radulska, Grzegorz Burnat, Leszek Kalinowski, Joanna M Wierońska. Serotonergic-Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168612. [PMID: 34445318] - Alessandro Poli, Shidqiyyah Abdul-Hamid, Antonio Enrico Zaurito, Francesca Campagnoli, Valeria Bevilacqua, Bhavwanti Sheth, Roberta Fiume, Massimiliano Pagani, Sergio Abrignani, Nullin Divecha. PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
Proceedings of the National Academy of Sciences of the United States of America.
2021 08; 118(31):. doi:
10.1073/pnas.2010053118. [PMID: 34312224] - Shu-Juan Yu, Jun-Sheng Zhang, Hei He, Jin-Hai Yu, Jie Bao, Hua Zhang. Thiophene enantiomers from the aerial parts of Eclipta prostrata.
Journal of Asian natural products research.
2021 Aug; 23(8):745-753. doi:
10.1080/10286020.2020.1769610. [PMID: 32447963] - De-Juan Li, Qin Yue, Lu Liu, Ke-Ke Che, Xue-Mei Liu, Chang-Hua Hu. Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats.
Acta pharmacologica Sinica.
2021 Aug; 42(8):1267-1279. doi:
10.1038/s41401-021-00680-x. [PMID: 33976388] - Jie Bai, Li-Yuan Xie, Li Yang, Run-Qin Wang, Xuan Chen, Shuang Hu. Reversed lipid micellar hollow-fiber liquid-phase microextraction of rotigotine in rat plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jul; 1178(?):122583. doi:
10.1016/j.jchromb.2021.122583. [PMID: 34224964] - Hideyuki Okuma, Kentaro Mori, Suguru Nakamura, Tetsuo Sekine, Yoshihiro Ogawa, Kyoichiro Tsuchiya. Ipragliflozin Ameliorates Diabetic Nephropathy Associated with Perirenal Adipose Expansion in Mice.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147329. [PMID: 34298949] - Takashi Hara, Yasukazu Hijikata, Yukiko Matsubara, Norio Watanabe. Pharmacological interventions versus placebo, no treatment or usual care for osteoporosis in people with chronic kidney disease stages 3-5D.
The Cochrane database of systematic reviews.
2021 Jul; 7(?):CD013424. doi:
10.1002/14651858.cd013424.pub2. [PMID: 34231877] - Vivian Rodriguez-Cruz, Marilyn E Morris. γ-Hydroxybutyric Acid-Ethanol Drug-Drug Interaction: Reversal of Toxicity with Monocarboxylate Transporter 1 Inhibitors.
The Journal of pharmacology and experimental therapeutics.
2021 07; 378(1):42-50. doi:
10.1124/jpet.121.000566. [PMID: 33963018] - Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio. Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway.
American journal of physiology. Cell physiology.
2021 07; 321(1):C82-C93. doi:
10.1152/ajpcell.00568.2020. [PMID: 34038245] - Shumin Yue, Tian Wang, Yunqi Yang, Yiqian Fan, Lin Zhou, Mingan Li, Fenghua Fu. Lipopolysaccharide/D-galactosamine-induced acute liver injury could be attenuated by dopamine receptor agonist rotigotine via regulating NF-κB signaling pathway.
International immunopharmacology.
2021 Jul; 96(?):107798. doi:
10.1016/j.intimp.2021.107798. [PMID: 34162160] - Flávio Augusto Sanches Politi, Renata Vieira Bueno, Lucas André Zeoly, Rafaela Regina Fantatto, Josimar de Oliveira Eloy, Marlus Chorilli, Fernando Coelho, Rafael Victório Carvalho Guido, Ana Carolina de Souza Chagas, Maysa Furlan. Anthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus.
Acta tropica.
2021 Jul; 219(?):105920. doi:
10.1016/j.actatropica.2021.105920. [PMID: 33861973] - Atsuo Tahara. Effects of SGLT2 inhibitor ipragliflozin alone and combined with pioglitazone on fluid retention in type 2 diabetic mice with NASH.
European journal of pharmacology.
