4733-35-1 (BioDeep_00000865475)
Main id: BioDeep_00000402817
PANOMIX_OTCML-2023
代谢物信息卡片
(1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[8,7-g]benzofuran-10,11-quinone
化学式: C19H20O3 (296.1412)
中文名称: 隐丹参酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
InChI: InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
描述信息
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
同义名列表
18 个代谢物同义名
(1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[8,7-g]benzofuran-10,11-quinone; Phenanthro[1,2-b]furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (1R)-; (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[8,7-g][1]benzoxole-10,11-dione; Phenanthro(1,2-b)furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (R)-; (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[8,7-g]benzofuran-10,11-dione; (-)-Cryptotanshinone; Cryptotanshinone; SPECTRUM1505812; NCGC00163650-01; MLS001049002; NCI60_031208; ZINC02109876; SMR000387041; 35825-57-1; BB_NC-1574; 4733-35-1; Cryptotanshinon; Tanshinone c
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:149838
- PubChem: 160254
- DrugBank: DB15579
- ChEMBL: CHEMBL187460
- CAS: 35825-57-1
- CAS: 4733-35-1
- medchemexpress: HY-N0174
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Xinni Yang, Xianlan She, Zhishuang Zhao, Jian Ren, Peiying Wang, Haoqi Dong, Qin-Shi Zhao, Jiangxin Liu. In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma.
European journal of pharmacology.
2024 May; 971(?):176522. doi:
10.1016/j.ejphar.2024.176522. [PMID: 38522640] - Tong Wang, Mengmeng Zhang, Muhammad Khan, Jingjing Li, Xiao Wu, Tonghui Ma, Yongming Li. Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 170(?):115956. doi:
10.1016/j.biopha.2023.115956. [PMID: 38039759] - Zongjia Li, Wei Wei, Miaomiao Zhang, Xinyue Guo, Bailin Zhang, Dapeng Wang, Xiue Jiang, Fangxin Liu, Jilin Tang. Cryptotanshinone-Doped Photothermal Synergistic MXene@PDA Nanosheets with Antibacterial and Anti-Inflammatory Properties for Wound Healing.
Advanced healthcare materials.
2023 11; 12(28):e2301060. doi:
10.1002/adhm.202301060. [PMID: 37387333] - Yi-Chao Liu, Jun-Wen Wang, Jia Li, Ying Guo, Feng-Juan Han, Wei-Hong Lu, Qiong Wu. Mechanism of cryptotanshinone to improve endocrine and metabolic functions in the endometrium of PCOS rats.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 3):117346. doi:
10.1016/j.jep.2023.117346. [PMID: 37879506] - Farzaneh Khodadadi, Farajollah Shahriai Ahmadi, Majid Talebi, Adam Matkowski, Antoni Szumny, Mahvash Afshari, Mehdi Rahimmalek. Metabolic and Transcriptomic Approaches of Chitosan and Water Stress on Polyphenolic and Terpenoid Components and Gene Expression in Salvia abrotanoides (Karl.) and S. yangii.
International journal of molecular sciences.
2023 Oct; 24(20):. doi:
10.3390/ijms242015426. [PMID: 37895107] - Yueting Yu, Jia Wang, Qingze Liu, Fangyong Wei, Xuejun Xie, Mei Zhang. Integrated serum pharmacochemistry and serum pharmacology to investigate the active components and mechanism of Bushen Huoxue Prescription in the treatment of diabetic retinopathy.
Journal of pharmaceutical and biomedical analysis.
2023 Jul; 235(?):115586. doi:
10.1016/j.jpba.2023.115586. [PMID: 37494766] - Zahra Sadeghi, Antonietta Cerulli, Stefania Marzocco, Mahdi Moridi Farimani, Milena Masullo, Sonia Piacente. Anti-inflammatory Activity of Tanshinone-Related Diterpenes from Perovskia artemisioides Roots.
Journal of natural products.
2023 04; 86(4):812-821. doi:
10.1021/acs.jnatprod.2c01004. [PMID: 37040078] - Yue Li, Qian Wang, Jingyi Jin, Bo Tan, Jie Ren, Guochao Song, Bin Zou, Fengyi Weng, Dongming Yan, Furong Qiu. 15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation.
Toxicology letters.
2023 Feb; 377(?):62-70. doi:
10.1016/j.toxlet.2023.02.005. [PMID: 36804361] - Jiahao Fang, Yuzhen He, Yuhong Cao, Yiwei Shi, Hui Wang, Zhanying Hong, Yifeng Chai. Effect of P-Glycoprotein on the Blood-Brain Barrier Transport of the Major Active Constituents of Salvia miltiorrhiza Based on the MDCK-MDR1 Cell Model.
ACS chemical neuroscience.
