Temocaprilat (BioDeep_00000008631)

 

Secondary id: BioDeep_00000015451

human metabolite


代谢物信息卡片


(2S)-2-{[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid

化学式: C21H24N2O5S2 (448.1126574)
中文名称: 替卡普里拉特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(SCC(C(=O)N1CC(=O)O)NC(CCC2=CC=CC=C2)C(=O)O)C3=CC=CS3
InChI: InChI=1S/C21H24N2O5S2/c24-19(25)12-23-11-18(17-7-4-10-29-17)30-13-16(20(23)26)22-15(21(27)28)9-8-14-5-2-1-3-6-14/h1-7,10,15-16,18,22H,8-9,11-13H2,(H,24,25)(H,27,28)

描述信息

Temocaprilat belongs to the class of organic compounds known as phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.

同义名列表

4 个代谢物同义名

(2S)-2-{[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid; temocaprilate; Temocaprilat; RS 5139



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kazuya Maeda, Ichiro Ieiri, Kuninobu Yasuda, Akiharu Fujino, Hiroaki Fujiwara, Kenji Otsubo, Masaru Hirano, Takao Watanabe, Yoshiaki Kitamura, Hiroyuki Kusuhara, Yuichi Sugiyama. Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril. Clinical pharmacology and therapeutics. 2006 May; 79(5):427-39. doi: 10.1016/j.clpt.2006.01.011. [PMID: 16678545]
  • Yukiko Takada, Hidetaka Tachizawa, Hiroko Kurihara, Motoe Takayanagi, Takahiro Sasamoto, Masahiro Akashi, Mitsuhiko Aiso, Yoriyuki Takamori, Naoyo Sano, Hajime Takikawa. Comparison of urinary excretion of pravastatin and temocapril in bile duct-ligated rats and Eisai hyperbilirubinemic rats (EHBR). Journal of hepato-biliary-pancreatic surgery. 2004; 11(2):125-8. doi: 10.1007/s00534-003-0872-5. [PMID: 15127276]
  • Toshio Miyata, Charles van Ypersele de Strihou, Yasuhiko Ueda, Kohji Ichimori, Reiko Inagi, Hiroshi Onogi, Naoyoshi Ishikawa, Masaomi Nangaku, Kiyoshi Kurokawa. Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms. Journal of the American Society of Nephrology : JASN. 2002 Oct; 13(10):2478-87. doi: 10.1097/01.asn.0000032418.67267.f2. [PMID: 12239236]
  • H Nagashima, Y Sakomura, Y Aoka, K Uto, Kameyama Ki, M Ogawa, S Aomi, H Koyanagi, N Ishizuka, M Naruse, M Kawana, H Kasanuki. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis in cystic medial degeneration associated with Marfan's syndrome. Circulation. 2001 Sep; 104(12 Suppl 1):I282-7. doi: 10.1161/hc37t1.094856. [PMID: 11568070]
  • K Püchler, B Sierakowski, I Roots. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. British journal of clinical pharmacology. 1998 Oct; 46(4):363-7. doi: 10.1046/j.1365-2125.1998.t01-1-00785.x. [PMID: 9803985]
  • K Püchler, K M Eckl, L Fritsche, K Renneisen, H H Neumayer, B Sierakowski, A T Lavrijssen, T Thomsen, I Roots. Pharmacokinetics of temocapril and temocaprilat after 14 once daily oral doses of temocapril in hypertensive patients with varying degrees of renal impairment. British journal of clinical pharmacology. 1997 Dec; 44(6):531-6. doi: 10.1046/j.1365-2125.1997.t01-1-00622.x. [PMID: 9431827]
  • H Shioya, M Shimojo, Y Kawahara. Enzyme immunoassay of the active metabolite (RS-5139) of angiotensin converting enzyme inhibitor (CS-622). Journal of immunoassay. 1991; 12(1):15-28. doi: 10.1080/01971529108055054. [PMID: 2040710]