2021 Jun; 901(?):174076. doi:
10.1016/j.ejphar.2021.174076. [PMID: 33798599] - Hao Zhao, Jingwen Xu, Endong Zhang, Ruilian Qi, Yiming Huang, Fengting Lv, Libing Liu, Qi Gu, Shu Wang. 3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment.
ACS applied materials & interfaces.
2021 Jun; 13(22):25759-25770. doi:
10.1021/acsami.1c04967. [PMID: 34036779] - Jaemin Lee, Michaela R Elliott, Toshihiko Yamada, Geunhwa Jung. Field Assessment of Six Point-Mutations in SDH Subunit Genes Conferring Varying Resistance Levels to SDHIs in Clarireedia spp.
Plant disease.
2021 Jun; 105(6):1685-1691. doi:
10.1094/pdis-06-20-1344-re. [PMID: 33944573] - Joseph Tsemeugne, Lahngong M Shinyuy, Sorel K D Djeukoua, Emmanuel F Sopbue, Moses N Ngemenya. Evaluation of macrofilaricidal and microfilaricidal activities against Onchocerca ochengi and cytotoxicity of some synthesized azo compounds containing thiophene backbone.
Parasitology research.
2021 Jun; 120(6):2087-2094. doi:
10.1007/s00436-021-07162-3. [PMID: 33864105] - Bangqing Wu, Lijun Wu, Yingju He, Zongning Yin, Li Deng. Engineered PLGA microspheres for extended release of brexpiprazole: in vitro and in vivo studies.
Drug development and industrial pharmacy.
2021 Jun; 47(6):1001-1010. doi:
10.1080/03639045.2021.1934859. [PMID: 34032181] - Qiang Liu, Jiangwei Tian, Ye Tian, Qinchao Sun, Dan Sun, Dewen Liu, Feifei Wang, Haijun Xu, Guoliang Ying, Jigang Wang, Ali K Yetisen, Nan Jiang. Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy.
Acta biomaterialia.
2021 06; 127(?):287-297. doi:
10.1016/j.actbio.2021.03.064. [PMID: 33831570] - Moying Wang, Stephen Van Vleet, Rebecca McGee, Timothy Paulitz, Lyndon Porter, Kurtis Schroeder, George Vandemark, Weidong Chen. Chickpea Seed Rot and Damping-Off Caused by Metalaxyl-Resistant Pythium ultimum and Its Management with Ethaboxam.
Plant disease.
2021 Jun; 105(6):1728-1737. doi:
10.1094/pdis-08-20-1659-re. [PMID: 33118871] - Yutaka Seino, Kohei Kaku, Takashi Kadowaki, Taro Okamoto, Asako Sato, Masayoshi Shirakawa, Edward A O'Neill, Samuel S Engel, Keith D Kaufman. A randomized, placebo-controlled trial to assess the efficacy and safety of sitagliptin in Japanese patients with type 2 diabetes and inadequate glycaemic control on ipragliflozin.
Diabetes, obesity & metabolism.
2021 06; 23(6):1342-1350. doi:
10.1111/dom.14346. [PMID: 33565686] - Kouji Fukuyama, Motohiro Okada. Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115623. [PMID: 34070699] - Brad Hayes, Scott Wiseman, Daniel E Snyder. Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe.
Parasites & vectors.
2021 May; 14(1):258. doi:
10.1186/s13071-021-04766-7. [PMID: 34001223] - Li-Ching Chang, Chiu-Yen Chung, Chun-Hui Chiu, Martin Hsiu-Chu Lin, Jen-Tsung Yang. The Effect of Polybutylcyanoacrylate Nanoparticles as a Protos Delivery Vehicle on Dental Bone Formation.
International journal of molecular sciences.
2021 May; 22(9):. doi:
10.3390/ijms22094873. [PMID: 34062952] - Xiao Gao, Mingwei Guo, Ming Liu, Li Zhang, Zhiyi Yao. A fluorometric and colorimetric approach for the rapid detection of berberine hydrochloride based on an anionic polythiophene derivative.
Luminescence : the journal of biological and chemical luminescence.
2021 May; 36(3):668-673. doi:
10.1002/bio.3986. [PMID: 33179429]