2023 02; 14(4):766-772. doi:
10.1021/acschemneuro.2c00757. [PMID: 36704945] - Annika Roth, Piwen Zhao, Sebastian T Soukup, Claudia Guigas, Joachim Stärke, Sabine E Kulling, Patrick Diel. Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems.
Toxicology letters.
2023 Feb; 375(?):21-28. doi:
10.1016/j.toxlet.2022.12.002. [PMID: 36563867] - Xiao-Tian Jiang, Ye Qiu, Cong-Hua Li. Cryptotanshinone inhibits oral squamous cell carcinoma through the autophagic pathway.
Neoplasma.
2023 Feb; 70(1):114-122. doi:
10.4149/neo_2023_220924n957. [PMID: 36704921] - Ling-Ling Zheng, Mei-Lan Chen, Li-Ping Kang, Ying-Li Wang, Xiu-Teng Zhou. [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(2):349-355. doi:
10.19540/j.cnki.cjcmm.20221017.101. [PMID: 36725224] - Tokio Terado, Chul Jang Kim, Akiyo Ushio, Kahori Minami, Yukihiro Tambe, Susumu Kageyama, Akihiro Kawauchi, Toshiyuki Tsunoda, Senji Shirasawa, Hiroyuki Tanaka, Hirokazu Inoue. Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells.
International journal of oncology.
2022 Sep; 61(3):. doi:
10.3892/ijo.2022.5398. [PMID: 35894141] - Zhaoming Zhu, Quanfu Zeng, Zhuxian Wang, Yaqi Xue, Tingting Chen, Yi Hu, Yuan Wang, Yufan Wu, Qun Shen, Cuiping Jiang, Chunyan Shen, Li Liu, Hongxia Zhu, Qiang Liu. Skin microbiome reconstruction and lipid metabolism profile alteration reveal the treatment mechanism of Cryptotanshinone in the acne rat.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 101(?):154101. doi:
10.1016/j.phymed.2022.154101. [PMID: 35472695] - Mingxiao Wen, Xiaoqing Dou, Shuzhen Zhang, Bin Wang, Jiangyan Xu, Wenchao Zhang, Feifei Wang. CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone.
Molecular medicine reports.
2022 Jul; 26(1):. doi:
10.3892/mmr.2022.12761. [PMID: 35656892] - Li-Ming Fan, Yu-Qin Zhang, Ya-Ping Chen, Lin-Lin Chen, Wei-Heng Xu, Li-Hong Nan, Wei Xu, Bin Lu, Yan Wang, Ke-Dan Chu, Jun-Ping Zhang. Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation.
International immunopharmacology.
2022 Jul; 108(?):108894. doi:
10.1016/j.intimp.2022.108894. [PMID: 35729830] - Haswanth Vundavilli, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael Bittner, Tasha Miller, Heather M Wilson-Robles. Anti-tumor effects of cryptotanshinone (C19H20O3) in human osteosarcoma cell lines.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112993. doi:
10.1016/j.biopha.2022.112993. [PMID: 35462337] - Jiangxin Liu, Jian Ren, Kun Yang, Shuang Chen, Xinni Yang, Qin-Shi Zhao. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase.
European journal of medicinal chemistry.
2022 May; 235(?):114294. doi:
10.1016/j.ejmech.2022.114294. [PMID: 35358772] - Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Apr; 80(?):105324. doi:
10.1016/j.tiv.2022.105324. [PMID: 35101544] - Valentina Zanrè, Rachele Campagnari, Antonietta Cerulli, Milena Masullo, Alessia Cardile, Sonia Piacente, Marta Menegazzi. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031121. [PMID: 35163058] - Jie Liu, Yun Shi, Chengyuan Wu, Bangzhen Hong, Daiyin Peng, Nianjun Yu, Guokai Wang, Lei Wang, Weidong Chen. Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and Rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation.
Current drug metabolism.
2022; 23(6):473-483. doi:
10.2174/1389200223666220517115845. [PMID: 35585828] - Honglin Liu, Jiani Xie, Limin Fan, Yue Xia, Xia Peng, Jianhua Zhou, Xiaorong Ni. Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
Oxidative medicine and cellular longevity.
2022; 2022(?):8011850. doi:
10.1155/2022/8011850. [PMID: 35419170] - Danning Shi, Hongbo Li, Zeye Zhang, Yueshuang He, Meng Chen, Liping Sun, Piwen Zhao. Cryptotanshinone inhibits proliferation and induces apoptosis of breast cancer MCF-7 cells via GPER mediated PI3K/AKT signaling pathway.
PloS one.
2022; 17(1):e0262389. doi:
10.1371/journal.pone.0262389. [PMID: 35061800] - Jiwei Zhong, Haidan Wang, Yun Zhuang, Qun Shen. Identification of the antibacterial mechanism of cryptotanshinone on methicillin-resistant Staphylococcus aureus using bioinformatics analysis.
Scientific reports.
2021 11; 11(1):21726. doi:
10.1038/s41598-021-01121-9. [PMID: 34741111] - Yu Gu, Weiming Liu, Gaoqin Liu, Xin Li, Peirong Lu. Assessing the protective effects of cryptotanshinone on CoCl2‑induced hypoxia in RPE cells.
Molecular medicine reports.
2021 Oct; 24(4):. doi:
10.3892/mmr.2021.12379. [PMID: 34435647] - Yongpeng Zhang, Fei Luo, Haixia Zhang, Wei He, Ting Liu, Yue Wu, Lei Zhang, Gang Shi. Cryptotanshinone ameliorates cardiac injury and cardiomyocyte apoptosis in rats with coronary microembolization.
Drug development research.
2021 06; 82(4):581-588. doi:
10.1002/ddr.21777. [PMID: 33340142] - Huayao Li, Chundi Gao, Cun Liu, Lijuan Liu, Jing Zhuang, Jing Yang, Chao Zhou, Fubin Feng, Changgang Sun, Jibiao Wu. A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111332. doi:
10.1016/j.biopha.2021.111332. [PMID: 33548911] - Ying-Shih Su, Min Zhan Kuo, Yi Ting Kuo, Shu-Wei Huang, Chia-Jung Lee, Zheng-Yuan Su, Yu-Hui Ni, Dian-Kun Li, Tien-Yuan Wu. Diterpenoid anthraquinones as chemopreventive agents altered microRNA and transcriptome expressions in cancer cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Apr; 136(?):111260. doi:
10.1016/j.biopha.2021.111260. [PMID: 33465676] - Xiuhong Li, Bin Zhang, Pengda Ma, Ruizhi Cao, Xiaobing Yang, Juane Dong. Plasma Membrane H+-ATPase SmPHA4 Negatively Regulates the Biosynthesis of Tanshinones in Salvia miltiorrhiza.
International journal of molecular sciences.
2021 Mar; 22(7):. doi:
10.3390/ijms22073353. [PMID: 33805926] - Dong-Jun Fu, Jun Li, Bin Yu. Annual review of LSD1/KDM1A inhibitors in 2020.
European journal of medicinal chemistry.
2021 Mar; 214(?):113254. doi:
10.1016/j.ejmech.2021.113254. [PMID: 33581557] - Xiaoping Wang, Qianbin Sun, Qianqian Jiang, Yanyan Jiang, Yawen Zhang, Jing Cao, Linghui Lu, Chun Li, Peng Wei, Qiyan Wang, Yong Wang. Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro.
Molecules (Basel, Switzerland).
2021 Mar; 26(5):. doi:
10.3390/molecules26051460. [PMID: 33800264] - Hefeng Wang, Wenhui Pang, Xingsheng Xu, Beian You, Cuijuan Zhang, Dan Li. Cryptotanshinone Attenuates Ischemia/Reperfusion-induced Apoptosis in Myocardium by Upregulating MAPK3.
Journal of cardiovascular pharmacology.
2021 03; 77(3):370-377. doi:
10.1097/fjc.0000000000000971. [PMID: 33662979] - Hongbin Liu, Xiaoyan Zhan, Guang Xu, Zhilei Wang, Ruisheng Li, Yan Wang, Qin Qin, Wei Shi, Xiaorong Hou, Ruichuang Yang, Jian Wang, Xiaohe Xiao, Zhaofang Bai. Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases.
Pharmacological research.
2021 02; 164(?):105384. doi:
10.1016/j.phrs.2020.105384. [PMID: 33352229] - Mei-Ting Liu, Jing Zhao, Shao-Ping Li. Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza.
Journal of chromatography. A.
2021 Jan; 1637(?):461826. doi:
10.1016/j.chroma.2020.461826. [PMID: 33387914] - Gang Shi, Ying Wang, Jie Yang, Ting Liu, Fei Luo, Guoyin Jin, Yuan Ma, Yongpeng Zhang. Effect of Cryptotanshinone on Measures of Rat Cardiomyocyte Oxidative Stress and Gene Activation Associated with Apoptosis.
Cardiorenal medicine.
2021; 11(1):18-26. doi:
10.1159/000507184. [PMID: 33326961] - Milad Ashrafizadeh, Ali Zarrabi, Sima Orouei, Sedigheh Saberifar, Saeed Salami, Kiavash Hushmandi, Masoud Najafi. Recent advances and future directions in anti-tumor activity of cryptotanshinone: A mechanistic review.
Phytotherapy research : PTR.
2021 Jan; 35(1):155-179. doi:
10.1002/ptr.6815. [PMID: 33507609] - Lin Wang, Rui Wang, Guang-Yi Wei, Rui-Ping Zhang, Ying Zhu, Zhe Wang, Shu-Mei Wang, Guan-Hua Du. Cryptotanshinone alleviates chemotherapy-induced colitis in mice with colon cancer via regulating fecal-bacteria-related lipid metabolism.
Pharmacological research.
2021 01; 163(?):105232. doi:
10.1016/j.phrs.2020.105232. [PMID: 33027716] - Bin Zhang, Xueying Li, Xiuhong Li, Zhigang Lu, Xiaona Cai, Qing Ou Yang, Pengda Ma, Juane Dong. Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca2+-Dependent Manner in Salvia miltiorrhiza Hairy Roots.
International journal of molecular sciences.
2020 Dec; 21(24):. doi:
10.3390/ijms21249576. [PMID: 33339149] - Min Song, Lu Chen, Lusha Zhang, Chunxiao Li, Joel Wake Coffie, Zhirui Fang, Liyuan Zhang, Shaoxia Wang, Xiumei Gao, Hong Wang. Cryptotanshinone enhances wound healing in type 2 diabetes with modulatory effects on inflammation, angiogenesis and extracellular matrix remodelling.
Pharmaceutical biology.
2020 Dec; 58(1):845-853. doi:
10.1080/13880209.2020.1803369. [PMID: 32870741] - Jie Li, Bo Li, Lu Luo, Fulin Cao, Bingyue Yang, Jing Gao, Yonggang Yan, Gang Zhang, Liang Peng, Benxiang Hu. Increased phenolic acid and tanshinone production and transcriptional responses of biosynthetic genes in hairy root cultures of Salvia przewalskii Maxim. treated with methyl jasmonate and salicylic acid.
Molecular biology reports.
2020 Nov; 47(11):8565-8578. doi:
10.1007/s11033-020-05899-1. [PMID: 33048323] - Yijiao Yang, Ling Yang, Cao Qi, Guohua Hu, Longhui Wang, Zhuojun Sun, Xiaorong Ni. Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1/TLR4/NF‑κB signaling pathway.
Molecular medicine reports.
2020 Nov; 22(5):3851-3861. doi:
10.3892/mmr.2020.11469. [PMID: 32901834] - Jing-Shuai Wu, Qin-Yu Meng, Xiao-Hui Shi, Lu-Xin Liu, Zhen-Kun Zhang, Hua-Shi Guan, Chang-Lun Shao, Chang-Yun Wang. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway.
Bioorganic chemistry.
2020 11; 104(?):104246. doi:
10.1016/j.bioorg.2020.104246. [PMID: 32911197] - Linlin Chen, Quanjun Yang, Hong Zhang, Lili Wan, Bo Xin, Yan Cao, Junping Zhang, Cheng Guo. Cryptotanshinone prevents muscle wasting in CT26-induced cancer cachexia through inhibiting STAT3 signaling pathway.
Journal of ethnopharmacology.
2020 Oct; 260(?):113066. doi:
10.1016/j.jep.2020.113066. [PMID: 32505837] - Zhe-Rui Zhang, Ya-Nan Zhang, Xiao-Dan Li, Hong-Qing Zhang, Shu-Qi Xiao, Fei Deng, Zhi-Ming Yuan, Han-Qing Ye, Bo Zhang. A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2.
Signal transduction and targeted therapy.
2020 10; 5(1):218. doi:
10.1038/s41392-020-00343-z. [PMID: 33011739] - Jing-Shuai Wu, Qin-Yu Meng, Ya-Hui Zhang, Xiao-Hui Shi, Xiu-Mei Fu, Peng Zhang, Xin Li, Chang-Lun Shao, Chang-Yun Wang. Annular oxygenation and rearrangement products of cryptotanshinone by biotransformation with marine-derived fungi Cochliobolus lunatus and Aspergillus terreus.
Bioorganic chemistry.
2020 10; 103(?):104192. doi:
10.1016/j.bioorg.2020.104192. [PMID: 32889382] - Xiangjing Min, Xi Zeng, Wenwen Zhao, Zhiwu Han, Ying Wang, Yantao Han, Lixia Pei, Xiuping Chen. Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.
Phytotherapy research : PTR.
2020 Oct; 34(10):2639-2648. doi:
10.1002/ptr.6693. [PMID: 32302031] - Yan-Hong Wu, Yu-Rui Wu, Bo Li, Zhu-Yun Yan. Cryptotanshinone: A review of its pharmacology activities and molecular mechanisms.
Fitoterapia.
2020 Sep; 145(?):104633. doi:
10.1016/j.fitote.2020.104633. [PMID: 32445662] - Na Wang, Xiujuan Dong, Dandan Shi, Na Li, Qun Zhang. Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus.
Archives of pharmacal research.
2020 Jul; 43(7):755-764. doi:
10.1007/s12272-020-01242-1. [PMID: 32601882] - Carmen De Caro, Federica Raucci, Anella Saviano, Claudia Cristiano, Gian Marco Casillo, Ritamaria Di Lorenzo, Antonia Sacchi, Sonia Laneri, Irene Dini, Simona De Vita, Maria Giovanna Chini, Giuseppe Bifulco, Antonio Calignano, Francesco Maione, Nicola Mascolo. Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Jun; 126(?):110042. doi:
10.1016/j.biopha.2020.110042. [PMID: 32203893] - Zhuxian Wang, Li Liu, Shijian Xiang, Cuiping Jiang, Wenfeng Wu, Shifa Ruan, Qunqun Du, Tingting Chen, Yaqi Xue, Huoji Chen, Lidong Weng, Hongxia Zhu, Qun Shen, Qiang Liu. Formulation and Characterization of a 3D-Printed Cryptotanshinone-Loaded Niosomal Hydrogel for Topical Therapy of Acne.
AAPS PharmSciTech.
2020 May; 21(5):159. doi:
10.1208/s12249-020-01677-1. [PMID: 32476076] - Ying Liu, Xingmei Xie, Xuefeng Hou, Junyi Shen, Jiangpei Shi, Haizhen Chen, Yuanzhi He, Zhi Wang, Nianping Feng. Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis.
Journal of nanobiotechnology.
2020 May; 18(1):83. doi:
10.1186/s12951-020-00638-x. [PMID: 32473632] - Le Li, Bin Wu, Qiangqiang Zhao, Jian Li, Yunfeng Han, Xiaohang Fan, Junli Dong, Pengcheng Li. Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway.
Aging.
2020 05; 12(10):9585-9603. doi:
10.18632/aging.103228. [PMID: 32457254] - Jianzhen Huang, Fang Zeng, Qinggang Xu, Jianmin Ma. Cryptotanshinone decreases granulosa cell apoptosis and restores ovarian function in mice with premature ovarian failure.
General physiology and biophysics.
2020 May; 39(3):277-283. doi:
10.4149/gpb_2019059. [PMID: 32525821] - Danning Shi, Piwen Zhao, Lixia Cui, Hongbo Li, Liping Sun, Jianzhao Niu, Meng Chen. Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells.
BMC pharmacology & toxicology.
2020 05; 21(1):32. doi:
10.1186/s40360-020-00410-9. [PMID: 32357920] - Yuanyuan Li, Zhuoni Hou, Feng Su, Jipeng Chen, Xiaodan Zhang, Ling Xu, Dongfeng Yang, Zongsuo Liang. Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy.
Molecules (Basel, Switzerland).
2020 Apr; 25(9):. doi:
10.3390/molecules25092043. [PMID: 32353926] - Xiaoling Nie, Yuan Liu, Ming Li, Xuesong Yu, Wanwen Yuan, Sixi Huang, Di Ren, Ying Wang, Yan Wang. SP94 Peptide-Functionalized PEG-PLGA Nanoparticle Loading with Cryptotanshinone for Targeting Therapy of Hepatocellular Carcinoma.
AAPS PharmSciTech.
2020 Apr; 21(4):124. doi:
10.1208/s12249-020-01655-7. [PMID: 32342227] - Shuna Cui, Shanshan Chen, Qingqing Wu, Tingting Chen, Shihua Li. A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza.
International immunopharmacology.
2020 Apr; 81(?):106040. doi:
10.1016/j.intimp.2019.106040. [PMID: 31818704] - Daifei Wang, Weibang Yu, Lin Cao, Chuncao Xu, Guoyao Tan, Zhongxiang Zhao, Min Huang, Jing Jin. Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats.
Biopharmaceutics & drug disposition.
2020 Feb; 41(1-2):54-63. doi:
10.1002/bdd.2213. [PMID: 31943245] - Arulkumar Nagappan, Ji-Hyun Kim, Dae Young Jung, Myeong Ho Jung. Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways.
International journal of molecular sciences.
2019 Dec; 21(1):. doi:
10.3390/ijms21010265. [PMID: 31906014] - Tao Bai, Kang Yang, Cong Qin, Tao Xu, Xi Yu, Jie Zhang. Cryptotanshinone ameliorates renal ischaemia-reperfusion injury by inhibiting apoptosis and inflammatory response.
Basic & clinical pharmacology & toxicology.
2019 Nov; 125(5):420-429. doi:
10.1111/bcpt.13275. [PMID: 31219678] - Mingya Ding, Wenfang Ma, Xiaoyan Wang, Shujing Chen, Shuhan Zou, Jinna Wei, Yuqiao Yang, Jin Li, Xuejing Yang, Hui Wang, Yuhong Li, Qilong Wang, Haoping Mao, Xiu-Mei Gao, Yan-Xu Chang. A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease.
Journal of ethnopharmacology.
2019 Oct; 242(?):112055. doi:
10.1016/j.jep.2019.112055. [PMID: 31276751] - Lindsay K Caesar, Sabina Nogo, Cassandra N Naphen, Nadja B Cech. Simplify: A Mass Spectrometry Metabolomics Approach to Identify Additives and Synergists from Complex Mixtures.
Analytical chemistry.
2019 09; 91(17):11297-11305. doi:
10.1021/acs.analchem.9b02377. [PMID: 31365233] - Yu Du, Lijun Du, Zhixing He, Jia Zhou, Chengping Wen, Yun Zhang. Cryptotanshinone ameliorates the pathogenesis of systemic lupus erythematosus by blocking T cell proliferation.
International immunopharmacology.
2019 Sep; 74(?):105677. doi:
10.1016/j.intimp.2019.105677. [PMID: 31177018] - Stefan Esch, Simone König, Bertan Bopp, Joachim Jose, Simone Brandt, Andreas Hensel. Cryptotanshinone from Salvia miltiorrhiza Roots Reduces Cytokeratin CK1/10 Expression in Keratinocytes by Activation of Peptidyl-prolyl-cis-trans-isomerase FKBP1A.
Planta medica.
2019 May; 85(7):552-562. doi:
10.1055/a-0660-0441. [PMID: 30036889] - Jin He, Xiaoyi Zhong, Lin Zhao, Hua Gan. JAK2/STAT3/BMP-2 axis and NF-κB pathway are involved in erythropoietin-induced calcification in rat vascular smooth muscle cells.
Clinical and experimental nephrology.
2019 Apr; 23(4):501-512. doi:
10.1007/s10157-018-1666-z. [PMID: 30406500] - Octavio Galindo-Hernández, Iván Córdova-Guerrero, Laura Janeth Díaz-Rubio, Ángel Pulido-Capiz, José Fernando Díaz-Villanueva, César Yahel Castañeda-Sánchez, Nicolás Serafín-Higuera, Víctor García-González. Protein translation associated to PERK arm is a new target for regulation of metainflammation: A connection with hepatocyte cholesterol.
Journal of cellular biochemistry.
2019 03; 120(3):4158-4171. doi:
10.1002/jcb.27701. [PMID: 30320914] - Jia-Hau Yen, Hung Sen Huang, Chia Ju Chuang, Sheng-Teng Huang. Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone.
Journal of experimental & clinical cancer research : CR.
2019 Jan; 38(1):42. doi:
10.1186/s13046-018-1008-8. [PMID: 30691497] - Jia Fu, Yanni Lv, Qianqian Jia, Yuanyuan Lin, Shengli Han. Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors.
Talanta.
2019 Jan; 192(?):248-254. doi:
10.1016/j.talanta.2018.09.053. [PMID: 30348386] - Wei Wang, Xiao Wang, Xian-Sheng Zhang, Chao-Zhao Liang. Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-κB in Mice with Unilateral Ureteral Obstruction.
Basic & clinical pharmacology & toxicology.
2018 Dec; 123(6):714-720. doi:
10.1111/bcpt.13091. [PMID: 29972887] - Julia Huei-Mei Chang, Chih-Hsueh Lin, Marthandam Asokan Shibu, Yung-Chen Chou, Jer-Yuh Liu, Yen-Hong Chou, Chia-Yao Shen, Yu-Lan Yeh, Vijaya Padma Viswanadha, Chih-Yang Huang. Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.
Environmental toxicology.
2018 Dec; 33(12):1254-1260. doi:
10.1002/tox.22633. [PMID: 30208247] - Sang-A Kim, Ok-Hwa Kang, Dong-Yeul Kwon. Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway.
International journal of molecular sciences.
2018 Sep; 19(9):. doi:
10.3390/ijms19092739. [PMID: 30217003] - Jin Zeng, Yu-Juan Fan, Bo Tan, Hui-Zong Su, Yue Li, Lin-Lin Zhang, Jian Jiang, Fu-Rong Qiu. Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro.
Acta pharmacologica Sinica.
2018 Aug; 39(8):1393-1404. doi:
10.1038/aps.2017.144. [PMID: 29417949] - Hongwei Gao, Liting Huang, Fang Ding, Ke Yang, Yulin Feng, Hongzhen Tang, Qiong-Ming Xu, Jianfang Feng, Shilin Yang. Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation.
Scientific reports.
2018 05; 8(1):8460. doi:
10.1038/s41598-018-26828-0. [PMID: 29855534] - Feng Liu, Xia DU, Pei-Rong Liu, Yu-Hong Sun, Yan-Min Zhang. Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology.
Chinese journal of natural medicines.
2018 Apr; 16(4):302-312. doi:
10.1016/s1875-5364(18)30060-8. [PMID: 29703330] - Lipeng Tang, Songmin He, Xieqi Wang, Hongying Liu, Ying Zhu, Bing Feng, Zuqing Su, Wei Zhu, Bo Liu, Fangfang Xu, Chutian Li, Jie Zhao, Xirun Zheng, Chuanjian Lu, Guangjuan Zheng. Cryptotanshinone reduces psoriatic epidermal hyperplasia via inhibiting the activation of STAT3.
Experimental dermatology.
2018 03; 27(3):268-275. doi:
10.1111/exd.13511. [PMID: 29427477] - Francesco Maione, Marialuisa Piccolo, Simona De Vita, Maria Giovanna Chini, Claudia Cristiano, Carmen De Caro, Pellegrino Lippiello, Maria Concetta Miniaci, Rita Santamaria, Carlo Irace, Vincenzo De Feo, Antonio Calignano, Nicola Mascolo, Giuseppe Bifulco. Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer's disease.
Pharmacological research.
2018 03; 129(?):482-490. doi:
10.1016/j.phrs.2017.11.018. [PMID: 29158049] - Da Hye Kim, Pradeep Paudel, Ting Yu, Thi Men Ngo, Jeong Ah Kim, Hyun Ah Jung, Takako Yokozawa, Jae Sue Choi. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B.
Chemico-biological interactions.
2017 Dec; 278(?):65-73. doi:
10.1016/j.cbi.2017.10.013. [PMID: 29031618] - Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs).
Pharmaceutical biology.
2017 Dec; 55(1):1703-1709. doi:
10.3109/13880209.2015.1045621. [PMID: 28466663] - Weixin Zhu, Weihong Qiu, Ailan Lu. Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT‑eNOS signaling pathway.
Molecular medicine reports.
2017 Dec; 16(6):9361-9366. doi:
10.3892/mmr.2017.7824. [PMID: 29152647] - Amina M Medhat, Khaled Sh Azab, Mahmoud M Said, Neama M El Fatih, Nermeen M El Bakary. Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2017 Oct; 39(10):1010428317728480. doi:
10.1177/1010428317728480. [PMID: 29022496] - Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zheng. Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma.
Oncotarget.
2017 Jul; 8(30):50023-50033. doi:
10.18632/oncotarget.18483. [PMID: 28654902] - Guoqiang Jiang, Jia Liu, Baoyin Ren, Lin Zhang, Lawrence Owusu, Likun Liu, Jing Zhang, Yawei Tang, Weiling Li. Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro.
Journal of ethnopharmacology.
2017 Jun; 205(?):33-40. doi:
10.1016/j.jep.2017.04.026. [PMID: 28456578] - Xiaoming Xu, Li Wu, Xinbin Zhou, Nanyang Zhou, Qin Zhuang, Jinxiu Yang, Jin Dai, Haibing Wang, Shenjie Chen, Wei Mao. Cryptotanshinone inhibits VEGF-induced angiogenesis by targeting the VEGFR2 signaling pathway.
Microvascular research.
2017 05; 111(?):25-31. doi:
10.1016/j.mvr.2016.12.011. [PMID: 28040437] - Shih-Hsiang Lo, Chao-Tien Hsu, Ho-Shan Niu, Chiang-Shan Niu, Juei-Tang Cheng, Zhih-Cherng Chen. Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats.
Phytotherapy research : PTR.
2017 Apr; 31(4):638-646. doi:
10.1002/ptr.5777. [PMID: 28176375] - Bin Li, Guanghong Cui, Guoan Shen, Zhilai Zhan, Luqi Huang, Jiachun Chen, Xiaoquan Qi. Targeted mutagenesis in the medicinal plant Salvia miltiorrhiza.
Scientific reports.
2017 03; 7(?):43320. doi:
10.1038/srep43320. [PMID: 28256553] - Feng Liu, Zhuang-Zhuang Huang, Yu-Hong Sun, Ting Li, Dong-Hua Yang, Gang Xu, Ying-Ying Su, Tao Zhang. Four Main Active Ingredients Derived from a Traditional Chinese Medicine Guanxin Shutong Capsule Cause Cardioprotection during Myocardial Ischemia Injury Calcium Overload Suppression.
Phytotherapy research : PTR.
2017 Mar; 31(3):507-515. doi:
10.1002/ptr.5787. [PMID: 28164397] - Jiye Wang, Guangji Zhang, Chunyan Dai, Xiufei Gao, Jianbin Wu, Li Shen, Zhe Chen, Pei Liu. Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity.
The Journal of international medical research.
2017 Feb; 45(1):220-230. doi:
10.1177/0300060516685513. [PMID: 28222632] - Zhong Xue, Bing Xu, Xinyuan Shi, Chan Yang, Xianglong Cui, Gan Luo, Yanjiang Qiao. Overall uncertainty measurement for near infrared analysis of cryptotanshinone in tanshinone extract.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2017 Jan; 170(?):39-47. doi:
10.1016/j.saa.2016.07.003. [PMID: 27404670] - F Sezer Senol, Sylwester Ślusarczyk, Adam Matkowski, Alfonso Pérez-Garrido, Francisco Girón-Rodríguez, José P Cerón-Carrasco, Helena den-Haan, Jorge Peña-García, Horacio Pérez-Sánchez, Krzysztof Domaradzki, Ilkay Erdogan Orhan. Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.
Phytochemistry.
2017 Jan; 133(?):33-44. doi:
10.1016/j.phytochem.2016.10.012. [PMID: 27817931] - Madeleine Ong, Jie Peng, Xingliang Jin, Xianqin Qu. Chinese Herbal Medicine for the Optimal Management of Polycystic Ovary Syndrome.
The American journal of Chinese medicine.
2017; 45(3):405-422. doi:
10.1142/s0192415x17500252. [PMID: 28359195] - Xuan Ding, Yan Cao, Yongfang Yuan, Zhirong Gong, Yue Liu, Liang Zhao, Lei Lv, Guoqing Zhang, Dongyao Wang, Dan Jia, Zhenyu Zhu, Zhanying Hong, Xiaofei Chen, Yifeng Chai. Development of APTES-Decorated HepG2 Cancer Stem Cell Membrane Chromatography for Screening Active Components from Salvia miltiorrhiza.
Analytical chemistry.
2016 12; 88(24):12081-12089. doi:
10.1021/acs.analchem.6b02709. [PMID: 28193057] - Hong-Die Cai, Shu-Lan Su, Yonghui Li, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Dawei Qian, Jinao Duan. Simultaneous Determination of Four Tanshinones by UPLC-TQ/MS and Their Pharmacokinetic Application after Administration of Single Ethanol Extract of Danshen Combined with Water Extract in Normal and Adenine-Induced Chronic Renal Failure Rats.
Molecules (Basel, Switzerland).
2016 Nov; 21(12):. doi:
10.3390/molecules21121630. [PMID: 27916808] - Zhijie Zhu, Yang Zhao, Junbo Li, Li Tao, Peiliang Shi, Zhonghong Wei, Xiaobo Sheng, Dandan Shen, Zhaoguo Liu, Liang Zhou, Chao Tian, Fangtian Fan, Cunsi Shen, Pingting Zhu, Aiyun Wang, Wenxing Chen, Qingshun Zhao, Yin Lu. Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR.
Molecular carcinogenesis.
2016 10; 55(10):1399-410. doi:
10.1002/mc.22383. [PMID: 26310813] - Tinghong Ye, Shirui Zhu, Yongxia Zhu, Qiang Feng, Bing He, Yiong Xiong, Lifeng Zhao, Yiwen Zhang, Luoting Yu, Li Yang. Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Aug; 82(?):319-26. doi:
10.1016/j.biopha.2016.05.015. [PMID: 27470369] - Hao Ren, Dawei Qian, Shulan Su, Hanliang Guan, Wei Zhang, Erxin Shang, Jinao Duan. Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them.
Drug testing and analysis.
2016 Jul; 8(7):744-54. doi:
10.1002/dta.1840. [PMID: 26382027] - Zuraini Ahmad, Chin Theng Ng, Lai Yen Fong, Nurul Ain Abu Bakar, Nor Hayuti Mohd Hussain, Kok Pian Ang, Gwendoline Cheng Lian Ee, Muhammad Nazrul Hakim. Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro.
The journal of physiological sciences : JPS.
2016 May; 66(3):213-20. doi:
10.1007/s12576-015-0410-7. [PMID: 26732386] - Man Wang, Jiaqin Wang, Yue Zhang, Qian Xia, Wentao Bi, Xiaodi Yang, David Da Yong Chen. Fast environment-friendly ball mill-assisted deep eutectic solvent-based extraction of natural products.
Journal of chromatography. A.
2016 Apr; 1443(?):262-6. doi:
10.1016/j.chroma.2016.03.061. [PMID: 27033981] - Barnabas Oche, Lu Chen, Ya-Ke Ma, Yue Yang, Chun-Xiao Li, Xiao Geng, Li-Zhen Qiu, Xiu-Mei Gao, Hong Wang. Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ.
Archives of pharmacal research.
2016 Feb; 39(2):249-258. doi:
10.1007/s12272-015-0671-y. [PMID: 26481132] - Naimur Rahman, Miso Jeon, Ho-Yeon Song, Yong-Sik Kim. Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Jan; 23(1):58-67. doi:
10.1016/j.phymed.2015.12.004. [PMID: 26902408]
